Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ITE5_LEIDO

TriTrypDb:

LdBPK_322450.1 , LdCL_320029800 , LDHU3_32.3040

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.768
CLV_C14_Caspase3-7	65	69	PF00656	0.488
CLV_NRD_NRD_1	118	120	PF00675	0.738
CLV_NRD_NRD_1	152	154	PF00675	0.766
CLV_NRD_NRD_1	272	274	PF00675	0.674
CLV_NRD_NRD_1	34	36	PF00675	0.660
CLV_NRD_NRD_1	414	416	PF00675	0.795
CLV_NRD_NRD_1	423	425	PF00675	0.721
CLV_NRD_NRD_1	56	58	PF00675	0.503
CLV_NRD_NRD_1	71	73	PF00675	0.509
CLV_NRD_NRD_1	96	98	PF00675	0.664
CLV_PCSK_FUR_1	54	58	PF00082	0.469
CLV_PCSK_KEX2_1	118	120	PF00082	0.734
CLV_PCSK_KEX2_1	152	154	PF00082	0.766
CLV_PCSK_KEX2_1	247	249	PF00082	0.659
CLV_PCSK_KEX2_1	34	36	PF00082	0.660
CLV_PCSK_KEX2_1	346	348	PF00082	0.797
CLV_PCSK_KEX2_1	414	416	PF00082	0.754
CLV_PCSK_KEX2_1	423	425	PF00082	0.682
CLV_PCSK_KEX2_1	56	58	PF00082	0.606
CLV_PCSK_KEX2_1	71	73	PF00082	0.534
CLV_PCSK_KEX2_1	96	98	PF00082	0.664
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.659
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.797
CLV_PCSK_PC7_1	30	36	PF00082	0.659
CLV_PCSK_SKI1_1	153	157	PF00082	0.752
CLV_PCSK_SKI1_1	205	209	PF00082	0.763
CLV_PCSK_SKI1_1	226	230	PF00082	0.772
CLV_PCSK_SKI1_1	332	336	PF00082	0.779
CLV_PCSK_SKI1_1	96	100	PF00082	0.656
DEG_SIAH_1	119	127	PF03145	0.623
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.770
DOC_MAPK_DCC_7	396	405	PF00069	0.766
DOC_MAPK_gen_1	171	180	PF00069	0.688
DOC_MAPK_gen_1	244	251	PF00069	0.750
DOC_MAPK_gen_1	396	405	PF00069	0.828
DOC_PP1_RVXF_1	245	252	PF00149	0.810
DOC_PP2B_LxvP_1	399	402	PF13499	0.763
DOC_USP7_MATH_1	131	135	PF00917	0.669
DOC_USP7_MATH_1	136	140	PF00917	0.590
DOC_USP7_MATH_1	206	210	PF00917	0.602
DOC_USP7_MATH_1	224	228	PF00917	0.701
DOC_USP7_MATH_1	284	288	PF00917	0.754
DOC_USP7_MATH_1	330	334	PF00917	0.783
DOC_USP7_MATH_1	356	360	PF00917	0.679
DOC_WW_Pin1_4	127	132	PF00397	0.755
DOC_WW_Pin1_4	209	214	PF00397	0.723
DOC_WW_Pin1_4	216	221	PF00397	0.655
DOC_WW_Pin1_4	239	244	PF00397	0.824
DOC_WW_Pin1_4	357	362	PF00397	0.846
DOC_WW_Pin1_4	386	391	PF00397	0.708
DOC_WW_Pin1_4	404	409	PF00397	0.774
LIG_14-3-3_CanoR_1	273	277	PF00244	0.640
LIG_14-3-3_CanoR_1	332	337	PF00244	0.679
LIG_14-3-3_CanoR_1	423	427	PF00244	0.838
LIG_BRCT_BRCA1_1	321	325	PF00533	0.722
LIG_CSL_BTD_1	221	224	PF09270	0.624
LIG_FHA_1	173	179	PF00498	0.588
LIG_FHA_1	324	330	PF00498	0.819
LIG_FHA_1	34	40	PF00498	0.654
LIG_FHA_2	23	29	PF00498	0.653
LIG_FHA_2	431	437	PF00498	0.726
LIG_FHA_2	63	69	PF00498	0.594
LIG_LIR_Gen_1	254	265	PF02991	0.755
LIG_LIR_Nem_3	254	260	PF02991	0.754
LIG_LIR_Nem_3	9	15	PF02991	0.502
LIG_Rb_LxCxE_1	38	59	PF01857	0.535
LIG_SH2_CRK	12	16	PF00017	0.541
LIG_SH2_GRB2like	392	395	PF00017	0.713
LIG_SH3_1	218	224	PF00018	0.627
LIG_SH3_2	114	119	PF14604	0.723
LIG_SH3_2	221	226	PF14604	0.626
LIG_SH3_3	111	117	PF00018	0.702
LIG_SH3_3	120	126	PF00018	0.623
LIG_SH3_3	207	213	PF00018	0.794
LIG_SH3_3	217	223	PF00018	0.803
LIG_SH3_3	287	293	PF00018	0.685
LIG_SUMO_SIM_par_1	401	407	PF11976	0.773
LIG_TRAF2_1	7	10	PF00917	0.663
LIG_TRAF2_1	88	91	PF00917	0.657
LIG_UBA3_1	166	173	PF00899	0.675
MOD_CDC14_SPxK_1	360	363	PF00782	0.856
MOD_CDK_SPK_2	239	244	PF00069	0.664
MOD_CDK_SPK_2	404	409	PF00069	0.774
MOD_CDK_SPxK_1	357	363	PF00069	0.850
MOD_CDK_SPxxK_3	239	246	PF00069	0.724
MOD_CK1_1	209	215	PF00069	0.766
MOD_CK1_1	407	413	PF00069	0.832
MOD_CK1_1	418	424	PF00069	0.834
MOD_CK2_1	183	189	PF00069	0.618
MOD_CK2_1	239	245	PF00069	0.726
MOD_CK2_1	4	10	PF00069	0.680
MOD_CK2_1	430	436	PF00069	0.726
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.611
MOD_GlcNHglycan	133	136	PF01048	0.668
MOD_GlcNHglycan	140	143	PF01048	0.711
MOD_GlcNHglycan	144	147	PF01048	0.660
MOD_GlcNHglycan	286	289	PF01048	0.704
MOD_GlcNHglycan	293	296	PF01048	0.674
MOD_GlcNHglycan	321	324	PF01048	0.735
MOD_GlcNHglycan	332	335	PF01048	0.654
MOD_GlcNHglycan	382	385	PF01048	0.837
MOD_GlcNHglycan	409	412	PF01048	0.853
MOD_GlcNHglycan	418	421	PF01048	0.766
MOD_GlcNHglycan	6	9	PF01048	0.674
MOD_GSK3_1	127	134	PF00069	0.810
MOD_GSK3_1	136	143	PF00069	0.648
MOD_GSK3_1	180	187	PF00069	0.623
MOD_GSK3_1	205	212	PF00069	0.651
MOD_GSK3_1	222	229	PF00069	0.639
MOD_GSK3_1	291	298	PF00069	0.610
MOD_GSK3_1	311	318	PF00069	0.820
MOD_GSK3_1	319	326	PF00069	0.712
MOD_GSK3_1	328	335	PF00069	0.526
MOD_GSK3_1	348	355	PF00069	0.635
MOD_GSK3_1	386	393	PF00069	0.706
MOD_GSK3_1	415	422	PF00069	0.769
MOD_GSK3_1	427	434	PF00069	0.643
MOD_N-GLC_1	295	300	PF02516	0.745
MOD_N-GLC_1	311	316	PF02516	0.597
MOD_N-GLC_1	415	420	PF02516	0.784
MOD_N-GLC_2	307	309	PF02516	0.747
MOD_NEK2_2	159	164	PF00069	0.420
MOD_NEK2_2	323	328	PF00069	0.824
MOD_PIKK_1	22	28	PF00454	0.587
MOD_PIKK_1	315	321	PF00454	0.787
MOD_PIKK_1	354	360	PF00454	0.732
MOD_PIKK_1	62	68	PF00454	0.594
MOD_PKA_2	194	200	PF00069	0.749
MOD_PKA_2	258	264	PF00069	0.799
MOD_PKA_2	269	275	PF00069	0.618
MOD_PKA_2	319	325	PF00069	0.683
MOD_PKA_2	33	39	PF00069	0.654
MOD_PKA_2	348	354	PF00069	0.648
MOD_PKA_2	422	428	PF00069	0.826
MOD_PKA_2	430	436	PF00069	0.688
MOD_PKA_2	82	88	PF00069	0.674
MOD_Plk_1	153	159	PF00069	0.788
MOD_Plk_1	295	301	PF00069	0.736
MOD_Plk_4	153	159	PF00069	0.788
MOD_Plk_4	206	212	PF00069	0.811
MOD_Plk_4	272	278	PF00069	0.730
MOD_Plk_4	332	338	PF00069	0.620
MOD_ProDKin_1	127	133	PF00069	0.754
MOD_ProDKin_1	209	215	PF00069	0.726
MOD_ProDKin_1	216	222	PF00069	0.656
MOD_ProDKin_1	239	245	PF00069	0.824
MOD_ProDKin_1	357	363	PF00069	0.850
MOD_ProDKin_1	386	392	PF00069	0.709
MOD_ProDKin_1	404	410	PF00069	0.775
MOD_SUMO_rev_2	241	249	PF00179	0.805
TRG_DiLeu_BaEn_1	10	15	PF01217	0.653
TRG_ENDOCYTIC_2	12	15	PF00928	0.653
TRG_ER_diArg_1	117	119	PF00400	0.791
TRG_ER_diArg_1	151	153	PF00400	0.755
TRG_ER_diArg_1	347	350	PF00400	0.594
TRG_ER_diArg_1	396	399	PF00400	0.575
TRG_ER_diArg_1	54	57	PF00400	0.480
TRG_ER_diArg_1	71	73	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKM1	Leishmania braziliensis	61%	100%
A4I853	Leishmania infantum	99%	100%
E9B310	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q545	Leishmania major	85%	100%