LeishMANIAdb
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Casein_kinase_1_isoform_2_putative/GeneDB:LmjF.30.3470

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Casein_kinase_1_isoform_2_putative/GeneDB:LmjF.30.3470
Gene product:
casein kinase 1 isoform 2, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8ISA0_LEIDO
TriTrypDb:
LdBPK_303530.1 , LdCL_300040900 , LDHU3_30.4690
Length:
376

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3Q8ISA0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ISA0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009987 cellular process 1 13
GO:0016310 phosphorylation 5 13
GO:0019538 protein metabolic process 3 13
GO:0036211 protein modification process 4 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0006810 transport 3 1
GO:0006897 endocytosis 5 1
GO:0007165 signal transduction 2 1
GO:0016192 vesicle-mediated transport 4 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004672 protein kinase activity 3 13
GO:0004674 protein serine/threonine kinase activity 4 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016301 kinase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 109 111 PF00675 0.211
CLV_NRD_NRD_1 203 205 PF00675 0.255
CLV_PCSK_FUR_1 4 8 PF00082 0.655
CLV_PCSK_KEX2_1 203 205 PF00082 0.255
CLV_PCSK_KEX2_1 231 233 PF00082 0.390
CLV_PCSK_KEX2_1 6 8 PF00082 0.629
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.390
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.649
CLV_PCSK_SKI1_1 139 143 PF00082 0.238
CLV_PCSK_SKI1_1 174 178 PF00082 0.268
CLV_PCSK_SKI1_1 182 186 PF00082 0.216
CLV_PCSK_SKI1_1 240 244 PF00082 0.410
CLV_PCSK_SKI1_1 355 359 PF00082 0.524
DEG_APCC_DBOX_1 203 211 PF00400 0.251
DOC_CYCLIN_RxL_1 264 274 PF00134 0.320
DOC_CYCLIN_RxL_1 352 360 PF00134 0.521
DOC_MAPK_gen_1 4 13 PF00069 0.623
DOC_MAPK_MEF2A_6 115 124 PF00069 0.311
DOC_PP1_RVXF_1 265 272 PF00149 0.313
DOC_SPAK_OSR1_1 16 20 PF12202 0.311
DOC_USP7_MATH_1 315 319 PF00917 0.577
DOC_USP7_MATH_1 327 331 PF00917 0.669
DOC_USP7_UBL2_3 111 115 PF12436 0.285
DOC_WW_Pin1_4 226 231 PF00397 0.380
DOC_WW_Pin1_4 244 249 PF00397 0.250
LIG_14-3-3_CanoR_1 110 115 PF00244 0.204
LIG_APCC_ABBAyCdc20_2 174 180 PF00400 0.237
LIG_BIR_III_4 314 318 PF00653 0.471
LIG_BRCT_BRCA1_1 267 271 PF00533 0.350
LIG_BRCT_BRCA1_1 340 344 PF00533 0.636
LIG_FHA_1 264 270 PF00498 0.406
LIG_FHA_1 338 344 PF00498 0.675
LIG_FHA_1 72 78 PF00498 0.320
LIG_FHA_1 88 94 PF00498 0.366
LIG_GBD_Chelix_1 156 164 PF00786 0.393
LIG_LIR_Gen_1 233 242 PF02991 0.407
LIG_LIR_Gen_1 296 307 PF02991 0.443
LIG_LIR_Gen_1 88 97 PF02991 0.257
LIG_LIR_Nem_3 113 117 PF02991 0.237
LIG_LIR_Nem_3 187 193 PF02991 0.251
LIG_LIR_Nem_3 233 239 PF02991 0.445
LIG_LIR_Nem_3 261 265 PF02991 0.319
LIG_LIR_Nem_3 296 302 PF02991 0.416
LIG_LIR_Nem_3 30 35 PF02991 0.314
LIG_LIR_Nem_3 368 372 PF02991 0.616
LIG_PCNA_PIPBox_1 363 372 PF02747 0.442
LIG_PDZ_Class_3 371 376 PF00595 0.639
LIG_Pex14_2 28 32 PF04695 0.357
LIG_PTB_Apo_2 356 363 PF02174 0.680
LIG_PTB_Apo_2 59 66 PF02174 0.419
LIG_PTB_Phospho_1 59 65 PF10480 0.433
LIG_RPA_C_Fungi 311 323 PF08784 0.576
LIG_SH2_PTP2 190 193 PF00017 0.311
LIG_SH2_SRC 130 133 PF00017 0.393
LIG_SH2_SRC 178 181 PF00017 0.303
LIG_SH2_STAP1 265 269 PF00017 0.313
LIG_SH2_STAP1 277 281 PF00017 0.262
LIG_SH2_STAP1 295 299 PF00017 0.466
LIG_SH2_STAP1 89 93 PF00017 0.393
LIG_SH2_STAT3 255 258 PF00017 0.330
LIG_SH2_STAT3 297 300 PF00017 0.420
LIG_SH2_STAT5 130 133 PF00017 0.332
LIG_SH2_STAT5 136 139 PF00017 0.294
LIG_SH2_STAT5 158 161 PF00017 0.272
LIG_SH2_STAT5 190 193 PF00017 0.238
LIG_SH2_STAT5 212 215 PF00017 0.249
LIG_SH2_STAT5 216 219 PF00017 0.247
LIG_SH2_STAT5 262 265 PF00017 0.302
LIG_SH2_STAT5 279 282 PF00017 0.242
LIG_SH2_STAT5 297 300 PF00017 0.412
LIG_SH2_STAT5 82 85 PF00017 0.384
LIG_SH2_STAT5 89 92 PF00017 0.351
LIG_SH3_3 72 78 PF00018 0.229
LIG_SUMO_SIM_anti_2 90 95 PF11976 0.303
LIG_SUMO_SIM_par_1 88 95 PF11976 0.399
LIG_TRAF2_2 256 261 PF00917 0.436
MOD_CDC14_SPxK_1 229 232 PF00782 0.393
MOD_CDK_SPK_2 226 231 PF00069 0.393
MOD_CDK_SPxK_1 226 232 PF00069 0.393
MOD_CK1_1 113 119 PF00069 0.258
MOD_CK1_1 192 198 PF00069 0.266
MOD_CK1_1 318 324 PF00069 0.624
MOD_CK2_1 244 250 PF00069 0.428
MOD_CK2_1 302 308 PF00069 0.426
MOD_GlcNHglycan 285 288 PF01048 0.344
MOD_GlcNHglycan 317 320 PF01048 0.559
MOD_GlcNHglycan 324 327 PF01048 0.614
MOD_GlcNHglycan 347 350 PF01048 0.654
MOD_GlcNHglycan 38 41 PF01048 0.288
MOD_GSK3_1 180 187 PF00069 0.285
MOD_GSK3_1 318 325 PF00069 0.680
MOD_GSK3_1 333 340 PF00069 0.579
MOD_GSK3_1 353 360 PF00069 0.713
MOD_N-GLC_2 69 71 PF02516 0.311
MOD_NEK2_1 184 189 PF00069 0.238
MOD_NEK2_1 283 288 PF00069 0.482
MOD_NEK2_1 322 327 PF00069 0.725
MOD_NEK2_1 338 343 PF00069 0.651
MOD_NEK2_1 353 358 PF00069 0.426
MOD_PK_1 189 195 PF00069 0.251
MOD_PKA_1 110 116 PF00069 0.254
MOD_PKA_2 168 174 PF00069 0.325
MOD_PKA_2 315 321 PF00069 0.569
MOD_PKA_2 322 328 PF00069 0.623
MOD_Plk_1 275 281 PF00069 0.293
MOD_Plk_1 87 93 PF00069 0.458
MOD_Plk_4 208 214 PF00069 0.386
MOD_Plk_4 339 345 PF00069 0.656
MOD_Plk_4 353 359 PF00069 0.590
MOD_Plk_4 77 83 PF00069 0.376
MOD_Plk_4 87 93 PF00069 0.345
MOD_ProDKin_1 226 232 PF00069 0.380
MOD_ProDKin_1 244 250 PF00069 0.253
MOD_SUMO_for_1 141 144 PF00179 0.311
MOD_SUMO_for_1 45 48 PF00179 0.251
MOD_SUMO_rev_2 237 245 PF00179 0.371
MOD_SUMO_rev_2 303 312 PF00179 0.525
TRG_ENDOCYTIC_2 190 193 PF00928 0.238
TRG_ENDOCYTIC_2 299 302 PF00928 0.410
TRG_ENDOCYTIC_2 369 372 PF00928 0.614
TRG_ENDOCYTIC_2 65 68 PF00928 0.260
TRG_ENDOCYTIC_2 89 92 PF00928 0.284
TRG_Pf-PMV_PEXEL_1 197 201 PF00026 0.323
TRG_Pf-PMV_PEXEL_1 257 261 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.309

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3F5 Leptomonas seymouri 48% 100%
A0A0N1HU44 Leptomonas seymouri 45% 100%
A0A0N1HU45 Leptomonas seymouri 74% 97%
A0A0N1I2H3 Leptomonas seymouri 38% 100%
A0A0N1IKB0 Leptomonas seymouri 34% 66%
A0A0N1PDW7 Leptomonas seymouri 24% 95%
A0A0S4IVY6 Bodo saltans 43% 91%
A0A0S4JA30 Bodo saltans 43% 100%
A0A0S4JCG2 Bodo saltans 24% 84%
A0A0S4JN06 Bodo saltans 51% 100%
A0A0S4JP58 Bodo saltans 47% 88%
A0A0S4JXJ0 Bodo saltans 40% 100%
A0A1X0NIT3 Trypanosomatidae 51% 100%
A0A1X0NRZ9 Trypanosomatidae 24% 100%
A0A1X0NXJ1 Trypanosomatidae 40% 100%
A0A1X0NZS9 Trypanosomatidae 45% 85%
A0A1X0P176 Trypanosomatidae 50% 97%
A0A3Q8IJ66 Leishmania donovani 44% 100%
A0A3R7K7C3 Trypanosoma rangeli 27% 74%
A0A3S7WNZ6 Leishmania donovani 37% 100%
A0A3S7WZA2 Leishmania donovani 42% 73%
A0A3S7X0V1 Leishmania donovani 32% 66%
A0A3S7X8X3 Leishmania donovani 46% 100%
A0A422MSV5 Trypanosoma rangeli 41% 100%
A0A422N5C9 Trypanosoma rangeli 49% 100%
A0A422NL83 Trypanosoma rangeli 41% 95%
A4H436 Leishmania braziliensis 37% 100%
A4HFV0 Leishmania braziliensis 33% 67%
A4HIT6 Leishmania braziliensis 81% 100%
A4HMD0 Leishmania braziliensis 46% 100%
A4HMD1 Leishmania braziliensis 48% 100%
A4HSC0 Leishmania infantum 37% 100%
A4I1K4 Leishmania infantum 42% 73%
A4I2Y4 Leishmania infantum 32% 66%
A4I638 Leishmania infantum 100% 100%
A4IAZ7 Leishmania infantum 46% 100%
A4IAZ8 Leishmania infantum 44% 100%
A7E3X2 Bos taurus 45% 82%
B9VVJ6 Trypanosoma brucei brucei 51% 100%
C9ZK43 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 94%
C9ZNJ6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
C9ZNJ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D0A1R2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 99%
D0A7J1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 92%
D3ZBE5 Rattus norvegicus 25% 100%
E9ADF5 Leishmania major 32% 67%
E9AKA2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AZ78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 66%
E9B1C3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9B5Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9B5Y1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
G5EFM9 Caenorhabditis elegans 26% 100%
O15726 Plasmodium falciparum (isolate Dd2) 43% 100%
O74135 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 86%
O76324 Drosophila melanogaster 46% 85%
O96999 Leishmania major 38% 100%
P23291 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 70%
P23292 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 69%
P25323 Dictyostelium discoideum 26% 100%
P29295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 76%
P33800 Variola virus (isolate Human/India/Ind3/1967) 27% 100%
P34516 Caenorhabditis elegans 29% 100%
P35507 Bos taurus 42% 100%
P35508 Bos taurus 49% 91%
P35509 Bos taurus 47% 100%
P39962 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 72%
P40230 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 42% 70%
P40233 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 84%
P40234 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 86%
P40235 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
P40236 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 94%
P42158 Arabidopsis thaliana 45% 84%
P42168 Caenorhabditis elegans 41% 100%
P48729 Homo sapiens 42% 100%
P48730 Homo sapiens 49% 91%
P49674 Homo sapiens 48% 90%
P54367 Drosophila melanogaster 45% 100%
P67827 Bos taurus 42% 100%
P67828 Oryctolagus cuniculus 42% 100%
P67829 Ovis aries 42% 100%
P67962 Gallus gallus 42% 100%
P67963 Xenopus laevis 42% 100%
P78368 Homo sapiens 46% 91%
P97633 Rattus norvegicus 42% 100%
Q06486 Rattus norvegicus 49% 91%
Q20471 Caenorhabditis elegans 48% 76%
Q2YDN8 Bos taurus 24% 83%
Q39050 Arabidopsis thaliana 47% 82%
Q4Q6U1 Leishmania major 94% 100%
Q4Q9T3 Leishmania major 44% 74%
Q4QBR6 Leishmania major 24% 100%
Q4R9A9 Macaca fascicularis 45% 99%
Q4V3C8 Arabidopsis thaliana 25% 77%
Q54DF7 Dictyostelium discoideum 36% 76%
Q556Y4 Dictyostelium discoideum 49% 88%
Q5BP74 Xenopus laevis 49% 91%
Q5PRD4 Danio rerio 46% 89%
Q5R4V3 Pongo abelii 46% 82%
Q5RC72 Pongo abelii 48% 91%
Q5XF24 Arabidopsis thaliana 47% 80%
Q5ZJS0 Gallus gallus 45% 82%
Q5ZLL1 Gallus gallus 48% 90%
Q62761 Rattus norvegicus 41% 96%
Q62762 Rattus norvegicus 46% 91%
Q62763 Rattus norvegicus 47% 84%
Q6K9N1 Oryza sativa subsp. japonica 48% 81%
Q6NRT0 Xenopus laevis 46% 82%
Q6P3K7 Danio rerio 49% 92%
Q6P647 Xenopus tropicalis 49% 91%
Q6QNL9 Eimeria tenella 46% 100%
Q6QNM1 Toxoplasma gondii 47% 100%
Q7RBX5 Plasmodium yoelii yoelii 43% 100%
Q7T2E3 Danio rerio 49% 93%
Q7ZUS1 Danio rerio 28% 88%
Q80X41 Mus musculus 30% 85%
Q86Y07 Homo sapiens 30% 74%
Q8BK63 Mus musculus 42% 100%
Q8BN21 Mus musculus 28% 75%
Q8BTH8 Mus musculus 45% 82%
Q8BVP5 Mus musculus 46% 91%
Q8C4X2 Mus musculus 46% 89%
Q8IHZ9 Plasmodium falciparum (isolate 3D7) 43% 100%
Q8LPI7 Arabidopsis thaliana 43% 91%
Q8LPJ1 Arabidopsis thaliana 45% 78%
Q8N752 Homo sapiens 42% 100%
Q8SQR2 Encephalitozoon cuniculi (strain GB-M1) 35% 100%
Q8SS96 Encephalitozoon cuniculi (strain GB-M1) 39% 100%
Q8TDX7 Homo sapiens 25% 100%
Q8VYK9 Arabidopsis thaliana 45% 86%
Q8WQ99 Caenorhabditis elegans 40% 92%
Q91FD5 Invertebrate iridescent virus 6 28% 91%
Q93Z18 Arabidopsis thaliana 43% 91%
Q95PZ9 Caenorhabditis elegans 28% 99%
Q9CAI5 Arabidopsis thaliana 48% 81%
Q9DC28 Mus musculus 49% 91%
Q9ES74 Mus musculus 25% 100%
Q9FFH8 Arabidopsis thaliana 48% 79%
Q9HCP0 Homo sapiens 45% 89%
Q9J509 Fowlpox virus (strain NVSL) 28% 100%
Q9J523 Fowlpox virus (strain NVSL) 26% 100%
Q9JMK2 Mus musculus 48% 90%
Q9LSX4 Arabidopsis thaliana 46% 78%
Q9LW62 Arabidopsis thaliana 46% 85%
Q9NHE1 Leishmania major 48% 100%
Q9NHE2 Leishmania major 47% 100%
Q9XF67 Arabidopsis thaliana 26% 77%
Q9Y6M4 Homo sapiens 46% 84%
Q9ZUP4 Arabidopsis thaliana 48% 87%
Q9ZWB3 Arabidopsis thaliana 47% 80%
V5AIW9 Trypanosoma cruzi 42% 100%
V5BMQ3 Trypanosoma cruzi 60% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS