Phosphatidylethanolamine-binding protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolamine-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8ITB2_LEIDO

TriTrypDb:

LdBPK_321850.1 , LdCL_320024000 , LDHU3_32.2340

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITB2

PDB structure(s): 7aih_X , 7ane_X

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.585
CLV_NRD_NRD_1	148	150	PF00675	0.401
CLV_NRD_NRD_1	2	4	PF00675	0.574
CLV_NRD_NRD_1	247	249	PF00675	0.730
CLV_NRD_NRD_1	48	50	PF00675	0.486
CLV_NRD_NRD_1	498	500	PF00675	0.476
CLV_PCSK_KEX2_1	2	4	PF00082	0.574
CLV_PCSK_KEX2_1	498	500	PF00082	0.476
CLV_PCSK_SKI1_1	2	6	PF00082	0.686
CLV_PCSK_SKI1_1	283	287	PF00082	0.397
CLV_PCSK_SKI1_1	352	356	PF00082	0.591
CLV_PCSK_SKI1_1	72	76	PF00082	0.391
DEG_MDM2_SWIB_1	414	422	PF02201	0.342
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DOC_ANK_TNKS_1	460	467	PF00023	0.438
DOC_CKS1_1	89	94	PF01111	0.360
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.480
DOC_MAPK_FxFP_2	66	69	PF00069	0.416
DOC_MAPK_FxFP_2	80	83	PF00069	0.402
DOC_MAPK_JIP1_4	452	458	PF00069	0.439
DOC_PP1_RVXF_1	490	497	PF00149	0.592
DOC_PP2B_LxvP_1	294	297	PF13499	0.480
DOC_PP2B_LxvP_1	97	100	PF13499	0.491
DOC_PP4_FxxP_1	66	69	PF00568	0.416
DOC_PP4_FxxP_1	80	83	PF00568	0.402
DOC_USP7_MATH_1	232	236	PF00917	0.676
DOC_USP7_MATH_1	366	370	PF00917	0.459
DOC_USP7_MATH_1	387	391	PF00917	0.601
DOC_USP7_MATH_1	464	468	PF00917	0.468
DOC_USP7_MATH_1	482	486	PF00917	0.456
DOC_WW_Pin1_4	131	136	PF00397	0.581
DOC_WW_Pin1_4	196	201	PF00397	0.555
DOC_WW_Pin1_4	262	267	PF00397	0.318
DOC_WW_Pin1_4	88	93	PF00397	0.355
DOC_WW_Pin1_4	95	100	PF00397	0.507
LIG_14-3-3_CanoR_1	248	258	PF00244	0.442
LIG_14-3-3_CanoR_1	498	503	PF00244	0.566
LIG_APCC_ABBA_1	224	229	PF00400	0.371
LIG_BRCT_BRCA1_1	167	171	PF00533	0.331
LIG_deltaCOP1_diTrp_1	23	30	PF00928	0.672
LIG_EVH1_1	117	121	PF00568	0.425
LIG_EVH1_2	221	225	PF00568	0.394
LIG_EVH1_2	99	103	PF00568	0.420
LIG_FHA_1	308	314	PF00498	0.494
LIG_FHA_1	333	339	PF00498	0.380
LIG_FHA_1	343	349	PF00498	0.408
LIG_FHA_1	89	95	PF00498	0.368
LIG_FHA_2	108	114	PF00498	0.524
LIG_FHA_2	353	359	PF00498	0.498
LIG_FHA_2	414	420	PF00498	0.356
LIG_FHA_2	85	91	PF00498	0.509
LIG_LIR_Apic_2	23	28	PF02991	0.648
LIG_LIR_Apic_2	267	273	PF02991	0.395
LIG_LIR_Apic_2	65	69	PF02991	0.414
LIG_LIR_Apic_2	77	83	PF02991	0.406
LIG_LIR_Gen_1	260	269	PF02991	0.357
LIG_LIR_Gen_1	424	434	PF02991	0.515
LIG_LIR_Gen_1	447	456	PF02991	0.538
LIG_LIR_Nem_3	102	106	PF02991	0.405
LIG_LIR_Nem_3	115	120	PF02991	0.410
LIG_LIR_Nem_3	260	264	PF02991	0.354
LIG_LIR_Nem_3	424	429	PF02991	0.505
LIG_LIR_Nem_3	81	85	PF02991	0.535
LIG_LYPXL_yS_3	117	120	PF13949	0.406
LIG_Pex14_2	103	107	PF04695	0.409
LIG_Pex14_2	414	418	PF04695	0.339
LIG_REV1ctd_RIR_1	411	421	PF16727	0.356
LIG_SH2_CRK	25	29	PF00017	0.584
LIG_SH2_CRK	259	263	PF00017	0.318
LIG_SH2_CRK	270	274	PF00017	0.403
LIG_SH2_GRB2like	106	109	PF00017	0.407
LIG_SH2_NCK_1	426	430	PF00017	0.487
LIG_SH2_PTP2	323	326	PF00017	0.379
LIG_SH2_SRC	157	160	PF00017	0.417
LIG_SH2_STAP1	20	24	PF00017	0.680
LIG_SH2_STAP1	259	263	PF00017	0.318
LIG_SH2_STAP1	70	74	PF00017	0.403
LIG_SH2_STAP1	85	89	PF00017	0.383
LIG_SH2_STAT5	147	150	PF00017	0.356
LIG_SH2_STAT5	157	160	PF00017	0.382
LIG_SH2_STAT5	259	262	PF00017	0.320
LIG_SH2_STAT5	323	326	PF00017	0.363
LIG_SH3_2	266	271	PF14604	0.358
LIG_SH3_3	115	121	PF00018	0.445
LIG_SH3_3	124	130	PF00018	0.387
LIG_SH3_3	166	172	PF00018	0.349
LIG_SH3_3	187	193	PF00018	0.482
LIG_SH3_3	215	221	PF00018	0.383
LIG_SH3_3	263	269	PF00018	0.347
LIG_SH3_3	316	322	PF00018	0.397
LIG_SH3_3	402	408	PF00018	0.380
LIG_SH3_3	426	432	PF00018	0.451
LIG_SH3_3	506	512	PF00018	0.560
LIG_TRAF2_1	356	359	PF00917	0.547
LIG_TRFH_1	95	99	PF08558	0.493
LIG_TYR_ITSM	113	120	PF00017	0.505
LIG_UBA3_1	144	150	PF00899	0.486
LIG_WRC_WIRS_1	258	263	PF05994	0.442
MOD_CDK_SPK_2	131	136	PF00069	0.462
MOD_CDK_SPK_2	196	201	PF00069	0.545
MOD_CK1_1	131	137	PF00069	0.515
MOD_CK1_1	235	241	PF00069	0.702
MOD_CK1_1	375	381	PF00069	0.639
MOD_CK1_1	497	503	PF00069	0.512
MOD_CK2_1	107	113	PF00069	0.439
MOD_CK2_1	352	358	PF00069	0.589
MOD_CK2_1	75	81	PF00069	0.549
MOD_GlcNHglycan	234	237	PF01048	0.659
MOD_GlcNHglycan	374	377	PF01048	0.561
MOD_GlcNHglycan	380	383	PF01048	0.612
MOD_GlcNHglycan	387	390	PF01048	0.598
MOD_GSK3_1	244	251	PF00069	0.713
MOD_GSK3_1	29	36	PF00069	0.551
MOD_GSK3_1	409	416	PF00069	0.347
MOD_GSK3_1	482	489	PF00069	0.470
MOD_GSK3_1	494	501	PF00069	0.512
MOD_GSK3_1	5	12	PF00069	0.677
MOD_GSK3_1	84	91	PF00069	0.472
MOD_LATS_1	350	356	PF00433	0.455
MOD_N-GLC_1	107	112	PF02516	0.385
MOD_N-GLC_1	165	170	PF02516	0.332
MOD_N-GLC_1	95	100	PF02516	0.465
MOD_NEK2_1	112	117	PF00069	0.427
MOD_NEK2_1	203	208	PF00069	0.340
MOD_NEK2_1	342	347	PF00069	0.434
MOD_NEK2_1	413	418	PF00069	0.355
MOD_NEK2_1	486	491	PF00069	0.477
MOD_NEK2_1	494	499	PF00069	0.532
MOD_NEK2_1	75	80	PF00069	0.438
MOD_NEK2_2	393	398	PF00069	0.486
MOD_NEK2_2	409	414	PF00069	0.369
MOD_PIKK_1	129	135	PF00454	0.525
MOD_PIKK_1	29	35	PF00454	0.672
MOD_PKA_1	248	254	PF00069	0.696
MOD_PKA_1	498	504	PF00069	0.558
MOD_PKA_2	179	185	PF00069	0.573
MOD_PKA_2	497	503	PF00069	0.473
MOD_Plk_1	112	118	PF00069	0.422
MOD_Plk_1	165	171	PF00069	0.342
MOD_Plk_1	70	76	PF00069	0.415
MOD_Plk_4	165	171	PF00069	0.365
MOD_Plk_4	220	226	PF00069	0.361
MOD_Plk_4	257	263	PF00069	0.334
MOD_Plk_4	409	415	PF00069	0.337
MOD_Plk_4	70	76	PF00069	0.397
MOD_ProDKin_1	131	137	PF00069	0.571
MOD_ProDKin_1	196	202	PF00069	0.546
MOD_ProDKin_1	262	268	PF00069	0.322
MOD_ProDKin_1	88	94	PF00069	0.360
MOD_ProDKin_1	95	101	PF00069	0.508
MOD_SUMO_rev_2	43	51	PF00179	0.481
TRG_DiLeu_BaEn_1	441	446	PF01217	0.558
TRG_ENDOCYTIC_2	117	120	PF00928	0.434
TRG_ENDOCYTIC_2	212	215	PF00928	0.343
TRG_ENDOCYTIC_2	258	261	PF00928	0.334
TRG_ENDOCYTIC_2	426	429	PF00928	0.516
TRG_ER_diArg_1	1	3	PF00400	0.568
TRG_ER_diArg_1	178	181	PF00400	0.454
TRG_ER_diArg_1	456	459	PF00400	0.458
TRG_ER_diArg_1	461	464	PF00400	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF7	Leptomonas seymouri	74%	100%
A0A0S4JIJ2	Bodo saltans	45%	100%
A0A1X0NW02	Trypanosomatidae	60%	100%
A0A422NH53	Trypanosoma rangeli	61%	100%
A4HKG4	Leishmania braziliensis	86%	100%
A4I7Z2	Leishmania infantum	100%	100%
D0AA60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B2V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5A3	Leishmania major	94%	100%
V5BP31	Trypanosoma cruzi	60%	100%