Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ISG1_LEIDO

TriTrypDb:

LdBPK_310720.1 , LdCL_310012900

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ISG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.611
CLV_C14_Caspase3-7	210	214	PF00656	0.597
CLV_C14_Caspase3-7	268	272	PF00656	0.684
CLV_NRD_NRD_1	55	57	PF00675	0.752
CLV_PCSK_KEX2_1	55	57	PF00082	0.752
CLV_PCSK_SKI1_1	276	280	PF00082	0.670
DEG_SCF_FBW7_1	109	116	PF00400	0.670
DEG_SCF_FBW7_1	446	453	PF00400	0.699
DOC_CKS1_1	110	115	PF01111	0.725
DOC_CKS1_1	138	143	PF01111	0.717
DOC_CKS1_1	196	201	PF01111	0.635
DOC_CKS1_1	447	452	PF01111	0.700
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.568
DOC_MAPK_DCC_7	101	110	PF00069	0.664
DOC_MAPK_gen_1	303	311	PF00069	0.515
DOC_MAPK_MEF2A_6	101	110	PF00069	0.664
DOC_MAPK_MEF2A_6	14	21	PF00069	0.548
DOC_MAPK_MEF2A_6	299	306	PF00069	0.493
DOC_MAPK_NFAT4_5	299	307	PF00069	0.496
DOC_PP2B_LxvP_1	378	381	PF13499	0.561
DOC_PP2B_LxvP_1	382	385	PF13499	0.584
DOC_PP4_FxxP_1	135	138	PF00568	0.780
DOC_PP4_MxPP_1	422	425	PF00568	0.746
DOC_USP7_MATH_1	177	181	PF00917	0.741
DOC_USP7_MATH_1	189	193	PF00917	0.529
DOC_USP7_MATH_1	450	454	PF00917	0.653
DOC_WW_Pin1_4	109	114	PF00397	0.677
DOC_WW_Pin1_4	119	124	PF00397	0.854
DOC_WW_Pin1_4	137	142	PF00397	0.522
DOC_WW_Pin1_4	195	200	PF00397	0.616
DOC_WW_Pin1_4	316	321	PF00397	0.780
DOC_WW_Pin1_4	446	451	PF00397	0.767
DOC_WW_Pin1_4	65	70	PF00397	0.577
LIG_14-3-3_CanoR_1	251	255	PF00244	0.496
LIG_14-3-3_CanoR_1	299	303	PF00244	0.499
LIG_14-3-3_CanoR_1	55	61	PF00244	0.621
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_4	10	14	PF00653	0.693
LIG_BRCT_BRCA1_1	179	183	PF00533	0.746
LIG_CSL_BTD_1	317	320	PF09270	0.713
LIG_FHA_1	138	144	PF00498	0.626
LIG_FHA_1	196	202	PF00498	0.654
LIG_FHA_1	251	257	PF00498	0.494
LIG_FHA_1	343	349	PF00498	0.708
LIG_FHA_1	55	61	PF00498	0.621
LIG_IRF3_LxIS_1	191	197	PF10401	0.675
LIG_LIR_Apic_2	136	142	PF02991	0.672
LIG_LIR_Apic_2	253	257	PF02991	0.500
LIG_LIR_Apic_2	336	342	PF02991	0.594
LIG_LIR_Apic_2	477	481	PF02991	0.580
LIG_LIR_Gen_1	2	11	PF02991	0.663
LIG_LIR_Nem_3	2	8	PF02991	0.667
LIG_LIR_Nem_3	42	48	PF02991	0.548
LIG_LIR_Nem_3	473	478	PF02991	0.754
LIG_LIR_Nem_3	98	103	PF02991	0.674
LIG_LYPXL_S_1	230	234	PF13949	0.580
LIG_LYPXL_yS_3	231	234	PF13949	0.635
LIG_MAD2	101	109	PF02301	0.546
LIG_NRBOX	374	380	PF00104	0.536
LIG_NRP_CendR_1	479	482	PF00754	0.694
LIG_Pex14_1	96	100	PF04695	0.609
LIG_Pex14_2	419	423	PF04695	0.654
LIG_PTB_Apo_2	94	101	PF02174	0.608
LIG_SH2_CRK	139	143	PF00017	0.756
LIG_SH2_CRK	254	258	PF00017	0.521
LIG_SH2_CRK	364	368	PF00017	0.674
LIG_SH2_CRK	478	482	PF00017	0.746
LIG_SH2_CRK	5	9	PF00017	0.651
LIG_SH2_NCK_1	5	9	PF00017	0.651
LIG_SH2_PTP2	16	19	PF00017	0.531
LIG_SH2_PTP2	45	48	PF00017	0.542
LIG_SH2_SRC	16	19	PF00017	0.531
LIG_SH2_STAP1	252	256	PF00017	0.490
LIG_SH2_STAP1	5	9	PF00017	0.651
LIG_SH2_STAT3	187	190	PF00017	0.668
LIG_SH2_STAT5	139	142	PF00017	0.756
LIG_SH2_STAT5	16	19	PF00017	0.531
LIG_SH2_STAT5	252	255	PF00017	0.496
LIG_SH2_STAT5	358	361	PF00017	0.605
LIG_SH2_STAT5	45	48	PF00017	0.542
LIG_SH3_3	114	120	PF00018	0.685
LIG_SH3_3	135	141	PF00018	0.757
LIG_SH3_3	338	344	PF00018	0.634
LIG_SH3_3	411	417	PF00018	0.662
LIG_SH3_3	437	443	PF00018	0.728
LIG_SH3_3	444	450	PF00018	0.708
LIG_SH3_3	99	105	PF00018	0.625
LIG_SUMO_SIM_anti_2	275	282	PF11976	0.670
LIG_SUMO_SIM_par_1	275	282	PF11976	0.670
LIG_TYR_ITIM	229	234	PF00017	0.586
MOD_CDK_SPK_2	113	118	PF00069	0.718
MOD_CK1_1	122	128	PF00069	0.793
MOD_CK1_1	197	203	PF00069	0.592
MOD_CK1_1	324	330	PF00069	0.674
MOD_CK1_1	467	473	PF00069	0.814
MOD_CK1_1	62	68	PF00069	0.575
MOD_GlcNHglycan	124	127	PF01048	0.852
MOD_GlcNHglycan	135	138	PF01048	0.674
MOD_GlcNHglycan	145	148	PF01048	0.674
MOD_GlcNHglycan	149	152	PF01048	0.679
MOD_GlcNHglycan	158	162	PF01048	0.665
MOD_GlcNHglycan	171	174	PF01048	0.674
MOD_GlcNHglycan	180	183	PF01048	0.615
MOD_GlcNHglycan	202	205	PF01048	0.723
MOD_GlcNHglycan	210	213	PF01048	0.683
MOD_GlcNHglycan	240	243	PF01048	0.562
MOD_GlcNHglycan	295	298	PF01048	0.513
MOD_GlcNHglycan	335	338	PF01048	0.647
MOD_GlcNHglycan	388	391	PF01048	0.620
MOD_GlcNHglycan	452	455	PF01048	0.714
MOD_GlcNHglycan	466	469	PF01048	0.596
MOD_GlcNHglycan	5	8	PF01048	0.594
MOD_GlcNHglycan	62	65	PF01048	0.609
MOD_GlcNHglycan	74	77	PF01048	0.669
MOD_GSK3_1	108	115	PF00069	0.651
MOD_GSK3_1	133	140	PF00069	0.629
MOD_GSK3_1	143	150	PF00069	0.665
MOD_GSK3_1	165	172	PF00069	0.770
MOD_GSK3_1	190	197	PF00069	0.643
MOD_GSK3_1	238	245	PF00069	0.695
MOD_GSK3_1	326	333	PF00069	0.617
MOD_GSK3_1	394	401	PF00069	0.710
MOD_GSK3_1	446	453	PF00069	0.699
MOD_GSK3_1	466	473	PF00069	0.664
MOD_GSK3_1	55	62	PF00069	0.629
MOD_NEK2_1	143	148	PF00069	0.617
MOD_NEK2_1	194	199	PF00069	0.720
MOD_NEK2_1	238	243	PF00069	0.507
MOD_NEK2_1	348	353	PF00069	0.683
MOD_NEK2_1	398	403	PF00069	0.667
MOD_NEK2_1	60	65	PF00069	0.621
MOD_NEK2_1	72	77	PF00069	0.658
MOD_NEK2_2	418	423	PF00069	0.685
MOD_PIKK_1	467	473	PF00454	0.747
MOD_PIKK_1	74	80	PF00454	0.573
MOD_PKA_1	55	61	PF00069	0.759
MOD_PKA_2	217	223	PF00069	0.757
MOD_PKA_2	250	256	PF00069	0.487
MOD_PKA_2	298	304	PF00069	0.507
MOD_PKA_2	54	60	PF00069	0.619
MOD_PKA_2	72	78	PF00069	0.661
MOD_Plk_1	324	330	PF00069	0.628
MOD_Plk_1	461	467	PF00069	0.730
MOD_Plk_2-3	87	93	PF00069	0.628
MOD_Plk_4	190	196	PF00069	0.620
MOD_Plk_4	284	290	PF00069	0.556
MOD_Plk_4	394	400	PF00069	0.694
MOD_Plk_4	470	476	PF00069	0.662
MOD_ProDKin_1	109	115	PF00069	0.680
MOD_ProDKin_1	119	125	PF00069	0.846
MOD_ProDKin_1	137	143	PF00069	0.579
MOD_ProDKin_1	195	201	PF00069	0.617
MOD_ProDKin_1	316	322	PF00069	0.783
MOD_ProDKin_1	446	452	PF00069	0.767
MOD_ProDKin_1	65	71	PF00069	0.578
TRG_DiLeu_BaEn_1	275	280	PF01217	0.671
TRG_ENDOCYTIC_2	16	19	PF00928	0.488
TRG_ENDOCYTIC_2	231	234	PF00928	0.635
TRG_ENDOCYTIC_2	45	48	PF00928	0.683
TRG_ENDOCYTIC_2	5	8	PF00928	0.661
TRG_ER_diArg_1	302	305	PF00400	0.492
TRG_ER_diArg_1	54	56	PF00400	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K0	Leptomonas seymouri	43%	100%
A4HJ47	Leishmania braziliensis	68%	100%
A4I6G3	Leishmania infantum	100%	100%
E9B1M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q6J4	Leishmania major	90%	100%