Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IS65_LEIDO

TriTrypDb:

LdBPK_302820.1 , LdCL_300033800 , LDHU3_30.3750

Length:

205

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IS65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS65

PDB structure(s): 7aih_Ar , 7am2_Ar , 7ane_Ar

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.393
CLV_NRD_NRD_1	155	157	PF00675	0.463
CLV_NRD_NRD_1	195	197	PF00675	0.399
CLV_NRD_NRD_1	92	94	PF00675	0.379
CLV_PCSK_KEX2_1	155	157	PF00082	0.463
CLV_PCSK_KEX2_1	187	189	PF00082	0.388
CLV_PCSK_KEX2_1	43	45	PF00082	0.493
CLV_PCSK_KEX2_1	94	96	PF00082	0.377
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.388
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.493
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.377
CLV_PCSK_PC7_1	151	157	PF00082	0.443
CLV_PCSK_SKI1_1	187	191	PF00082	0.383
CLV_PCSK_SKI1_1	26	30	PF00082	0.401
CLV_PCSK_SKI1_1	40	44	PF00082	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DEG_SCF_FBW7_2	57	62	PF00400	0.482
DOC_MAPK_gen_1	187	195	PF00069	0.376
DOC_MAPK_gen_1	93	100	PF00069	0.371
DOC_MAPK_MEF2A_6	9	17	PF00069	0.447
DOC_PP1_RVXF_1	144	151	PF00149	0.412
DOC_PP2B_LxvP_1	169	172	PF13499	0.376
DOC_WW_Pin1_4	55	60	PF00397	0.461
LIG_14-3-3_CanoR_1	113	117	PF00244	0.400
LIG_14-3-3_CanoR_1	196	202	PF00244	0.460
LIG_FHA_1	104	110	PF00498	0.365
LIG_FHA_1	23	29	PF00498	0.385
LIG_LIR_Gen_1	74	85	PF02991	0.422
LIG_LIR_Gen_1	86	92	PF02991	0.371
LIG_LIR_Nem_3	106	111	PF02991	0.266
LIG_LIR_Nem_3	18	22	PF02991	0.383
LIG_LIR_Nem_3	199	204	PF02991	0.462
LIG_LIR_Nem_3	74	80	PF02991	0.428
LIG_LIR_Nem_3	86	90	PF02991	0.374
LIG_LIR_Nem_3	99	104	PF02991	0.334
LIG_Pex14_1	166	170	PF04695	0.361
LIG_Pex14_1	97	101	PF04695	0.356
LIG_SH2_CRK	201	205	PF00017	0.565
LIG_SH2_GRB2like	184	187	PF00017	0.412
LIG_SH2_PTP2	19	22	PF00017	0.406
LIG_SH2_SRC	170	173	PF00017	0.390
LIG_SH2_SRC	19	22	PF00017	0.518
LIG_SH2_STAP1	77	81	PF00017	0.426
LIG_SH2_STAT5	108	111	PF00017	0.362
LIG_SH2_STAT5	170	173	PF00017	0.390
LIG_SH2_STAT5	19	22	PF00017	0.406
LIG_TRAF2_1	36	39	PF00917	0.382
LIG_TYR_ITIM	17	22	PF00017	0.393
MOD_LATS_1	194	200	PF00433	0.450
MOD_N-GLC_2	165	167	PF02516	0.349
MOD_NEK2_1	2	7	PF00069	0.502
MOD_NEK2_1	24	29	PF00069	0.381
MOD_PKA_1	196	202	PF00069	0.479
MOD_PKA_2	112	118	PF00069	0.403
MOD_PKA_2	154	160	PF00069	0.400
MOD_PKA_2	2	8	PF00069	0.494
MOD_ProDKin_1	55	61	PF00069	0.467
MOD_SUMO_for_1	42	45	PF00179	0.434
MOD_SUMO_rev_2	180	189	PF00179	0.412
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.410
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.606
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.419
TRG_ENDOCYTIC_2	101	104	PF00928	0.354
TRG_ENDOCYTIC_2	108	111	PF00928	0.356
TRG_ENDOCYTIC_2	19	22	PF00928	0.371
TRG_ENDOCYTIC_2	201	204	PF00928	0.560
TRG_ENDOCYTIC_2	77	80	PF00928	0.429
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV5	Leptomonas seymouri	98%	100%
A0A0S4ITY2	Bodo saltans	81%	100%
A0A1X0P1S8	Trypanosomatidae	82%	100%
A0A3R7NR49	Trypanosoma rangeli	84%	100%
A4HIL4	Leishmania braziliensis	98%	100%
A4I5V9	Leishmania infantum	100%	100%
C9ZR78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9B154	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q712	Leishmania major	98%	100%
V5BSJ7	Trypanosoma cruzi	84%	100%