ATP_synthase_delta_(OSCP)_subunit_putative/Pfam:P F00213

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase delta (OSCP) subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IS23_LEIDO

TriTrypDb:

LdBPK_367070.1 , LdCL_360083300 , LDHU3_36.9440

Length:

258

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase delta subunit OSCP Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0000274	mitochondrial proton-transporting ATP synthase, stator stalk	4	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	1
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	1
GO:0045265	proton-transporting ATP synthase, stator stalk	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IS23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS23

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015986	proton motive force-driven ATP synthesis	9	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042776	proton motive force-driven mitochondrial ATP synthesis	10	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046034	ATP metabolic process	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015252	proton channel activity	6	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0016874	ligase activity	2	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.408
CLV_NRD_NRD_1	3	5	PF00675	0.493
CLV_PCSK_KEX2_1	135	137	PF00082	0.298
CLV_PCSK_KEX2_1	158	160	PF00082	0.210
CLV_PCSK_KEX2_1	3	5	PF00082	0.493
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.298
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.243
CLV_PCSK_SKI1_1	135	139	PF00082	0.328
CLV_PCSK_SKI1_1	94	98	PF00082	0.357
CLV_Separin_Metazoa	237	241	PF03568	0.411
DEG_APCC_DBOX_1	239	247	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DOC_ANK_TNKS_1	183	190	PF00023	0.378
DOC_CKS1_1	17	22	PF01111	0.368
DOC_CYCLIN_yClb3_PxF_3	78	86	PF00134	0.378
DOC_MAPK_gen_1	133	143	PF00069	0.239
DOC_MAPK_gen_1	240	248	PF00069	0.465
DOC_MAPK_gen_1	3	11	PF00069	0.598
DOC_MAPK_MEF2A_6	3	11	PF00069	0.495
DOC_PP2B_LxvP_1	99	102	PF13499	0.378
DOC_PP4_FxxP_1	17	20	PF00568	0.391
DOC_USP7_MATH_1	43	47	PF00917	0.314
DOC_USP7_MATH_1	59	63	PF00917	0.238
DOC_USP7_UBL2_3	51	55	PF12436	0.253
DOC_WW_Pin1_4	16	21	PF00397	0.409
LIG_14-3-3_CanoR_1	136	143	PF00244	0.336
LIG_14-3-3_CanoR_1	224	234	PF00244	0.494
LIG_14-3-3_CanoR_1	3	8	PF00244	0.501
LIG_Actin_WH2_2	239	257	PF00022	0.518
LIG_BRCT_BRCA1_1	45	49	PF00533	0.282
LIG_BRCT_BRCA1_2	45	51	PF00533	0.295
LIG_FHA_1	102	108	PF00498	0.253
LIG_FHA_1	136	142	PF00498	0.323
LIG_FHA_1	234	240	PF00498	0.401
LIG_FHA_1	85	91	PF00498	0.253
LIG_FHA_2	17	23	PF00498	0.373
LIG_FHA_2	226	232	PF00498	0.450
LIG_LIR_Apic_2	14	20	PF02991	0.445
LIG_LIR_Gen_1	214	225	PF02991	0.446
LIG_LIR_Gen_1	46	57	PF02991	0.257
LIG_LIR_Gen_1	62	70	PF02991	0.364
LIG_LIR_Nem_3	124	129	PF02991	0.254
LIG_LIR_Nem_3	214	220	PF02991	0.453
LIG_LIR_Nem_3	46	52	PF02991	0.257
LIG_LIR_Nem_3	62	66	PF02991	0.364
LIG_LIR_Nem_3	69	73	PF02991	0.240
LIG_LIR_Nem_3	95	99	PF02991	0.251
LIG_Pex14_2	105	109	PF04695	0.238
LIG_SH2_CRK	174	178	PF00017	0.298
LIG_SH2_CRK	217	221	PF00017	0.460
LIG_SH2_GRB2like	129	132	PF00017	0.253
LIG_SH2_GRB2like	198	201	PF00017	0.238
LIG_SH2_GRB2like	217	220	PF00017	0.452
LIG_SH2_NCK_1	174	178	PF00017	0.310
LIG_SH2_NCK_1	217	221	PF00017	0.479
LIG_SH2_PTP2	142	145	PF00017	0.210
LIG_SH2_SRC	129	132	PF00017	0.253
LIG_SH2_SRC	242	245	PF00017	0.373
LIG_SH2_STAP1	126	130	PF00017	0.273
LIG_SH2_STAP1	28	32	PF00017	0.370
LIG_SH2_STAT5	129	132	PF00017	0.253
LIG_SH2_STAT5	142	145	PF00017	0.268
LIG_SH2_STAT5	174	177	PF00017	0.303
LIG_SH2_STAT5	18	21	PF00017	0.354
LIG_SH2_STAT5	198	201	PF00017	0.238
LIG_SH2_STAT5	217	220	PF00017	0.462
LIG_SH2_STAT5	242	245	PF00017	0.369
LIG_SH3_3	75	81	PF00018	0.378
LIG_SUMO_SIM_par_1	86	92	PF11976	0.381
LIG_TRAF2_1	20	23	PF00917	0.488
LIG_TRFH_1	174	178	PF08558	0.362
LIG_WW_3	221	225	PF00397	0.577
MOD_CK1_1	100	106	PF00069	0.286
MOD_CK1_1	226	232	PF00069	0.635
MOD_CK1_1	62	68	PF00069	0.248
MOD_CK2_1	16	22	PF00069	0.381
MOD_CK2_1	182	188	PF00069	0.404
MOD_CK2_1	225	231	PF00069	0.491
MOD_CK2_1	27	33	PF00069	0.332
MOD_GlcNHglycan	211	214	PF01048	0.607
MOD_GlcNHglycan	99	102	PF01048	0.382
MOD_GSK3_1	41	48	PF00069	0.455
MOD_GSK3_1	84	91	PF00069	0.378
MOD_GSK3_1	97	104	PF00069	0.378
MOD_NEK2_1	11	16	PF00069	0.537
MOD_NEK2_1	225	230	PF00069	0.530
MOD_PIKK_1	206	212	PF00454	0.620
MOD_PKA_1	135	141	PF00069	0.328
MOD_PKA_1	3	9	PF00069	0.493
MOD_PKA_2	135	141	PF00069	0.426
MOD_PKA_2	223	229	PF00069	0.532
MOD_PKA_2	3	9	PF00069	0.499
MOD_Plk_1	182	188	PF00069	0.268
MOD_Plk_2-3	244	250	PF00069	0.497
MOD_Plk_4	125	131	PF00069	0.253
MOD_Plk_4	172	178	PF00069	0.258
MOD_Plk_4	194	200	PF00069	0.377
MOD_Plk_4	244	250	PF00069	0.562
MOD_Plk_4	62	68	PF00069	0.328
MOD_ProDKin_1	16	22	PF00069	0.407
MOD_SUMO_rev_2	162	171	PF00179	0.295
MOD_SUMO_rev_2	21	27	PF00179	0.432
MOD_SUMO_rev_2	91	99	PF00179	0.239
TRG_DiLeu_BaEn_4	22	28	PF01217	0.479
TRG_ENDOCYTIC_2	174	177	PF00928	0.298
TRG_ENDOCYTIC_2	217	220	PF00928	0.462
TRG_ENDOCYTIC_2	54	57	PF00928	0.423
TRG_ER_diArg_1	2	4	PF00400	0.490
TRG_NES_CRM1_1	237	252	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D0	Leptomonas seymouri	84%	100%
A0A0S4JTF5	Bodo saltans	58%	100%
A0A1X0NM19	Trypanosomatidae	65%	100%
A0A3S5IS13	Trypanosoma rangeli	66%	100%
A4HQJ8	Leishmania braziliensis	88%	100%
A4ICB6	Leishmania infantum	100%	100%
D0A3P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AUB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q079	Leishmania major	96%	100%
V5AXN2	Trypanosoma cruzi	66%	91%