LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8ISE9_LEIDO
TriTrypDb:
LdBPK_310550.1 , LdCL_310011000 , LDHU3_31.0780
Length:
677

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ISE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISE9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.758
CLV_C14_Caspase3-7 378 382 PF00656 0.709
CLV_C14_Caspase3-7 669 673 PF00656 0.712
CLV_NRD_NRD_1 214 216 PF00675 0.709
CLV_NRD_NRD_1 471 473 PF00675 0.816
CLV_NRD_NRD_1 639 641 PF00675 0.710
CLV_PCSK_FUR_1 637 641 PF00082 0.719
CLV_PCSK_KEX2_1 214 216 PF00082 0.709
CLV_PCSK_KEX2_1 338 340 PF00082 0.630
CLV_PCSK_KEX2_1 471 473 PF00082 0.816
CLV_PCSK_KEX2_1 639 641 PF00082 0.710
CLV_PCSK_PC1ET2_1 338 340 PF00082 0.630
CLV_PCSK_SKI1_1 191 195 PF00082 0.696
CLV_PCSK_SKI1_1 332 336 PF00082 0.801
DEG_APCC_DBOX_1 534 542 PF00400 0.738
DEG_COP1_1 5 14 PF00400 0.553
DEG_Nend_UBRbox_2 1 3 PF02207 0.632
DEG_SPOP_SBC_1 270 274 PF00917 0.633
DEG_SPOP_SBC_1 279 283 PF00917 0.579
DEG_SPOP_SBC_1 324 328 PF00917 0.715
DEG_SPOP_SBC_1 491 495 PF00917 0.777
DOC_CKS1_1 224 229 PF01111 0.719
DOC_CKS1_1 461 466 PF01111 0.752
DOC_CYCLIN_yCln2_LP_2 137 143 PF00134 0.787
DOC_MAPK_gen_1 651 659 PF00069 0.687
DOC_MAPK_MEF2A_6 652 661 PF00069 0.759
DOC_PIKK_1 128 136 PF02985 0.723
DOC_PP2B_LxvP_1 150 153 PF13499 0.650
DOC_PP2B_LxvP_1 438 441 PF13499 0.654
DOC_PP2B_LxvP_1 507 510 PF13499 0.732
DOC_PP2B_LxvP_1 548 551 PF13499 0.700
DOC_PP4_FxxP_1 15 18 PF00568 0.729
DOC_PP4_FxxP_1 22 25 PF00568 0.634
DOC_PP4_FxxP_1 221 224 PF00568 0.597
DOC_PP4_FxxP_1 647 650 PF00568 0.712
DOC_PP4_MxPP_1 1 4 PF00568 0.685
DOC_USP7_MATH_1 189 193 PF00917 0.758
DOC_USP7_MATH_1 234 238 PF00917 0.749
DOC_USP7_MATH_1 244 248 PF00917 0.690
DOC_USP7_MATH_1 271 275 PF00917 0.720
DOC_USP7_MATH_1 279 283 PF00917 0.632
DOC_USP7_MATH_1 30 34 PF00917 0.649
DOC_USP7_MATH_1 324 328 PF00917 0.743
DOC_USP7_MATH_1 393 397 PF00917 0.651
DOC_USP7_MATH_1 402 406 PF00917 0.775
DOC_USP7_MATH_1 419 423 PF00917 0.581
DOC_USP7_MATH_1 424 428 PF00917 0.672
DOC_USP7_MATH_1 441 445 PF00917 0.571
DOC_USP7_MATH_1 456 460 PF00917 0.563
DOC_USP7_MATH_1 479 483 PF00917 0.630
DOC_USP7_MATH_1 551 555 PF00917 0.712
DOC_USP7_MATH_1 625 629 PF00917 0.634
DOC_USP7_MATH_2 156 162 PF00917 0.561
DOC_WW_Pin1_4 200 205 PF00397 0.723
DOC_WW_Pin1_4 220 225 PF00397 0.498
DOC_WW_Pin1_4 26 31 PF00397 0.714
DOC_WW_Pin1_4 262 267 PF00397 0.722
DOC_WW_Pin1_4 35 40 PF00397 0.682
DOC_WW_Pin1_4 383 388 PF00397 0.757
DOC_WW_Pin1_4 398 403 PF00397 0.643
DOC_WW_Pin1_4 45 50 PF00397 0.539
DOC_WW_Pin1_4 454 459 PF00397 0.749
DOC_WW_Pin1_4 460 465 PF00397 0.732
DOC_WW_Pin1_4 475 480 PF00397 0.659
DOC_WW_Pin1_4 494 499 PF00397 0.511
DOC_WW_Pin1_4 502 507 PF00397 0.702
DOC_WW_Pin1_4 533 538 PF00397 0.684
DOC_WW_Pin1_4 563 568 PF00397 0.774
DOC_WW_Pin1_4 570 575 PF00397 0.723
DOC_WW_Pin1_4 76 81 PF00397 0.743
DOC_WW_Pin1_4 91 96 PF00397 0.531
LIG_14-3-3_CanoR_1 287 296 PF00244 0.755
LIG_14-3-3_CanoR_1 471 481 PF00244 0.783
LIG_14-3-3_CanoR_1 593 599 PF00244 0.725
LIG_14-3-3_CanoR_1 639 643 PF00244 0.711
LIG_14-3-3_CanoR_1 667 672 PF00244 0.600
LIG_14-3-3_CanoR_1 84 93 PF00244 0.715
LIG_BRCT_BRCA1_1 18 22 PF00533 0.680
LIG_BRCT_BRCA1_1 431 435 PF00533 0.768
LIG_CSL_BTD_1 92 95 PF09270 0.770
LIG_CtBP_PxDLS_1 501 505 PF00389 0.611
LIG_EVH1_2 310 314 PF00568 0.619
LIG_FHA_1 114 120 PF00498 0.786
LIG_FHA_1 265 271 PF00498 0.646
LIG_FHA_1 291 297 PF00498 0.828
LIG_FHA_1 522 528 PF00498 0.684
LIG_FHA_1 55 61 PF00498 0.719
LIG_FHA_1 6 12 PF00498 0.794
LIG_FHA_1 63 69 PF00498 0.739
LIG_FHA_2 161 167 PF00498 0.751
LIG_LIR_Apic_2 13 18 PF02991 0.733
LIG_LIR_Apic_2 19 25 PF02991 0.646
LIG_LIR_Apic_2 219 224 PF02991 0.532
LIG_LIR_Gen_1 192 202 PF02991 0.545
LIG_LIR_Nem_3 192 197 PF02991 0.533
LIG_LIR_Nem_3 345 349 PF02991 0.797
LIG_LIR_Nem_3 432 438 PF02991 0.700
LIG_Pex14_2 55 59 PF04695 0.680
LIG_SH3_2 263 268 PF14604 0.688
LIG_SH3_2 372 377 PF14604 0.720
LIG_SH3_3 150 156 PF00018 0.710
LIG_SH3_3 221 227 PF00018 0.707
LIG_SH3_3 260 266 PF00018 0.688
LIG_SH3_3 273 279 PF00018 0.591
LIG_SH3_3 293 299 PF00018 0.816
LIG_SH3_3 369 375 PF00018 0.715
LIG_SH3_3 396 402 PF00018 0.758
LIG_SH3_3 495 501 PF00018 0.767
LIG_SH3_3 503 509 PF00018 0.685
LIG_SH3_3 531 537 PF00018 0.704
LIG_SH3_3 561 567 PF00018 0.728
LIG_SH3_3 65 71 PF00018 0.797
LIG_SUMO_SIM_anti_2 444 450 PF11976 0.700
LIG_SUMO_SIM_par_1 172 179 PF11976 0.683
LIG_SUMO_SIM_par_1 500 505 PF11976 0.683
LIG_TRAF2_1 162 165 PF00917 0.832
LIG_TRAF2_1 449 452 PF00917 0.800
LIG_UBA3_1 642 651 PF00899 0.699
LIG_WRC_WIRS_1 177 182 PF05994 0.628
LIG_WRC_WIRS_1 343 348 PF05994 0.792
LIG_WRC_WIRS_1 52 57 PF05994 0.715
LIG_WW_3 310 314 PF00397 0.741
MOD_CDC14_SPxK_1 265 268 PF00782 0.726
MOD_CDC14_SPxK_1 48 51 PF00782 0.801
MOD_CDK_SPK_2 475 480 PF00069 0.804
MOD_CDK_SPxK_1 262 268 PF00069 0.724
MOD_CDK_SPxK_1 45 51 PF00069 0.806
MOD_CK1_1 120 126 PF00069 0.794
MOD_CK1_1 203 209 PF00069 0.758
MOD_CK1_1 223 229 PF00069 0.501
MOD_CK1_1 274 280 PF00069 0.651
MOD_CK1_1 286 292 PF00069 0.741
MOD_CK1_1 327 333 PF00069 0.752
MOD_CK1_1 33 39 PF00069 0.755
MOD_CK1_1 352 358 PF00069 0.789
MOD_CK1_1 379 385 PF00069 0.712
MOD_CK1_1 45 51 PF00069 0.692
MOD_CK1_1 457 463 PF00069 0.719
MOD_CK1_1 475 481 PF00069 0.594
MOD_CK1_1 482 488 PF00069 0.704
MOD_CK1_1 54 60 PF00069 0.620
MOD_CK1_1 554 560 PF00069 0.775
MOD_CK1_1 605 611 PF00069 0.786
MOD_CK1_1 612 618 PF00069 0.698
MOD_CK1_1 62 68 PF00069 0.539
MOD_CK1_1 666 672 PF00069 0.732
MOD_CK1_1 91 97 PF00069 0.704
MOD_CK2_1 109 115 PF00069 0.778
MOD_CK2_1 122 128 PF00069 0.600
MOD_CK2_1 158 164 PF00069 0.749
MOD_CK2_1 446 452 PF00069 0.794
MOD_CK2_1 533 539 PF00069 0.742
MOD_DYRK1A_RPxSP_1 398 402 PF00069 0.706
MOD_GlcNHglycan 143 146 PF01048 0.719
MOD_GlcNHglycan 160 163 PF01048 0.565
MOD_GlcNHglycan 18 21 PF01048 0.696
MOD_GlcNHglycan 180 183 PF01048 0.547
MOD_GlcNHglycan 241 245 PF01048 0.790
MOD_GlcNHglycan 246 249 PF01048 0.710
MOD_GlcNHglycan 250 253 PF01048 0.649
MOD_GlcNHglycan 32 35 PF01048 0.672
MOD_GlcNHglycan 381 385 PF01048 0.782
MOD_GlcNHglycan 416 420 PF01048 0.674
MOD_GlcNHglycan 430 434 PF01048 0.628
MOD_GlcNHglycan 441 444 PF01048 0.655
MOD_GlcNHglycan 494 497 PF01048 0.723
MOD_GlcNHglycan 511 514 PF01048 0.551
MOD_GlcNHglycan 556 559 PF01048 0.725
MOD_GlcNHglycan 615 618 PF01048 0.789
MOD_GlcNHglycan 62 65 PF01048 0.716
MOD_GlcNHglycan 627 630 PF01048 0.626
MOD_GSK3_1 109 116 PF00069 0.785
MOD_GSK3_1 216 223 PF00069 0.578
MOD_GSK3_1 240 247 PF00069 0.776
MOD_GSK3_1 26 33 PF00069 0.751
MOD_GSK3_1 270 277 PF00069 0.601
MOD_GSK3_1 279 286 PF00069 0.673
MOD_GSK3_1 323 330 PF00069 0.770
MOD_GSK3_1 349 356 PF00069 0.783
MOD_GSK3_1 35 42 PF00069 0.741
MOD_GSK3_1 376 383 PF00069 0.722
MOD_GSK3_1 394 401 PF00069 0.640
MOD_GSK3_1 402 409 PF00069 0.699
MOD_GSK3_1 415 422 PF00069 0.687
MOD_GSK3_1 424 431 PF00069 0.645
MOD_GSK3_1 456 463 PF00069 0.737
MOD_GSK3_1 467 474 PF00069 0.703
MOD_GSK3_1 475 482 PF00069 0.558
MOD_GSK3_1 486 493 PF00069 0.545
MOD_GSK3_1 51 58 PF00069 0.559
MOD_GSK3_1 588 595 PF00069 0.733
MOD_GSK3_1 59 66 PF00069 0.667
MOD_GSK3_1 601 608 PF00069 0.628
MOD_GSK3_1 609 616 PF00069 0.690
MOD_GSK3_1 663 670 PF00069 0.769
MOD_GSK3_1 84 91 PF00069 0.790
MOD_N-GLC_1 393 398 PF02516 0.700
MOD_N-GLC_1 402 407 PF02516 0.712
MOD_N-GLC_1 472 477 PF02516 0.821
MOD_N-GLC_1 487 492 PF02516 0.575
MOD_NEK2_1 240 245 PF00069 0.724
MOD_NEK2_1 255 260 PF00069 0.626
MOD_NEK2_1 314 319 PF00069 0.739
MOD_NEK2_1 429 434 PF00069 0.733
MOD_NEK2_1 492 497 PF00069 0.709
MOD_NEK2_1 55 60 PF00069 0.771
MOD_NEK2_1 586 591 PF00069 0.808
MOD_NEK2_1 602 607 PF00069 0.552
MOD_NEK2_2 189 194 PF00069 0.719
MOD_NEK2_2 216 221 PF00069 0.545
MOD_NEK2_2 342 347 PF00069 0.685
MOD_NEK2_2 358 363 PF00069 0.557
MOD_PIKK_1 325 331 PF00454 0.674
MOD_PIKK_1 42 48 PF00454 0.816
MOD_PIKK_1 447 453 PF00454 0.728
MOD_PIKK_1 588 594 PF00454 0.709
MOD_PK_1 667 673 PF00069 0.602
MOD_PKA_1 471 477 PF00069 0.809
MOD_PKA_2 120 126 PF00069 0.794
MOD_PKA_2 16 22 PF00069 0.747
MOD_PKA_2 279 285 PF00069 0.667
MOD_PKA_2 286 292 PF00069 0.759
MOD_PKA_2 353 359 PF00069 0.728
MOD_PKA_2 376 382 PF00069 0.748
MOD_PKA_2 467 473 PF00069 0.809
MOD_PKA_2 479 485 PF00069 0.591
MOD_PKA_2 592 598 PF00069 0.697
MOD_PKA_2 638 644 PF00069 0.713
MOD_PKA_2 666 672 PF00069 0.670
MOD_Plk_1 358 364 PF00069 0.746
MOD_Plk_1 394 400 PF00069 0.743
MOD_Plk_1 415 421 PF00069 0.744
MOD_Plk_1 487 493 PF00069 0.762
MOD_Plk_1 609 615 PF00069 0.724
MOD_Plk_2-3 160 166 PF00069 0.751
MOD_Plk_4 10 16 PF00069 0.813
MOD_Plk_4 216 222 PF00069 0.544
MOD_Plk_4 434 440 PF00069 0.519
MOD_Plk_4 479 485 PF00069 0.633
MOD_Plk_4 55 61 PF00069 0.784
MOD_Plk_4 551 557 PF00069 0.770
MOD_Plk_4 602 608 PF00069 0.719
MOD_Plk_4 63 69 PF00069 0.678
MOD_Plk_4 657 663 PF00069 0.570
MOD_ProDKin_1 200 206 PF00069 0.725
MOD_ProDKin_1 220 226 PF00069 0.496
MOD_ProDKin_1 26 32 PF00069 0.716
MOD_ProDKin_1 262 268 PF00069 0.724
MOD_ProDKin_1 35 41 PF00069 0.677
MOD_ProDKin_1 383 389 PF00069 0.756
MOD_ProDKin_1 398 404 PF00069 0.645
MOD_ProDKin_1 45 51 PF00069 0.539
MOD_ProDKin_1 454 460 PF00069 0.750
MOD_ProDKin_1 475 481 PF00069 0.797
MOD_ProDKin_1 494 500 PF00069 0.518
MOD_ProDKin_1 502 508 PF00069 0.702
MOD_ProDKin_1 533 539 PF00069 0.742
MOD_ProDKin_1 563 569 PF00069 0.776
MOD_ProDKin_1 570 576 PF00069 0.722
MOD_ProDKin_1 76 82 PF00069 0.745
MOD_ProDKin_1 91 97 PF00069 0.533
TRG_DiLeu_BaEn_4 165 171 PF01217 0.812
TRG_ER_diArg_1 213 215 PF00400 0.711

Homologs

Protein Taxonomy Sequence identity Coverage
A4HJ31 Leishmania braziliensis 59% 99%
A4I6L0 Leishmania infantum 98% 100%
E9B1K3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q6L0 Leishmania major 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS