AKAP7_2'5'_RNA_ligase-like_domain/2'-5'_RNA_ligas e_superfamily

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IT33_LEIDO

TriTrypDb:

LdBPK_320680.1 , LdCL_320012300 , LDHU3_32.0840

Length:

282

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IT33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT33

PDB structure(s): 7ane_ar

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	1
GO:0010646	regulation of cell communication	4	1
GO:0010738	regulation of protein kinase A signaling	6	1
GO:0023051	regulation of signaling	3	1
GO:0048583	regulation of response to stimulus	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016874	ligase activity	2	3
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0034237	protein kinase A regulatory subunit binding	4	1
GO:0051018	protein kinase A binding	3	1
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.314
CLV_NRD_NRD_1	46	48	PF00675	0.480
CLV_PCSK_FUR_1	44	48	PF00082	0.456
CLV_PCSK_KEX2_1	195	197	PF00082	0.311
CLV_PCSK_KEX2_1	46	48	PF00082	0.481
CLV_PCSK_SKI1_1	175	179	PF00082	0.252
DEG_APCC_DBOX_1	257	265	PF00400	0.557
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.455
DOC_MAPK_gen_1	10	19	PF00069	0.621
DOC_MAPK_gen_1	195	205	PF00069	0.519
DOC_MAPK_gen_1	68	78	PF00069	0.344
DOC_MAPK_HePTP_8	193	205	PF00069	0.522
DOC_MAPK_MEF2A_6	113	120	PF00069	0.463
DOC_MAPK_MEF2A_6	158	165	PF00069	0.530
DOC_MAPK_MEF2A_6	196	205	PF00069	0.522
DOC_MAPK_MEF2A_6	71	80	PF00069	0.297
DOC_MAPK_MEF2A_6	83	90	PF00069	0.513
DOC_MAPK_NFAT4_5	198	206	PF00069	0.404
DOC_MIT_MIM_1	159	168	PF04212	0.530
DOC_PP1_RVXF_1	13	20	PF00149	0.468
DOC_PP1_RVXF_1	173	179	PF00149	0.452
DOC_PP2B_LxvP_1	107	110	PF13499	0.464
DOC_PP2B_LxvP_1	76	79	PF13499	0.456
DOC_USP7_MATH_1	100	104	PF00917	0.502
DOC_USP7_MATH_1	213	217	PF00917	0.463
DOC_USP7_MATH_1	79	83	PF00917	0.404
DOC_USP7_UBL2_3	265	269	PF12436	0.557
LIG_14-3-3_CanoR_1	10	19	PF00244	0.539
LIG_14-3-3_CanoR_1	29	33	PF00244	0.633
LIG_14-3-3_CanoR_1	50	54	PF00244	0.471
LIG_14-3-3_CanoR_1	59	63	PF00244	0.431
LIG_14-3-3_CanoR_1	83	87	PF00244	0.499
LIG_BRCT_BRCA1_1	95	99	PF00533	0.557
LIG_FHA_1	115	121	PF00498	0.462
LIG_FHA_1	71	77	PF00498	0.314
LIG_FHA_1	83	89	PF00498	0.513
LIG_FHA_2	154	160	PF00498	0.559
LIG_FHA_2	186	192	PF00498	0.557
LIG_GBD_Chelix_1	193	201	PF00786	0.204
LIG_IRF3_LxIS_1	234	241	PF10401	0.502
LIG_LIR_Gen_1	184	194	PF02991	0.493
LIG_LIR_Gen_1	253	264	PF02991	0.471
LIG_LIR_Gen_1	73	81	PF02991	0.445
LIG_LIR_Nem_3	184	190	PF02991	0.509
LIG_LIR_Nem_3	250	254	PF02991	0.492
LIG_LIR_Nem_3	255	259	PF02991	0.493
LIG_LIR_Nem_3	73	78	PF02991	0.451
LIG_MYND_1	106	110	PF01753	0.477
LIG_SH2_CRK	273	277	PF00017	0.513
LIG_SH2_SRC	217	220	PF00017	0.463
LIG_SH2_STAT3	45	48	PF00017	0.554
LIG_SH2_STAT5	18	21	PF00017	0.441
LIG_SH2_STAT5	217	220	PF00017	0.462
LIG_WRC_WIRS_1	168	173	PF05994	0.463
MOD_CK1_1	52	58	PF00069	0.495
MOD_CK1_1	67	73	PF00069	0.402
MOD_CK1_1	82	88	PF00069	0.496
MOD_CK2_1	153	159	PF00069	0.535
MOD_CK2_1	31	37	PF00069	0.552
MOD_GlcNHglycan	133	136	PF01048	0.302
MOD_GlcNHglycan	277	280	PF01048	0.204
MOD_GlcNHglycan	33	36	PF01048	0.650
MOD_GSK3_1	185	192	PF00069	0.506
MOD_GSK3_1	48	55	PF00069	0.463
MOD_GSK3_1	66	73	PF00069	0.404
MOD_N-GLC_1	100	105	PF02516	0.302
MOD_NEK2_1	114	119	PF00069	0.460
MOD_NEK2_1	49	54	PF00069	0.510
MOD_NEK2_1	93	98	PF00069	0.547
MOD_NEK2_2	153	158	PF00069	0.502
MOD_PIKK_1	226	232	PF00454	0.479
MOD_PKA_2	226	232	PF00069	0.509
MOD_PKA_2	28	34	PF00069	0.656
MOD_PKA_2	49	55	PF00069	0.458
MOD_PKA_2	58	64	PF00069	0.410
MOD_PKA_2	67	73	PF00069	0.319
MOD_PKA_2	82	88	PF00069	0.498
MOD_Plk_1	100	106	PF00069	0.553
MOD_Plk_1	252	258	PF00069	0.452
MOD_Plk_4	189	195	PF00069	0.544
MOD_Plk_4	213	219	PF00069	0.463
MOD_Plk_4	49	55	PF00069	0.571
MOD_Plk_4	93	99	PF00069	0.544
MOD_SUMO_for_1	264	267	PF00179	0.549
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.477
TRG_ENDOCYTIC_2	18	21	PF00928	0.441
TRG_ENDOCYTIC_2	272	275	PF00928	0.513
TRG_ER_diArg_1	194	196	PF00400	0.513
TRG_ER_diArg_1	45	47	PF00400	0.459
TRG_ER_diArg_1	86	89	PF00400	0.513
TRG_ER_diArg_1	9	12	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P807	Leptomonas seymouri	71%	97%
A0A0S4KLM6	Bodo saltans	38%	99%
A0A1X0NUR0	Trypanosomatidae	56%	100%
A0A3R7MGW2	Trypanosoma rangeli	57%	100%
A4HK45	Leishmania braziliensis	85%	100%
A4I7L7	Leishmania infantum	100%	100%
D0A9T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B2I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5L8	Leishmania major	95%	100%
Q6JP77	Rattus norvegicus	24%	80%
Q7TN79	Mus musculus	24%	90%
V5D6Q6	Trypanosoma cruzi	58%	100%