Kinetoplast-associated_protein_3_putative/GeneDB: LmjF.32.3780

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein 3, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ITR1_LEIDO

TriTrypDb:

LdBPK_323930.1 , LdCL_320045300 , LDHU3_32.5060

Length:

136

Annotations

Annotations by Jardim et al.

Kinetoplastid proteins, kinetoplast DNA-associated

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8ITR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.502
CLV_NRD_NRD_1	113	115	PF00675	0.486
CLV_NRD_NRD_1	123	125	PF00675	0.480
CLV_NRD_NRD_1	3	5	PF00675	0.444
CLV_NRD_NRD_1	34	36	PF00675	0.374
CLV_NRD_NRD_1	48	50	PF00675	0.333
CLV_NRD_NRD_1	57	59	PF00675	0.304
CLV_NRD_NRD_1	87	89	PF00675	0.568
CLV_NRD_NRD_1	9	11	PF00675	0.296
CLV_PCSK_FUR_1	55	59	PF00082	0.340
CLV_PCSK_KEX2_1	110	112	PF00082	0.474
CLV_PCSK_KEX2_1	123	125	PF00082	0.644
CLV_PCSK_KEX2_1	3	5	PF00082	0.444
CLV_PCSK_KEX2_1	57	59	PF00082	0.324
CLV_PCSK_KEX2_1	9	11	PF00082	0.296
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.474
CLV_PCSK_SKI1_1	107	111	PF00082	0.453
CLV_PCSK_SKI1_1	115	119	PF00082	0.485
CLV_PCSK_SKI1_1	124	128	PF00082	0.508
CLV_PCSK_SKI1_1	28	32	PF00082	0.608
CLV_PCSK_SKI1_1	4	8	PF00082	0.628
CLV_PCSK_SKI1_1	49	53	PF00082	0.318
CLV_PCSK_SKI1_1	57	61	PF00082	0.338
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DOC_CKS1_1	44	49	PF01111	0.335
DOC_MAPK_gen_1	98	105	PF00069	0.358
DOC_PP2B_LxvP_1	79	82	PF13499	0.341
DOC_USP7_MATH_1	122	126	PF00917	0.501
DOC_USP7_UBL2_3	115	119	PF12436	0.483
DOC_USP7_UBL2_3	128	132	PF12436	0.524
DOC_WW_Pin1_4	43	48	PF00397	0.443
DOC_WW_Pin1_4	9	14	PF00397	0.324
LIG_14-3-3_CanoR_1	123	127	PF00244	0.672
LIG_14-3-3_CanoR_1	3	9	PF00244	0.510
LIG_14-3-3_CanoR_1	35	41	PF00244	0.342
LIG_14-3-3_CanoR_1	57	62	PF00244	0.436
LIG_Actin_WH2_2	14	30	PF00022	0.301
LIG_FHA_1	100	106	PF00498	0.370
LIG_FHA_1	22	28	PF00498	0.359
LIG_LIR_Gen_1	12	21	PF02991	0.317
LIG_LIR_Gen_1	65	75	PF02991	0.298
LIG_LIR_Nem_3	12	17	PF02991	0.313
LIG_LIR_Nem_3	60	64	PF02991	0.341
LIG_LIR_Nem_3	65	70	PF02991	0.298
LIG_LYPXL_yS_3	61	64	PF13949	0.336
LIG_PCNA_PIPBox_1	87	96	PF02747	0.300
LIG_PCNA_yPIPBox_3	84	94	PF02747	0.313
LIG_SH2_CRK	41	45	PF00017	0.336
LIG_SH3_3	100	106	PF00018	0.370
LIG_SH3_3	27	33	PF00018	0.308
LIG_SH3_3	56	62	PF00018	0.329
LIG_TYR_ITIM	59	64	PF00017	0.332
MOD_CDK_SPxK_1	43	49	PF00069	0.438
MOD_CDK_SPxxK_3	43	50	PF00069	0.342
MOD_CK1_1	12	18	PF00069	0.315
MOD_CK1_1	42	48	PF00069	0.333
MOD_CK2_1	42	48	PF00069	0.369
MOD_GlcNHglycan	107	110	PF01048	0.493
MOD_GlcNHglycan	133	136	PF01048	0.525
MOD_GlcNHglycan	36	39	PF01048	0.391
MOD_GSK3_1	122	129	PF00069	0.502
MOD_GSK3_1	39	46	PF00069	0.329
MOD_N-GLC_1	99	104	PF02516	0.360
MOD_NEK2_1	2	7	PF00069	0.552
MOD_NEK2_1	21	26	PF00069	0.312
MOD_PKA_1	57	63	PF00069	0.335
MOD_PKA_2	122	128	PF00069	0.503
MOD_PKA_2	2	8	PF00069	0.432
MOD_PKA_2	34	40	PF00069	0.338
MOD_PKA_2	57	63	PF00069	0.339
MOD_PKB_1	55	63	PF00069	0.362
MOD_ProDKin_1	43	49	PF00069	0.442
MOD_ProDKin_1	9	15	PF00069	0.327
MOD_SUMO_rev_2	42	52	PF00179	0.343
TRG_ENDOCYTIC_2	41	44	PF00928	0.338
TRG_ENDOCYTIC_2	61	64	PF00928	0.246
TRG_ENDOCYTIC_2	67	70	PF00928	0.290
TRG_ER_diArg_1	122	124	PF00400	0.468
TRG_ER_diArg_1	2	4	PF00400	0.454
TRG_ER_diArg_1	55	58	PF00400	0.325
TRG_ER_diArg_1	8	10	PF00400	0.337
TRG_ER_diLys_1	131	136	PF00400	0.483
TRG_NLS_Bipartite_1	118	135	PF00514	0.452
TRG_NLS_Bipartite_1	98	115	PF00514	0.435
TRG_NLS_MonoExtC_3	109	114	PF00514	0.470
TRG_NLS_MonoExtC_3	117	122	PF00514	0.452
TRG_NLS_MonoExtN_4	107	114	PF00514	0.464
TRG_NLS_MonoExtN_4	115	122	PF00514	0.449
TRG_NLS_MonoExtN_4	128	135	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIB3	Leptomonas seymouri	64%	100%
A0A1X0NSD7	Trypanosomatidae	42%	75%
A0A3Q8IGK7	Leishmania donovani	38%	100%
A0A422P329	Trypanosoma rangeli	46%	71%
A4HL14	Leishmania braziliensis	35%	100%
A4HL15	Leishmania braziliensis	80%	100%
A4I8J5	Leishmania infantum	38%	100%
A4I8J6	Leishmania infantum	100%	100%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4P4	Leishmania major	94%	100%
Q4Q4P5	Leishmania major	37%	100%
Q8IS98	Crithidia fasciculata	63%	100%
Q9TY83	Crithidia fasciculata	33%	100%
Q9TY84	Crithidia fasciculata	33%	100%