C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ISC2_LEIDO

TriTrypDb:

LdBPK_310090.1 , LdCL_310005700 , LDHU3_31.0110

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ISC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISC2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.742
CLV_C14_Caspase3-7	20	24	PF00656	0.581
CLV_NRD_NRD_1	110	112	PF00675	0.540
CLV_PCSK_KEX2_1	110	112	PF00082	0.561
DOC_MAPK_gen_1	101	109	PF00069	0.490
DOC_USP7_MATH_1	190	194	PF00917	0.756
DOC_USP7_UBL2_3	185	189	PF12436	0.664
DOC_USP7_UBL2_3	197	201	PF12436	0.709
DOC_USP7_UBL2_3	205	209	PF12436	0.636
DOC_USP7_UBL2_3	213	217	PF12436	0.699
LIG_14-3-3_CanoR_1	128	136	PF00244	0.482
LIG_14-3-3_CanoR_1	18	22	PF00244	0.586
LIG_BIR_III_4	8	12	PF00653	0.623
LIG_BRCT_BRCA1_1	138	142	PF00533	0.428
LIG_CaM_IQ_9	133	149	PF13499	0.428
LIG_FHA_2	120	126	PF00498	0.538
LIG_FHA_2	167	173	PF00498	0.654
LIG_LIR_Gen_1	90	100	PF02991	0.577
LIG_PTB_Apo_2	55	62	PF02174	0.624
LIG_PTB_Phospho_1	55	61	PF10480	0.625
LIG_SH2_CRK	40	44	PF00017	0.624
LIG_SH2_CRK	48	52	PF00017	0.572
LIG_SH2_CRK	61	65	PF00017	0.632
LIG_SH2_NCK_1	16	20	PF00017	0.612
LIG_SH2_NCK_1	40	44	PF00017	0.575
LIG_SH2_NCK_1	61	65	PF00017	0.631
LIG_SH2_SRC	48	51	PF00017	0.601
LIG_SH2_STAT3	7	10	PF00017	0.636
LIG_SH3_3	212	218	PF00018	0.607
LIG_SH3_3	66	72	PF00018	0.632
MOD_CK1_1	17	23	PF00069	0.519
MOD_CK1_1	87	93	PF00069	0.542
MOD_CK2_1	119	125	PF00069	0.570
MOD_CK2_1	190	196	PF00069	0.772
MOD_GlcNHglycan	207	212	PF01048	0.746
MOD_GlcNHglycan	86	89	PF01048	0.738
MOD_GSK3_1	191	198	PF00069	0.722
MOD_N-GLC_1	26	31	PF02516	0.643
MOD_NEK2_1	136	141	PF00069	0.507
MOD_OFUCOSY	133	140	PF10250	0.420
MOD_PIKK_1	119	125	PF00454	0.450
MOD_PKA_2	127	133	PF00069	0.417
MOD_PKA_2	17	23	PF00069	0.637
MOD_Plk_1	191	197	PF00069	0.594
MOD_Plk_1	199	205	PF00069	0.725
MOD_SUMO_for_1	204	207	PF00179	0.660
MOD_SUMO_rev_2	193	203	PF00179	0.699
TRG_ENDOCYTIC_2	93	96	PF00928	0.641
TRG_ER_diArg_1	109	111	PF00400	0.596
TRG_NLS_MonoExtN_4	108	115	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA54	Leptomonas seymouri	66%	100%
A0A1X0P7C1	Trypanosomatidae	46%	100%
A4HIX2	Leishmania braziliensis	80%	100%
A4I6A1	Leishmania infantum	99%	100%
D0A543	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B1F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6Q6	Leishmania major	95%	100%