Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ISB1_LEIDO

TriTrypDb:

LdBPK_303740.1 , LdCL_300042800 , LDHU3_30.4970

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ISB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.485
CLV_C14_Caspase3-7	227	231	PF00656	0.521
CLV_NRD_NRD_1	122	124	PF00675	0.565
CLV_NRD_NRD_1	139	141	PF00675	0.563
CLV_NRD_NRD_1	193	195	PF00675	0.475
CLV_NRD_NRD_1	246	248	PF00675	0.586
CLV_NRD_NRD_1	422	424	PF00675	0.511
CLV_NRD_NRD_1	60	62	PF00675	0.568
CLV_PCSK_KEX2_1	122	124	PF00082	0.554
CLV_PCSK_KEX2_1	138	140	PF00082	0.494
CLV_PCSK_KEX2_1	192	194	PF00082	0.468
CLV_PCSK_KEX2_1	288	290	PF00082	0.514
CLV_PCSK_KEX2_1	421	423	PF00082	0.578
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.501
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.441
CLV_PCSK_PC7_1	418	424	PF00082	0.364
CLV_PCSK_SKI1_1	115	119	PF00082	0.532
CLV_PCSK_SKI1_1	133	137	PF00082	0.488
CLV_PCSK_SKI1_1	2	6	PF00082	0.522
CLV_PCSK_SKI1_1	274	278	PF00082	0.399
CLV_PCSK_SKI1_1	288	292	PF00082	0.386
CLV_PCSK_SKI1_1	295	299	PF00082	0.426
CLV_PCSK_SKI1_1	423	427	PF00082	0.519
CLV_PCSK_SKI1_1	431	435	PF00082	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DOC_CYCLIN_RxL_1	426	436	PF00134	0.472
DOC_MAPK_gen_1	178	186	PF00069	0.459
DOC_MAPK_gen_1	353	362	PF00069	0.419
DOC_USP7_MATH_1	241	245	PF00917	0.544
DOC_USP7_UBL2_3	188	192	PF12436	0.496
DOC_USP7_UBL2_3	291	295	PF12436	0.542
LIG_14-3-3_CanoR_1	193	200	PF00244	0.580
LIG_EH1_1	328	336	PF00400	0.489
LIG_FHA_1	160	166	PF00498	0.466
LIG_FHA_1	185	191	PF00498	0.560
LIG_FHA_1	354	360	PF00498	0.511
LIG_FHA_1	376	382	PF00498	0.504
LIG_FHA_1	387	393	PF00498	0.425
LIG_FHA_2	194	200	PF00498	0.487
LIG_FHA_2	254	260	PF00498	0.528
LIG_FHA_2	262	268	PF00498	0.514
LIG_FHA_2	349	355	PF00498	0.440
LIG_FHA_2	364	370	PF00498	0.375
LIG_FHA_2	377	383	PF00498	0.502
LIG_LIR_Gen_1	201	210	PF02991	0.538
LIG_LIR_LC3C_4	187	191	PF02991	0.268
LIG_LIR_Nem_3	201	207	PF02991	0.499
LIG_LIR_Nem_3	52	56	PF02991	0.510
LIG_LIR_Nem_3	73	78	PF02991	0.612
LIG_SH2_CRK	346	350	PF00017	0.438
LIG_SH2_CRK	75	79	PF00017	0.629
LIG_SH2_STAT5	134	137	PF00017	0.431
LIG_SH2_STAT5	58	61	PF00017	0.474
LIG_SH3_3	316	322	PF00018	0.489
LIG_SUMO_SIM_par_1	182	187	PF11976	0.534
LIG_SUMO_SIM_par_1	358	364	PF11976	0.555
LIG_TRAF2_1	217	220	PF00917	0.558
LIG_TRAF2_1	336	339	PF00917	0.420
LIG_TRAF2_1	391	394	PF00917	0.407
LIG_TRAF2_1	437	440	PF00917	0.396
LIG_UBA3_1	143	150	PF00899	0.556
LIG_UBA3_1	183	188	PF00899	0.412
LIG_UBA3_1	362	370	PF00899	0.424
LIG_UBA3_1	78	87	PF00899	0.531
LIG_WRC_WIRS_1	33	38	PF05994	0.526
MOD_CK1_1	35	41	PF00069	0.629
MOD_CK1_1	361	367	PF00069	0.531
MOD_CK2_1	151	157	PF00069	0.492
MOD_CK2_1	253	259	PF00069	0.526
MOD_CK2_1	261	267	PF00069	0.515
MOD_CK2_1	312	318	PF00069	0.547
MOD_CK2_1	348	354	PF00069	0.475
MOD_CK2_1	363	369	PF00069	0.479
MOD_CK2_1	376	382	PF00069	0.532
MOD_CK2_1	429	435	PF00069	0.450
MOD_Cter_Amidation	59	62	PF01082	0.618
MOD_GlcNHglycan	251	256	PF01048	0.523
MOD_GlcNHglycan	399	402	PF01048	0.441
MOD_GlcNHglycan	435	438	PF01048	0.532
MOD_GSK3_1	211	218	PF00069	0.480
MOD_GSK3_1	28	35	PF00069	0.579
MOD_GSK3_1	429	436	PF00069	0.466
MOD_N-GLC_1	68	73	PF02516	0.488
MOD_N-GLC_2	57	59	PF02516	0.353
MOD_NEK2_1	184	189	PF00069	0.436
MOD_NEK2_1	363	368	PF00069	0.465
MOD_NEK2_1	433	438	PF00069	0.452
MOD_NEK2_1	49	54	PF00069	0.590
MOD_PIKK_1	115	121	PF00454	0.615
MOD_PIKK_1	312	318	PF00454	0.528
MOD_PK_1	358	364	PF00069	0.542
MOD_PKA_1	192	198	PF00069	0.536
MOD_PKA_2	192	198	PF00069	0.510
MOD_PKA_2	211	217	PF00069	0.294
MOD_PKA_2	63	69	PF00069	0.541
MOD_Plk_1	101	107	PF00069	0.461
MOD_Plk_1	151	157	PF00069	0.533
MOD_Plk_1	212	218	PF00069	0.414
MOD_Plk_1	261	267	PF00069	0.525
MOD_Plk_1	68	74	PF00069	0.647
MOD_Plk_2-3	253	259	PF00069	0.449
MOD_Plk_4	199	205	PF00069	0.516
MOD_Plk_4	32	38	PF00069	0.540
MOD_Plk_4	358	364	PF00069	0.492
MOD_Plk_4	429	435	PF00069	0.595
MOD_SUMO_rev_2	126	135	PF00179	0.598
MOD_SUMO_rev_2	166	172	PF00179	0.515
TRG_DiLeu_BaEn_1	102	107	PF01217	0.565
TRG_DiLeu_BaEn_1	369	374	PF01217	0.348
TRG_DiLeu_BaEn_2	31	37	PF01217	0.507
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.338
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.602
TRG_DiLeu_LyEn_5	102	107	PF01217	0.556
TRG_ENDOCYTIC_2	204	207	PF00928	0.467
TRG_ENDOCYTIC_2	346	349	PF00928	0.396
TRG_ENDOCYTIC_2	75	78	PF00928	0.490
TRG_ER_diArg_1	122	124	PF00400	0.605
TRG_ER_diArg_1	138	140	PF00400	0.525
TRG_ER_diArg_1	161	164	PF00400	0.563
TRG_ER_diArg_1	421	423	PF00400	0.407
TRG_NLS_Bipartite_1	178	196	PF00514	0.383
TRG_NLS_MonoCore_2	60	65	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II28	Leptomonas seymouri	68%	100%
A0A0S4JDF0	Bodo saltans	26%	100%
A0A0S4JHV1	Bodo saltans	26%	72%
A0A1X0P1A4	Trypanosomatidae	39%	99%
A0A422NMD4	Trypanosoma rangeli	37%	98%
A4HIV4	Leishmania braziliensis	70%	100%
A4I659	Leishmania infantum	100%	100%
C9ZRH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	97%
E9B1E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6S0	Leishmania major	92%	100%
V5B747	Trypanosoma cruzi	38%	98%