Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ISN5_LEIDO

TriTrypDb:

LdBPK_311780.1 , LdCL_310025100 , LDHU3_31.3070

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ISN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.635
CLV_NRD_NRD_1	123	125	PF00675	0.613
CLV_NRD_NRD_1	128	130	PF00675	0.597
CLV_NRD_NRD_1	173	175	PF00675	0.553
CLV_NRD_NRD_1	189	191	PF00675	0.514
CLV_NRD_NRD_1	353	355	PF00675	0.486
CLV_NRD_NRD_1	360	362	PF00675	0.530
CLV_NRD_NRD_1	84	86	PF00675	0.580
CLV_NRD_NRD_1	88	90	PF00675	0.572
CLV_PCSK_KEX2_1	123	125	PF00082	0.613
CLV_PCSK_KEX2_1	128	130	PF00082	0.597
CLV_PCSK_KEX2_1	189	191	PF00082	0.518
CLV_PCSK_KEX2_1	269	271	PF00082	0.555
CLV_PCSK_KEX2_1	353	355	PF00082	0.494
CLV_PCSK_KEX2_1	360	362	PF00082	0.542
CLV_PCSK_KEX2_1	84	86	PF00082	0.580
CLV_PCSK_KEX2_1	88	90	PF00082	0.572
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.635
CLV_PCSK_PC7_1	124	130	PF00082	0.648
CLV_PCSK_PC7_1	185	191	PF00082	0.544
CLV_PCSK_PC7_1	84	90	PF00082	0.539
CLV_PCSK_SKI1_1	100	104	PF00082	0.687
CLV_PCSK_SKI1_1	257	261	PF00082	0.640
CLV_PCSK_SKI1_1	313	317	PF00082	0.784
CLV_PCSK_SKI1_1	354	358	PF00082	0.553
CLV_PCSK_SKI1_1	84	88	PF00082	0.587
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.762
DOC_MAPK_gen_1	100	108	PF00069	0.622
DOC_MAPK_gen_1	84	94	PF00069	0.576
DOC_MAPK_MEF2A_6	88	96	PF00069	0.586
DOC_PP2B_LxvP_1	108	111	PF13499	0.661
DOC_PP4_FxxP_1	326	329	PF00568	0.701
DOC_PP4_FxxP_1	71	74	PF00568	0.597
DOC_USP7_MATH_1	148	152	PF00917	0.607
DOC_USP7_MATH_1	8	12	PF00917	0.713
DOC_USP7_UBL2_3	309	313	PF12436	0.753
DOC_WW_Pin1_4	19	24	PF00397	0.739
DOC_WW_Pin1_4	191	196	PF00397	0.592
DOC_WW_Pin1_4	220	225	PF00397	0.693
DOC_WW_Pin1_4	314	319	PF00397	0.790
DOC_WW_Pin1_4	38	43	PF00397	0.761
DOC_WW_Pin1_4	4	9	PF00397	0.561
DOC_WW_Pin1_4	59	64	PF00397	0.743
DOC_WW_Pin1_4	72	77	PF00397	0.590
LIG_14-3-3_CanoR_1	123	127	PF00244	0.653
LIG_14-3-3_CanoR_1	263	267	PF00244	0.561
LIG_14-3-3_CanoR_1	360	368	PF00244	0.587
LIG_14-3-3_CanoR_1	88	96	PF00244	0.625
LIG_Actin_WH2_2	73	90	PF00022	0.542
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BIR_III_3	1	5	PF00653	0.758
LIG_FHA_1	19	25	PF00498	0.583
LIG_FHA_1	245	251	PF00498	0.533
LIG_FHA_1	274	280	PF00498	0.666
LIG_FHA_1	285	291	PF00498	0.700
LIG_FHA_1	59	65	PF00498	0.715
LIG_FHA_1	8	14	PF00498	0.640
LIG_FHA_2	171	177	PF00498	0.576
LIG_FHA_2	287	293	PF00498	0.748
LIG_FHA_2	332	338	PF00498	0.655
LIG_FHA_2	360	366	PF00498	0.580
LIG_Integrin_RGD_1	164	166	PF01839	0.760
LIG_LIR_Apic_2	323	329	PF02991	0.708
LIG_LIR_Apic_2	365	371	PF02991	0.598
LIG_LIR_Apic_2	68	74	PF02991	0.600
LIG_LIR_Gen_1	213	224	PF02991	0.615
LIG_LIR_Gen_1	334	343	PF02991	0.554
LIG_LIR_Nem_3	334	338	PF02991	0.557
LIG_PCNA_PIPBox_1	80	89	PF02747	0.660
LIG_Pex14_2	168	172	PF04695	0.726
LIG_SH2_CRK	368	372	PF00017	0.607
LIG_SH2_STAT5	187	190	PF00017	0.567
LIG_SH2_STAT5	255	258	PF00017	0.671
LIG_SH3_1	192	198	PF00018	0.680
LIG_SH3_3	103	109	PF00018	0.656
LIG_SH3_3	11	17	PF00018	0.645
LIG_SH3_3	157	163	PF00018	0.650
LIG_SH3_3	192	198	PF00018	0.582
LIG_SH3_3	2	8	PF00018	0.637
LIG_SH3_3	226	232	PF00018	0.689
LIG_SH3_3	275	281	PF00018	0.614
LIG_SH3_3	321	327	PF00018	0.666
LIG_SH3_3	41	47	PF00018	0.709
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.705
LIG_SUMO_SIM_par_1	341	346	PF11976	0.638
MOD_CDC14_SPxK_1	22	25	PF00782	0.757
MOD_CDK_SPxK_1	19	25	PF00069	0.763
MOD_CK1_1	18	24	PF00069	0.735
MOD_CK1_1	298	304	PF00069	0.732
MOD_CK1_1	31	37	PF00069	0.707
MOD_CK1_1	317	323	PF00069	0.519
MOD_CK1_1	55	61	PF00069	0.699
MOD_CK1_1	7	13	PF00069	0.636
MOD_CK1_1	75	81	PF00069	0.507
MOD_CK2_1	132	138	PF00069	0.716
MOD_CK2_1	170	176	PF00069	0.579
MOD_CK2_1	286	292	PF00069	0.760
MOD_CK2_1	359	365	PF00069	0.575
MOD_GlcNHglycan	150	153	PF01048	0.627
MOD_GlcNHglycan	155	159	PF01048	0.604
MOD_GlcNHglycan	297	300	PF01048	0.705
MOD_GlcNHglycan	35	38	PF01048	0.696
MOD_GlcNHglycan	57	60	PF01048	0.710
MOD_GlcNHglycan	77	80	PF01048	0.388
MOD_GSK3_1	12	19	PF00069	0.644
MOD_GSK3_1	28	35	PF00069	0.655
MOD_GSK3_1	291	298	PF00069	0.683
MOD_GSK3_1	316	323	PF00069	0.698
MOD_GSK3_1	4	11	PF00069	0.717
MOD_GSK3_1	55	62	PF00069	0.754
MOD_LATS_1	359	365	PF00433	0.575
MOD_NEK2_1	132	137	PF00069	0.631
MOD_NEK2_1	168	173	PF00069	0.712
MOD_NEK2_1	293	298	PF00069	0.681
MOD_NEK2_1	87	92	PF00069	0.610
MOD_NEK2_2	255	260	PF00069	0.664
MOD_PIKK_1	8	14	PF00454	0.627
MOD_PK_1	88	94	PF00069	0.623
MOD_PKA_1	88	94	PF00069	0.544
MOD_PKA_2	122	128	PF00069	0.654
MOD_PKA_2	262	268	PF00069	0.583
MOD_PKA_2	359	365	PF00069	0.560
MOD_PKA_2	87	93	PF00069	0.618
MOD_Plk_1	168	174	PF00069	0.710
MOD_Plk_1	28	34	PF00069	0.682
MOD_Plk_4	262	268	PF00069	0.631
MOD_Plk_4	88	94	PF00069	0.634
MOD_ProDKin_1	19	25	PF00069	0.740
MOD_ProDKin_1	191	197	PF00069	0.583
MOD_ProDKin_1	220	226	PF00069	0.691
MOD_ProDKin_1	314	320	PF00069	0.791
MOD_ProDKin_1	38	44	PF00069	0.760
MOD_ProDKin_1	4	10	PF00069	0.563
MOD_ProDKin_1	59	65	PF00069	0.743
MOD_ProDKin_1	72	78	PF00069	0.584
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.651
TRG_ENDOCYTIC_2	335	338	PF00928	0.655
TRG_ER_diArg_1	127	129	PF00400	0.606
TRG_ER_diArg_1	188	190	PF00400	0.516
TRG_ER_diArg_1	83	85	PF00400	0.574
TRG_ER_diArg_1	87	89	PF00400	0.579
TRG_NES_CRM1_1	254	268	PF08389	0.656
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V3	Leptomonas seymouri	40%	92%
A4I6V3	Leishmania infantum	99%	100%
E9B1X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q686	Leishmania major	88%	100%