Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IT90_LEIDO

TriTrypDb:

LdBPK_321480.1 , LdCL_320020500 , LDHU3_32.1870

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IT90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.548
CLV_C14_Caspase3-7	458	462	PF00656	0.426
CLV_C14_Caspase3-7	518	522	PF00656	0.482
CLV_NRD_NRD_1	385	387	PF00675	0.482
CLV_NRD_NRD_1	48	50	PF00675	0.574
CLV_NRD_NRD_1	548	550	PF00675	0.410
CLV_NRD_NRD_1	687	689	PF00675	0.549
CLV_PCSK_KEX2_1	23	25	PF00082	0.473
CLV_PCSK_KEX2_1	413	415	PF00082	0.460
CLV_PCSK_KEX2_1	420	422	PF00082	0.433
CLV_PCSK_KEX2_1	48	50	PF00082	0.577
CLV_PCSK_KEX2_1	497	499	PF00082	0.526
CLV_PCSK_KEX2_1	548	550	PF00082	0.522
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.497
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.460
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.433
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.491
CLV_PCSK_SKI1_1	17	21	PF00082	0.588
CLV_PCSK_SKI1_1	184	188	PF00082	0.495
CLV_PCSK_SKI1_1	218	222	PF00082	0.429
CLV_PCSK_SKI1_1	318	322	PF00082	0.592
CLV_PCSK_SKI1_1	414	418	PF00082	0.597
CLV_PCSK_SKI1_1	527	531	PF00082	0.419
CLV_PCSK_SKI1_1	589	593	PF00082	0.513
CLV_PCSK_SKI1_1	643	647	PF00082	0.386
DEG_APCC_DBOX_1	91	99	PF00400	0.592
DOC_CKS1_1	274	279	PF01111	0.453
DOC_CYCLIN_RxL_1	215	224	PF00134	0.427
DOC_CYCLIN_RxL_1	613	625	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.465
DOC_MAPK_gen_1	670	679	PF00069	0.538
DOC_MAPK_MEF2A_6	255	264	PF00069	0.510
DOC_PP1_RVXF_1	15	22	PF00149	0.443
DOC_PP1_RVXF_1	379	386	PF00149	0.421
DOC_PP2B_LxvP_1	321	324	PF13499	0.688
DOC_PP2B_LxvP_1	512	515	PF13499	0.457
DOC_USP7_MATH_1	105	109	PF00917	0.663
DOC_USP7_MATH_1	110	114	PF00917	0.705
DOC_USP7_MATH_1	150	154	PF00917	0.568
DOC_USP7_MATH_1	156	160	PF00917	0.512
DOC_USP7_MATH_1	403	407	PF00917	0.613
DOC_USP7_MATH_1	515	519	PF00917	0.551
DOC_USP7_MATH_1	571	575	PF00917	0.450
DOC_USP7_MATH_1	620	624	PF00917	0.539
DOC_USP7_MATH_1	653	657	PF00917	0.491
DOC_WW_Pin1_4	126	131	PF00397	0.660
DOC_WW_Pin1_4	273	278	PF00397	0.414
DOC_WW_Pin1_4	482	487	PF00397	0.687
DOC_WW_Pin1_4	57	62	PF00397	0.616
LIG_14-3-3_CanoR_1	107	117	PF00244	0.562
LIG_14-3-3_CanoR_1	166	171	PF00244	0.495
LIG_14-3-3_CanoR_1	503	507	PF00244	0.457
LIG_14-3-3_CanoR_1	527	536	PF00244	0.457
LIG_14-3-3_CanoR_1	583	589	PF00244	0.490
LIG_14-3-3_CanoR_1	634	639	PF00244	0.490
LIG_14-3-3_CanoR_1	643	651	PF00244	0.387
LIG_Actin_WH2_2	428	445	PF00022	0.505
LIG_BRCT_BRCA1_1	605	609	PF00533	0.377
LIG_CaM_IQ_9	77	92	PF13499	0.593
LIG_Clathr_ClatBox_1	608	612	PF01394	0.361
LIG_EH1_1	3	11	PF00400	0.551
LIG_eIF4E_1	363	369	PF01652	0.527
LIG_FHA_1	127	133	PF00498	0.633
LIG_FHA_1	14	20	PF00498	0.610
LIG_FHA_1	274	280	PF00498	0.401
LIG_FHA_1	33	39	PF00498	0.567
LIG_FHA_1	455	461	PF00498	0.572
LIG_FHA_1	506	512	PF00498	0.492
LIG_FHA_1	538	544	PF00498	0.383
LIG_FHA_1	58	64	PF00498	0.591
LIG_FHA_1	623	629	PF00498	0.425
LIG_FHA_2	155	161	PF00498	0.543
LIG_FHA_2	405	411	PF00498	0.546
LIG_FHA_2	526	532	PF00498	0.449
LIG_FHA_2	585	591	PF00498	0.454
LIG_LIR_Gen_1	185	196	PF02991	0.462
LIG_LIR_Gen_1	540	547	PF02991	0.461
LIG_LIR_Gen_1	623	632	PF02991	0.436
LIG_LIR_Nem_3	185	191	PF02991	0.413
LIG_LIR_Nem_3	390	396	PF02991	0.566
LIG_LIR_Nem_3	540	545	PF02991	0.463
LIG_LIR_Nem_3	623	629	PF02991	0.437
LIG_NRBOX	506	512	PF00104	0.492
LIG_Pex14_2	271	275	PF04695	0.411
LIG_RPA_C_Fungi	629	641	PF08784	0.468
LIG_RPA_C_Fungi	665	677	PF08784	0.356
LIG_SH2_CRK	133	137	PF00017	0.643
LIG_SH2_CRK	33	37	PF00017	0.505
LIG_SH2_CRK	345	349	PF00017	0.331
LIG_SH2_CRK	626	630	PF00017	0.470
LIG_SH2_GRB2like	207	210	PF00017	0.513
LIG_SH2_NCK_1	170	174	PF00017	0.399
LIG_SH2_NCK_1	33	37	PF00017	0.549
LIG_SH2_SRC	343	346	PF00017	0.488
LIG_SH2_STAP1	292	296	PF00017	0.415
LIG_SH2_STAT3	207	210	PF00017	0.513
LIG_SH2_STAT5	207	210	PF00017	0.438
LIG_SH2_STAT5	233	236	PF00017	0.395
LIG_SH2_STAT5	33	36	PF00017	0.589
LIG_SH2_STAT5	343	346	PF00017	0.552
LIG_SH2_STAT5	363	366	PF00017	0.506
LIG_SH2_STAT5	395	398	PF00017	0.523
LIG_SH2_STAT5	578	581	PF00017	0.477
LIG_SH2_STAT5	79	82	PF00017	0.556
LIG_SH3_1	133	139	PF00018	0.580
LIG_SH3_2	136	141	PF14604	0.577
LIG_SH3_3	133	139	PF00018	0.582
LIG_SH3_3	24	30	PF00018	0.640
LIG_SH3_3	344	350	PF00018	0.382
LIG_SUMO_SIM_par_1	113	121	PF11976	0.526
LIG_SUMO_SIM_par_1	659	665	PF11976	0.373
LIG_TRAF2_1	158	161	PF00917	0.445
LIG_TRFH_1	440	444	PF08558	0.510
LIG_UBA3_1	379	387	PF00899	0.484
LIG_UBA3_1	9	17	PF00899	0.554
LIG_WRC_WIRS_1	268	273	PF05994	0.342
MOD_CDK_SPK_2	482	487	PF00069	0.623
MOD_CK1_1	108	114	PF00069	0.748
MOD_CK1_1	121	127	PF00069	0.537
MOD_CK1_1	154	160	PF00069	0.541
MOD_CK1_1	270	276	PF00069	0.456
MOD_CK1_1	359	365	PF00069	0.448
MOD_CK1_1	401	407	PF00069	0.645
MOD_CK1_1	59	65	PF00069	0.678
MOD_CK2_1	154	160	PF00069	0.440
MOD_CK2_1	168	174	PF00069	0.418
MOD_CK2_1	525	531	PF00069	0.487
MOD_CK2_1	584	590	PF00069	0.476
MOD_CK2_1	651	657	PF00069	0.473
MOD_CK2_1	681	687	PF00069	0.656
MOD_GlcNHglycan	106	110	PF01048	0.694
MOD_GlcNHglycan	112	115	PF01048	0.453
MOD_GlcNHglycan	358	361	PF01048	0.506
MOD_GlcNHglycan	373	376	PF01048	0.356
MOD_GlcNHglycan	400	403	PF01048	0.578
MOD_GlcNHglycan	426	429	PF01048	0.688
MOD_GlcNHglycan	444	447	PF01048	0.427
MOD_GlcNHglycan	492	495	PF01048	0.631
MOD_GlcNHglycan	500	503	PF01048	0.515
MOD_GlcNHglycan	605	608	PF01048	0.370
MOD_GlcNHglycan	99	102	PF01048	0.670
MOD_GSK3_1	150	157	PF00069	0.462
MOD_GSK3_1	216	223	PF00069	0.418
MOD_GSK3_1	397	404	PF00069	0.536
MOD_GSK3_1	498	505	PF00069	0.474
MOD_GSK3_1	537	544	PF00069	0.412
MOD_GSK3_1	567	574	PF00069	0.482
MOD_GSK3_1	630	637	PF00069	0.457
MOD_N-GLC_1	221	226	PF02516	0.526
MOD_NEK2_1	12	17	PF00069	0.557
MOD_NEK2_1	220	225	PF00069	0.463
MOD_NEK2_1	327	332	PF00069	0.682
MOD_NEK2_1	396	401	PF00069	0.385
MOD_NEK2_1	470	475	PF00069	0.618
MOD_NEK2_1	480	485	PF00069	0.515
MOD_NEK2_1	492	497	PF00069	0.455
MOD_NEK2_1	520	525	PF00069	0.436
MOD_NEK2_1	621	626	PF00069	0.450
MOD_NEK2_1	630	635	PF00069	0.363
MOD_NEK2_2	584	589	PF00069	0.368
MOD_PIKK_1	121	127	PF00454	0.658
MOD_PIKK_1	270	276	PF00454	0.466
MOD_PIKK_1	302	308	PF00454	0.592
MOD_PIKK_1	310	316	PF00454	0.578
MOD_PIKK_1	40	46	PF00454	0.574
MOD_PIKK_1	537	543	PF00454	0.460
MOD_PKA_2	327	333	PF00069	0.593
MOD_PKA_2	442	448	PF00069	0.497
MOD_PKA_2	502	508	PF00069	0.358
MOD_Plk_1	520	526	PF00069	0.420
MOD_Plk_4	359	365	PF00069	0.464
MOD_Plk_4	448	454	PF00069	0.382
MOD_Plk_4	502	508	PF00069	0.358
MOD_Plk_4	520	526	PF00069	0.423
MOD_Plk_4	541	547	PF00069	0.386
MOD_Plk_4	59	65	PF00069	0.648
MOD_Plk_4	675	681	PF00069	0.529
MOD_ProDKin_1	126	132	PF00069	0.660
MOD_ProDKin_1	273	279	PF00069	0.407
MOD_ProDKin_1	482	488	PF00069	0.680
MOD_ProDKin_1	57	63	PF00069	0.617
MOD_SUMO_rev_2	684	690	PF00179	0.520
TRG_DiLeu_BaEn_1	73	78	PF01217	0.564
TRG_DiLeu_BaEn_1	94	99	PF01217	0.630
TRG_DiLeu_BaEn_4	73	79	PF01217	0.606
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.529
TRG_ENDOCYTIC_2	233	236	PF00928	0.481
TRG_ENDOCYTIC_2	33	36	PF00928	0.531
TRG_ENDOCYTIC_2	345	348	PF00928	0.362
TRG_ENDOCYTIC_2	626	629	PF00928	0.421
TRG_ER_diArg_1	440	443	PF00400	0.509
TRG_ER_diArg_1	547	549	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE35	Leptomonas seymouri	57%	100%
A0A1X0NVV3	Trypanosomatidae	34%	100%
A4I7V9	Leishmania infantum	100%	100%
D0AA22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AIV0	Leishmania braziliensis	76%	100%
E9B2R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5E0	Leishmania major	88%	100%
V5BJJ3	Trypanosoma cruzi	35%	100%