3'-5' exonuclease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ISV5_LEIDO

TriTrypDb:

LdBPK_312780.1 , LdCL_310035900 , LDHU3_31.4900

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8ISV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISV5

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	5
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	5
GO:0000469	cleavage involved in rRNA processing	7	5
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006364	rRNA processing	8	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0016072	rRNA metabolic process	7	5
GO:0031123	RNA 3'-end processing	7	5
GO:0031125	rRNA 3'-end processing	9	5
GO:0034470	ncRNA processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034660	ncRNA metabolic process	6	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043628	regulatory ncRNA 3'-end processing	8	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	5
GO:0090501	RNA phosphodiester bond hydrolysis	6	5
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0005488	binding	1	10
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0008408	3'-5' exonuclease activity	6	6
GO:0000175	3'-5'-RNA exonuclease activity	7	5
GO:0004532	RNA exonuclease activity	5	5
GO:0004540	RNA nuclease activity	4	5
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	5
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.443
CLV_C14_Caspase3-7	282	286	PF00656	0.545
CLV_C14_Caspase3-7	423	427	PF00656	0.617
CLV_NRD_NRD_1	149	151	PF00675	0.543
CLV_NRD_NRD_1	4	6	PF00675	0.383
CLV_NRD_NRD_1	453	455	PF00675	0.501
CLV_NRD_NRD_1	487	489	PF00675	0.379
CLV_NRD_NRD_1	514	516	PF00675	0.441
CLV_NRD_NRD_1	657	659	PF00675	0.738
CLV_NRD_NRD_1	661	663	PF00675	0.729
CLV_NRD_NRD_1	682	684	PF00675	0.551
CLV_NRD_NRD_1	72	74	PF00675	0.514
CLV_PCSK_KEX2_1	149	151	PF00082	0.466
CLV_PCSK_KEX2_1	3	5	PF00082	0.386
CLV_PCSK_KEX2_1	453	455	PF00082	0.501
CLV_PCSK_KEX2_1	487	489	PF00082	0.490
CLV_PCSK_KEX2_1	514	516	PF00082	0.441
CLV_PCSK_KEX2_1	656	658	PF00082	0.751
CLV_PCSK_KEX2_1	661	663	PF00082	0.705
CLV_PCSK_KEX2_1	682	684	PF00082	0.519
CLV_PCSK_KEX2_1	72	74	PF00082	0.522
CLV_PCSK_PC7_1	657	663	PF00082	0.565
CLV_PCSK_SKI1_1	149	153	PF00082	0.439
CLV_PCSK_SKI1_1	213	217	PF00082	0.358
CLV_PCSK_SKI1_1	302	306	PF00082	0.465
CLV_PCSK_SKI1_1	487	491	PF00082	0.427
CLV_PCSK_SKI1_1	603	607	PF00082	0.324
CLV_PCSK_SKI1_1	72	76	PF00082	0.515
CLV_PCSK_SKI1_1	734	738	PF00082	0.433
CLV_PCSK_SKI1_1	764	768	PF00082	0.370
CLV_PCSK_SKI1_1	839	843	PF00082	0.396
DEG_APCC_DBOX_1	586	594	PF00400	0.476
DEG_APCC_DBOX_1	602	610	PF00400	0.278
DEG_APCC_DBOX_1	71	79	PF00400	0.482
DEG_APCC_DBOX_1	733	741	PF00400	0.453
DEG_APCC_KENBOX_2	462	466	PF00400	0.341
DEG_APCC_KENBOX_2	635	639	PF00400	0.519
DEG_COP1_1	42	52	PF00400	0.480
DEG_MDM2_SWIB_1	39	47	PF02201	0.434
DEG_SCF_FBW7_2	568	575	PF00400	0.542
DOC_CDC14_PxL_1	779	787	PF14671	0.502
DOC_CKS1_1	408	413	PF01111	0.473
DOC_CKS1_1	569	574	PF01111	0.593
DOC_CKS1_1	640	645	PF01111	0.611
DOC_CYCLIN_RxL_1	833	846	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.470
DOC_MAPK_gen_1	149	158	PF00069	0.405
DOC_MAPK_gen_1	460	468	PF00069	0.460
DOC_MAPK_MEF2A_6	487	495	PF00069	0.374
DOC_PP1_RVXF_1	402	409	PF00149	0.412
DOC_PP2B_LxvP_1	47	50	PF13499	0.580
DOC_PP4_FxxP_1	459	462	PF00568	0.414
DOC_PP4_FxxP_1	528	531	PF00568	0.360
DOC_SPAK_OSR1_1	478	482	PF12202	0.334
DOC_USP7_MATH_1	193	197	PF00917	0.478
DOC_USP7_MATH_1	257	261	PF00917	0.308
DOC_USP7_MATH_1	281	285	PF00917	0.667
DOC_USP7_MATH_1	344	348	PF00917	0.673
DOC_USP7_MATH_1	629	633	PF00917	0.667
DOC_USP7_MATH_1	795	799	PF00917	0.666
DOC_USP7_MATH_1	809	813	PF00917	0.753
DOC_WW_Pin1_4	243	248	PF00397	0.379
DOC_WW_Pin1_4	407	412	PF00397	0.496
DOC_WW_Pin1_4	568	573	PF00397	0.712
DOC_WW_Pin1_4	639	644	PF00397	0.704
DOC_WW_Pin1_4	649	654	PF00397	0.719
DOC_WW_Pin1_4	810	815	PF00397	0.732
DOC_WW_Pin1_4	881	886	PF00397	0.502
LIG_14-3-3_CanoR_1	128	133	PF00244	0.417
LIG_14-3-3_CanoR_1	682	686	PF00244	0.527
LIG_14-3-3_CanoR_1	865	871	PF00244	0.341
LIG_Actin_WH2_2	131	146	PF00022	0.383
LIG_Actin_WH2_2	185	200	PF00022	0.365
LIG_AP2alpha_2	111	113	PF02296	0.467
LIG_APCC_ABBA_1	156	161	PF00400	0.467
LIG_APCC_ABBA_1	163	168	PF00400	0.475
LIG_APCC_ABBA_1	599	604	PF00400	0.366
LIG_BIR_III_4	336	340	PF00653	0.515
LIG_BIR_III_4	745	749	PF00653	0.538
LIG_BRCT_BRCA1_1	269	273	PF00533	0.389
LIG_BRCT_BRCA1_1	32	36	PF00533	0.470
LIG_BRCT_BRCA1_1	831	835	PF00533	0.366
LIG_DLG_GKlike_1	208	215	PF00625	0.439
LIG_EH1_1	834	842	PF00400	0.436
LIG_FHA_1	138	144	PF00498	0.461
LIG_FHA_1	207	213	PF00498	0.519
LIG_FHA_1	328	334	PF00498	0.516
LIG_FHA_1	42	48	PF00498	0.470
LIG_FHA_1	682	688	PF00498	0.500
LIG_FHA_1	78	84	PF00498	0.342
LIG_FHA_1	87	93	PF00498	0.274
LIG_FHA_2	198	204	PF00498	0.609
LIG_FHA_2	221	227	PF00498	0.401
LIG_FHA_2	280	286	PF00498	0.648
LIG_FHA_2	293	299	PF00498	0.372
LIG_FHA_2	389	395	PF00498	0.531
LIG_FHA_2	421	427	PF00498	0.540
LIG_FHA_2	784	790	PF00498	0.592
LIG_FHA_2	882	888	PF00498	0.481
LIG_LIR_Apic_2	457	462	PF02991	0.415
LIG_LIR_Apic_2	526	531	PF02991	0.352
LIG_LIR_Gen_1	22	32	PF02991	0.357
LIG_LIR_Gen_1	445	452	PF02991	0.469
LIG_LIR_Gen_1	499	507	PF02991	0.331
LIG_LIR_Gen_1	541	548	PF02991	0.445
LIG_LIR_Gen_1	595	601	PF02991	0.375
LIG_LIR_Gen_1	832	842	PF02991	0.350
LIG_LIR_LC3C_4	429	433	PF02991	0.333
LIG_LIR_Nem_3	117	123	PF02991	0.535
LIG_LIR_Nem_3	22	27	PF02991	0.329
LIG_LIR_Nem_3	33	39	PF02991	0.291
LIG_LIR_Nem_3	443	447	PF02991	0.475
LIG_LIR_Nem_3	499	503	PF02991	0.337
LIG_LIR_Nem_3	541	546	PF02991	0.451
LIG_LIR_Nem_3	595	599	PF02991	0.373
LIG_LIR_Nem_3	695	700	PF02991	0.491
LIG_LIR_Nem_3	832	838	PF02991	0.352
LIG_LIR_Nem_3	9	15	PF02991	0.324
LIG_LYPXL_S_1	696	700	PF13949	0.397
LIG_PAM2_1	25	37	PF00658	0.332
LIG_Pex14_1	866	870	PF04695	0.336
LIG_Pex14_2	39	43	PF04695	0.414
LIG_Pex14_2	440	444	PF04695	0.379
LIG_Pex14_2	862	866	PF04695	0.340
LIG_Rb_LxCxE_1	295	314	PF01857	0.548
LIG_REV1ctd_RIR_1	697	706	PF16727	0.496
LIG_RPA_C_Fungi	666	678	PF08784	0.582
LIG_SH2_CRK	34	38	PF00017	0.400
LIG_SH2_CRK	372	376	PF00017	0.377
LIG_SH2_CRK	500	504	PF00017	0.365
LIG_SH2_CRK	517	521	PF00017	0.436
LIG_SH2_GRB2like	372	375	PF00017	0.353
LIG_SH2_GRB2like	396	399	PF00017	0.464
LIG_SH2_NCK_1	372	376	PF00017	0.376
LIG_SH2_NCK_1	845	849	PF00017	0.454
LIG_SH2_SRC	372	375	PF00017	0.377
LIG_SH2_SRC	543	546	PF00017	0.443
LIG_SH2_SRC	561	564	PF00017	0.605
LIG_SH2_SRC	829	832	PF00017	0.474
LIG_SH2_STAP1	139	143	PF00017	0.385
LIG_SH2_STAP1	261	265	PF00017	0.421
LIG_SH2_STAP1	500	504	PF00017	0.323
LIG_SH2_STAP1	543	547	PF00017	0.478
LIG_SH2_STAP1	86	90	PF00017	0.319
LIG_SH2_STAT3	252	255	PF00017	0.349
LIG_SH2_STAT3	458	461	PF00017	0.363
LIG_SH2_STAT5	139	142	PF00017	0.384
LIG_SH2_STAT5	396	399	PF00017	0.388
LIG_SH2_STAT5	458	461	PF00017	0.363
LIG_SH2_STAT5	689	692	PF00017	0.421
LIG_SH2_STAT5	829	832	PF00017	0.490
LIG_SH3_3	109	115	PF00018	0.580
LIG_SH3_3	272	278	PF00018	0.393
LIG_SH3_3	374	380	PF00018	0.485
LIG_SH3_3	4	10	PF00018	0.382
LIG_SH3_3	637	643	PF00018	0.701
LIG_SUMO_SIM_anti_2	131	136	PF11976	0.434
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.364
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.444
LIG_SUMO_SIM_anti_2	501	506	PF11976	0.322
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.442
LIG_SUMO_SIM_anti_2	776	784	PF11976	0.448
LIG_SUMO_SIM_par_1	179	185	PF11976	0.421
LIG_TRAF2_1	200	203	PF00917	0.668
LIG_TRAF2_1	560	563	PF00917	0.598
LIG_TYR_ITIM	32	37	PF00017	0.355
LIG_UBA3_1	532	538	PF00899	0.424
LIG_WRC_WIRS_1	609	614	PF05994	0.427
MOD_CDK_SPxxK_3	649	656	PF00069	0.609
MOD_CK1_1	211	217	PF00069	0.550
MOD_CK1_1	220	226	PF00069	0.473
MOD_CK1_1	284	290	PF00069	0.657
MOD_CK1_1	496	502	PF00069	0.390
MOD_CK1_1	66	72	PF00069	0.654
MOD_CK1_1	762	768	PF00069	0.447
MOD_CK1_1	798	804	PF00069	0.729
MOD_CK1_1	822	828	PF00069	0.604
MOD_CK1_1	84	90	PF00069	0.228
MOD_CK1_1	846	852	PF00069	0.534
MOD_CK2_1	19	25	PF00069	0.445
MOD_CK2_1	197	203	PF00069	0.528
MOD_CK2_1	220	226	PF00069	0.461
MOD_CK2_1	292	298	PF00069	0.454
MOD_CK2_1	783	789	PF00069	0.590
MOD_CK2_1	794	800	PF00069	0.707
MOD_CK2_1	866	872	PF00069	0.461
MOD_Cter_Amidation	654	657	PF01082	0.569
MOD_GlcNHglycan	116	119	PF01048	0.586
MOD_GlcNHglycan	175	178	PF01048	0.461
MOD_GlcNHglycan	219	222	PF01048	0.438
MOD_GlcNHglycan	269	272	PF01048	0.584
MOD_GlcNHglycan	27	30	PF01048	0.527
MOD_GlcNHglycan	313	316	PF01048	0.572
MOD_GlcNHglycan	319	322	PF01048	0.584
MOD_GlcNHglycan	344	347	PF01048	0.510
MOD_GlcNHglycan	471	474	PF01048	0.438
MOD_GlcNHglycan	557	560	PF01048	0.420
MOD_GlcNHglycan	631	634	PF01048	0.697
MOD_GlcNHglycan	649	652	PF01048	0.693
MOD_GlcNHglycan	65	68	PF01048	0.673
MOD_GlcNHglycan	728	731	PF01048	0.574
MOD_GlcNHglycan	740	743	PF01048	0.630
MOD_GlcNHglycan	753	756	PF01048	0.717
MOD_GlcNHglycan	849	852	PF01048	0.509
MOD_GSK3_1	193	200	PF00069	0.520
MOD_GSK3_1	202	209	PF00069	0.422
MOD_GSK3_1	384	391	PF00069	0.422
MOD_GSK3_1	489	496	PF00069	0.338
MOD_GSK3_1	62	69	PF00069	0.685
MOD_GSK3_1	647	654	PF00069	0.759
MOD_GSK3_1	77	84	PF00069	0.296
MOD_GSK3_1	794	801	PF00069	0.770
MOD_GSK3_1	843	850	PF00069	0.468
MOD_N-GLC_1	327	332	PF02516	0.503
MOD_N-GLC_1	342	347	PF02516	0.532
MOD_N-GLC_1	373	378	PF02516	0.365
MOD_N-GLC_1	760	765	PF02516	0.505
MOD_N-GLC_2	217	219	PF02516	0.413
MOD_N-GLC_2	465	467	PF02516	0.328
MOD_NEK2_1	197	202	PF00069	0.590
MOD_NEK2_1	316	321	PF00069	0.617
MOD_NEK2_1	41	46	PF00069	0.374
MOD_NEK2_1	431	436	PF00069	0.396
MOD_NEK2_1	510	515	PF00069	0.424
MOD_NEK2_1	735	740	PF00069	0.504
MOD_NEK2_2	193	198	PF00069	0.498
MOD_NEK2_2	292	297	PF00069	0.481
MOD_PK_1	128	134	PF00069	0.395
MOD_PKA_1	656	662	PF00069	0.627
MOD_PKA_2	647	653	PF00069	0.593
MOD_PKA_2	656	662	PF00069	0.557
MOD_PKA_2	681	687	PF00069	0.473
MOD_PKA_2	751	757	PF00069	0.656
MOD_PKA_2	801	807	PF00069	0.808
MOD_PKA_2	866	872	PF00069	0.409
MOD_PKB_1	664	672	PF00069	0.630
MOD_Plk_1	193	199	PF00069	0.420
MOD_Plk_1	202	208	PF00069	0.444
MOD_Plk_1	257	263	PF00069	0.316
MOD_Plk_1	373	379	PF00069	0.364
MOD_Plk_1	442	448	PF00069	0.411
MOD_Plk_2-3	373	379	PF00069	0.364
MOD_Plk_2-3	420	426	PF00069	0.412
MOD_Plk_4	19	25	PF00069	0.403
MOD_Plk_4	202	208	PF00069	0.633
MOD_Plk_4	436	442	PF00069	0.281
MOD_Plk_4	489	495	PF00069	0.312
MOD_Plk_4	595	601	PF00069	0.381
MOD_Plk_4	673	679	PF00069	0.579
MOD_Plk_4	692	698	PF00069	0.387
MOD_Plk_4	86	92	PF00069	0.301
MOD_Plk_4	866	872	PF00069	0.386
MOD_ProDKin_1	243	249	PF00069	0.373
MOD_ProDKin_1	407	413	PF00069	0.500
MOD_ProDKin_1	568	574	PF00069	0.715
MOD_ProDKin_1	639	645	PF00069	0.706
MOD_ProDKin_1	649	655	PF00069	0.721
MOD_ProDKin_1	810	816	PF00069	0.732
MOD_ProDKin_1	881	887	PF00069	0.498
MOD_SUMO_for_1	548	551	PF00179	0.374
MOD_SUMO_rev_2	161	165	PF00179	0.474
MOD_SUMO_rev_2	418	423	PF00179	0.502
TRG_DiLeu_BaEn_1	774	779	PF01217	0.417
TRG_DiLeu_BaEn_3	680	686	PF01217	0.440
TRG_DiLeu_BaEn_4	419	425	PF01217	0.441
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.341
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.548
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.386
TRG_ENDOCYTIC_2	139	142	PF00928	0.429
TRG_ENDOCYTIC_2	20	23	PF00928	0.509
TRG_ENDOCYTIC_2	34	37	PF00928	0.322
TRG_ENDOCYTIC_2	372	375	PF00928	0.378
TRG_ENDOCYTIC_2	447	450	PF00928	0.529
TRG_ENDOCYTIC_2	486	489	PF00928	0.409
TRG_ENDOCYTIC_2	500	503	PF00928	0.369
TRG_ENDOCYTIC_2	517	520	PF00928	0.470
TRG_ENDOCYTIC_2	543	546	PF00928	0.443
TRG_ENDOCYTIC_2	620	623	PF00928	0.558
TRG_ENDOCYTIC_2	697	700	PF00928	0.442
TRG_ER_diArg_1	149	151	PF00400	0.396
TRG_ER_diArg_1	2	5	PF00400	0.434
TRG_ER_diArg_1	452	454	PF00400	0.516
TRG_ER_diArg_1	486	488	PF00400	0.484
TRG_ER_diArg_1	514	516	PF00400	0.400
TRG_ER_diArg_1	586	589	PF00400	0.482
TRG_ER_diArg_1	656	658	PF00400	0.661
TRG_ER_diArg_1	661	664	PF00400	0.628
TRG_ER_diArg_1	72	74	PF00400	0.559
TRG_NES_CRM1_1	173	185	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE4	Leptomonas seymouri	54%	97%
A0A1X0NK05	Trypanosomatidae	35%	100%
A0A422NPF9	Trypanosoma rangeli	36%	100%
A4HJQ7	Leishmania braziliensis	78%	100%
A4I774	Leishmania infantum	100%	100%
E9B268	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q5Z1	Leishmania major	93%	100%
V5D1X6	Trypanosoma cruzi	36%	100%