Hypothetical_protein_conserved

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IST7_LEIDO

TriTrypDb:

LdBPK_312440.1 , LdCL_310032400 , LDHU3_31.4420

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 122, 236, 239, 36
Promastigote/Amastigote: 124

Expansion

Sequence features

A0A3Q8IST7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IST7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.692
CLV_NRD_NRD_1	448	450	PF00675	0.535
CLV_PCSK_KEX2_1	32	34	PF00082	0.705
CLV_PCSK_KEX2_1	448	450	PF00082	0.537
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.705
DEG_APCC_DBOX_1	472	480	PF00400	0.562
DEG_APCC_DBOX_1	483	491	PF00400	0.563
DEG_ODPH_VHL_1	376	388	PF01847	0.714
DEG_SCF_FBW7_2	471	478	PF00400	0.559
DEG_SPOP_SBC_1	65	69	PF00917	0.811
DOC_CDC14_PxL_1	250	258	PF14671	0.735
DOC_CDC14_PxL_1	303	311	PF14671	0.565
DOC_CKS1_1	42	47	PF01111	0.614
DOC_CKS1_1	472	477	PF01111	0.574
DOC_MAPK_FxFP_2	515	518	PF00069	0.487
DOC_MAPK_MEF2A_6	43	51	PF00069	0.617
DOC_MAPK_RevD_3	18	33	PF00069	0.710
DOC_PP2B_LxvP_1	468	471	PF13499	0.507
DOC_PP4_FxxP_1	193	196	PF00568	0.796
DOC_PP4_FxxP_1	434	437	PF00568	0.525
DOC_PP4_FxxP_1	515	518	PF00568	0.487
DOC_USP7_MATH_1	274	278	PF00917	0.615
DOC_USP7_MATH_1	318	322	PF00917	0.755
DOC_USP7_MATH_1	65	69	PF00917	0.657
DOC_USP7_UBL2_3	418	422	PF12436	0.713
DOC_WW_Pin1_4	121	126	PF00397	0.747
DOC_WW_Pin1_4	136	141	PF00397	0.596
DOC_WW_Pin1_4	198	203	PF00397	0.766
DOC_WW_Pin1_4	233	238	PF00397	0.812
DOC_WW_Pin1_4	367	372	PF00397	0.765
DOC_WW_Pin1_4	41	46	PF00397	0.616
DOC_WW_Pin1_4	471	476	PF00397	0.560
DOC_WW_Pin1_4	80	85	PF00397	0.659
DOC_WW_Pin1_4	97	102	PF00397	0.632
LIG_14-3-3_CanoR_1	164	170	PF00244	0.752
LIG_14-3-3_CanoR_1	233	237	PF00244	0.646
LIG_14-3-3_CanoR_1	264	273	PF00244	0.671
LIG_14-3-3_CanoR_1	399	406	PF00244	0.799
LIG_14-3-3_CanoR_1	416	424	PF00244	0.578
LIG_deltaCOP1_diTrp_1	453	462	PF00928	0.477
LIG_deltaCOP1_diTrp_1	498	507	PF00928	0.447
LIG_deltaCOP1_diTrp_1	53	62	PF00928	0.618
LIG_EVH1_1	435	439	PF00568	0.518
LIG_EVH1_1	468	472	PF00568	0.503
LIG_FHA_1	1	7	PF00498	0.669
LIG_FHA_1	125	131	PF00498	0.786
LIG_FHA_1	44	50	PF00498	0.595
LIG_FHA_1	463	469	PF00498	0.502
LIG_FHA_2	177	183	PF00498	0.705
LIG_FHA_2	207	213	PF00498	0.632
LIG_FHA_2	48	54	PF00498	0.615
LIG_FXI_DFP_1	514	518	PF00024	0.481
LIG_Integrin_RGD_1	25	27	PF01839	0.783
LIG_LIR_Apic_2	190	196	PF02991	0.788
LIG_LIR_Apic_2	59	65	PF02991	0.632
LIG_LIR_Gen_1	498	508	PF02991	0.445
LIG_LIR_Gen_1	525	536	PF02991	0.559
LIG_LIR_Nem_3	174	180	PF02991	0.602
LIG_LIR_Nem_3	453	458	PF02991	0.478
LIG_LIR_Nem_3	504	510	PF02991	0.437
LIG_LIR_Nem_3	525	531	PF02991	0.698
LIG_LYPXL_yS_3	306	309	PF13949	0.568
LIG_MYND_3	253	257	PF01753	0.726
LIG_NRBOX	423	429	PF00104	0.533
LIG_PCNA_yPIPBox_3	186	197	PF02747	0.679
LIG_Pex14_2	430	434	PF04695	0.547
LIG_Rb_pABgroove_1	509	517	PF01858	0.471
LIG_SH2_SRC	281	284	PF00017	0.691
LIG_SH2_STAP1	165	169	PF00017	0.689
LIG_SH2_STAP1	173	177	PF00017	0.598
LIG_SH2_STAP1	458	462	PF00017	0.476
LIG_SH2_STAT5	207	210	PF00017	0.729
LIG_SH2_STAT5	252	255	PF00017	0.598
LIG_SH2_STAT5	281	284	PF00017	0.554
LIG_SH2_STAT5	423	426	PF00017	0.533
LIG_SH3_1	345	351	PF00018	0.710
LIG_SH3_2	437	442	PF14604	0.534
LIG_SH3_3	148	154	PF00018	0.657
LIG_SH3_3	157	163	PF00018	0.602
LIG_SH3_3	199	205	PF00018	0.712
LIG_SH3_3	284	290	PF00018	0.708
LIG_SH3_3	345	351	PF00018	0.807
LIG_SH3_3	39	45	PF00018	0.612
LIG_SH3_3	433	439	PF00018	0.530
LIG_SH3_3	466	472	PF00018	0.511
LIG_SH3_CIN85_PxpxPR_1	437	442	PF14604	0.534
LIG_SUMO_SIM_par_1	46	53	PF11976	0.620
LIG_TRAF2_1	209	212	PF00917	0.717
LIG_TRAF2_1	313	316	PF00917	0.605
LIG_WW_3	439	443	PF00397	0.547
LIG_WW_3	470	474	PF00397	0.542
MOD_CDC14_SPxK_1	201	204	PF00782	0.724
MOD_CDK_SPxK_1	198	204	PF00069	0.726
MOD_CDK_SPxxK_3	80	87	PF00069	0.720
MOD_CK1_1	124	130	PF00069	0.768
MOD_CK1_1	236	242	PF00069	0.730
MOD_CK1_1	244	250	PF00069	0.614
MOD_CK1_1	328	334	PF00069	0.634
MOD_CK1_1	389	395	PF00069	0.705
MOD_CK1_1	398	404	PF00069	0.803
MOD_CK1_1	80	86	PF00069	0.669
MOD_CK2_1	176	182	PF00069	0.704
MOD_CK2_1	206	212	PF00069	0.636
MOD_CK2_1	274	280	PF00069	0.528
MOD_CK2_1	47	53	PF00069	0.620
MOD_CK2_1	66	72	PF00069	0.657
MOD_GlcNHglycan	217	220	PF01048	0.636
MOD_GlcNHglycan	243	246	PF01048	0.631
MOD_GlcNHglycan	267	270	PF01048	0.544
MOD_GlcNHglycan	388	391	PF01048	0.687
MOD_GlcNHglycan	400	403	PF01048	0.803
MOD_GlcNHglycan	406	409	PF01048	0.656
MOD_GlcNHglycan	57	61	PF01048	0.753
MOD_GlcNHglycan	79	82	PF01048	0.658
MOD_GlcNHglycan	95	98	PF01048	0.638
MOD_GSK3_1	172	179	PF00069	0.792
MOD_GSK3_1	206	213	PF00069	0.730
MOD_GSK3_1	225	232	PF00069	0.622
MOD_GSK3_1	241	248	PF00069	0.635
MOD_GSK3_1	291	298	PF00069	0.598
MOD_GSK3_1	318	325	PF00069	0.656
MOD_GSK3_1	391	398	PF00069	0.747
MOD_GSK3_1	418	425	PF00069	0.572
MOD_GSK3_1	43	50	PF00069	0.626
MOD_GSK3_1	93	100	PF00069	0.638
MOD_N-GLC_1	307	312	PF02516	0.705
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	296	301	PF00069	0.567
MOD_NEK2_1	386	391	PF00069	0.646
MOD_NEK2_1	47	52	PF00069	0.619
MOD_NEK2_2	165	170	PF00069	0.671
MOD_PIKK_1	187	193	PF00454	0.778
MOD_PIKK_1	296	302	PF00454	0.556
MOD_PKA_1	32	38	PF00069	0.691
MOD_PKA_2	16	22	PF00069	0.744
MOD_PKA_2	163	169	PF00069	0.777
MOD_PKA_2	232	238	PF00069	0.636
MOD_PKA_2	32	38	PF00069	0.558
MOD_PKA_2	398	404	PF00069	0.802
MOD_PKA_2	77	83	PF00069	0.671
MOD_Plk_1	187	193	PF00069	0.781
MOD_Plk_1	211	217	PF00069	0.619
MOD_Plk_1	33	39	PF00069	0.640
MOD_Plk_4	248	254	PF00069	0.705
MOD_Plk_4	274	280	PF00069	0.721
MOD_Plk_4	33	39	PF00069	0.659
MOD_Plk_4	43	49	PF00069	0.581
MOD_Plk_4	66	72	PF00069	0.666
MOD_ProDKin_1	121	127	PF00069	0.745
MOD_ProDKin_1	136	142	PF00069	0.596
MOD_ProDKin_1	198	204	PF00069	0.767
MOD_ProDKin_1	233	239	PF00069	0.810
MOD_ProDKin_1	367	373	PF00069	0.766
MOD_ProDKin_1	41	47	PF00069	0.619
MOD_ProDKin_1	471	477	PF00069	0.565
MOD_ProDKin_1	80	86	PF00069	0.657
MOD_ProDKin_1	97	103	PF00069	0.632
MOD_SUMO_for_1	31	34	PF00179	0.702
MOD_SUMO_for_1	444	447	PF00179	0.559
MOD_SUMO_rev_2	419	424	PF00179	0.684
TRG_ENDOCYTIC_2	207	210	PF00928	0.836
TRG_ENDOCYTIC_2	306	309	PF00928	0.568
TRG_ER_diArg_1	194	197	PF00400	0.693
TRG_ER_diArg_1	448	451	PF00400	0.537
TRG_ER_diArg_1	483	486	PF00400	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC95	Leptomonas seymouri	52%	91%
A4HJM0	Leishmania braziliensis	73%	99%
A4I742	Leishmania infantum	100%	100%
E9B236	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q625	Leishmania major	93%	100%