Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITJ0_LEIDO

TriTrypDb:

LdBPK_323000.1 , LdCL_320036000 , LDHU3_32.3780

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.777
CLV_NRD_NRD_1	323	325	PF00675	0.741
CLV_NRD_NRD_1	392	394	PF00675	0.681
CLV_NRD_NRD_1	721	723	PF00675	0.643
CLV_NRD_NRD_1	744	746	PF00675	0.666
CLV_PCSK_KEX2_1	323	325	PF00082	0.741
CLV_PCSK_KEX2_1	392	394	PF00082	0.681
CLV_PCSK_KEX2_1	721	723	PF00082	0.643
CLV_PCSK_KEX2_1	744	746	PF00082	0.597
CLV_PCSK_KEX2_1	91	93	PF00082	0.556
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.556
CLV_PCSK_SKI1_1	323	327	PF00082	0.732
CLV_PCSK_SKI1_1	377	381	PF00082	0.650
CLV_PCSK_SKI1_1	384	388	PF00082	0.562
CLV_PCSK_SKI1_1	468	472	PF00082	0.535
CLV_PCSK_SKI1_1	477	481	PF00082	0.549
CLV_PCSK_SKI1_1	88	92	PF00082	0.668
CLV_PCSK_SKI1_1	96	100	PF00082	0.537
DEG_SCF_FBW7_1	447	454	PF00400	0.758
DEG_SPOP_SBC_1	363	367	PF00917	0.832
DEG_SPOP_SBC_1	446	450	PF00917	0.833
DOC_CKS1_1	511	516	PF01111	0.598
DOC_MAPK_gen_1	473	481	PF00069	0.545
DOC_PP1_RVXF_1	133	140	PF00149	0.692
DOC_PP2B_LxvP_1	552	555	PF13499	0.600
DOC_PP4_FxxP_1	585	588	PF00568	0.483
DOC_USP7_MATH_1	126	130	PF00917	0.668
DOC_USP7_MATH_1	195	199	PF00917	0.717
DOC_USP7_MATH_1	230	234	PF00917	0.806
DOC_USP7_MATH_1	283	287	PF00917	0.805
DOC_USP7_MATH_1	295	299	PF00917	0.531
DOC_USP7_MATH_1	330	334	PF00917	0.552
DOC_USP7_MATH_1	362	366	PF00917	0.796
DOC_USP7_MATH_1	439	443	PF00917	0.812
DOC_USP7_MATH_1	451	455	PF00917	0.661
DOC_USP7_MATH_1	59	63	PF00917	0.653
DOC_USP7_MATH_1	734	738	PF00917	0.556
DOC_WW_Pin1_4	180	185	PF00397	0.793
DOC_WW_Pin1_4	248	253	PF00397	0.762
DOC_WW_Pin1_4	258	263	PF00397	0.656
DOC_WW_Pin1_4	401	406	PF00397	0.729
DOC_WW_Pin1_4	429	434	PF00397	0.723
DOC_WW_Pin1_4	447	452	PF00397	0.561
DOC_WW_Pin1_4	5	10	PF00397	0.826
DOC_WW_Pin1_4	510	515	PF00397	0.597
DOC_WW_Pin1_4	565	570	PF00397	0.545
DOC_WW_Pin1_4	74	79	PF00397	0.748
LIG_14-3-3_CanoR_1	218	222	PF00244	0.702
LIG_14-3-3_CanoR_1	287	293	PF00244	0.706
LIG_14-3-3_CanoR_1	377	383	PF00244	0.773
LIG_14-3-3_CanoR_1	412	417	PF00244	0.815
LIG_14-3-3_CanoR_1	438	447	PF00244	0.759
LIG_14-3-3_CanoR_1	556	560	PF00244	0.551
LIG_14-3-3_CanoR_1	606	610	PF00244	0.608
LIG_14-3-3_CanoR_1	683	692	PF00244	0.518
LIG_14-3-3_CanoR_1	744	750	PF00244	0.639
LIG_14-3-3_CanoR_1	92	98	PF00244	0.554
LIG_AP2alpha_2	70	72	PF02296	0.658
LIG_BIR_III_2	239	243	PF00653	0.759
LIG_BIR_III_4	279	283	PF00653	0.750
LIG_BRCT_BRCA1_1	231	235	PF00533	0.810
LIG_FHA_1	132	138	PF00498	0.772
LIG_FHA_1	189	195	PF00498	0.729
LIG_FHA_1	209	215	PF00498	0.470
LIG_FHA_1	249	255	PF00498	0.838
LIG_FHA_1	305	311	PF00498	0.604
LIG_FHA_1	430	436	PF00498	0.681
LIG_FHA_1	447	453	PF00498	0.730
LIG_FHA_1	488	494	PF00498	0.578
LIG_FHA_1	510	516	PF00498	0.576
LIG_FHA_1	530	536	PF00498	0.357
LIG_FHA_1	547	553	PF00498	0.670
LIG_FHA_1	730	736	PF00498	0.659
LIG_FHA_2	106	112	PF00498	0.556
LIG_FHA_2	274	280	PF00498	0.828
LIG_FHA_2	365	371	PF00498	0.757
LIG_FHA_2	413	419	PF00498	0.833
LIG_FHA_2	420	426	PF00498	0.747
LIG_FHA_2	92	98	PF00498	0.654
LIG_LIR_Gen_1	111	120	PF02991	0.651
LIG_LIR_Gen_1	378	387	PF02991	0.614
LIG_LIR_Gen_1	44	51	PF02991	0.553
LIG_LIR_Gen_1	549	559	PF02991	0.586
LIG_LIR_Gen_1	70	79	PF02991	0.746
LIG_LIR_Gen_1	704	714	PF02991	0.539
LIG_LIR_Nem_3	111	116	PF02991	0.740
LIG_LIR_Nem_3	378	382	PF02991	0.622
LIG_LIR_Nem_3	44	48	PF02991	0.525
LIG_LIR_Nem_3	549	554	PF02991	0.597
LIG_LIR_Nem_3	608	614	PF02991	0.508
LIG_LIR_Nem_3	70	75	PF02991	0.672
LIG_LIR_Nem_3	702	708	PF02991	0.556
LIG_NRBOX	518	524	PF00104	0.657
LIG_REV1ctd_RIR_1	495	504	PF16727	0.566
LIG_SH2_GRB2like	115	118	PF00017	0.682
LIG_SH2_SRC	115	118	PF00017	0.760
LIG_SH2_STAT3	693	696	PF00017	0.555
LIG_SH2_STAT5	115	118	PF00017	0.760
LIG_SH2_STAT5	27	30	PF00017	0.749
LIG_SH2_STAT5	551	554	PF00017	0.666
LIG_SH2_STAT5	678	681	PF00017	0.670
LIG_SH2_STAT5	693	696	PF00017	0.414
LIG_SH3_3	239	245	PF00018	0.814
LIG_SH3_3	542	548	PF00018	0.572
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.587
LIG_SUMO_SIM_par_1	210	215	PF11976	0.688
LIG_SUMO_SIM_par_1	253	259	PF11976	0.821
LIG_SUMO_SIM_par_1	306	311	PF11976	0.668
LIG_SUMO_SIM_par_1	531	537	PF11976	0.689
LIG_SUMO_SIM_par_1	635	640	PF11976	0.628
LIG_TRAF2_1	256	259	PF00917	0.737
LIG_TRAF2_1	653	656	PF00917	0.755
LIG_TYR_ITSM	547	554	PF00017	0.689
LIG_WRC_WIRS_1	376	381	PF05994	0.676
LIG_WW_1	690	693	PF00397	0.609
MOD_CDK_SPK_2	429	434	PF00069	0.793
MOD_CK1_1	157	163	PF00069	0.731
MOD_CK1_1	198	204	PF00069	0.648
MOD_CK1_1	228	234	PF00069	0.819
MOD_CK1_1	261	267	PF00069	0.693
MOD_CK1_1	281	287	PF00069	0.553
MOD_CK1_1	378	384	PF00069	0.654
MOD_CK1_1	419	425	PF00069	0.730
MOD_CK1_1	442	448	PF00069	0.814
MOD_CK1_1	5	11	PF00069	0.826
MOD_CK1_1	63	69	PF00069	0.597
MOD_CK2_1	253	259	PF00069	0.744
MOD_CK2_1	362	368	PF00069	0.672
MOD_CK2_1	412	418	PF00069	0.789
MOD_CK2_1	419	425	PF00069	0.727
MOD_CK2_1	695	701	PF00069	0.602
MOD_CK2_1	79	85	PF00069	0.523
MOD_CK2_1	91	97	PF00069	0.524
MOD_GlcNHglycan	128	131	PF01048	0.714
MOD_GlcNHglycan	156	159	PF01048	0.619
MOD_GlcNHglycan	176	179	PF01048	0.854
MOD_GlcNHglycan	196	200	PF01048	0.588
MOD_GlcNHglycan	227	230	PF01048	0.805
MOD_GlcNHglycan	278	283	PF01048	0.709
MOD_GlcNHglycan	292	295	PF01048	0.608
MOD_GlcNHglycan	297	300	PF01048	0.570
MOD_GlcNHglycan	352	356	PF01048	0.744
MOD_GlcNHglycan	441	444	PF01048	0.840
MOD_GlcNHglycan	52	55	PF01048	0.589
MOD_GlcNHglycan	525	529	PF01048	0.543
MOD_GlcNHglycan	570	573	PF01048	0.594
MOD_GlcNHglycan	697	700	PF01048	0.717
MOD_GlcNHglycan	736	739	PF01048	0.603
MOD_GSK3_1	1	8	PF00069	0.832
MOD_GSK3_1	197	204	PF00069	0.603
MOD_GSK3_1	225	232	PF00069	0.803
MOD_GSK3_1	27	34	PF00069	0.733
MOD_GSK3_1	278	285	PF00069	0.717
MOD_GSK3_1	330	337	PF00069	0.659
MOD_GSK3_1	362	369	PF00069	0.817
MOD_GSK3_1	401	408	PF00069	0.734
MOD_GSK3_1	412	419	PF00069	0.712
MOD_GSK3_1	429	436	PF00069	0.742
MOD_GSK3_1	441	448	PF00069	0.843
MOD_GSK3_1	568	575	PF00069	0.488
MOD_GSK3_1	59	66	PF00069	0.650
MOD_GSK3_1	637	644	PF00069	0.573
MOD_GSK3_1	695	702	PF00069	0.598
MOD_GSK3_1	70	77	PF00069	0.670
MOD_GSK3_1	740	747	PF00069	0.519
MOD_N-GLC_1	154	159	PF02516	0.727
MOD_N-GLC_1	699	704	PF02516	0.639
MOD_N-GLC_2	658	660	PF02516	0.532
MOD_NEK2_1	105	110	PF00069	0.667
MOD_NEK2_1	197	202	PF00069	0.748
MOD_NEK2_1	217	222	PF00069	0.528
MOD_NEK2_1	288	293	PF00069	0.698
MOD_NEK2_1	351	356	PF00069	0.765
MOD_NEK2_1	41	46	PF00069	0.543
MOD_NEK2_1	488	493	PF00069	0.663
MOD_NEK2_1	523	528	PF00069	0.559
MOD_NEK2_1	570	575	PF00069	0.536
MOD_NEK2_1	637	642	PF00069	0.713
MOD_NEK2_1	713	718	PF00069	0.707
MOD_NEK2_2	133	138	PF00069	0.801
MOD_NEK2_2	665	670	PF00069	0.705
MOD_PIKK_1	451	457	PF00454	0.838
MOD_PIKK_1	546	552	PF00454	0.685
MOD_PIKK_1	622	628	PF00454	0.504
MOD_PIKK_1	713	719	PF00454	0.610
MOD_PIKK_1	729	735	PF00454	0.650
MOD_PKA_1	744	750	PF00069	0.579
MOD_PKA_1	91	97	PF00069	0.539
MOD_PKA_2	173	179	PF00069	0.648
MOD_PKA_2	201	207	PF00069	0.686
MOD_PKA_2	217	223	PF00069	0.632
MOD_PKA_2	433	439	PF00069	0.738
MOD_PKA_2	555	561	PF00069	0.546
MOD_PKA_2	605	611	PF00069	0.652
MOD_PKA_2	622	628	PF00069	0.353
MOD_PKA_2	744	750	PF00069	0.546
MOD_PKA_2	91	97	PF00069	0.560
MOD_PKB_1	47	55	PF00069	0.663
MOD_Plk_1	105	111	PF00069	0.556
MOD_Plk_1	21	27	PF00069	0.669
MOD_Plk_1	488	494	PF00069	0.663
MOD_Plk_1	524	530	PF00069	0.645
MOD_Plk_1	665	671	PF00069	0.650
MOD_Plk_1	699	705	PF00069	0.603
MOD_Plk_2-3	701	707	PF00069	0.633
MOD_Plk_4	488	494	PF00069	0.663
MOD_Plk_4	701	707	PF00069	0.633
MOD_ProDKin_1	180	186	PF00069	0.791
MOD_ProDKin_1	248	254	PF00069	0.761
MOD_ProDKin_1	258	264	PF00069	0.650
MOD_ProDKin_1	401	407	PF00069	0.726
MOD_ProDKin_1	429	435	PF00069	0.722
MOD_ProDKin_1	447	453	PF00069	0.560
MOD_ProDKin_1	5	11	PF00069	0.826
MOD_ProDKin_1	510	516	PF00069	0.598
MOD_ProDKin_1	565	571	PF00069	0.546
MOD_ProDKin_1	74	80	PF00069	0.745
MOD_SUMO_for_1	600	603	PF00179	0.604
TRG_DiLeu_BaEn_1	525	530	PF01217	0.567
TRG_DiLeu_BaEn_2	466	472	PF01217	0.648
TRG_ENDOCYTIC_2	551	554	PF00928	0.586
TRG_ER_diArg_1	392	394	PF00400	0.681
TRG_ER_diArg_1	472	475	PF00400	0.537
TRG_ER_diArg_1	720	722	PF00400	0.647
TRG_NES_CRM1_1	97	111	PF08389	0.660
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.669
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B7	Leptomonas seymouri	45%	100%
A4HKS7	Leishmania braziliensis	75%	99%
A4I8A7	Leishmania infantum	100%	100%
E9B365	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4Y9	Leishmania major	95%	100%