RNA-dependent RNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IS88_LEIDO

TriTrypDb:

LdBPK_303260.1 , LdCL_300038200 , LDHU3_30.4350

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IS88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS88

PDB structure(s): 7ane_ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.500
CLV_C14_Caspase3-7	242	246	PF00656	0.499
CLV_NRD_NRD_1	282	284	PF00675	0.449
CLV_NRD_NRD_1	298	300	PF00675	0.277
CLV_NRD_NRD_1	329	331	PF00675	0.522
CLV_PCSK_KEX2_1	284	286	PF00082	0.483
CLV_PCSK_KEX2_1	298	300	PF00082	0.292
CLV_PCSK_KEX2_1	329	331	PF00082	0.508
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.525
CLV_PCSK_SKI1_1	116	120	PF00082	0.386
CLV_PCSK_SKI1_1	228	232	PF00082	0.408
CLV_PCSK_SKI1_1	314	318	PF00082	0.362
CLV_PCSK_SKI1_1	329	333	PF00082	0.460
CLV_PCSK_SKI1_1	48	52	PF00082	0.483
CLV_PCSK_SKI1_1	68	72	PF00082	0.223
DEG_Nend_Nbox_1	1	3	PF02207	0.494
DEG_SPOP_SBC_1	323	327	PF00917	0.449
DOC_CYCLIN_RxL_1	53	65	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	317	320	PF00134	0.361
DOC_MAPK_DCC_7	344	352	PF00069	0.475
DOC_MAPK_gen_1	113	122	PF00069	0.423
DOC_MAPK_gen_1	298	306	PF00069	0.425
DOC_MAPK_gen_1	310	318	PF00069	0.385
DOC_MAPK_HePTP_8	296	308	PF00069	0.454
DOC_MAPK_MEF2A_6	116	124	PF00069	0.427
DOC_MAPK_MEF2A_6	299	308	PF00069	0.460
DOC_MAPK_MEF2A_6	344	352	PF00069	0.462
DOC_PP1_RVXF_1	100	106	PF00149	0.439
DOC_PP2B_LxvP_1	304	307	PF13499	0.418
DOC_PP2B_LxvP_1	316	319	PF13499	0.338
DOC_PP4_FxxP_1	35	38	PF00568	0.497
DOC_SPAK_OSR1_1	208	212	PF12202	0.493
DOC_USP7_UBL2_3	102	106	PF12436	0.539
DOC_WW_Pin1_4	336	341	PF00397	0.509
DOC_WW_Pin1_4	81	86	PF00397	0.539
LIG_14-3-3_CanoR_1	298	303	PF00244	0.427
LIG_14-3-3_CanoR_1	329	338	PF00244	0.470
LIG_BRCT_BRCA1_1	267	271	PF00533	0.484
LIG_DLG_GKlike_1	298	306	PF00625	0.444
LIG_EH_1	170	174	PF12763	0.423
LIG_eIF4E_1	184	190	PF01652	0.511
LIG_FHA_1	160	166	PF00498	0.473
LIG_FHA_1	330	336	PF00498	0.502
LIG_FHA_2	14	20	PF00498	0.500
LIG_FHA_2	145	151	PF00498	0.453
LIG_FHA_2	237	243	PF00498	0.531
LIG_FHA_2	249	255	PF00498	0.398
LIG_FHA_2	332	338	PF00498	0.432
LIG_FHA_2	368	374	PF00498	0.434
LIG_Integrin_isoDGR_2	226	228	PF01839	0.609
LIG_LIR_Apic_2	254	260	PF02991	0.556
LIG_LIR_Apic_2	34	38	PF02991	0.500
LIG_LIR_Gen_1	117	125	PF02991	0.393
LIG_LIR_Gen_1	149	160	PF02991	0.507
LIG_LIR_Gen_1	261	270	PF02991	0.362
LIG_LIR_Gen_1	361	371	PF02991	0.445
LIG_LIR_Gen_1	373	379	PF02991	0.439
LIG_LIR_Nem_3	117	122	PF02991	0.381
LIG_LIR_Nem_3	149	155	PF02991	0.412
LIG_LIR_Nem_3	182	187	PF02991	0.439
LIG_LIR_Nem_3	192	196	PF02991	0.359
LIG_LIR_Nem_3	261	265	PF02991	0.357
LIG_LIR_Nem_3	361	367	PF02991	0.441
LIG_LIR_Nem_3	373	379	PF02991	0.419
LIG_LYPXL_yS_3	184	187	PF13949	0.391
LIG_MYND_1	39	43	PF01753	0.532
LIG_PDZ_Class_2	374	379	PF00595	0.436
LIG_Pex14_1	349	353	PF04695	0.396
LIG_Pex14_2	148	152	PF04695	0.393
LIG_SH2_SRC	322	325	PF00017	0.454
LIG_SH2_STAP1	353	357	PF00017	0.384
LIG_SH2_STAT5	166	169	PF00017	0.502
LIG_SH2_STAT5	179	182	PF00017	0.462
LIG_SH2_STAT5	24	27	PF00017	0.517
LIG_SH2_STAT5	264	267	PF00017	0.413
LIG_SH2_STAT5	322	325	PF00017	0.356
LIG_SH2_STAT5	364	367	PF00017	0.461
LIG_SH3_3	154	160	PF00018	0.544
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.525
LIG_SUMO_SIM_par_1	271	276	PF11976	0.271
LIG_TYR_ITIM	362	367	PF00017	0.511
LIG_UBA3_1	210	217	PF00899	0.493
LIG_WW_1	319	322	PF00397	0.380
MOD_CK1_1	236	242	PF00069	0.480
MOD_CK1_1	339	345	PF00069	0.541
MOD_CK1_1	84	90	PF00069	0.454
MOD_CK2_1	13	19	PF00069	0.484
MOD_CK2_1	144	150	PF00069	0.485
MOD_CK2_1	339	345	PF00069	0.481
MOD_CK2_1	348	354	PF00069	0.430
MOD_CK2_1	367	373	PF00069	0.326
MOD_CK2_1	41	47	PF00069	0.394
MOD_CK2_1	84	90	PF00069	0.446
MOD_GlcNHglycan	199	202	PF01048	0.513
MOD_GlcNHglycan	233	236	PF01048	0.512
MOD_GlcNHglycan	275	278	PF01048	0.302
MOD_GSK3_1	212	219	PF00069	0.415
MOD_GSK3_1	248	255	PF00069	0.479
MOD_NEK2_1	231	236	PF00069	0.488
MOD_NEK2_1	271	276	PF00069	0.506
MOD_NEK2_1	331	336	PF00069	0.541
MOD_NEK2_1	367	372	PF00069	0.420
MOD_NEK2_2	348	353	PF00069	0.522
MOD_PK_1	216	222	PF00069	0.358
MOD_PKA_1	216	222	PF00069	0.358
MOD_PKA_1	298	304	PF00069	0.427
MOD_PKA_1	329	335	PF00069	0.512
MOD_PKA_2	202	208	PF00069	0.363
MOD_PKA_2	265	271	PF00069	0.516
MOD_PKA_2	298	304	PF00069	0.413
MOD_PKA_2	329	335	PF00069	0.486
MOD_Plk_1	13	19	PF00069	0.418
MOD_Plk_1	252	258	PF00069	0.517
MOD_Plk_1	323	329	PF00069	0.516
MOD_Plk_1	367	373	PF00069	0.477
MOD_Plk_1	6	12	PF00069	0.624
MOD_Plk_2-3	13	19	PF00069	0.550
MOD_Plk_4	13	19	PF00069	0.545
MOD_Plk_4	20	26	PF00069	0.280
MOD_Plk_4	236	242	PF00069	0.474
MOD_Plk_4	252	258	PF00069	0.373
MOD_Plk_4	298	304	PF00069	0.427
MOD_Plk_4	331	337	PF00069	0.494
MOD_Plk_4	6	12	PF00069	0.610
MOD_ProDKin_1	336	342	PF00069	0.504
MOD_ProDKin_1	81	87	PF00069	0.536
MOD_SUMO_rev_2	65	70	PF00179	0.521
TRG_DiLeu_BaEn_4	98	104	PF01217	0.424
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.503
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.455
TRG_ENDOCYTIC_2	184	187	PF00928	0.375
TRG_ENDOCYTIC_2	364	367	PF00928	0.470
TRG_ENDOCYTIC_2	5	8	PF00928	0.578
TRG_ER_diArg_1	282	285	PF00400	0.420
TRG_ER_diArg_1	311	314	PF00400	0.365
TRG_ER_diArg_1	328	330	PF00400	0.525
TRG_NES_CRM1_1	134	145	PF08389	0.393
TRG_NES_CRM1_1	7	19	PF08389	0.586
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A9	Leptomonas seymouri	78%	91%
A0A0S4JLK9	Bodo saltans	48%	90%
A0A1X0P1F3	Trypanosomatidae	55%	98%
A0A422P0Y0	Trypanosoma rangeli	54%	93%
A4HIR0	Leishmania braziliensis	87%	100%
A4I605	Leishmania infantum	100%	100%
C9ZRC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
E9B196	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6W8	Leishmania major	96%	100%
V5BMY6	Trypanosoma cruzi	54%	92%