AAA family ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Valosin-containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IS46_LEIDO

TriTrypDb:

LdBPK_361420.1 , LdCL_300030900 , LDHU3_30.3390

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IS46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS46

Function

Biological processes
Term	Name	Level	Count
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0042254	ribosome biogenesis	5	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0044085	cellular component biogenesis	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051054	positive regulation of DNA metabolic process	6	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0051972	regulation of telomerase activity	5	1
GO:0051973	positive regulation of telomerase activity	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000278	regulation of DNA biosynthetic process	6	1
GO:2000573	positive regulation of DNA biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0016887	ATP hydrolysis activity	7	16
GO:0017076	purine nucleotide binding	4	16
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:1990275	preribosome binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.590
CLV_C14_Caspase3-7	802	806	PF00656	0.352
CLV_C14_Caspase3-7	826	830	PF00656	0.352
CLV_C14_Caspase3-7	852	856	PF00656	0.424
CLV_C14_Caspase3-7	902	906	PF00656	0.450
CLV_NRD_NRD_1	342	344	PF00675	0.449
CLV_NRD_NRD_1	567	569	PF00675	0.526
CLV_NRD_NRD_1	866	868	PF00675	0.290
CLV_PCSK_KEX2_1	143	145	PF00082	0.559
CLV_PCSK_KEX2_1	32	34	PF00082	0.597
CLV_PCSK_KEX2_1	342	344	PF00082	0.415
CLV_PCSK_KEX2_1	567	569	PF00082	0.476
CLV_PCSK_KEX2_1	689	691	PF00082	0.609
CLV_PCSK_KEX2_1	866	868	PF00082	0.374
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.559
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.657
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.609
CLV_PCSK_SKI1_1	23	27	PF00082	0.448
CLV_PCSK_SKI1_1	306	310	PF00082	0.596
CLV_PCSK_SKI1_1	359	363	PF00082	0.454
CLV_PCSK_SKI1_1	737	741	PF00082	0.312
CLV_PCSK_SKI1_1	749	753	PF00082	0.287
CLV_PCSK_SKI1_1	785	789	PF00082	0.352
CLV_PCSK_SKI1_1	839	843	PF00082	0.407
DEG_APCC_DBOX_1	363	371	PF00400	0.429
DEG_APCC_DBOX_1	613	621	PF00400	0.595
DEG_COP1_1	322	331	PF00400	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.427
DEG_SPOP_SBC_1	68	72	PF00917	0.720
DEG_SPOP_SBC_1	82	86	PF00917	0.690
DOC_ANK_TNKS_1	38	45	PF00023	0.570
DOC_CDC14_PxL_1	299	307	PF14671	0.344
DOC_CDC14_PxL_1	869	877	PF14671	0.500
DOC_CYCLIN_yClb1_LxF_4	839	845	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	34	37	PF00134	0.661
DOC_MAPK_gen_1	567	573	PF00069	0.407
DOC_MAPK_gen_1	689	695	PF00069	0.576
DOC_MAPK_gen_1	838	845	PF00069	0.420
DOC_MAPK_gen_1	860	870	PF00069	0.352
DOC_MAPK_MEF2A_6	348	356	PF00069	0.496
DOC_MAPK_MEF2A_6	792	800	PF00069	0.352
DOC_MAPK_MEF2A_6	863	872	PF00069	0.352
DOC_PP1_RVXF_1	487	494	PF00149	0.539
DOC_PP2B_LxvP_1	117	120	PF13499	0.574
DOC_PP2B_LxvP_1	34	37	PF13499	0.661
DOC_PP2B_LxvP_1	600	603	PF13499	0.528
DOC_PP4_FxxP_1	26	29	PF00568	0.545
DOC_PP4_FxxP_1	61	64	PF00568	0.552
DOC_SPAK_OSR1_1	690	694	PF12202	0.575
DOC_USP7_MATH_1	164	168	PF00917	0.768
DOC_USP7_MATH_1	193	197	PF00917	0.707
DOC_USP7_MATH_1	478	482	PF00917	0.583
DOC_USP7_MATH_1	520	524	PF00917	0.484
DOC_USP7_MATH_1	579	583	PF00917	0.456
DOC_USP7_MATH_1	629	633	PF00917	0.470
DOC_USP7_MATH_1	665	669	PF00917	0.434
DOC_USP7_MATH_1	745	749	PF00917	0.303
DOC_USP7_MATH_1	757	761	PF00917	0.386
DOC_USP7_MATH_1	82	86	PF00917	0.750
DOC_USP7_MATH_1	928	932	PF00917	0.329
DOC_USP7_MATH_1	93	97	PF00917	0.591
DOC_USP7_UBL2_3	179	183	PF12436	0.718
DOC_WW_Pin1_4	151	156	PF00397	0.573
DOC_WW_Pin1_4	169	174	PF00397	0.587
DOC_WW_Pin1_4	419	424	PF00397	0.750
DOC_WW_Pin1_4	731	736	PF00397	0.409
DOC_WW_Pin1_4	792	797	PF00397	0.420
LIG_14-3-3_CanoR_1	125	133	PF00244	0.557
LIG_14-3-3_CanoR_1	21	26	PF00244	0.442
LIG_14-3-3_CanoR_1	306	311	PF00244	0.411
LIG_14-3-3_CanoR_1	342	346	PF00244	0.440
LIG_14-3-3_CanoR_1	355	361	PF00244	0.320
LIG_14-3-3_CanoR_1	364	368	PF00244	0.363
LIG_14-3-3_CanoR_1	419	423	PF00244	0.581
LIG_14-3-3_CanoR_1	519	525	PF00244	0.536
LIG_14-3-3_CanoR_1	547	553	PF00244	0.428
LIG_14-3-3_CanoR_1	666	671	PF00244	0.419
LIG_14-3-3_CanoR_1	677	685	PF00244	0.566
LIG_14-3-3_CanoR_1	813	821	PF00244	0.333
LIG_BRCT_BRCA1_1	438	442	PF00533	0.434
LIG_BRCT_BRCA1_1	724	728	PF00533	0.475
LIG_deltaCOP1_diTrp_1	336	341	PF00928	0.542
LIG_deltaCOP1_diTrp_1	718	726	PF00928	0.521
LIG_deltaCOP1_diTrp_1	952	960	PF00928	0.410
LIG_FHA_1	22	28	PF00498	0.445
LIG_FHA_1	355	361	PF00498	0.544
LIG_FHA_1	364	370	PF00498	0.516
LIG_FHA_1	43	49	PF00498	0.553
LIG_FHA_1	443	449	PF00498	0.476
LIG_FHA_1	486	492	PF00498	0.499
LIG_FHA_1	655	661	PF00498	0.423
LIG_FHA_2	126	132	PF00498	0.621
LIG_FHA_2	206	212	PF00498	0.624
LIG_FHA_2	426	432	PF00498	0.640
LIG_FHA_2	645	651	PF00498	0.369
LIG_FHA_2	670	676	PF00498	0.585
LIG_FHA_2	697	703	PF00498	0.405
LIG_FHA_2	710	716	PF00498	0.321
LIG_FHA_2	824	830	PF00498	0.352
LIG_FHA_2	872	878	PF00498	0.588
LIG_FHA_2	906	912	PF00498	0.359
LIG_FHA_2	932	938	PF00498	0.305
LIG_HCF-1_HBM_1	431	434	PF13415	0.511
LIG_LIR_Apic_2	24	29	PF02991	0.445
LIG_LIR_Gen_1	334	345	PF02991	0.472
LIG_LIR_Gen_1	492	500	PF02991	0.450
LIG_LIR_Gen_1	699	707	PF02991	0.443
LIG_LIR_Gen_1	725	736	PF02991	0.540
LIG_LIR_Gen_1	918	928	PF02991	0.287
LIG_LIR_LC3C_4	445	448	PF02991	0.470
LIG_LIR_Nem_3	252	257	PF02991	0.513
LIG_LIR_Nem_3	334	340	PF02991	0.489
LIG_LIR_Nem_3	438	443	PF02991	0.609
LIG_LIR_Nem_3	492	496	PF02991	0.427
LIG_LIR_Nem_3	699	703	PF02991	0.424
LIG_LIR_Nem_3	725	731	PF02991	0.486
LIG_LIR_Nem_3	918	924	PF02991	0.287
LIG_MYND_1	294	298	PF01753	0.471
LIG_MYND_1	36	40	PF01753	0.546
LIG_PCNA_yPIPBox_3	642	655	PF02747	0.403
LIG_Pex14_1	337	341	PF04695	0.534
LIG_Pex14_2	2	6	PF04695	0.407
LIG_PTB_Apo_2	880	887	PF02174	0.283
LIG_REV1ctd_RIR_1	2	12	PF16727	0.412
LIG_SH2_CRK	258	262	PF00017	0.406
LIG_SH2_CRK	742	746	PF00017	0.336
LIG_SH2_PTP2	351	354	PF00017	0.513
LIG_SH2_PTP2	869	872	PF00017	0.352
LIG_SH2_STAT5	351	354	PF00017	0.464
LIG_SH2_STAT5	490	493	PF00017	0.426
LIG_SH2_STAT5	869	872	PF00017	0.352
LIG_SH2_STAT5	899	902	PF00017	0.287
LIG_SH2_STAT5	907	910	PF00017	0.281
LIG_SH3_2	873	878	PF14604	0.399
LIG_SH3_3	292	298	PF00018	0.423
LIG_SH3_3	34	40	PF00018	0.552
LIG_SH3_3	690	696	PF00018	0.441
LIG_SH3_3	730	736	PF00018	0.332
LIG_SH3_3	764	770	PF00018	0.287
LIG_SH3_3	855	861	PF00018	0.318
LIG_SH3_3	867	873	PF00018	0.400
LIG_SH3_3	89	95	PF00018	0.534
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.403
LIG_SUMO_SIM_anti_2	911	918	PF11976	0.287
LIG_SUMO_SIM_par_1	283	289	PF11976	0.539
LIG_SUMO_SIM_par_1	365	371	PF11976	0.515
LIG_SUMO_SIM_par_1	444	450	PF11976	0.341
LIG_SUMO_SIM_par_1	560	566	PF11976	0.552
LIG_SUMO_SIM_par_1	596	601	PF11976	0.452
LIG_SUMO_SIM_par_1	632	641	PF11976	0.509
LIG_TRAF2_1	428	431	PF00917	0.686
LIG_TYR_ITIM	349	354	PF00017	0.493
LIG_TYR_ITSM	250	257	PF00017	0.530
MOD_CDK_SPK_2	174	179	PF00069	0.700
MOD_CDK_SPxK_1	731	737	PF00069	0.450
MOD_CDK_SPxxK_3	174	181	PF00069	0.569
MOD_CK1_1	167	173	PF00069	0.692
MOD_CK1_1	330	336	PF00069	0.639
MOD_CK1_1	435	441	PF00069	0.577
MOD_CK1_1	464	470	PF00069	0.431
MOD_CK1_1	505	511	PF00069	0.492
MOD_CK1_1	543	549	PF00069	0.532
MOD_CK1_1	596	602	PF00069	0.355
MOD_CK1_1	70	76	PF00069	0.709
MOD_CK1_1	77	83	PF00069	0.712
MOD_CK1_1	931	937	PF00069	0.434
MOD_CK2_1	330	336	PF00069	0.643
MOD_CK2_1	425	431	PF00069	0.694
MOD_CK2_1	464	470	PF00069	0.466
MOD_CK2_1	871	877	PF00069	0.504
MOD_CK2_1	905	911	PF00069	0.294
MOD_DYRK1A_RPxSP_1	419	423	PF00069	0.581
MOD_DYRK1A_RPxSP_1	792	796	PF00069	0.420
MOD_GlcNHglycan	110	113	PF01048	0.729
MOD_GlcNHglycan	16	19	PF01048	0.421
MOD_GlcNHglycan	169	172	PF01048	0.688
MOD_GlcNHglycan	205	208	PF01048	0.570
MOD_GlcNHglycan	243	246	PF01048	0.433
MOD_GlcNHglycan	266	269	PF01048	0.664
MOD_GlcNHglycan	405	408	PF01048	0.666
MOD_GlcNHglycan	413	416	PF01048	0.711
MOD_GlcNHglycan	434	437	PF01048	0.665
MOD_GlcNHglycan	463	466	PF01048	0.479
MOD_GlcNHglycan	480	483	PF01048	0.569
MOD_GlcNHglycan	522	525	PF01048	0.542
MOD_GlcNHglycan	542	545	PF01048	0.355
MOD_GlcNHglycan	575	578	PF01048	0.340
MOD_GlcNHglycan	588	591	PF01048	0.406
MOD_GlcNHglycan	603	606	PF01048	0.404
MOD_GlcNHglycan	679	682	PF01048	0.487
MOD_GlcNHglycan	705	708	PF01048	0.469
MOD_GlcNHglycan	80	83	PF01048	0.534
MOD_GSK3_1	132	139	PF00069	0.827
MOD_GSK3_1	151	158	PF00069	0.549
MOD_GSK3_1	199	206	PF00069	0.640
MOD_GSK3_1	327	334	PF00069	0.514
MOD_GSK3_1	359	366	PF00069	0.432
MOD_GSK3_1	418	425	PF00069	0.670
MOD_GSK3_1	432	439	PF00069	0.699
MOD_GSK3_1	478	485	PF00069	0.738
MOD_GSK3_1	502	509	PF00069	0.463
MOD_GSK3_1	520	527	PF00069	0.399
MOD_GSK3_1	539	546	PF00069	0.345
MOD_GSK3_1	665	672	PF00069	0.548
MOD_GSK3_1	67	74	PF00069	0.716
MOD_GSK3_1	722	729	PF00069	0.521
MOD_GSK3_1	76	83	PF00069	0.711
MOD_GSK3_1	819	826	PF00069	0.287
MOD_GSK3_1	901	908	PF00069	0.287
MOD_LATS_1	19	25	PF00433	0.437
MOD_LATS_1	962	968	PF00433	0.524
MOD_N-GLC_1	125	130	PF02516	0.581
MOD_N-GLC_1	696	701	PF02516	0.475
MOD_N-GLC_1	731	736	PF02516	0.542
MOD_N-GLC_1	757	762	PF02516	0.352
MOD_NEK2_1	231	236	PF00069	0.528
MOD_NEK2_1	250	255	PF00069	0.315
MOD_NEK2_1	264	269	PF00069	0.413
MOD_NEK2_1	341	346	PF00069	0.587
MOD_NEK2_1	354	359	PF00069	0.344
MOD_NEK2_1	370	375	PF00069	0.546
MOD_NEK2_1	403	408	PF00069	0.605
MOD_NEK2_1	442	447	PF00069	0.364
MOD_NEK2_1	593	598	PF00069	0.515
MOD_NEK2_1	6	11	PF00069	0.420
MOD_NEK2_1	654	659	PF00069	0.384
MOD_NEK2_1	67	72	PF00069	0.556
MOD_NEK2_1	691	696	PF00069	0.455
MOD_PIKK_1	354	360	PF00454	0.459
MOD_PIKK_1	380	386	PF00454	0.646
MOD_PIKK_1	644	650	PF00454	0.384
MOD_PIKK_1	819	825	PF00454	0.287
MOD_PKA_1	964	970	PF00069	0.721
MOD_PKA_2	124	130	PF00069	0.793
MOD_PKA_2	264	270	PF00069	0.587
MOD_PKA_2	341	347	PF00069	0.437
MOD_PKA_2	354	360	PF00069	0.288
MOD_PKA_2	363	369	PF00069	0.338
MOD_PKA_2	380	386	PF00069	0.495
MOD_PKA_2	418	424	PF00069	0.781
MOD_PKA_2	520	526	PF00069	0.520
MOD_PKA_2	59	65	PF00069	0.658
MOD_PKA_2	665	671	PF00069	0.562
MOD_Plk_1	285	291	PF00069	0.486
MOD_Plk_1	370	376	PF00069	0.575
MOD_Plk_1	691	697	PF00069	0.532
MOD_Plk_1	757	763	PF00069	0.420
MOD_Plk_2-3	426	432	PF00069	0.587
MOD_Plk_4	212	218	PF00069	0.514
MOD_Plk_4	442	448	PF00069	0.445
MOD_Plk_4	524	530	PF00069	0.525
MOD_Plk_4	548	554	PF00069	0.446
MOD_Plk_4	588	594	PF00069	0.460
MOD_Plk_4	722	728	PF00069	0.487
MOD_Plk_4	747	753	PF00069	0.352
MOD_ProDKin_1	151	157	PF00069	0.573
MOD_ProDKin_1	169	175	PF00069	0.590
MOD_ProDKin_1	419	425	PF00069	0.749
MOD_ProDKin_1	731	737	PF00069	0.407
MOD_ProDKin_1	792	798	PF00069	0.420
MOD_SUMO_rev_2	131	135	PF00179	0.577
MOD_SUMO_rev_2	702	712	PF00179	0.455
MOD_SUMO_rev_2	836	841	PF00179	0.279
TRG_ENDOCYTIC_2	254	257	PF00928	0.534
TRG_ENDOCYTIC_2	258	261	PF00928	0.494
TRG_ENDOCYTIC_2	351	354	PF00928	0.382
TRG_ENDOCYTIC_2	869	872	PF00928	0.352
TRG_ER_diArg_1	20	23	PF00400	0.536
TRG_ER_diArg_1	341	343	PF00400	0.413
TRG_ER_diArg_1	567	569	PF00400	0.484
TRG_ER_diArg_1	58	61	PF00400	0.734
TRG_ER_diArg_1	866	868	PF00400	0.420
TRG_ER_diArg_1	945	948	PF00400	0.428
TRG_NLS_MonoExtN_4	29	35	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	785	789	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	819	823	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H1	Leptomonas seymouri	59%	100%
A0A1X0P1J4	Trypanosomatidae	49%	100%
A0A3R7M308	Trypanosoma rangeli	50%	100%
A0A3S7X0L3	Leishmania donovani	32%	100%
A4HFM9	Leishmania braziliensis	32%	100%
A4HII5	Leishmania braziliensis	76%	100%
A4I2Q7	Leishmania infantum	32%	100%
A4I5S8	Leishmania infantum	99%	100%
C9ZR48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AD83	Leishmania major	33%	100%
E9AZ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B124	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q741	Leishmania major	92%	100%
V5AUZ1	Trypanosoma cruzi	48%	100%