KRR1 small subunit processome component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IS78_LEIDO

TriTrypDb:

LdBPK_303050.1 , LdCL_300036100 , LDHU3_30.4060

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1

Expansion

Sequence features

A0A3Q8IS78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS78

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.719
CLV_NRD_NRD_1	128	130	PF00675	0.389
CLV_NRD_NRD_1	133	135	PF00675	0.193
CLV_NRD_NRD_1	232	234	PF00675	0.577
CLV_NRD_NRD_1	244	246	PF00675	0.633
CLV_NRD_NRD_1	280	282	PF00675	0.605
CLV_NRD_NRD_1	78	80	PF00675	0.238
CLV_PCSK_FUR_1	278	282	PF00082	0.556
CLV_PCSK_KEX2_1	128	130	PF00082	0.389
CLV_PCSK_KEX2_1	132	134	PF00082	0.384
CLV_PCSK_KEX2_1	198	200	PF00082	0.410
CLV_PCSK_KEX2_1	203	205	PF00082	0.438
CLV_PCSK_KEX2_1	244	246	PF00082	0.626
CLV_PCSK_KEX2_1	261	263	PF00082	0.385
CLV_PCSK_KEX2_1	280	282	PF00082	0.502
CLV_PCSK_KEX2_1	311	313	PF00082	0.649
CLV_PCSK_KEX2_1	78	80	PF00082	0.252
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.403
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.410
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.438
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.626
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.385
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.552
CLV_PCSK_PC7_1	128	134	PF00082	0.385
CLV_PCSK_PC7_1	199	205	PF00082	0.419
CLV_PCSK_SKI1_1	129	133	PF00082	0.382
CLV_PCSK_SKI1_1	193	197	PF00082	0.376
CLV_PCSK_SKI1_1	233	237	PF00082	0.522
CLV_PCSK_SKI1_1	241	245	PF00082	0.542
CLV_PCSK_SKI1_1	252	256	PF00082	0.483
DEG_COP1_1	7	16	PF00400	0.441
DEG_ODPH_VHL_1	275	288	PF01847	0.647
DOC_MAPK_gen_1	278	288	PF00069	0.652
DOC_PP4_FxxP_1	11	14	PF00568	0.578
DOC_PP4_FxxP_1	274	277	PF00568	0.600
DOC_USP7_MATH_1	267	271	PF00917	0.455
DOC_USP7_MATH_1	294	298	PF00917	0.665
DOC_USP7_MATH_1	4	8	PF00917	0.435
DOC_USP7_UBL2_3	226	230	PF12436	0.501
DOC_USP7_UBL2_3	237	241	PF12436	0.490
DOC_USP7_UBL2_3	246	250	PF12436	0.528
DOC_WW_Pin1_4	290	295	PF00397	0.663
LIG_14-3-3_CanoR_1	280	288	PF00244	0.436
LIG_14-3-3_CanoR_1	78	82	PF00244	0.428
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BIR_III_3	1	5	PF00653	0.458
LIG_BRCT_BRCA1_1	8	12	PF00533	0.533
LIG_deltaCOP1_diTrp_1	210	215	PF00928	0.439
LIG_eIF4E_1	190	196	PF01652	0.371
LIG_EVH1_1	255	259	PF00568	0.498
LIG_FHA_1	112	118	PF00498	0.366
LIG_FHA_1	160	166	PF00498	0.344
LIG_FHA_1	170	176	PF00498	0.361
LIG_FHA_1	281	287	PF00498	0.435
LIG_FHA_2	15	21	PF00498	0.426
LIG_LIR_Apic_2	9	14	PF02991	0.492
LIG_LIR_Gen_1	152	163	PF02991	0.344
LIG_LIR_Gen_1	210	219	PF02991	0.436
LIG_LIR_Gen_1	30	41	PF02991	0.364
LIG_LIR_Gen_1	82	92	PF02991	0.438
LIG_LIR_Nem_3	152	158	PF02991	0.334
LIG_LIR_Nem_3	210	215	PF02991	0.439
LIG_LIR_Nem_3	30	36	PF02991	0.305
LIG_LIR_Nem_3	47	52	PF02991	0.395
LIG_LIR_Nem_3	80	84	PF02991	0.438
LIG_LIR_Nem_3	91	95	PF02991	0.438
LIG_MLH1_MIPbox_1	8	12	PF16413	0.533
LIG_NRBOX	191	197	PF00104	0.369
LIG_Pex14_2	33	37	PF04695	0.438
LIG_SH2_NCK_1	84	88	PF00017	0.518
LIG_SH2_PTP2	155	158	PF00017	0.329
LIG_SH2_SRC	40	43	PF00017	0.430
LIG_SH2_SRC	84	87	PF00017	0.452
LIG_SH2_STAT5	155	158	PF00017	0.329
LIG_SH2_STAT5	40	43	PF00017	0.438
LIG_SH2_STAT5	44	47	PF00017	0.438
LIG_SH3_2	256	261	PF14604	0.489
LIG_SH3_3	162	168	PF00018	0.340
LIG_SH3_3	253	259	PF00018	0.505
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.331
LIG_TRAF2_1	51	54	PF00917	0.518
LIG_UBA3_1	117	123	PF00899	0.373
MOD_CK1_1	290	296	PF00069	0.677
MOD_CK1_1	299	305	PF00069	0.726
MOD_CK2_1	174	180	PF00069	0.484
MOD_CK2_1	199	205	PF00069	0.525
MOD_CK2_1	36	42	PF00069	0.452
MOD_GlcNHglycan	269	272	PF01048	0.464
MOD_GlcNHglycan	289	292	PF01048	0.668
MOD_GlcNHglycan	296	299	PF01048	0.651
MOD_GSK3_1	2	9	PF00069	0.560
MOD_GSK3_1	28	35	PF00069	0.390
MOD_GSK3_1	290	297	PF00069	0.700
MOD_GSK3_1	302	309	PF00069	0.715
MOD_GSK3_1	36	43	PF00069	0.438
MOD_GSK3_1	70	77	PF00069	0.436
MOD_N-GLC_1	118	123	PF02516	0.443
MOD_NEK2_1	174	179	PF00069	0.447
MOD_NEK2_1	68	73	PF00069	0.452
MOD_PIKK_1	14	20	PF00454	0.438
MOD_PIKK_1	169	175	PF00454	0.493
MOD_PIKK_1	219	225	PF00454	0.590
MOD_PK_1	123	129	PF00069	0.539
MOD_PK_1	250	256	PF00069	0.439
MOD_PKA_1	280	286	PF00069	0.559
MOD_PKA_2	280	286	PF00069	0.431
MOD_PKA_2	302	308	PF00069	0.521
MOD_PKA_2	77	83	PF00069	0.428
MOD_PKB_1	278	286	PF00069	0.563
MOD_Plk_1	118	124	PF00069	0.490
MOD_Plk_1	210	216	PF00069	0.433
MOD_Plk_1	250	256	PF00069	0.502
MOD_Plk_1	28	34	PF00069	0.401
MOD_Plk_4	250	256	PF00069	0.568
MOD_Plk_4	32	38	PF00069	0.443
MOD_Plk_4	40	46	PF00069	0.417
MOD_ProDKin_1	290	296	PF00069	0.668
MOD_SUMO_for_1	197	200	PF00179	0.401
MOD_SUMO_for_1	207	210	PF00179	0.417
MOD_SUMO_for_1	235	238	PF00179	0.487
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.389
TRG_ENDOCYTIC_2	155	158	PF00928	0.329
TRG_ENDOCYTIC_2	84	87	PF00928	0.438
TRG_ER_diArg_1	127	129	PF00400	0.404
TRG_ER_diArg_1	277	280	PF00400	0.549
TRG_NES_CRM1_1	91	106	PF08389	0.438
TRG_NLS_Bipartite_1	220	237	PF00514	0.514
TRG_NLS_MonoExtC_3	232	237	PF00514	0.517
TRG_NLS_MonoExtN_4	230	237	PF00514	0.518
TRG_NLS_MonoExtN_4	241	248	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB2	Leptomonas seymouri	91%	100%
A0A0S4ITS6	Bodo saltans	77%	94%
A0A1X0P2J2	Trypanosomatidae	81%	100%
A0A3R7RRF4	Trypanosoma rangeli	82%	100%
A4HIN5	Leishmania braziliensis	89%	100%
A4I5Y2	Leishmania infantum	100%	100%
B3LU25	Saccharomyces cerevisiae (strain RM11-1a)	50%	100%
B3MM49	Drosophila ananassae	51%	94%
B3N899	Drosophila erecta	50%	93%
B4G9L6	Drosophila persimilis	46%	94%
B4JDU5	Drosophila grimshawi	45%	94%
B4KF66	Drosophila mojavensis	45%	93%
B4LTY6	Drosophila virilis	44%	94%
B4N0P7	Drosophila willistoni	46%	93%
B4P2Y8	Drosophila yakuba	46%	93%
B5VEQ2	Saccharomyces cerevisiae (strain AWRI1631)	50%	100%
C8Z430	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	50%	100%
C9ZRA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E7LRT8	Saccharomyces cerevisiae (strain VIN 13)	50%	100%
E7QBZ1	Saccharomyces cerevisiae (strain Zymaflore VL3)	50%	100%
E9B175	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74777	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	98%
P25586	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	100%
Q13601	Homo sapiens	47%	84%
Q3B7L9	Bos taurus	47%	84%
Q4Q6Y9	Leishmania major	95%	100%
Q54UU6	Dictyostelium discoideum	50%	86%
Q8BGA5	Mus musculus	48%	84%
Q9VPU8	Drosophila melanogaster	46%	93%