Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IS54_LEIDO

TriTrypDb:

LdBPK_302650.1 , LdCL_300032100 , LDHU3_30.3550

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IS54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.628
CLV_NRD_NRD_1	28	30	PF00675	0.407
CLV_PCSK_FUR_1	23	27	PF00082	0.334
CLV_PCSK_KEX2_1	25	27	PF00082	0.338
CLV_PCSK_KEX2_1	28	30	PF00082	0.397
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.453
CLV_PCSK_SKI1_1	29	33	PF00082	0.482
DOC_MAPK_gen_1	23	33	PF00069	0.357
DOC_WW_Pin1_4	108	113	PF00397	0.523
LIG_14-3-3_CanoR_1	55	61	PF00244	0.418
LIG_14-3-3_CanoR_1	68	76	PF00244	0.431
LIG_APCC_ABBA_1	31	36	PF00400	0.361
LIG_BRCT_BRCA1_1	53	57	PF00533	0.490
LIG_BRCT_BRCA1_1	72	76	PF00533	0.289
LIG_FHA_1	11	17	PF00498	0.674
LIG_FHA_1	147	153	PF00498	0.631
LIG_FHA_1	28	34	PF00498	0.270
LIG_FHA_1	57	63	PF00498	0.368
LIG_FHA_1	64	70	PF00498	0.434
LIG_FHA_2	145	151	PF00498	0.610
LIG_FHA_2	99	105	PF00498	0.544
LIG_LIR_Gen_1	100	110	PF02991	0.411
LIG_LIR_Nem_3	100	106	PF02991	0.300
LIG_LIR_Nem_3	85	91	PF02991	0.419
LIG_SH2_STAP1	58	62	PF00017	0.371
LIG_SH2_STAT3	64	67	PF00017	0.508
LIG_SH2_STAT5	21	24	PF00017	0.331
LIG_SH2_STAT5	34	37	PF00017	0.358
LIG_SH2_STAT5	58	61	PF00017	0.386
LIG_SUMO_SIM_anti_2	149	156	PF11976	0.570
MOD_CK1_1	70	76	PF00069	0.422
MOD_CK2_1	98	104	PF00069	0.541
MOD_GlcNHglycan	76	79	PF01048	0.412
MOD_GSK3_1	125	132	PF00069	0.670
MOD_GSK3_1	142	149	PF00069	0.721
MOD_GSK3_1	63	70	PF00069	0.450
MOD_GSK3_1	74	81	PF00069	0.484
MOD_GSK3_1	89	96	PF00069	0.364
MOD_NEK2_1	1	6	PF00069	0.638
MOD_PIKK_1	63	69	PF00454	0.454
MOD_PKA_2	27	33	PF00069	0.489
MOD_PKA_2	67	73	PF00069	0.506
MOD_Plk_1	70	76	PF00069	0.417
MOD_Plk_2-3	98	104	PF00069	0.505
MOD_Plk_4	71	77	PF00069	0.390
MOD_Plk_4	98	104	PF00069	0.595
MOD_ProDKin_1	108	114	PF00069	0.537
TRG_ENDOCYTIC_2	21	24	PF00928	0.331
TRG_ENDOCYTIC_2	34	37	PF00928	0.358
TRG_ER_diArg_1	26	29	PF00400	0.392
TRG_NLS_MonoExtC_3	24	29	PF00514	0.473
TRG_NLS_MonoExtN_4	23	29	PF00514	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G5	Leptomonas seymouri	72%	100%
A0A3R7LZP3	Trypanosoma rangeli	50%	99%
A4HIJ8	Leishmania braziliensis	77%	100%
A4I5U2	Leishmania infantum	100%	100%
C9ZR62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9B137	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q729	Leishmania major	96%	100%
V5DP06	Trypanosoma cruzi	49%	99%