Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ISH4_LEIDO

TriTrypDb:

LdBPK_310840.1 , LdCL_310014300 , LDHU3_31.1250

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

A0A3Q8ISH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.839
CLV_NRD_NRD_1	28	30	PF00675	0.745
CLV_NRD_NRD_1	280	282	PF00675	0.507
CLV_NRD_NRD_1	295	297	PF00675	0.362
CLV_NRD_NRD_1	334	336	PF00675	0.336
CLV_NRD_NRD_1	392	394	PF00675	0.446
CLV_PCSK_FUR_1	26	30	PF00082	0.649
CLV_PCSK_KEX2_1	28	30	PF00082	0.745
CLV_PCSK_KEX2_1	280	282	PF00082	0.508
CLV_PCSK_KEX2_1	334	336	PF00082	0.336
CLV_PCSK_KEX2_1	394	396	PF00082	0.461
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.454
CLV_PCSK_PC7_1	24	30	PF00082	0.649
CLV_PCSK_PC7_1	330	336	PF00082	0.344
CLV_PCSK_SKI1_1	385	389	PF00082	0.438
CLV_PCSK_SKI1_1	426	430	PF00082	0.265
CLV_PCSK_SKI1_1	463	467	PF00082	0.465
CLV_PCSK_SKI1_1	503	507	PF00082	0.333
CLV_PCSK_SKI1_1	616	620	PF00082	0.366
CLV_PCSK_SKI1_1	70	74	PF00082	0.597
CLV_PCSK_SKI1_1	95	99	PF00082	0.587
DEG_Nend_UBRbox_2	1	3	PF02207	0.486
DOC_MAPK_DCC_7	591	599	PF00069	0.342
DOC_MAPK_gen_1	146	156	PF00069	0.580
DOC_MAPK_gen_1	296	304	PF00069	0.603
DOC_MAPK_MEF2A_6	149	158	PF00069	0.569
DOC_MAPK_MEF2A_6	499	506	PF00069	0.526
DOC_MAPK_MEF2A_6	591	599	PF00069	0.322
DOC_MAPK_MEF2A_6	77	86	PF00069	0.318
DOC_PIKK_1	75	82	PF02985	0.387
DOC_PP1_RVXF_1	501	507	PF00149	0.280
DOC_PP1_RVXF_1	93	100	PF00149	0.344
DOC_PP2B_LxvP_1	154	157	PF13499	0.591
DOC_PP2B_LxvP_1	254	257	PF13499	0.655
DOC_PP4_FxxP_1	316	319	PF00568	0.604
DOC_USP7_MATH_1	109	113	PF00917	0.293
DOC_USP7_MATH_1	142	146	PF00917	0.523
DOC_USP7_MATH_1	225	229	PF00917	0.671
DOC_USP7_MATH_1	257	261	PF00917	0.753
DOC_USP7_MATH_1	386	390	PF00917	0.571
DOC_USP7_MATH_1	424	428	PF00917	0.584
DOC_USP7_MATH_1	557	561	PF00917	0.458
DOC_USP7_MATH_1	60	64	PF00917	0.503
DOC_WW_Pin1_4	133	138	PF00397	0.686
DOC_WW_Pin1_4	52	57	PF00397	0.561
DOC_WW_Pin1_4	84	89	PF00397	0.393
LIG_14-3-3_CanoR_1	182	188	PF00244	0.772
LIG_14-3-3_CanoR_1	503	509	PF00244	0.343
LIG_14-3-3_CanoR_1	95	100	PF00244	0.352
LIG_Actin_WH2_2	75	93	PF00022	0.441
LIG_APCC_ABBA_1	617	622	PF00400	0.518
LIG_APCC_ABBAyCdc20_2	616	622	PF00400	0.517
LIG_BH_BH3_1	441	457	PF00452	0.346
LIG_BIR_III_4	556	560	PF00653	0.283
LIG_BRCT_BRCA1_1	437	441	PF00533	0.465
LIG_Clathr_ClatBox_1	129	133	PF01394	0.292
LIG_eIF4E_1	113	119	PF01652	0.370
LIG_eIF4E_1	612	618	PF01652	0.529
LIG_FHA_1	124	130	PF00498	0.372
LIG_FHA_1	376	382	PF00498	0.494
LIG_FHA_1	413	419	PF00498	0.564
LIG_FHA_1	475	481	PF00498	0.432
LIG_FHA_1	515	521	PF00498	0.336
LIG_FHA_1	598	604	PF00498	0.432
LIG_FHA_1	62	68	PF00498	0.417
LIG_FHA_1	96	102	PF00498	0.368
LIG_FHA_2	134	140	PF00498	0.577
LIG_FHA_2	235	241	PF00498	0.735
LIG_FHA_2	245	251	PF00498	0.742
LIG_GBD_Chelix_1	432	440	PF00786	0.412
LIG_LIR_Apic_2	314	319	PF02991	0.592
LIG_LIR_Gen_1	171	179	PF02991	0.801
LIG_LIR_Gen_1	434	445	PF02991	0.385
LIG_LIR_Gen_1	579	589	PF02991	0.356
LIG_LIR_LC3C_4	517	521	PF02991	0.295
LIG_LIR_Nem_3	111	116	PF02991	0.415
LIG_LIR_Nem_3	171	175	PF02991	0.796
LIG_LIR_Nem_3	427	432	PF02991	0.372
LIG_LIR_Nem_3	434	440	PF02991	0.331
LIG_LIR_Nem_3	579	585	PF02991	0.335
LIG_LIR_Nem_3	607	612	PF02991	0.357
LIG_MAD2	70	78	PF02301	0.353
LIG_NRBOX	435	441	PF00104	0.277
LIG_PCNA_PIPBox_1	348	357	PF02747	0.590
LIG_PCNA_yPIPBox_3	347	355	PF02747	0.608
LIG_PCNA_yPIPBox_3	524	534	PF02747	0.258
LIG_Pex14_2	312	316	PF04695	0.572
LIG_Pex14_2	437	441	PF04695	0.413
LIG_Pex14_2	460	464	PF04695	0.389
LIG_SH2_CRK	352	356	PF00017	0.620
LIG_SH2_CRK	405	409	PF00017	0.629
LIG_SH2_NCK_1	135	139	PF00017	0.618
LIG_SH2_NCK_1	195	199	PF00017	0.662
LIG_SH2_PTP2	115	118	PF00017	0.512
LIG_SH2_STAP1	531	535	PF00017	0.410
LIG_SH2_STAP1	582	586	PF00017	0.367
LIG_SH2_STAP1	609	613	PF00017	0.420
LIG_SH2_STAT5	115	118	PF00017	0.359
LIG_SH2_STAT5	135	138	PF00017	0.610
LIG_SH2_STAT5	291	294	PF00017	0.600
LIG_SH2_STAT5	336	339	PF00017	0.559
LIG_SH2_STAT5	419	422	PF00017	0.603
LIG_SH2_STAT5	444	447	PF00017	0.406
LIG_SH2_STAT5	584	587	PF00017	0.458
LIG_SH2_STAT5	612	615	PF00017	0.467
LIG_SH3_3	470	476	PF00018	0.500
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.427
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.436
LIG_SUMO_SIM_anti_2	600	607	PF11976	0.394
LIG_SUMO_SIM_par_1	447	454	PF11976	0.562
LIG_SUMO_SIM_par_1	491	496	PF11976	0.632
LIG_SUMO_SIM_par_1	82	87	PF11976	0.428
LIG_SxIP_EBH_1	416	426	PF03271	0.519
LIG_TRAF2_1	260	263	PF00917	0.674
LIG_TRAF2_1	396	399	PF00917	0.698
LIG_TYR_ITSM	109	116	PF00017	0.371
LIG_UBA3_1	417	422	PF00899	0.487
LIG_UBA3_1	515	524	PF00899	0.318
LIG_WRC_WIRS_1	291	296	PF05994	0.457
LIG_WRC_WIRS_1	457	462	PF05994	0.541
LIG_WRC_WIRS_1	465	470	PF05994	0.452
MOD_CDK_SPxxK_3	84	91	PF00069	0.452
MOD_CK1_1	120	126	PF00069	0.351
MOD_CK1_1	427	433	PF00069	0.303
MOD_CK1_1	450	456	PF00069	0.549
MOD_CK1_1	459	465	PF00069	0.546
MOD_CK1_1	569	575	PF00069	0.439
MOD_CK2_1	234	240	PF00069	0.682
MOD_CK2_1	257	263	PF00069	0.715
MOD_CK2_1	386	392	PF00069	0.518
MOD_GlcNHglycan	177	180	PF01048	0.745
MOD_GlcNHglycan	225	228	PF01048	0.635
MOD_GlcNHglycan	231	234	PF01048	0.651
MOD_GlcNHglycan	282	285	PF01048	0.510
MOD_GlcNHglycan	429	432	PF01048	0.442
MOD_GlcNHglycan	559	562	PF01048	0.503
MOD_GSK3_1	118	125	PF00069	0.405
MOD_GSK3_1	225	232	PF00069	0.621
MOD_GSK3_1	236	243	PF00069	0.598
MOD_GSK3_1	427	434	PF00069	0.437
MOD_GSK3_1	464	471	PF00069	0.395
MOD_GSK3_1	50	57	PF00069	0.719
MOD_LATS_1	278	284	PF00433	0.438
MOD_N-GLC_1	577	582	PF02516	0.530
MOD_N-GLC_2	566	568	PF02516	0.522
MOD_NEK2_1	118	123	PF00069	0.340
MOD_NEK2_1	223	228	PF00069	0.717
MOD_NEK2_1	229	234	PF00069	0.757
MOD_NEK2_1	282	287	PF00069	0.569
MOD_NEK2_1	411	416	PF00069	0.438
MOD_NEK2_1	418	423	PF00069	0.415
MOD_NEK2_1	435	440	PF00069	0.263
MOD_NEK2_1	456	461	PF00069	0.474
MOD_NEK2_1	464	469	PF00069	0.331
MOD_NEK2_1	484	489	PF00069	0.333
MOD_NEK2_1	604	609	PF00069	0.399
MOD_NEK2_2	353	358	PF00069	0.499
MOD_NEK2_2	424	429	PF00069	0.492
MOD_PIKK_1	244	250	PF00454	0.677
MOD_PIKK_1	484	490	PF00454	0.289
MOD_PKA_1	280	286	PF00069	0.496
MOD_PKA_2	280	286	PF00069	0.501
MOD_PKA_2	50	56	PF00069	0.598
MOD_Plk_1	173	179	PF00069	0.588
MOD_Plk_1	375	381	PF00069	0.504
MOD_Plk_1	577	583	PF00069	0.532
MOD_Plk_4	109	115	PF00069	0.471
MOD_Plk_4	125	131	PF00069	0.309
MOD_Plk_4	290	296	PF00069	0.534
MOD_Plk_4	311	317	PF00069	0.479
MOD_Plk_4	431	437	PF00069	0.372
MOD_Plk_4	456	462	PF00069	0.455
MOD_Plk_4	468	474	PF00069	0.366
MOD_Plk_4	514	520	PF00069	0.379
MOD_Plk_4	604	610	PF00069	0.357
MOD_Plk_4	95	101	PF00069	0.421
MOD_ProDKin_1	133	139	PF00069	0.613
MOD_ProDKin_1	52	58	PF00069	0.713
MOD_ProDKin_1	84	90	PF00069	0.473
MOD_SUMO_for_1	387	390	PF00179	0.489
MOD_SUMO_rev_2	133	142	PF00179	0.454
MOD_SUMO_rev_2	389	396	PF00179	0.576
MOD_SUMO_rev_2	87	93	PF00179	0.479
TRG_DiLeu_BaEn_1	376	381	PF01217	0.420
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.415
TRG_ENDOCYTIC_2	113	116	PF00928	0.354
TRG_ENDOCYTIC_2	258	261	PF00928	0.598
TRG_ENDOCYTIC_2	276	279	PF00928	0.661
TRG_ENDOCYTIC_2	291	294	PF00928	0.512
TRG_ENDOCYTIC_2	313	316	PF00928	0.452
TRG_ENDOCYTIC_2	352	355	PF00928	0.461
TRG_ENDOCYTIC_2	444	447	PF00928	0.374
TRG_ENDOCYTIC_2	531	534	PF00928	0.475
TRG_ENDOCYTIC_2	582	585	PF00928	0.484
TRG_ENDOCYTIC_2	612	615	PF00928	0.438
TRG_ER_diArg_1	26	29	PF00400	0.756
TRG_ER_diArg_1	279	281	PF00400	0.626
TRG_ER_diArg_1	333	335	PF00400	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	39%	100%
A0A0N1HRT9	Leptomonas seymouri	36%	100%
A0A0N1P9A0	Leptomonas seymouri	33%	100%
A0A0N1PBU6	Leptomonas seymouri	37%	100%
A0A1X0P9W4	Trypanosomatidae	32%	100%
A0A3Q8IFF3	Leishmania donovani	70%	99%
A0A3S7X483	Leishmania donovani	50%	97%
A0A3S7X888	Leishmania donovani	33%	99%
A4HB26	Leishmania braziliensis	34%	100%
A4HJ59	Leishmania braziliensis	41%	100%
A4HJ60	Leishmania braziliensis	55%	100%
A4I6H4	Leishmania infantum	50%	100%
A4I6H5	Leishmania infantum	99%	100%
A4IA83	Leishmania infantum	33%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q6I2	Leishmania major	90%	100%
Q4Q6I3	Leishmania major	51%	100%