Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IT10_LEIDO

TriTrypDb:

LdBPK_320350.1 , LdCL_320008400 , LDHU3_32.0430

Length:

893

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IT10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IT10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.670
CLV_C14_Caspase3-7	46	50	PF00656	0.667
CLV_C14_Caspase3-7	51	55	PF00656	0.696
CLV_NRD_NRD_1	103	105	PF00675	0.597
CLV_NRD_NRD_1	405	407	PF00675	0.640
CLV_NRD_NRD_1	43	45	PF00675	0.590
CLV_NRD_NRD_1	434	436	PF00675	0.566
CLV_NRD_NRD_1	453	455	PF00675	0.305
CLV_NRD_NRD_1	731	733	PF00675	0.802
CLV_NRD_NRD_1	747	749	PF00675	0.612
CLV_NRD_NRD_1	757	759	PF00675	0.658
CLV_NRD_NRD_1	807	809	PF00675	0.756
CLV_NRD_NRD_1	881	883	PF00675	0.808
CLV_PCSK_FUR_1	451	455	PF00082	0.594
CLV_PCSK_KEX2_1	103	105	PF00082	0.597
CLV_PCSK_KEX2_1	405	407	PF00082	0.620
CLV_PCSK_KEX2_1	43	45	PF00082	0.710
CLV_PCSK_KEX2_1	434	436	PF00082	0.573
CLV_PCSK_KEX2_1	453	455	PF00082	0.330
CLV_PCSK_KEX2_1	747	749	PF00082	0.699
CLV_PCSK_KEX2_1	759	761	PF00082	0.644
CLV_PCSK_KEX2_1	807	809	PF00082	0.774
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.707
CLV_PCSK_SKI1_1	106	110	PF00082	0.603
CLV_PCSK_SKI1_1	468	472	PF00082	0.441
CLV_PCSK_SKI1_1	583	587	PF00082	0.412
CLV_PCSK_SKI1_1	732	736	PF00082	0.785
CLV_PCSK_SKI1_1	882	886	PF00082	0.664
CLV_Separin_Metazoa	100	104	PF03568	0.632
CLV_Separin_Metazoa	397	401	PF03568	0.637
DEG_APCC_DBOX_1	569	577	PF00400	0.525
DEG_COP1_1	335	343	PF00400	0.601
DEG_SCF_FBW7_1	736	741	PF00400	0.758
DEG_SPOP_SBC_1	122	126	PF00917	0.590
DEG_SPOP_SBC_1	160	164	PF00917	0.668
DEG_SPOP_SBC_1	175	179	PF00917	0.801
DEG_SPOP_SBC_1	216	220	PF00917	0.634
DEG_SPOP_SBC_1	477	481	PF00917	0.653
DEG_SPOP_SBC_1	842	846	PF00917	0.828
DOC_CKS1_1	548	553	PF01111	0.615
DOC_CKS1_1	668	673	PF01111	0.635
DOC_CKS1_1	735	740	PF01111	0.801
DOC_CYCLIN_RxL_1	104	116	PF00134	0.513
DOC_CYCLIN_RxL_1	580	589	PF00134	0.498
DOC_MAPK_gen_1	147	156	PF00069	0.660
DOC_MAPK_gen_1	451	461	PF00069	0.562
DOC_MAPK_MEF2A_6	454	463	PF00069	0.550
DOC_PP1_RVXF_1	227	234	PF00149	0.670
DOC_PP2B_LxvP_1	134	137	PF13499	0.642
DOC_PP4_FxxP_1	735	738	PF00568	0.686
DOC_USP7_MATH_1	121	125	PF00917	0.813
DOC_USP7_MATH_1	204	208	PF00917	0.794
DOC_USP7_MATH_1	22	26	PF00917	0.632
DOC_USP7_MATH_1	267	271	PF00917	0.781
DOC_USP7_MATH_1	325	329	PF00917	0.739
DOC_USP7_MATH_1	33	37	PF00917	0.534
DOC_USP7_MATH_1	361	365	PF00917	0.668
DOC_USP7_MATH_1	476	480	PF00917	0.706
DOC_USP7_MATH_1	50	54	PF00917	0.503
DOC_USP7_MATH_1	644	648	PF00917	0.731
DOC_USP7_MATH_1	676	680	PF00917	0.756
DOC_USP7_MATH_1	782	786	PF00917	0.716
DOC_USP7_MATH_1	824	828	PF00917	0.756
DOC_USP7_MATH_1	836	840	PF00917	0.779
DOC_USP7_MATH_1	842	846	PF00917	0.797
DOC_USP7_MATH_1	853	857	PF00917	0.531
DOC_USP7_MATH_1	863	867	PF00917	0.608
DOC_WW_Pin1_4	200	205	PF00397	0.748
DOC_WW_Pin1_4	547	552	PF00397	0.590
DOC_WW_Pin1_4	64	69	PF00397	0.781
DOC_WW_Pin1_4	667	672	PF00397	0.751
DOC_WW_Pin1_4	693	698	PF00397	0.691
DOC_WW_Pin1_4	702	707	PF00397	0.578
DOC_WW_Pin1_4	734	739	PF00397	0.726
DOC_WW_Pin1_4	800	805	PF00397	0.749
LIG_14-3-3_CanoR_1	147	156	PF00244	0.680
LIG_14-3-3_CanoR_1	171	176	PF00244	0.748
LIG_14-3-3_CanoR_1	438	444	PF00244	0.443
LIG_14-3-3_CanoR_1	454	460	PF00244	0.425
LIG_14-3-3_CanoR_1	522	530	PF00244	0.433
LIG_14-3-3_CanoR_1	632	636	PF00244	0.631
LIG_14-3-3_CanoR_1	652	658	PF00244	0.463
LIG_14-3-3_CanoR_1	683	688	PF00244	0.781
LIG_14-3-3_CanoR_1	717	721	PF00244	0.679
LIG_14-3-3_CanoR_1	760	765	PF00244	0.748
LIG_14-3-3_CanoR_1	807	813	PF00244	0.763
LIG_14-3-3_CanoR_1	835	841	PF00244	0.668
LIG_14-3-3_CanoR_1	869	878	PF00244	0.678
LIG_BRCT_BRCA1_1	296	300	PF00533	0.706
LIG_CtBP_PxDLS_1	728	733	PF00389	0.586
LIG_EVH1_1	735	739	PF00568	0.739
LIG_FHA_1	107	113	PF00498	0.602
LIG_FHA_1	204	210	PF00498	0.740
LIG_FHA_1	431	437	PF00498	0.579
LIG_FHA_1	530	536	PF00498	0.506
LIG_FHA_1	57	63	PF00498	0.605
LIG_FHA_1	847	853	PF00498	0.630
LIG_FHA_1	871	877	PF00498	0.723
LIG_FHA_2	125	131	PF00498	0.714
LIG_FHA_2	178	184	PF00498	0.617
LIG_FHA_2	203	209	PF00498	0.765
LIG_FHA_2	234	240	PF00498	0.641
LIG_FHA_2	392	398	PF00498	0.611
LIG_FHA_2	44	50	PF00498	0.779
LIG_FHA_2	507	513	PF00498	0.551
LIG_FHA_2	608	614	PF00498	0.631
LIG_KLC1_Yacidic_2	604	609	PF13176	0.534
LIG_LIR_Apic_2	290	296	PF02991	0.716
LIG_LIR_Apic_2	545	551	PF02991	0.563
LIG_LIR_Apic_2	633	638	PF02991	0.662
LIG_LIR_Gen_1	239	248	PF02991	0.533
LIG_LIR_Gen_1	297	308	PF02991	0.549
LIG_LIR_Gen_1	394	403	PF02991	0.658
LIG_LIR_Gen_1	589	599	PF02991	0.392
LIG_LIR_Nem_3	239	243	PF02991	0.544
LIG_LIR_Nem_3	297	303	PF02991	0.579
LIG_LIR_Nem_3	394	398	PF02991	0.705
LIG_LIR_Nem_3	589	594	PF02991	0.398
LIG_LIR_Nem_3	600	606	PF02991	0.392
LIG_LIR_Nem_3	789	793	PF02991	0.766
LIG_NRBOX	242	248	PF00104	0.620
LIG_PCNA_yPIPBox_3	139	149	PF02747	0.643
LIG_Pex14_1	597	601	PF04695	0.479
LIG_Pex14_2	591	595	PF04695	0.425
LIG_PTB_Apo_2	234	241	PF02174	0.555
LIG_RPA_C_Fungi	345	357	PF08784	0.552
LIG_SH2_CRK	293	297	PF00017	0.666
LIG_SH2_CRK	635	639	PF00017	0.689
LIG_SH2_NCK_1	293	297	PF00017	0.666
LIG_SH2_NCK_1	548	552	PF00017	0.607
LIG_SH2_NCK_1	554	558	PF00017	0.671
LIG_SH2_SRC	293	296	PF00017	0.755
LIG_SH2_SRC	464	467	PF00017	0.506
LIG_SH2_STAP1	603	607	PF00017	0.549
LIG_SH2_STAT5	145	148	PF00017	0.646
LIG_SH2_STAT5	45	48	PF00017	0.518
LIG_SH2_STAT5	601	604	PF00017	0.493
LIG_SH2_STAT5	607	610	PF00017	0.604
LIG_SH2_STAT5	71	74	PF00017	0.584
LIG_SH3_1	733	739	PF00018	0.789
LIG_SH3_1	883	889	PF00018	0.753
LIG_SH3_3	466	472	PF00018	0.502
LIG_SH3_3	685	691	PF00018	0.807
LIG_SH3_3	703	709	PF00018	0.638
LIG_SH3_3	733	739	PF00018	0.695
LIG_SH3_3	768	774	PF00018	0.722
LIG_SH3_3	845	851	PF00018	0.740
LIG_SH3_3	883	889	PF00018	0.706
LIG_SUMO_SIM_par_1	526	532	PF11976	0.550
LIG_TRAF2_1	181	184	PF00917	0.678
LIG_TRAF2_1	394	397	PF00917	0.657
LIG_TRAF2_1	647	650	PF00917	0.728
LIG_UBA3_1	153	157	PF00899	0.563
LIG_WRC_WIRS_1	591	596	PF05994	0.419
MOD_CDK_SPxxK_3	800	807	PF00069	0.752
MOD_CK1_1	124	130	PF00069	0.759
MOD_CK1_1	170	176	PF00069	0.811
MOD_CK1_1	177	183	PF00069	0.688
MOD_CK1_1	203	209	PF00069	0.645
MOD_CK1_1	278	284	PF00069	0.772
MOD_CK1_1	289	295	PF00069	0.550
MOD_CK1_1	529	535	PF00069	0.491
MOD_CK1_1	53	59	PF00069	0.647
MOD_CK1_1	575	581	PF00069	0.499
MOD_CK1_1	60	66	PF00069	0.645
MOD_CK1_1	69	75	PF00069	0.509
MOD_CK1_1	719	725	PF00069	0.695
MOD_CK1_1	727	733	PF00069	0.632
MOD_CK1_1	791	797	PF00069	0.795
MOD_CK1_1	871	877	PF00069	0.730
MOD_CK2_1	124	130	PF00069	0.743
MOD_CK2_1	177	183	PF00069	0.747
MOD_CK2_1	233	239	PF00069	0.636
MOD_CK2_1	391	397	PF00069	0.613
MOD_CK2_1	506	512	PF00069	0.515
MOD_CK2_1	586	592	PF00069	0.453
MOD_CK2_1	607	613	PF00069	0.643
MOD_CK2_1	644	650	PF00069	0.725
MOD_CK2_1	93	99	PF00069	0.576
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.572
MOD_GlcNHglycan	119	122	PF01048	0.687
MOD_GlcNHglycan	163	166	PF01048	0.653
MOD_GlcNHglycan	180	183	PF01048	0.699
MOD_GlcNHglycan	190	193	PF01048	0.629
MOD_GlcNHglycan	219	222	PF01048	0.655
MOD_GlcNHglycan	224	227	PF01048	0.667
MOD_GlcNHglycan	24	27	PF01048	0.601
MOD_GlcNHglycan	269	272	PF01048	0.744
MOD_GlcNHglycan	326	330	PF01048	0.771
MOD_GlcNHglycan	332	335	PF01048	0.791
MOD_GlcNHglycan	358	361	PF01048	0.554
MOD_GlcNHglycan	411	414	PF01048	0.654
MOD_GlcNHglycan	523	526	PF01048	0.434
MOD_GlcNHglycan	588	591	PF01048	0.560
MOD_GlcNHglycan	645	649	PF01048	0.696
MOD_GlcNHglycan	653	656	PF01048	0.724
MOD_GlcNHglycan	676	679	PF01048	0.750
MOD_GlcNHglycan	722	725	PF01048	0.750
MOD_GlcNHglycan	726	729	PF01048	0.696
MOD_GlcNHglycan	740	743	PF01048	0.587
MOD_GlcNHglycan	780	783	PF01048	0.795
MOD_GlcNHglycan	790	793	PF01048	0.792
MOD_GlcNHglycan	795	798	PF01048	0.745
MOD_GlcNHglycan	855	858	PF01048	0.745
MOD_GSK3_1	113	120	PF00069	0.668
MOD_GSK3_1	121	128	PF00069	0.654
MOD_GSK3_1	167	174	PF00069	0.669
MOD_GSK3_1	184	191	PF00069	0.794
MOD_GSK3_1	200	207	PF00069	0.576
MOD_GSK3_1	215	222	PF00069	0.673
MOD_GSK3_1	278	285	PF00069	0.745
MOD_GSK3_1	352	359	PF00069	0.546
MOD_GSK3_1	361	368	PF00069	0.663
MOD_GSK3_1	370	377	PF00069	0.615
MOD_GSK3_1	401	408	PF00069	0.698
MOD_GSK3_1	48	55	PF00069	0.720
MOD_GSK3_1	56	63	PF00069	0.626
MOD_GSK3_1	586	593	PF00069	0.491
MOD_GSK3_1	663	670	PF00069	0.715
MOD_GSK3_1	689	696	PF00069	0.767
MOD_GSK3_1	716	723	PF00069	0.780
MOD_GSK3_1	734	741	PF00069	0.544
MOD_GSK3_1	778	785	PF00069	0.716
MOD_GSK3_1	788	795	PF00069	0.739
MOD_GSK3_1	842	849	PF00069	0.668
MOD_GSK3_1	865	872	PF00069	0.743
MOD_N-GLC_1	749	754	PF02516	0.740
MOD_N-GLC_1	853	858	PF02516	0.766
MOD_NEK2_1	112	117	PF00069	0.671
MOD_NEK2_1	161	166	PF00069	0.673
MOD_NEK2_1	21	26	PF00069	0.621
MOD_NEK2_1	439	444	PF00069	0.494
MOD_NEK2_1	455	460	PF00069	0.495
MOD_NEK2_1	586	591	PF00069	0.424
MOD_NEK2_1	630	635	PF00069	0.551
MOD_NEK2_1	716	721	PF00069	0.761
MOD_NEK2_1	749	754	PF00069	0.809
MOD_NEK2_1	780	785	PF00069	0.745
MOD_NEK2_1	786	791	PF00069	0.711
MOD_NEK2_1	793	798	PF00069	0.728
MOD_NEK2_1	870	875	PF00069	0.767
MOD_NEK2_2	590	595	PF00069	0.542
MOD_NEK2_2	782	787	PF00069	0.580
MOD_PIKK_1	184	190	PF00454	0.767
MOD_PKA_1	405	411	PF00069	0.764
MOD_PKA_1	43	49	PF00069	0.622
MOD_PKA_1	759	765	PF00069	0.766
MOD_PKA_2	148	154	PF00069	0.669
MOD_PKA_2	170	176	PF00069	0.774
MOD_PKA_2	405	411	PF00069	0.764
MOD_PKA_2	43	49	PF00069	0.699
MOD_PKA_2	521	527	PF00069	0.434
MOD_PKA_2	631	637	PF00069	0.629
MOD_PKA_2	651	657	PF00069	0.461
MOD_PKA_2	716	722	PF00069	0.663
MOD_PKA_2	724	730	PF00069	0.640
MOD_PKA_2	759	765	PF00069	0.766
MOD_PKA_2	806	812	PF00069	0.824
MOD_PKA_2	868	874	PF00069	0.741
MOD_PKB_1	104	112	PF00069	0.651
MOD_PKB_1	147	155	PF00069	0.614
MOD_PKB_1	758	766	PF00069	0.752
MOD_Plk_1	371	377	PF00069	0.726
MOD_Plk_2-3	609	615	PF00069	0.610
MOD_Plk_4	149	155	PF00069	0.653
MOD_Plk_4	33	39	PF00069	0.566
MOD_Plk_4	361	367	PF00069	0.530
MOD_Plk_4	526	532	PF00069	0.554
MOD_Plk_4	572	578	PF00069	0.636
MOD_Plk_4	590	596	PF00069	0.352
MOD_Plk_4	663	669	PF00069	0.719
MOD_Plk_4	716	722	PF00069	0.784
MOD_ProDKin_1	200	206	PF00069	0.748
MOD_ProDKin_1	547	553	PF00069	0.600
MOD_ProDKin_1	64	70	PF00069	0.773
MOD_ProDKin_1	667	673	PF00069	0.745
MOD_ProDKin_1	693	699	PF00069	0.691
MOD_ProDKin_1	702	708	PF00069	0.581
MOD_ProDKin_1	734	740	PF00069	0.729
MOD_ProDKin_1	800	806	PF00069	0.750
MOD_SUMO_rev_2	197	203	PF00179	0.545
TRG_DiLeu_BaEn_1	239	244	PF01217	0.572
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.442
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.729
TRG_ENDOCYTIC_2	516	519	PF00928	0.473
TRG_ER_diArg_1	102	104	PF00400	0.590
TRG_ER_diArg_1	146	149	PF00400	0.630
TRG_ER_diArg_1	43	45	PF00400	0.538
TRG_ER_diArg_1	434	436	PF00400	0.513
TRG_ER_diArg_1	453	455	PF00400	0.473
TRG_ER_diArg_1	747	749	PF00400	0.701
TRG_ER_diArg_1	757	760	PF00400	0.653
TRG_NLS_Bipartite_1	747	763	PF00514	0.606
TRG_NLS_MonoCore_2	757	762	PF00514	0.737
TRG_NLS_MonoExtC_3	881	886	PF00514	0.734
TRG_NLS_MonoExtN_4	756	763	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	882	887	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P865	Leptomonas seymouri	44%	98%
A0A1X0P7Z7	Trypanosomatidae	25%	94%
A4HK14	Leishmania braziliensis	67%	100%
A4I7J8	Leishmania infantum	99%	100%
D0A0A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B2F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5Q1	Leishmania major	86%	100%