Ig-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ISU5_LEIDO

TriTrypDb:

LdBPK_312620.1 , LdCL_310034200 , LDHU3_31.4670

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ISU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.445
CLV_C14_Caspase3-7	469	473	PF00656	0.379
CLV_C14_Caspase3-7	50	54	PF00656	0.739
CLV_C14_Caspase3-7	672	676	PF00656	0.583
CLV_NRD_NRD_1	101	103	PF00675	0.617
CLV_NRD_NRD_1	261	263	PF00675	0.412
CLV_NRD_NRD_1	28	30	PF00675	0.393
CLV_NRD_NRD_1	445	447	PF00675	0.444
CLV_NRD_NRD_1	462	464	PF00675	0.417
CLV_NRD_NRD_1	488	490	PF00675	0.562
CLV_NRD_NRD_1	564	566	PF00675	0.583
CLV_NRD_NRD_1	62	64	PF00675	0.678
CLV_PCSK_FUR_1	562	566	PF00082	0.608
CLV_PCSK_KEX2_1	101	103	PF00082	0.613
CLV_PCSK_KEX2_1	261	263	PF00082	0.412
CLV_PCSK_KEX2_1	28	30	PF00082	0.393
CLV_PCSK_KEX2_1	356	358	PF00082	0.486
CLV_PCSK_KEX2_1	445	447	PF00082	0.408
CLV_PCSK_KEX2_1	462	464	PF00082	0.417
CLV_PCSK_KEX2_1	488	490	PF00082	0.562
CLV_PCSK_KEX2_1	564	566	PF00082	0.589
CLV_PCSK_KEX2_1	62	64	PF00082	0.678
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.486
CLV_PCSK_SKI1_1	102	106	PF00082	0.403
CLV_PCSK_SKI1_1	182	186	PF00082	0.461
CLV_PCSK_SKI1_1	249	253	PF00082	0.467
CLV_PCSK_SKI1_1	311	315	PF00082	0.386
CLV_PCSK_SKI1_1	356	360	PF00082	0.480
CLV_PCSK_SKI1_1	489	493	PF00082	0.517
DEG_APCC_DBOX_1	37	45	PF00400	0.429
DEG_APCC_DBOX_1	779	787	PF00400	0.543
DEG_MDM2_SWIB_1	260	267	PF02201	0.296
DEG_Nend_Nbox_1	1	3	PF02207	0.451
DEG_SPOP_SBC_1	54	58	PF00917	0.590
DOC_ANK_TNKS_1	657	664	PF00023	0.528
DOC_CKS1_1	647	652	PF01111	0.729
DOC_CYCLIN_RxL_1	176	187	PF00134	0.449
DOC_CYCLIN_RxL_1	379	388	PF00134	0.464
DOC_CYCLIN_yClb1_LxF_4	247	252	PF00134	0.383
DOC_MAPK_gen_1	101	112	PF00069	0.398
DOC_MAPK_gen_1	356	366	PF00069	0.348
DOC_PP1_RVXF_1	18	25	PF00149	0.462
DOC_PP1_RVXF_1	247	253	PF00149	0.545
DOC_PP4_FxxP_1	422	425	PF00568	0.451
DOC_USP7_MATH_1	206	210	PF00917	0.558
DOC_USP7_MATH_1	628	632	PF00917	0.649
DOC_USP7_MATH_1	668	672	PF00917	0.678
DOC_USP7_MATH_1	731	735	PF00917	0.677
DOC_USP7_MATH_1	740	744	PF00917	0.694
DOC_USP7_UBL2_3	356	360	PF12436	0.382
DOC_WW_Pin1_4	143	148	PF00397	0.636
DOC_WW_Pin1_4	228	233	PF00397	0.494
DOC_WW_Pin1_4	349	354	PF00397	0.427
DOC_WW_Pin1_4	436	441	PF00397	0.509
DOC_WW_Pin1_4	45	50	PF00397	0.614
DOC_WW_Pin1_4	626	631	PF00397	0.777
DOC_WW_Pin1_4	646	651	PF00397	0.779
DOC_WW_Pin1_4	75	80	PF00397	0.718
DOC_WW_Pin1_4	753	758	PF00397	0.566
LIG_14-3-3_CanoR_1	703	710	PF00244	0.592
LIG_14-3-3_CanoR_1	732	738	PF00244	0.540
LIG_AP2alpha_2	177	179	PF02296	0.387
LIG_FHA_1	105	111	PF00498	0.346
LIG_FHA_1	17	23	PF00498	0.368
LIG_FHA_1	350	356	PF00498	0.639
LIG_FHA_1	375	381	PF00498	0.549
LIG_FHA_1	401	407	PF00498	0.351
LIG_FHA_1	430	436	PF00498	0.539
LIG_FHA_1	437	443	PF00498	0.465
LIG_FHA_1	459	465	PF00498	0.507
LIG_FHA_1	641	647	PF00498	0.695
LIG_FHA_1	72	78	PF00498	0.548
LIG_FHA_2	112	118	PF00498	0.434
LIG_FHA_2	2	8	PF00498	0.509
LIG_FHA_2	322	328	PF00498	0.409
LIG_FHA_2	480	486	PF00498	0.502
LIG_FHA_2	54	60	PF00498	0.743
LIG_FHA_2	762	768	PF00498	0.601
LIG_LIR_Apic_2	420	425	PF02991	0.448
LIG_LIR_Apic_2	695	700	PF02991	0.655
LIG_LIR_Gen_1	183	192	PF02991	0.403
LIG_LIR_Gen_1	301	309	PF02991	0.447
LIG_LIR_Gen_1	391	402	PF02991	0.378
LIG_LIR_Gen_1	453	464	PF02991	0.518
LIG_LIR_Gen_1	513	523	PF02991	0.539
LIG_LIR_Gen_1	717	727	PF02991	0.500
LIG_LIR_Nem_3	126	132	PF02991	0.393
LIG_LIR_Nem_3	183	188	PF02991	0.384
LIG_LIR_Nem_3	190	195	PF02991	0.399
LIG_LIR_Nem_3	257	263	PF02991	0.375
LIG_LIR_Nem_3	301	306	PF02991	0.439
LIG_LIR_Nem_3	391	397	PF02991	0.356
LIG_LIR_Nem_3	420	426	PF02991	0.460
LIG_LIR_Nem_3	453	459	PF02991	0.500
LIG_LIR_Nem_3	513	518	PF02991	0.532
LIG_LIR_Nem_3	692	697	PF02991	0.628
LIG_LIR_Nem_3	717	722	PF02991	0.493
LIG_LYPXL_SIV_4	714	722	PF13949	0.490
LIG_MYND_1	151	155	PF01753	0.537
LIG_Pex14_2	13	17	PF04695	0.574
LIG_Pex14_2	260	264	PF04695	0.299
LIG_Rb_pABgroove_1	179	187	PF01858	0.456
LIG_REV1ctd_RIR_1	177	186	PF16727	0.451
LIG_SH2_CRK	273	277	PF00017	0.423
LIG_SH2_CRK	281	285	PF00017	0.374
LIG_SH2_CRK	438	442	PF00017	0.380
LIG_SH2_CRK	719	723	PF00017	0.602
LIG_SH2_NCK_1	715	719	PF00017	0.558
LIG_SH2_SRC	194	197	PF00017	0.338
LIG_SH2_STAP1	273	277	PF00017	0.509
LIG_SH2_STAP1	33	37	PF00017	0.449
LIG_SH2_STAP1	537	541	PF00017	0.516
LIG_SH2_STAP1	694	698	PF00017	0.518
LIG_SH2_STAP1	715	719	PF00017	0.486
LIG_SH2_STAT3	265	268	PF00017	0.372
LIG_SH2_STAT3	704	707	PF00017	0.503
LIG_SH2_STAT5	174	177	PF00017	0.451
LIG_SH2_STAT5	194	197	PF00017	0.281
LIG_SH2_STAT5	265	268	PF00017	0.380
LIG_SH2_STAT5	3	6	PF00017	0.480
LIG_SH2_STAT5	30	33	PF00017	0.464
LIG_SH2_STAT5	315	318	PF00017	0.329
LIG_SH2_STAT5	323	326	PF00017	0.395
LIG_SH2_STAT5	363	366	PF00017	0.338
LIG_SH2_STAT5	438	441	PF00017	0.361
LIG_SH2_STAT5	478	481	PF00017	0.393
LIG_SH2_STAT5	697	700	PF00017	0.601
LIG_SH2_STAT5	704	707	PF00017	0.615
LIG_SH3_3	145	151	PF00018	0.487
LIG_SH3_3	229	235	PF00018	0.495
LIG_SH3_3	241	247	PF00018	0.358
LIG_SH3_3	283	289	PF00018	0.399
LIG_SH3_3	422	428	PF00018	0.361
LIG_SH3_3	566	572	PF00018	0.569
LIG_SH3_3	88	94	PF00018	0.591
LIG_Sin3_3	586	593	PF02671	0.431
LIG_TRAF2_1	482	485	PF00917	0.418
LIG_TRAF2_1	706	709	PF00917	0.584
LIG_TRAF2_1	775	778	PF00917	0.544
LIG_TYR_ITIM	271	276	PF00017	0.424
LIG_WRC_WIRS_1	314	319	PF05994	0.389
MOD_CDK_SPK_2	228	233	PF00069	0.488
MOD_CDK_SPK_2	349	354	PF00069	0.427
MOD_CDK_SPxxK_3	349	356	PF00069	0.404
MOD_CK1_1	330	336	PF00069	0.534
MOD_CK1_1	348	354	PF00069	0.378
MOD_CK1_1	458	464	PF00069	0.466
MOD_CK1_1	474	480	PF00069	0.409
MOD_CK1_1	500	506	PF00069	0.599
MOD_CK1_1	626	632	PF00069	0.765
MOD_CK1_1	678	684	PF00069	0.714
MOD_CK1_1	685	691	PF00069	0.677
MOD_CK1_1	692	698	PF00069	0.618
MOD_CK1_1	720	726	PF00069	0.668
MOD_CK1_1	743	749	PF00069	0.742
MOD_CK1_1	80	86	PF00069	0.798
MOD_CK1_1	89	95	PF00069	0.505
MOD_CK2_1	1	7	PF00069	0.475
MOD_CK2_1	111	117	PF00069	0.444
MOD_CK2_1	157	163	PF00069	0.582
MOD_CK2_1	251	257	PF00069	0.498
MOD_CK2_1	321	327	PF00069	0.381
MOD_CK2_1	479	485	PF00069	0.555
MOD_CK2_1	549	555	PF00069	0.545
MOD_CK2_1	680	686	PF00069	0.742
MOD_CK2_1	703	709	PF00069	0.589
MOD_CK2_1	761	767	PF00069	0.655
MOD_GlcNHglycan	117	121	PF01048	0.490
MOD_GlcNHglycan	208	211	PF01048	0.557
MOD_GlcNHglycan	551	554	PF01048	0.521
MOD_GlcNHglycan	618	621	PF01048	0.719
MOD_GlcNHglycan	625	628	PF01048	0.725
MOD_GlcNHglycan	63	66	PF01048	0.819
MOD_GlcNHglycan	677	680	PF01048	0.715
MOD_GlcNHglycan	711	714	PF01048	0.732
MOD_GlcNHglycan	719	722	PF01048	0.678
MOD_GlcNHglycan	733	736	PF01048	0.562
MOD_GlcNHglycan	741	745	PF01048	0.651
MOD_GlcNHglycan	80	83	PF01048	0.624
MOD_GSK3_1	298	305	PF00069	0.520
MOD_GSK3_1	326	333	PF00069	0.595
MOD_GSK3_1	341	348	PF00069	0.688
MOD_GSK3_1	451	458	PF00069	0.435
MOD_GSK3_1	622	629	PF00069	0.690
MOD_GSK3_1	674	681	PF00069	0.727
MOD_GSK3_1	685	692	PF00069	0.692
MOD_GSK3_1	71	78	PF00069	0.727
MOD_GSK3_1	740	747	PF00069	0.741
MOD_N-GLC_1	167	172	PF02516	0.435
MOD_N-GLC_1	498	503	PF02516	0.626
MOD_N-GLC_1	747	752	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.520
MOD_NEK2_1	104	109	PF00069	0.311
MOD_NEK2_1	184	189	PF00069	0.461
MOD_NEK2_1	340	345	PF00069	0.733
MOD_NEK2_1	374	379	PF00069	0.441
MOD_NEK2_1	776	781	PF00069	0.689
MOD_NEK2_2	23	28	PF00069	0.504
MOD_OFUCOSY	449	455	PF10250	0.443
MOD_PIKK_1	157	163	PF00454	0.592
MOD_PIKK_1	666	672	PF00454	0.721
MOD_PIKK_1	703	709	PF00454	0.514
MOD_PKA_2	374	380	PF00069	0.475
MOD_PKA_2	61	67	PF00069	0.793
MOD_PKA_2	616	622	PF00069	0.603
MOD_PKA_2	657	663	PF00069	0.526
MOD_PKA_2	731	737	PF00069	0.537
MOD_PKB_1	599	607	PF00069	0.671
MOD_Plk_1	341	347	PF00069	0.703
MOD_Plk_1	471	477	PF00069	0.486
MOD_Plk_1	498	504	PF00069	0.499
MOD_Plk_1	601	607	PF00069	0.670
MOD_Plk_1	685	691	PF00069	0.637
MOD_Plk_1	692	698	PF00069	0.519
MOD_Plk_1	747	753	PF00069	0.759
MOD_Plk_1	761	767	PF00069	0.629
MOD_Plk_1	89	95	PF00069	0.483
MOD_Plk_2-3	761	767	PF00069	0.655
MOD_Plk_4	1	7	PF00069	0.477
MOD_Plk_4	217	223	PF00069	0.625
MOD_Plk_4	225	231	PF00069	0.549
MOD_Plk_4	266	272	PF00069	0.394
MOD_Plk_4	298	304	PF00069	0.427
MOD_Plk_4	313	319	PF00069	0.374
MOD_Plk_4	367	373	PF00069	0.436
MOD_Plk_4	474	480	PF00069	0.390
MOD_Plk_4	510	516	PF00069	0.430
MOD_Plk_4	685	691	PF00069	0.568
MOD_Plk_4	693	699	PF00069	0.476
MOD_ProDKin_1	143	149	PF00069	0.641
MOD_ProDKin_1	228	234	PF00069	0.502
MOD_ProDKin_1	349	355	PF00069	0.410
MOD_ProDKin_1	436	442	PF00069	0.501
MOD_ProDKin_1	45	51	PF00069	0.618
MOD_ProDKin_1	626	632	PF00069	0.779
MOD_ProDKin_1	646	652	PF00069	0.728
MOD_ProDKin_1	75	81	PF00069	0.716
MOD_ProDKin_1	753	759	PF00069	0.566
MOD_SUMO_for_1	235	238	PF00179	0.552
TRG_AP2beta_CARGO_1	190	199	PF09066	0.498
TRG_AP2beta_CARGO_1	453	463	PF09066	0.520
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.530
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.396
TRG_ENDOCYTIC_2	273	276	PF00928	0.412
TRG_ENDOCYTIC_2	281	284	PF00928	0.391
TRG_ENDOCYTIC_2	3	6	PF00928	0.364
TRG_ENDOCYTIC_2	315	318	PF00928	0.339
TRG_ENDOCYTIC_2	363	366	PF00928	0.338
TRG_ENDOCYTIC_2	438	441	PF00928	0.387
TRG_ENDOCYTIC_2	719	722	PF00928	0.699
TRG_ER_diArg_1	100	102	PF00400	0.613
TRG_ER_diArg_1	252	255	PF00400	0.417
TRG_ER_diArg_1	260	262	PF00400	0.386
TRG_ER_diArg_1	27	29	PF00400	0.457
TRG_ER_diArg_1	444	446	PF00400	0.421
TRG_ER_diArg_1	462	464	PF00400	0.349
TRG_ER_diArg_1	465	468	PF00400	0.406
TRG_ER_diArg_1	488	490	PF00400	0.553
TRG_ER_diArg_1	596	599	PF00400	0.645
TRG_NLS_MonoExtN_4	101	106	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	703	707	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	763	767	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	41%	88%
A0A0N1PBA0	Leptomonas seymouri	57%	96%
A0A1X0NIQ9	Trypanosomatidae	35%	100%
A0A3Q8ICR1	Leishmania donovani	42%	100%
A0A3R7KGN9	Trypanosoma rangeli	34%	100%
A4HJP3	Leishmania braziliensis	73%	99%
A4HJP4	Leishmania braziliensis	44%	100%
A4I760	Leishmania infantum	100%	100%
A4I761	Leishmania infantum	41%	100%
E9B254	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q605	Leishmania major	42%	78%
Q4Q606	Leishmania major	91%	100%
V5BC23	Trypanosoma cruzi	35%	100%