LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
long chain polyunsaturated fatty acid elongation enzyme-like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IT78_LEIDO
TriTrypDb:
LdBPK_321220.1 , LdCL_320017900 , LDHU3_32.1580
Length:
381

Annotations

LeishMANIAdb annotations

Related to ELOVL5 proteins found in multicellular animals. Probably also involved in very long chain fatty acid biosynthesis in ER.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3Q8IT78
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT78

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 10
GO:0006629 lipid metabolic process 3 10
GO:0006631 fatty acid metabolic process 4 10
GO:0006633 fatty acid biosynthetic process 5 10
GO:0008152 metabolic process 1 10
GO:0008610 lipid biosynthetic process 4 10
GO:0009058 biosynthetic process 2 10
GO:0009987 cellular process 1 10
GO:0016053 organic acid biosynthetic process 4 10
GO:0019752 carboxylic acid metabolic process 5 10
GO:0032787 monocarboxylic acid metabolic process 6 10
GO:0043436 oxoacid metabolic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044255 cellular lipid metabolic process 3 10
GO:0044281 small molecule metabolic process 2 10
GO:0044283 small molecule biosynthetic process 3 10
GO:0046394 carboxylic acid biosynthetic process 5 10
GO:0071704 organic substance metabolic process 2 10
GO:0072330 monocarboxylic acid biosynthetic process 6 10
GO:1901576 organic substance biosynthetic process 3 10
GO:0000038 very long-chain fatty acid metabolic process 5 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0019367 fatty acid elongation, saturated fatty acid 7 1
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0030497 fatty acid elongation 6 1
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 1
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 1
GO:0042761 very long-chain fatty acid biosynthetic process 6 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004312 fatty acid synthase activity 5 10
GO:0009922 fatty acid elongase activity 6 10
GO:0016740 transferase activity 2 10
GO:0016746 acyltransferase activity 3 10
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 10
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 34 38 PF00656 0.261
CLV_NRD_NRD_1 309 311 PF00675 0.430
CLV_PCSK_KEX2_1 308 310 PF00082 0.350
CLV_PCSK_KEX2_1 358 360 PF00082 0.395
CLV_PCSK_PC1ET2_1 358 360 PF00082 0.314
CLV_PCSK_SKI1_1 149 153 PF00082 0.406
CLV_PCSK_SKI1_1 178 182 PF00082 0.209
CLV_PCSK_SKI1_1 237 241 PF00082 0.191
DEG_MDM2_SWIB_1 192 200 PF02201 0.331
DEG_Nend_Nbox_1 1 3 PF02207 0.265
DOC_MAPK_MEF2A_6 275 283 PF00069 0.167
DOC_PP1_RVXF_1 150 156 PF00149 0.191
DOC_PP1_RVXF_1 159 166 PF00149 0.217
DOC_PP1_RVXF_1 176 183 PF00149 0.341
DOC_PP1_RVXF_1 42 48 PF00149 0.245
DOC_PP2B_LxvP_1 200 203 PF13499 0.331
DOC_USP7_MATH_1 314 318 PF00917 0.558
DOC_USP7_MATH_1 324 328 PF00917 0.579
DOC_USP7_MATH_1 38 42 PF00917 0.225
DOC_WW_Pin1_4 141 146 PF00397 0.215
LIG_14-3-3_CanoR_1 178 183 PF00244 0.361
LIG_14-3-3_CanoR_1 59 64 PF00244 0.245
LIG_Actin_WH2_2 262 277 PF00022 0.345
LIG_BRCT_BRCA1_1 61 65 PF00533 0.230
LIG_CaMK_CASK_1 265 271 PF00069 0.251
LIG_CSL_BTD_1 267 270 PF09270 0.331
LIG_deltaCOP1_diTrp_1 147 155 PF00928 0.192
LIG_EH1_1 75 83 PF00400 0.263
LIG_eIF4E_1 120 126 PF01652 0.320
LIG_eIF4E_1 224 230 PF01652 0.241
LIG_FHA_1 103 109 PF00498 0.508
LIG_FHA_1 188 194 PF00498 0.306
LIG_FHA_1 261 267 PF00498 0.273
LIG_FHA_1 88 94 PF00498 0.249
LIG_FHA_2 32 38 PF00498 0.400
LIG_GBD_Chelix_1 108 116 PF00786 0.251
LIG_IRF3_LxIS_1 123 128 PF10401 0.331
LIG_LIR_Gen_1 118 127 PF02991 0.271
LIG_LIR_Gen_1 181 186 PF02991 0.414
LIG_LIR_Gen_1 206 217 PF02991 0.206
LIG_LIR_Gen_1 262 270 PF02991 0.360
LIG_LIR_Gen_1 273 284 PF02991 0.328
LIG_LIR_Nem_3 118 123 PF02991 0.271
LIG_LIR_Nem_3 181 185 PF02991 0.391
LIG_LIR_Nem_3 241 246 PF02991 0.415
LIG_LIR_Nem_3 262 267 PF02991 0.285
LIG_LIR_Nem_3 273 279 PF02991 0.255
LIG_MYND_1 70 74 PF01753 0.272
LIG_PCNA_PIPBox_1 288 297 PF02747 0.271
LIG_Pex14_1 253 257 PF04695 0.251
LIG_Pex14_2 192 196 PF04695 0.238
LIG_Pex14_2 53 57 PF04695 0.238
LIG_PTB_Apo_2 299 306 PF02174 0.321
LIG_SH2_CRK 120 124 PF00017 0.309
LIG_SH2_CRK 177 181 PF00017 0.392
LIG_SH2_CRK 276 280 PF00017 0.226
LIG_SH2_CRK 95 99 PF00017 0.415
LIG_SH2_GRB2like 71 74 PF00017 0.267
LIG_SH2_SRC 71 74 PF00017 0.272
LIG_SH2_STAP1 209 213 PF00017 0.272
LIG_SH2_STAP1 264 268 PF00017 0.217
LIG_SH2_STAP1 276 280 PF00017 0.191
LIG_SH2_STAT5 158 161 PF00017 0.217
LIG_SH2_STAT5 225 228 PF00017 0.217
LIG_SH2_STAT5 71 74 PF00017 0.225
LIG_SH2_STAT5 84 87 PF00017 0.211
LIG_SH3_3 264 270 PF00018 0.340
LIG_SH3_3 64 70 PF00018 0.270
LIG_SUMO_SIM_anti_2 167 174 PF11976 0.331
LIG_TRAF2_1 270 273 PF00917 0.194
LIG_TYR_ITIM 274 279 PF00017 0.184
LIG_TYR_ITIM 82 87 PF00017 0.251
LIG_TYR_ITIM 93 98 PF00017 0.181
LIG_UBA3_1 153 161 PF00899 0.238
LIG_UBA3_1 170 174 PF00899 0.238
MOD_CK1_1 102 108 PF00069 0.246
MOD_CK1_1 207 213 PF00069 0.251
MOD_CK2_1 141 147 PF00069 0.331
MOD_GlcNHglycan 127 130 PF01048 0.271
MOD_GlcNHglycan 209 212 PF01048 0.217
MOD_GlcNHglycan 214 217 PF01048 0.217
MOD_GlcNHglycan 23 26 PF01048 0.362
MOD_GlcNHglycan 232 235 PF01048 0.238
MOD_GlcNHglycan 276 279 PF01048 0.255
MOD_GlcNHglycan 316 319 PF01048 0.569
MOD_GSK3_1 115 122 PF00069 0.205
MOD_GSK3_1 27 34 PF00069 0.338
MOD_GSK3_1 320 327 PF00069 0.668
MOD_GSK3_1 370 377 PF00069 0.471
MOD_GSK3_1 83 90 PF00069 0.207
MOD_N-GLC_1 303 308 PF02516 0.378
MOD_NEK2_1 119 124 PF00069 0.226
MOD_NEK2_1 125 130 PF00069 0.246
MOD_NEK2_1 157 162 PF00069 0.217
MOD_NEK2_1 21 26 PF00069 0.519
MOD_NEK2_1 212 217 PF00069 0.260
MOD_NEK2_1 245 250 PF00069 0.253
MOD_NEK2_1 27 32 PF00069 0.392
MOD_NEK2_1 274 279 PF00069 0.310
MOD_NEK2_1 374 379 PF00069 0.469
MOD_NEK2_1 39 44 PF00069 0.222
MOD_NEK2_1 87 92 PF00069 0.272
MOD_NEK2_2 99 104 PF00069 0.308
MOD_Plk_1 39 45 PF00069 0.312
MOD_Plk_4 115 121 PF00069 0.217
MOD_Plk_4 132 138 PF00069 0.217
MOD_Plk_4 165 171 PF00069 0.217
MOD_Plk_4 178 184 PF00069 0.217
MOD_Plk_4 187 193 PF00069 0.196
MOD_Plk_4 196 202 PF00069 0.160
MOD_Plk_4 204 210 PF00069 0.217
MOD_Plk_4 225 231 PF00069 0.229
MOD_Plk_4 77 83 PF00069 0.291
MOD_ProDKin_1 141 147 PF00069 0.251
MOD_SUMO_for_1 349 352 PF00179 0.369
MOD_SUMO_rev_2 272 277 PF00179 0.221
MOD_SUMO_rev_2 352 360 PF00179 0.402
TRG_DiLeu_BaEn_1 356 361 PF01217 0.423
TRG_DiLeu_BaLyEn_6 89 94 PF01217 0.370
TRG_ENDOCYTIC_2 120 123 PF00928 0.309
TRG_ENDOCYTIC_2 177 180 PF00928 0.219
TRG_ENDOCYTIC_2 209 212 PF00928 0.312
TRG_ENDOCYTIC_2 224 227 PF00928 0.203
TRG_ENDOCYTIC_2 264 267 PF00928 0.331
TRG_ENDOCYTIC_2 276 279 PF00928 0.331
TRG_ENDOCYTIC_2 29 32 PF00928 0.313
TRG_ENDOCYTIC_2 84 87 PF00928 0.244
TRG_ENDOCYTIC_2 95 98 PF00928 0.307
TRG_ER_diArg_1 308 310 PF00400 0.474
TRG_ER_diArg_1 58 61 PF00400 0.281

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 30% 100%
A0A0N0P994 Leptomonas seymouri 64% 100%
A0A0S4JCZ3 Bodo saltans 52% 100%
A0A0S4JH58 Bodo saltans 31% 100%
A0A0S4KMP5 Bodo saltans 52% 100%
A0A1X0NUJ4 Trypanosomatidae 55% 100%
A0A3Q8I9X8 Leishmania donovani 24% 100%
A0A3Q8IC05 Leishmania donovani 27% 100%
A4H7M6 Leishmania braziliensis 24% 100%
A4HKA3 Leishmania braziliensis 77% 100%
A4HW12 Leishmania infantum 26% 100%
A4HW18 Leishmania infantum 27% 100%
A4I7T3 Leishmania infantum 99% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B2P1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q5G6 Leishmania major 92% 100%
Q4QFQ9 Leishmania major 27% 100%
Q4QFR5 Leishmania major 24% 100%
Q9EQC4 Mus musculus 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS