Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8ISS4_LEIDO

TriTrypDb:

LdBPK_312260.1 , LdCL_310030600

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ISS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.620
CLV_C14_Caspase3-7	423	427	PF00656	0.575
CLV_NRD_NRD_1	112	114	PF00675	0.618
CLV_NRD_NRD_1	139	141	PF00675	0.641
CLV_NRD_NRD_1	150	152	PF00675	0.554
CLV_NRD_NRD_1	298	300	PF00675	0.625
CLV_NRD_NRD_1	444	446	PF00675	0.809
CLV_NRD_NRD_1	449	451	PF00675	0.750
CLV_PCSK_FUR_1	137	141	PF00082	0.638
CLV_PCSK_FUR_1	148	152	PF00082	0.557
CLV_PCSK_KEX2_1	112	114	PF00082	0.618
CLV_PCSK_KEX2_1	139	141	PF00082	0.641
CLV_PCSK_KEX2_1	150	152	PF00082	0.554
CLV_PCSK_KEX2_1	298	300	PF00082	0.625
CLV_PCSK_KEX2_1	396	398	PF00082	0.657
CLV_PCSK_KEX2_1	448	450	PF00082	0.788
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.657
CLV_PCSK_PC7_1	445	451	PF00082	0.642
CLV_PCSK_SKI1_1	450	454	PF00082	0.641
CLV_PCSK_SKI1_1	470	474	PF00082	0.533
CLV_PCSK_SKI1_1	94	98	PF00082	0.628
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DEG_SCF_FBW7_1	239	245	PF00400	0.638
DEG_SPOP_SBC_1	184	188	PF00917	0.583
DOC_CKS1_1	239	244	PF01111	0.638
DOC_MAPK_gen_1	148	156	PF00069	0.597
DOC_MAPK_gen_1	172	180	PF00069	0.582
DOC_MAPK_gen_1	445	454	PF00069	0.642
DOC_MAPK_gen_1	93	102	PF00069	0.631
DOC_MAPK_HePTP_8	90	102	PF00069	0.590
DOC_MAPK_MEF2A_6	148	156	PF00069	0.597
DOC_MAPK_MEF2A_6	93	102	PF00069	0.592
DOC_USP7_MATH_1	105	109	PF00917	0.649
DOC_USP7_MATH_1	120	124	PF00917	0.674
DOC_USP7_MATH_1	146	150	PF00917	0.702
DOC_USP7_MATH_1	190	194	PF00917	0.626
DOC_USP7_MATH_1	242	246	PF00917	0.636
DOC_USP7_MATH_1	265	269	PF00917	0.654
DOC_USP7_MATH_1	376	380	PF00917	0.714
DOC_USP7_MATH_1	42	46	PF00917	0.711
DOC_USP7_MATH_1	459	463	PF00917	0.590
DOC_USP7_MATH_1	96	100	PF00917	0.630
DOC_USP7_UBL2_3	93	97	PF12436	0.630
DOC_WW_Pin1_4	139	144	PF00397	0.676
DOC_WW_Pin1_4	227	232	PF00397	0.599
DOC_WW_Pin1_4	238	243	PF00397	0.595
DOC_WW_Pin1_4	252	257	PF00397	0.615
DOC_WW_Pin1_4	268	273	PF00397	0.542
DOC_WW_Pin1_4	302	307	PF00397	0.755
DOC_WW_Pin1_4	457	462	PF00397	0.767
DOC_WW_Pin1_4	57	62	PF00397	0.654
LIG_14-3-3_CanoR_1	112	117	PF00244	0.650
LIG_14-3-3_CanoR_1	165	173	PF00244	0.622
LIG_14-3-3_CanoR_1	181	185	PF00244	0.593
LIG_14-3-3_CanoR_1	19	25	PF00244	0.637
LIG_14-3-3_CanoR_1	223	231	PF00244	0.587
LIG_14-3-3_CanoR_1	261	265	PF00244	0.642
LIG_14-3-3_CanoR_1	448	453	PF00244	0.661
LIG_14-3-3_CanoR_1	75	81	PF00244	0.645
LIG_APCC_ABBA_1	154	159	PF00400	0.573
LIG_BRCT_BRCA1_1	253	257	PF00533	0.617
LIG_FHA_1	175	181	PF00498	0.583
LIG_FHA_1	449	455	PF00498	0.602
LIG_FHA_1	81	87	PF00498	0.606
LIG_FHA_2	421	427	PF00498	0.577
LIG_FHA_2	44	50	PF00498	0.671
LIG_FHA_2	451	457	PF00498	0.546
LIG_FHA_2	9	15	PF00498	0.581
LIG_LIR_Apic_2	388	394	PF02991	0.618
LIG_LIR_Apic_2	410	416	PF02991	0.590
LIG_LIR_Gen_1	13	22	PF02991	0.594
LIG_LIR_Gen_1	325	334	PF02991	0.577
LIG_LIR_Nem_3	13	18	PF02991	0.632
LIG_LIR_Nem_3	281	287	PF02991	0.608
LIG_LIR_Nem_3	325	330	PF02991	0.595
LIG_LIR_Nem_3	340	344	PF02991	0.543
LIG_SH2_CRK	373	377	PF00017	0.607
LIG_SH2_GRB2like	391	394	PF00017	0.617
LIG_SH2_NCK_1	373	377	PF00017	0.607
LIG_SH2_PTP2	391	394	PF00017	0.656
LIG_SH2_SRC	342	345	PF00017	0.616
LIG_SH2_SRC	391	394	PF00017	0.617
LIG_SH2_STAP1	206	210	PF00017	0.603
LIG_SH2_STAP1	31	35	PF00017	0.628
LIG_SH2_STAP1	339	343	PF00017	0.612
LIG_SH2_STAT5	329	332	PF00017	0.620
LIG_SH2_STAT5	391	394	PF00017	0.710
LIG_SH3_1	140	146	PF00018	0.633
LIG_SH3_1	304	310	PF00018	0.616
LIG_SH3_1	58	64	PF00018	0.623
LIG_SH3_2	143	148	PF14604	0.663
LIG_SH3_3	122	128	PF00018	0.649
LIG_SH3_3	140	146	PF00018	0.549
LIG_SH3_3	24	30	PF00018	0.591
LIG_SH3_3	269	275	PF00018	0.606
LIG_SH3_3	304	310	PF00018	0.694
LIG_SH3_3	32	38	PF00018	0.585
LIG_SH3_3	465	471	PF00018	0.593
LIG_SH3_3	58	64	PF00018	0.662
LIG_SH3_3	99	105	PF00018	0.633
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.564
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.546
LIG_SUMO_SIM_par_1	216	222	PF11976	0.577
LIG_SUMO_SIM_par_1	450	456	PF11976	0.545
LIG_TRAF2_1	364	367	PF00917	0.730
LIG_TRAF2_1	5	8	PF00917	0.622
LIG_WRC_WIRS_1	338	343	PF05994	0.610
LIG_WW_3	55	59	PF00397	0.628
LIG_WW_3	75	79	PF00397	0.642
MOD_CDK_SPK_2	229	234	PF00069	0.630
MOD_CDK_SPxK_1	57	63	PF00069	0.627
MOD_CDK_SPxxK_3	227	234	PF00069	0.623
MOD_CK1_1	115	121	PF00069	0.777
MOD_CK1_1	183	189	PF00069	0.611
MOD_CK1_1	226	232	PF00069	0.623
MOD_CK1_1	251	257	PF00069	0.617
MOD_CK1_1	260	266	PF00069	0.582
MOD_CK1_1	268	274	PF00069	0.535
MOD_CK1_1	276	282	PF00069	0.747
MOD_CK1_1	288	294	PF00069	0.625
MOD_CK1_1	320	326	PF00069	0.676
MOD_CK1_1	345	351	PF00069	0.575
MOD_CK1_1	424	430	PF00069	0.738
MOD_CK1_1	462	468	PF00069	0.709
MOD_CK2_1	271	277	PF00069	0.649
MOD_CK2_1	360	366	PF00069	0.730
MOD_CK2_1	43	49	PF00069	0.660
MOD_GlcNHglycan	107	110	PF01048	0.633
MOD_GlcNHglycan	174	177	PF01048	0.605
MOD_GlcNHglycan	225	228	PF01048	0.653
MOD_GlcNHglycan	250	253	PF01048	0.622
MOD_GlcNHglycan	262	265	PF01048	0.557
MOD_GlcNHglycan	267	270	PF01048	0.537
MOD_GlcNHglycan	321	325	PF01048	0.628
MOD_GlcNHglycan	362	365	PF01048	0.703
MOD_GlcNHglycan	423	426	PF01048	0.617
MOD_GlcNHglycan	72	75	PF01048	0.606
MOD_GSK3_1	135	142	PF00069	0.683
MOD_GSK3_1	180	187	PF00069	0.649
MOD_GSK3_1	190	197	PF00069	0.562
MOD_GSK3_1	217	224	PF00069	0.705
MOD_GSK3_1	237	244	PF00069	0.593
MOD_GSK3_1	248	255	PF00069	0.621
MOD_GSK3_1	273	280	PF00069	0.635
MOD_GSK3_1	288	295	PF00069	0.563
MOD_GSK3_1	352	359	PF00069	0.647
MOD_GSK3_1	420	427	PF00069	0.785
MOD_GSK3_1	76	83	PF00069	0.640
MOD_N-GLC_1	25	30	PF02516	0.618
MOD_N-GLC_1	252	257	PF02516	0.576
MOD_NEK2_1	219	224	PF00069	0.694
MOD_NEK2_1	257	262	PF00069	0.633
MOD_NEK2_1	438	443	PF00069	0.597
MOD_NEK2_2	107	112	PF00069	0.601
MOD_NEK2_2	337	342	PF00069	0.606
MOD_PIKK_1	120	126	PF00454	0.725
MOD_PK_1	82	88	PF00069	0.640
MOD_PKA_1	112	118	PF00069	0.610
MOD_PKA_1	448	454	PF00069	0.640
MOD_PKA_2	112	118	PF00069	0.657
MOD_PKA_2	164	170	PF00069	0.661
MOD_PKA_2	180	186	PF00069	0.562
MOD_PKA_2	260	266	PF00069	0.644
MOD_PKA_2	285	291	PF00069	0.615
MOD_PKA_2	360	366	PF00069	0.682
MOD_PKA_2	448	454	PF00069	0.684
MOD_PKB_1	172	180	PF00069	0.582
MOD_PKB_1	448	456	PF00069	0.545
MOD_Plk_1	206	212	PF00069	0.589
MOD_Plk_1	25	31	PF00069	0.602
MOD_Plk_2-3	8	14	PF00069	0.617
MOD_Plk_4	206	212	PF00069	0.565
MOD_Plk_4	242	248	PF00069	0.633
MOD_Plk_4	337	343	PF00069	0.607
MOD_Plk_4	450	456	PF00069	0.545
MOD_Plk_4	82	88	PF00069	0.602
MOD_ProDKin_1	139	145	PF00069	0.674
MOD_ProDKin_1	227	233	PF00069	0.601
MOD_ProDKin_1	238	244	PF00069	0.592
MOD_ProDKin_1	252	258	PF00069	0.616
MOD_ProDKin_1	268	274	PF00069	0.542
MOD_ProDKin_1	302	308	PF00069	0.756
MOD_ProDKin_1	457	463	PF00069	0.765
MOD_ProDKin_1	57	63	PF00069	0.656
MOD_SUMO_for_1	353	356	PF00179	0.582
MOD_SUMO_rev_2	406	416	PF00179	0.602
TRG_ER_diArg_1	111	113	PF00400	0.615
TRG_ER_diArg_1	137	140	PF00400	0.639
TRG_ER_diArg_1	148	151	PF00400	0.561
TRG_ER_diArg_1	448	450	PF00400	0.720
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I702	Leishmania infantum	98%	100%
E9B220	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%