RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)_putative/Pfam:PF00076

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ITD1_LEIDO

TriTrypDb:

LdBPK_322260.1 , LdCL_320028000 , LDHU3_32.2820

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8ITD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITD1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.773
CLV_NRD_NRD_1	256	258	PF00675	0.699
CLV_NRD_NRD_1	316	318	PF00675	0.816
CLV_NRD_NRD_1	386	388	PF00675	0.618
CLV_NRD_NRD_1	67	69	PF00675	0.343
CLV_PCSK_KEX2_1	112	114	PF00082	0.670
CLV_PCSK_KEX2_1	220	222	PF00082	0.616
CLV_PCSK_KEX2_1	256	258	PF00082	0.625
CLV_PCSK_KEX2_1	318	320	PF00082	0.805
CLV_PCSK_KEX2_1	395	397	PF00082	0.592
CLV_PCSK_KEX2_1	67	69	PF00082	0.331
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.670
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.616
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.805
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.634
CLV_PCSK_PC7_1	314	320	PF00082	0.776
CLV_PCSK_SKI1_1	220	224	PF00082	0.511
CLV_PCSK_SKI1_1	302	306	PF00082	0.707
CLV_PCSK_SKI1_1	369	373	PF00082	0.541
CLV_PCSK_SKI1_1	395	399	PF00082	0.635
DEG_APCC_DBOX_1	241	249	PF00400	0.601
DEG_APCC_DBOX_1	386	394	PF00400	0.545
DEG_COP1_1	374	384	PF00400	0.650
DEG_Nend_UBRbox_2	1	3	PF02207	0.687
DEG_SCF_FBW7_1	281	288	PF00400	0.722
DEG_SCF_FBW7_2	342	349	PF00400	0.746
DEG_SPOP_SBC_1	84	88	PF00917	0.680
DOC_CKS1_1	273	278	PF01111	0.741
DOC_CKS1_1	282	287	PF01111	0.695
DOC_CKS1_1	343	348	PF01111	0.753
DOC_CYCLIN_RxL_1	206	214	PF00134	0.489
DOC_CYCLIN_RxL_1	392	401	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	340	343	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.746
DOC_MAPK_gen_1	165	173	PF00069	0.608
DOC_PP2B_LxvP_1	340	343	PF13499	0.626
DOC_USP7_MATH_1	105	109	PF00917	0.743
DOC_USP7_MATH_1	121	125	PF00917	0.597
DOC_USP7_MATH_1	127	131	PF00917	0.600
DOC_USP7_MATH_1	146	150	PF00917	0.739
DOC_USP7_MATH_1	228	232	PF00917	0.566
DOC_USP7_MATH_1	244	248	PF00917	0.523
DOC_USP7_MATH_1	252	256	PF00917	0.636
DOC_USP7_MATH_1	274	278	PF00917	0.775
DOC_USP7_MATH_1	307	311	PF00917	0.703
DOC_USP7_MATH_1	322	326	PF00917	0.527
DOC_USP7_MATH_1	331	335	PF00917	0.787
DOC_USP7_MATH_1	83	87	PF00917	0.556
DOC_USP7_UBL2_3	301	305	PF12436	0.784
DOC_WW_Pin1_4	117	122	PF00397	0.650
DOC_WW_Pin1_4	267	272	PF00397	0.764
DOC_WW_Pin1_4	281	286	PF00397	0.630
DOC_WW_Pin1_4	293	298	PF00397	0.632
DOC_WW_Pin1_4	342	347	PF00397	0.740
LIG_14-3-3_CanoR_1	175	180	PF00244	0.617
LIG_14-3-3_CanoR_1	194	202	PF00244	0.345
LIG_14-3-3_CanoR_1	369	374	PF00244	0.543
LIG_14-3-3_CanoR_1	4	8	PF00244	0.655
LIG_14-3-3_CanoR_1	85	90	PF00244	0.715
LIG_BRCT_BRCA1_1	8	12	PF00533	0.456
LIG_FHA_1	176	182	PF00498	0.556
LIG_FHA_1	336	342	PF00498	0.780
LIG_FHA_2	319	325	PF00498	0.739
LIG_FHA_2	346	352	PF00498	0.675
LIG_FHA_2	59	65	PF00498	0.561
LIG_FHA_2	71	77	PF00498	0.561
LIG_LIR_Apic_2	116	121	PF02991	0.695
LIG_LIR_Gen_1	199	210	PF02991	0.478
LIG_LIR_Gen_1	37	45	PF02991	0.537
LIG_LIR_Gen_1	377	385	PF02991	0.604
LIG_LIR_Nem_3	10	16	PF02991	0.440
LIG_LIR_Nem_3	170	176	PF02991	0.638
LIG_LIR_Nem_3	199	205	PF02991	0.469
LIG_LIR_Nem_3	37	41	PF02991	0.470
LIG_LIR_Nem_3	377	381	PF02991	0.598
LIG_MLH1_MIPbox_1	9	13	PF16413	0.437
LIG_SH2_NCK_1	202	206	PF00017	0.474
LIG_SH2_STAT5	177	180	PF00017	0.474
LIG_SH3_1	111	117	PF00018	0.728
LIG_SH3_3	111	117	PF00018	0.779
LIG_SH3_3	265	271	PF00018	0.794
LIG_SH3_3	277	283	PF00018	0.600
LIG_SH3_3	286	292	PF00018	0.712
LIG_SH3_3	340	346	PF00018	0.759
LIG_SH3_3	378	384	PF00018	0.683
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.444
LIG_SUMO_SIM_anti_2	353	361	PF11976	0.567
LIG_SUMO_SIM_par_1	209	214	PF11976	0.493
LIG_TRAF2_1	197	200	PF00917	0.561
LIG_TRAF2_1	61	64	PF00917	0.490
LIG_WRC_WIRS_1	35	40	PF05994	0.543
LIG_WW_2	280	283	PF00397	0.580
MOD_CDK_SPxK_1	295	301	PF00069	0.583
MOD_CDK_SPxxK_3	295	302	PF00069	0.603
MOD_CK1_1	120	126	PF00069	0.796
MOD_CK1_1	325	331	PF00069	0.718
MOD_CK1_1	336	342	PF00069	0.674
MOD_CK1_1	6	12	PF00069	0.496
MOD_CK2_1	200	206	PF00069	0.610
MOD_CK2_1	318	324	PF00069	0.740
MOD_CK2_1	345	351	PF00069	0.651
MOD_CK2_1	358	364	PF00069	0.564
MOD_CK2_1	58	64	PF00069	0.490
MOD_CK2_1	70	76	PF00069	0.490
MOD_GlcNHglycan	101	104	PF01048	0.753
MOD_GlcNHglycan	129	132	PF01048	0.746
MOD_GlcNHglycan	202	205	PF01048	0.624
MOD_GlcNHglycan	230	233	PF01048	0.552
MOD_GlcNHglycan	305	308	PF01048	0.767
MOD_GlcNHglycan	309	312	PF01048	0.778
MOD_GlcNHglycan	324	327	PF01048	0.798
MOD_GlcNHglycan	328	331	PF01048	0.768
MOD_GlcNHglycan	333	336	PF01048	0.757
MOD_GlcNHglycan	373	376	PF01048	0.631
MOD_GSK3_1	117	124	PF00069	0.795
MOD_GSK3_1	155	162	PF00069	0.734
MOD_GSK3_1	281	288	PF00069	0.777
MOD_GSK3_1	3	10	PF00069	0.543
MOD_GSK3_1	303	310	PF00069	0.806
MOD_GSK3_1	318	325	PF00069	0.628
MOD_GSK3_1	331	338	PF00069	0.606
MOD_GSK3_1	341	348	PF00069	0.614
MOD_GSK3_1	79	86	PF00069	0.539
MOD_N-GLC_1	121	126	PF02516	0.800
MOD_NEK2_1	358	363	PF00069	0.651
MOD_NEK2_1	371	376	PF00069	0.583
MOD_NEK2_1	69	74	PF00069	0.494
MOD_NEK2_1	79	84	PF00069	0.481
MOD_PIKK_1	146	152	PF00454	0.658
MOD_PIKK_1	155	161	PF00454	0.661
MOD_PIKK_1	333	339	PF00454	0.742
MOD_PIKK_1	398	404	PF00454	0.582
MOD_PKA_1	318	324	PF00069	0.769
MOD_PKA_2	167	173	PF00069	0.630
MOD_PKA_2	3	9	PF00069	0.615
MOD_PKA_2	318	324	PF00069	0.749
MOD_PKA_2	79	85	PF00069	0.593
MOD_Plk_1	105	111	PF00069	0.731
MOD_Plk_2-3	70	76	PF00069	0.591
MOD_Plk_4	14	20	PF00069	0.341
MOD_Plk_4	184	190	PF00069	0.533
MOD_Plk_4	336	342	PF00069	0.806
MOD_Plk_4	7	13	PF00069	0.445
MOD_ProDKin_1	117	123	PF00069	0.649
MOD_ProDKin_1	267	273	PF00069	0.767
MOD_ProDKin_1	281	287	PF00069	0.634
MOD_ProDKin_1	293	299	PF00069	0.630
MOD_ProDKin_1	342	348	PF00069	0.732
MOD_SUMO_for_1	300	303	PF00179	0.742
MOD_SUMO_rev_2	214	222	PF00179	0.641
TRG_DiLeu_BaEn_1	218	223	PF01217	0.495
TRG_DiLeu_BaEn_1	354	359	PF01217	0.650
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.495
TRG_DiLeu_LyEn_5	218	223	PF01217	0.597
TRG_ENDOCYTIC_2	202	205	PF00928	0.468
TRG_ER_diArg_1	110	113	PF00400	0.775
TRG_ER_diArg_1	66	68	PF00400	0.561
TRG_NLS_MonoExtC_3	110	115	PF00514	0.814
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N7	Leptomonas seymouri	57%	100%
A0A1X0NU71	Trypanosomatidae	33%	100%
A0A3R7KNF2	Trypanosoma rangeli	34%	100%
A4HKK3	Leishmania braziliensis	83%	100%
A4I835	Leishmania infantum	100%	100%
E9B2Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q563	Leishmania major	94%	100%
V5BKQ1	Trypanosoma cruzi	38%	100%