RNA_binding_protein_putative/GeneDB:LmjF.32.0750

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear RNA binding domain

Species:

Leishmania donovani

UniProt:

A0A3Q8IT45_LEIDO

TriTrypDb:

LdBPK_320790.1 , LdCL_320013500 , LDHU3_32.0990

Length:

235

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IT45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT45

PDB structure(s): 5osg_h

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.533
CLV_NRD_NRD_1	86	88	PF00675	0.283
CLV_PCSK_KEX2_1	86	88	PF00082	0.278
CLV_PCSK_SKI1_1	111	115	PF00082	0.320
CLV_PCSK_SKI1_1	201	205	PF00082	0.735
CLV_PCSK_SKI1_1	79	83	PF00082	0.363
CLV_PCSK_SKI1_1	8	12	PF00082	0.745
CLV_PCSK_SKI1_1	89	93	PF00082	0.316
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.612
DOC_MAPK_gen_1	86	95	PF00069	0.479
DOC_MAPK_MEF2A_6	196	204	PF00069	0.581
DOC_PP2B_LxvP_1	119	122	PF13499	0.651
DOC_PP4_FxxP_1	139	142	PF00568	0.589
DOC_USP7_MATH_1	50	54	PF00917	0.724
DOC_USP7_UBL2_3	11	15	PF12436	0.550
DOC_USP7_UBL2_3	124	128	PF12436	0.600
DOC_USP7_UBL2_3	19	23	PF12436	0.660
DOC_USP7_UBL2_3	33	37	PF12436	0.568
DOC_USP7_UBL2_3	4	8	PF12436	0.687
DOC_WW_Pin1_4	123	128	PF00397	0.608
DOC_WW_Pin1_4	138	143	PF00397	0.647
DOC_WW_Pin1_4	176	181	PF00397	0.613
LIG_14-3-3_CanoR_1	145	154	PF00244	0.536
LIG_14-3-3_CanoR_1	196	201	PF00244	0.608
LIG_APCC_ABBA_1	105	110	PF00400	0.490
LIG_BRCT_BRCA1_1	135	139	PF00533	0.608
LIG_BRCT_BRCA1_1	140	144	PF00533	0.577
LIG_Clathr_ClatBox_1	92	96	PF01394	0.547
LIG_FHA_1	115	121	PF00498	0.534
LIG_FHA_1	197	203	PF00498	0.623
LIG_FHA_1	62	68	PF00498	0.654
LIG_LIR_Apic_2	136	142	PF02991	0.589
LIG_LIR_LC3C_4	117	121	PF02991	0.702
LIG_LIR_Nem_3	155	160	PF02991	0.614
LIG_SH2_CRK	90	94	PF00017	0.479
LIG_SH2_NCK_1	90	94	PF00017	0.479
LIG_SH2_SRC	176	179	PF00017	0.558
LIG_SH2_STAP1	90	94	PF00017	0.479
LIG_SH2_STAT5	176	179	PF00017	0.549
LIG_SH2_STAT5	58	61	PF00017	0.515
LIG_SH3_3	6	12	PF00018	0.773
LIG_SH3_4	11	18	PF00018	0.756
LIG_SH3_4	19	26	PF00018	0.753
LIG_SH3_4	33	40	PF00018	0.737
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.684
LIG_TRAF2_1	214	217	PF00917	0.675
MOD_CDK_SPK_2	123	128	PF00069	0.612
MOD_CDK_SPxxK_3	138	145	PF00069	0.588
MOD_CK1_1	205	211	PF00069	0.577
MOD_CK1_1	51	57	PF00069	0.668
MOD_GlcNHglycan	204	207	PF01048	0.706
MOD_GlcNHglycan	50	53	PF01048	0.734
MOD_GlcNHglycan	74	77	PF01048	0.271
MOD_GlcNHglycan	96	100	PF01048	0.324
MOD_GSK3_1	68	75	PF00069	0.510
MOD_N-GLC_1	133	138	PF02516	0.659
MOD_N-GLC_1	190	195	PF02516	0.563
MOD_NEK2_1	114	119	PF00069	0.565
MOD_NEK2_1	95	100	PF00069	0.524
MOD_PKA_2	144	150	PF00069	0.553
MOD_Plk_1	133	139	PF00069	0.646
MOD_Plk_4	114	120	PF00069	0.504
MOD_ProDKin_1	123	129	PF00069	0.604
MOD_ProDKin_1	138	144	PF00069	0.641
MOD_ProDKin_1	176	182	PF00069	0.614
TRG_ENDOCYTIC_2	174	177	PF00928	0.551
TRG_ENDOCYTIC_2	90	93	PF00928	0.479
TRG_ER_diArg_1	164	167	PF00400	0.512
TRG_ER_diArg_1	212	215	PF00400	0.681
TRG_ER_diArg_1	85	87	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM50	Leptomonas seymouri	85%	100%
A0A0S4JT34	Bodo saltans	61%	100%
A0A1X0NUY5	Trypanosomatidae	68%	100%
A0A3R7KPL2	Trypanosoma rangeli	70%	100%
A4HK56	Leishmania braziliensis	87%	100%
A4I7P2	Leishmania infantum	100%	100%
D0A9U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	90%
D0A9U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	84%
E9B2J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q5K7	Leishmania major	96%	100%