Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8ISJ9_LEIDO

TriTrypDb:

LdBPK_311170.1 , LdCL_310018400 , LDHU3_31.1920

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8ISJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.417
CLV_NRD_NRD_1	186	188	PF00675	0.483
CLV_NRD_NRD_1	22	24	PF00675	0.552
CLV_NRD_NRD_1	291	293	PF00675	0.384
CLV_NRD_NRD_1	339	341	PF00675	0.359
CLV_NRD_NRD_1	560	562	PF00675	0.656
CLV_PCSK_FUR_1	558	562	PF00082	0.571
CLV_PCSK_KEX2_1	129	131	PF00082	0.584
CLV_PCSK_KEX2_1	22	24	PF00082	0.584
CLV_PCSK_KEX2_1	248	250	PF00082	0.357
CLV_PCSK_KEX2_1	291	293	PF00082	0.384
CLV_PCSK_KEX2_1	339	341	PF00082	0.359
CLV_PCSK_KEX2_1	558	560	PF00082	0.555
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.584
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.357
CLV_PCSK_SKI1_1	113	117	PF00082	0.664
CLV_PCSK_SKI1_1	120	124	PF00082	0.723
CLV_PCSK_SKI1_1	161	165	PF00082	0.547
CLV_PCSK_SKI1_1	233	237	PF00082	0.420
CLV_PCSK_SKI1_1	291	295	PF00082	0.483
CLV_PCSK_SKI1_1	376	380	PF00082	0.497
CLV_PCSK_SKI1_1	457	461	PF00082	0.380
CLV_Separin_Metazoa	563	567	PF03568	0.537
DEG_APCC_DBOX_1	375	383	PF00400	0.452
DEG_APCC_DBOX_1	565	573	PF00400	0.516
DEG_APCC_DBOX_1	590	598	PF00400	0.490
DEG_APCC_DBOX_1	610	618	PF00400	0.571
DEG_SCF_FBW7_1	138	145	PF00400	0.571
DOC_CDC14_PxL_1	310	318	PF14671	0.353
DOC_CKS1_1	139	144	PF01111	0.530
DOC_CKS1_1	182	187	PF01111	0.425
DOC_CKS1_1	38	43	PF01111	0.561
DOC_CYCLIN_RxL_1	565	573	PF00134	0.516
DOC_MAPK_gen_1	520	529	PF00069	0.410
DOC_MAPK_MEF2A_6	120	128	PF00069	0.640
DOC_MIT_MIM_1	563	572	PF04212	0.523
DOC_PP1_RVXF_1	103	110	PF00149	0.540
DOC_PP1_SILK_1	157	162	PF00149	0.378
DOC_PP2B_LxvP_1	214	217	PF13499	0.424
DOC_PP2B_LxvP_1	363	366	PF13499	0.516
DOC_USP7_MATH_1	11	15	PF00917	0.545
DOC_USP7_MATH_1	137	141	PF00917	0.602
DOC_USP7_MATH_1	2	6	PF00917	0.559
DOC_USP7_MATH_1	217	221	PF00917	0.424
DOC_USP7_MATH_1	234	238	PF00917	0.272
DOC_USP7_MATH_1	426	430	PF00917	0.608
DOC_USP7_MATH_1	68	72	PF00917	0.588
DOC_USP7_UBL2_3	188	192	PF12436	0.445
DOC_WW_Pin1_4	138	143	PF00397	0.586
DOC_WW_Pin1_4	181	186	PF00397	0.469
DOC_WW_Pin1_4	37	42	PF00397	0.684
DOC_WW_Pin1_4	405	410	PF00397	0.478
DOC_WW_Pin1_4	422	427	PF00397	0.494
DOC_WW_Pin1_4	468	473	PF00397	0.381
LIG_14-3-3_CanoR_1	113	122	PF00244	0.537
LIG_14-3-3_CanoR_1	161	166	PF00244	0.506
LIG_14-3-3_CanoR_1	233	239	PF00244	0.493
LIG_14-3-3_CanoR_1	249	253	PF00244	0.519
LIG_14-3-3_CanoR_1	254	259	PF00244	0.480
LIG_14-3-3_CanoR_1	274	281	PF00244	0.526
LIG_14-3-3_CanoR_1	284	293	PF00244	0.338
LIG_14-3-3_CanoR_1	30	39	PF00244	0.539
LIG_14-3-3_CanoR_1	457	462	PF00244	0.448
LIG_14-3-3_CanoR_1	511	518	PF00244	0.537
LIG_14-3-3_CanoR_1	520	525	PF00244	0.441
LIG_14-3-3_CanoR_1	558	564	PF00244	0.631
LIG_14-3-3_CanoR_1	591	595	PF00244	0.545
LIG_Actin_WH2_2	260	276	PF00022	0.337
LIG_Actin_WH2_2	463	480	PF00022	0.390
LIG_Actin_WH2_2	497	515	PF00022	0.489
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BIR_III_4	282	286	PF00653	0.366
LIG_BRCT_BRCA1_1	374	378	PF00533	0.542
LIG_DLG_GKlike_1	254	261	PF00625	0.342
LIG_EVH1_2	152	156	PF00568	0.488
LIG_FHA_1	11	17	PF00498	0.615
LIG_FHA_1	121	127	PF00498	0.511
LIG_FHA_1	209	215	PF00498	0.535
LIG_FHA_1	32	38	PF00498	0.602
LIG_FHA_2	191	197	PF00498	0.442
LIG_FHA_2	200	206	PF00498	0.354
LIG_FHA_2	234	240	PF00498	0.479
LIG_FHA_2	458	464	PF00498	0.481
LIG_FHA_2	478	484	PF00498	0.359
LIG_FHA_2	545	551	PF00498	0.505
LIG_FHA_2	84	90	PF00498	0.749
LIG_LIR_Apic_2	131	137	PF02991	0.557
LIG_LIR_Gen_1	208	218	PF02991	0.473
LIG_LIR_Gen_1	351	361	PF02991	0.527
LIG_LIR_Gen_1	413	424	PF02991	0.599
LIG_LIR_Gen_1	428	438	PF02991	0.362
LIG_LIR_Gen_1	500	510	PF02991	0.363
LIG_LIR_Gen_1	89	96	PF02991	0.572
LIG_LIR_Nem_3	208	213	PF02991	0.413
LIG_LIR_Nem_3	320	326	PF02991	0.351
LIG_LIR_Nem_3	413	419	PF02991	0.699
LIG_LIR_Nem_3	428	433	PF02991	0.322
LIG_LIR_Nem_3	483	489	PF02991	0.369
LIG_LIR_Nem_3	500	506	PF02991	0.254
LIG_LIR_Nem_3	89	93	PF02991	0.572
LIG_Pex14_1	84	88	PF04695	0.467
LIG_SH2_CRK	134	138	PF00017	0.565
LIG_SH2_CRK	323	327	PF00017	0.378
LIG_SH2_CRK	90	94	PF00017	0.581
LIG_SH2_GRB2like	503	506	PF00017	0.403
LIG_SH2_PTP2	503	506	PF00017	0.361
LIG_SH2_SRC	88	91	PF00017	0.486
LIG_SH2_STAP1	57	61	PF00017	0.542
LIG_SH2_STAT5	39	42	PF00017	0.653
LIG_SH2_STAT5	416	419	PF00017	0.426
LIG_SH2_STAT5	503	506	PF00017	0.403
LIG_SH2_STAT5	54	57	PF00017	0.395
LIG_SH2_STAT5	79	82	PF00017	0.576
LIG_SH3_3	133	139	PF00018	0.523
LIG_SH3_3	237	243	PF00018	0.328
LIG_SH3_3	379	385	PF00018	0.517
LIG_SH3_3	38	44	PF00018	0.559
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.367
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.389
LIG_SUMO_SIM_par_1	417	422	PF11976	0.484
LIG_SUMO_SIM_par_1	440	447	PF11976	0.396
LIG_SUMO_SIM_par_1	568	573	PF11976	0.521
LIG_TRAF2_1	96	99	PF00917	0.563
LIG_TRAF2_2	167	172	PF00917	0.479
LIG_TYR_ITIM	414	419	PF00017	0.548
LIG_TYR_ITIM	501	506	PF00017	0.366
LIG_UBA3_1	197	206	PF00899	0.410
LIG_WRC_WIRS_1	207	212	PF05994	0.402
LIG_WW_2	136	139	PF00397	0.525
MOD_CDK_SPxK_1	181	187	PF00069	0.416
MOD_CDK_SPxxK_3	181	188	PF00069	0.425
MOD_CK1_1	140	146	PF00069	0.693
MOD_CK1_1	21	27	PF00069	0.544
MOD_CK1_1	220	226	PF00069	0.429
MOD_CK1_1	257	263	PF00069	0.500
MOD_CK1_1	425	431	PF00069	0.482
MOD_CK1_1	442	448	PF00069	0.425
MOD_CK2_1	190	196	PF00069	0.445
MOD_CK2_1	199	205	PF00069	0.352
MOD_CK2_1	233	239	PF00069	0.399
MOD_CK2_1	345	351	PF00069	0.385
MOD_CK2_1	428	434	PF00069	0.446
MOD_CK2_1	457	463	PF00069	0.434
MOD_CK2_1	520	526	PF00069	0.618
MOD_CK2_1	544	550	PF00069	0.561
MOD_CK2_1	83	89	PF00069	0.745
MOD_CK2_1	91	97	PF00069	0.514
MOD_GlcNHglycan	13	16	PF01048	0.783
MOD_GlcNHglycan	142	145	PF01048	0.655
MOD_GlcNHglycan	244	247	PF01048	0.520
MOD_GlcNHglycan	287	290	PF01048	0.340
MOD_GlcNHglycan	323	326	PF01048	0.444
MOD_GlcNHglycan	357	361	PF01048	0.609
MOD_GlcNHglycan	394	397	PF01048	0.608
MOD_GlcNHglycan	4	7	PF01048	0.700
MOD_GlcNHglycan	446	449	PF01048	0.368
MOD_GlcNHglycan	486	489	PF01048	0.508
MOD_GlcNHglycan	528	532	PF01048	0.486
MOD_GlcNHglycan	572	575	PF01048	0.728
MOD_GlcNHglycan	69	73	PF01048	0.610
MOD_GlcNHglycan	8	11	PF01048	0.734
MOD_GlcNHglycan	93	96	PF01048	0.582
MOD_GSK3_1	109	116	PF00069	0.555
MOD_GSK3_1	138	145	PF00069	0.606
MOD_GSK3_1	173	180	PF00069	0.503
MOD_GSK3_1	2	9	PF00069	0.644
MOD_GSK3_1	400	407	PF00069	0.625
MOD_GSK3_1	422	429	PF00069	0.601
MOD_GSK3_1	438	445	PF00069	0.276
MOD_GSK3_1	478	485	PF00069	0.378
MOD_GSK3_1	493	500	PF00069	0.277
MOD_GSK3_1	544	551	PF00069	0.532
MOD_GSK3_1	586	593	PF00069	0.591
MOD_N-GLC_1	285	290	PF02516	0.351
MOD_N-GLC_1	548	553	PF02516	0.525
MOD_NEK2_1	319	324	PF00069	0.496
MOD_NEK2_1	356	361	PF00069	0.548
MOD_NEK2_1	417	422	PF00069	0.532
MOD_NEK2_1	477	482	PF00069	0.361
MOD_NEK2_1	495	500	PF00069	0.540
MOD_NEK2_1	570	575	PF00069	0.730
MOD_NEK2_2	345	350	PF00069	0.375
MOD_PIKK_1	161	167	PF00454	0.461
MOD_PIKK_1	208	214	PF00454	0.433
MOD_PIKK_1	262	268	PF00454	0.377
MOD_PIKK_1	428	434	PF00454	0.453
MOD_PIKK_1	586	592	PF00454	0.552
MOD_PK_1	292	298	PF00069	0.348
MOD_PK_1	478	484	PF00069	0.510
MOD_PKA_1	248	254	PF00069	0.354
MOD_PKA_1	291	297	PF00069	0.361
MOD_PKA_1	559	565	PF00069	0.667
MOD_PKA_2	21	27	PF00069	0.513
MOD_PKA_2	248	254	PF00069	0.373
MOD_PKA_2	273	279	PF00069	0.352
MOD_PKA_2	291	297	PF00069	0.260
MOD_PKA_2	559	565	PF00069	0.600
MOD_PKA_2	590	596	PF00069	0.547
MOD_Plk_1	130	136	PF00069	0.551
MOD_Plk_1	319	325	PF00069	0.357
MOD_Plk_1	439	445	PF00069	0.537
MOD_Plk_1	482	488	PF00069	0.381
MOD_Plk_4	155	161	PF00069	0.470
MOD_Plk_4	222	228	PF00069	0.389
MOD_Plk_4	410	416	PF00069	0.620
MOD_Plk_4	439	445	PF00069	0.545
MOD_ProDKin_1	138	144	PF00069	0.584
MOD_ProDKin_1	181	187	PF00069	0.480
MOD_ProDKin_1	37	43	PF00069	0.682
MOD_ProDKin_1	405	411	PF00069	0.475
MOD_ProDKin_1	422	428	PF00069	0.485
MOD_ProDKin_1	468	474	PF00069	0.381
MOD_SUMO_for_1	128	131	PF00179	0.520
MOD_SUMO_rev_2	117	122	PF00179	0.539
TRG_DiLeu_BaEn_1	605	610	PF01217	0.543
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.525
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.506
TRG_ENDOCYTIC_2	323	326	PF00928	0.366
TRG_ENDOCYTIC_2	416	419	PF00928	0.593
TRG_ENDOCYTIC_2	503	506	PF00928	0.361
TRG_ENDOCYTIC_2	90	93	PF00928	0.631
TRG_ER_diArg_1	291	293	PF00400	0.384
TRG_ER_diArg_1	338	340	PF00400	0.361
TRG_ER_diArg_1	510	513	PF00400	0.450
TRG_ER_diArg_1	557	560	PF00400	0.580
TRG_ER_diArg_1	565	568	PF00400	0.490
TRG_NES_CRM1_1	266	277	PF08389	0.416
TRG_NES_CRM1_1	490	502	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NEN5	Trypanosomatidae	21%	100%
A4HJ96	Leishmania braziliensis	72%	100%
A4I6P1	Leishmania infantum	100%	100%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	77%
E9B1R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q6E7	Leishmania major	91%	100%