LeishMANIAdb
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60S ribosomal protein L18a

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosomal protein L18a
Gene product:
60S ribosomal protein L18a, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IT55_LEIDO
TriTrypDb:
LdBPK_350600.1 , LdCL_320014900 , LDHU3_32.1220 , LDHU3_35.0740
Length:
179

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L18a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 15
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 13
GO:0032991 protein-containing complex 1 14
GO:0043226 organelle 2 14
GO:0043228 non-membrane-bounded organelle 3 14
GO:0043229 intracellular organelle 3 14
GO:0043232 intracellular non-membrane-bounded organelle 4 14
GO:0110165 cellular anatomical entity 1 14
GO:1990904 ribonucleoprotein complex 2 14
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1

Expansion

Sequence features

A0A3Q8IT55
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT55

PDB structure(s): 6az3_R

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 14
GO:0006518 peptide metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009058 biosynthetic process 2 14
GO:0009059 macromolecule biosynthetic process 4 14
GO:0009987 cellular process 1 14
GO:0019538 protein metabolic process 3 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 14
GO:0043043 peptide biosynthetic process 5 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043603 amide metabolic process 3 14
GO:0043604 amide biosynthetic process 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0044249 cellular biosynthetic process 3 14
GO:0044260 obsolete cellular macromolecule metabolic process 3 14
GO:0044271 cellular nitrogen compound biosynthetic process 4 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 14
GO:0005198 structural molecule activity 1 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 156 158 PF00675 0.553
CLV_NRD_NRD_1 161 163 PF00675 0.497
CLV_PCSK_KEX2_1 156 158 PF00082 0.675
CLV_PCSK_KEX2_1 174 176 PF00082 0.414
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.527
CLV_PCSK_SKI1_1 156 160 PF00082 0.500
CLV_PCSK_SKI1_1 165 169 PF00082 0.526
CLV_PCSK_SKI1_1 64 68 PF00082 0.422
CLV_PCSK_SKI1_1 91 95 PF00082 0.533
DEG_APCC_DBOX_1 73 81 PF00400 0.504
DOC_MAPK_gen_1 117 125 PF00069 0.377
DOC_MAPK_gen_1 159 169 PF00069 0.520
DOC_MAPK_gen_1 40 49 PF00069 0.504
DOC_USP7_UBL2_3 159 163 PF12436 0.499
DOC_USP7_UBL2_3 170 174 PF12436 0.514
DOC_USP7_UBL2_3 50 54 PF12436 0.373
DOC_WW_Pin1_4 13 18 PF00397 0.406
LIG_FHA_1 100 106 PF00498 0.439
LIG_FHA_1 88 94 PF00498 0.406
LIG_FHA_2 54 60 PF00498 0.377
LIG_LIR_Gen_1 106 113 PF02991 0.377
LIG_LIR_Nem_3 106 112 PF02991 0.390
LIG_LIR_Nem_3 150 154 PF02991 0.495
LIG_LIR_Nem_3 95 99 PF02991 0.380
LIG_PDZ_Class_2 174 179 PF00595 0.551
LIG_Pex14_2 32 36 PF04695 0.393
LIG_SH2_CRK 144 148 PF00017 0.601
LIG_SH2_CRK 9 13 PF00017 0.393
LIG_SH2_GRB2like 120 123 PF00017 0.413
LIG_SH2_STAP1 89 93 PF00017 0.470
LIG_SH2_STAT3 82 85 PF00017 0.377
LIG_SH2_STAT5 76 79 PF00017 0.492
LIG_SH2_STAT5 89 92 PF00017 0.325
LIG_SH3_3 28 34 PF00018 0.403
MOD_CDK_SPxxK_3 13 20 PF00069 0.437
MOD_CK2_1 13 19 PF00069 0.437
MOD_GSK3_1 99 106 PF00069 0.469
MOD_N-GLC_1 147 152 PF02516 0.555
MOD_PIKK_1 103 109 PF00454 0.377
MOD_PIKK_1 81 87 PF00454 0.377
MOD_PK_1 137 143 PF00069 0.541
MOD_PKA_1 170 176 PF00069 0.525
MOD_Plk_1 147 153 PF00069 0.524
MOD_Plk_4 22 28 PF00069 0.393
MOD_ProDKin_1 13 19 PF00069 0.406
MOD_SUMO_rev_2 130 139 PF00179 0.601
MOD_SUMO_rev_2 62 72 PF00179 0.377
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.524
TRG_ENDOCYTIC_2 109 112 PF00928 0.379
TRG_ENDOCYTIC_2 120 123 PF00928 0.398
TRG_ENDOCYTIC_2 89 92 PF00928 0.394
TRG_ENDOCYTIC_2 9 12 PF00928 0.393
TRG_ER_diArg_1 117 120 PF00400 0.390
TRG_ER_diArg_1 156 158 PF00400 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4J901 Bodo saltans 77% 100%
A0A0S4KR94 Bodo saltans 77% 100%
A0A1D8PLC9 Candida albicans (strain SC5314 / ATCC MYA-2876) 40% 100%
A0A1X0NUM1 Trypanosomatidae 87% 100%
A0A3Q8II03 Leishmania donovani 99% 100%
A0A3R7KWM8 Trypanosoma rangeli 86% 100%
A0A422N9H1 Trypanosoma rangeli 87% 100%
A4HK69 Leishmania braziliensis 98% 100%
A4I7Q4 Leishmania infantum 100% 100%
D0A297 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 85% 100%
E9B2L2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9B5U1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O44480 Caenorhabditis elegans 38% 99%
O57561 Salmo salar 38% 100%
P0CT68 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 100%
P0CT69 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 100%
P0CX23 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P0CX24 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P0DJ18 Tetrahymena thermophila 32% 95%
P41093 Drosophila melanogaster 43% 100%
P51418 Arabidopsis thaliana 37% 100%
P62717 Mus musculus 37% 100%
P62718 Rattus norvegicus 37% 100%
Q02543 Homo sapiens 37% 100%
Q3T003 Bos taurus 37% 100%
Q4Q5J4 Leishmania major 99% 100%
Q54MK8 Dictyostelium discoideum 35% 100%
Q7ZWJ4 Danio rerio 40% 100%
Q8L7K0 Arabidopsis thaliana 37% 100%
Q8WQI7 Spodoptera frugiperda 39% 100%
Q90YU9 Ictalurus punctatus 40% 100%
Q943F3 Oryza sativa subsp. japonica 35% 100%
Q9ATF5 Castanea sativa 39% 100%
Q9LUD4 Arabidopsis thaliana 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS