Putative ACR, YagE family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YagE family COG1723, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IS20_LEIDO

TriTrypDb:

LdBPK_302230.1 , LdCL_300027800 , LDHU3_30.3030

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0016020	membrane	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IS20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.695
CLV_NRD_NRD_1	174	176	PF00675	0.415
CLV_NRD_NRD_1	189	191	PF00675	0.545
CLV_NRD_NRD_1	206	208	PF00675	0.437
CLV_NRD_NRD_1	222	224	PF00675	0.565
CLV_NRD_NRD_1	262	264	PF00675	0.377
CLV_NRD_NRD_1	298	300	PF00675	0.293
CLV_NRD_NRD_1	30	32	PF00675	0.539
CLV_NRD_NRD_1	435	437	PF00675	0.338
CLV_NRD_NRD_1	504	506	PF00675	0.338
CLV_PCSK_FUR_1	172	176	PF00082	0.476
CLV_PCSK_KEX2_1	174	176	PF00082	0.435
CLV_PCSK_KEX2_1	189	191	PF00082	0.543
CLV_PCSK_KEX2_1	206	208	PF00082	0.436
CLV_PCSK_KEX2_1	222	224	PF00082	0.565
CLV_PCSK_KEX2_1	262	264	PF00082	0.383
CLV_PCSK_KEX2_1	30	32	PF00082	0.539
CLV_PCSK_KEX2_1	434	436	PF00082	0.336
CLV_PCSK_KEX2_1	504	506	PF00082	0.338
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.378
CLV_PCSK_PC7_1	170	176	PF00082	0.401
CLV_PCSK_SKI1_1	174	178	PF00082	0.439
CLV_PCSK_SKI1_1	30	34	PF00082	0.457
CLV_PCSK_SKI1_1	367	371	PF00082	0.331
CLV_PCSK_SKI1_1	415	419	PF00082	0.284
CLV_PCSK_SKI1_1	90	94	PF00082	0.561
DEG_APCC_DBOX_1	113	121	PF00400	0.651
DEG_APCC_DBOX_1	169	177	PF00400	0.665
DEG_APCC_DBOX_1	249	257	PF00400	0.623
DEG_APCC_DBOX_1	504	512	PF00400	0.475
DEG_Nend_UBRbox_2	1	3	PF02207	0.732
DEG_ODPH_VHL_1	87	100	PF01847	0.725
DEG_SCF_FBW7_1	63	70	PF00400	0.825
DEG_SPOP_SBC_1	193	197	PF00917	0.658
DOC_CDC14_PxL_1	461	469	PF14671	0.551
DOC_CKS1_1	348	353	PF01111	0.511
DOC_CKS1_1	418	423	PF01111	0.578
DOC_CYCLIN_RxL_1	113	123	PF00134	0.662
DOC_CYCLIN_RxL_1	170	181	PF00134	0.680
DOC_CYCLIN_RxL_1	367	375	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.562
DOC_MAPK_gen_1	114	122	PF00069	0.662
DOC_MAPK_gen_1	434	446	PF00069	0.563
DOC_MAPK_MEF2A_6	114	122	PF00069	0.601
DOC_MAPK_MEF2A_6	386	393	PF00069	0.475
DOC_MAPK_RevD_3	161	175	PF00069	0.578
DOC_PP1_RVXF_1	368	375	PF00149	0.530
DOC_PP1_RVXF_1	481	487	PF00149	0.562
DOC_USP7_MATH_1	193	197	PF00917	0.658
DOC_USP7_MATH_1	213	217	PF00917	0.741
DOC_USP7_MATH_1	384	388	PF00917	0.516
DOC_USP7_MATH_1	450	454	PF00917	0.526
DOC_USP7_MATH_1	67	71	PF00917	0.740
DOC_WW_Pin1_4	162	167	PF00397	0.566
DOC_WW_Pin1_4	189	194	PF00397	0.675
DOC_WW_Pin1_4	347	352	PF00397	0.518
DOC_WW_Pin1_4	417	422	PF00397	0.578
DOC_WW_Pin1_4	63	68	PF00397	0.757
DOC_WW_Pin1_4	70	75	PF00397	0.683
DOC_WW_Pin1_4	93	98	PF00397	0.771
LIG_14-3-3_CanoR_1	189	193	PF00244	0.752
LIG_14-3-3_CanoR_1	263	273	PF00244	0.591
LIG_14-3-3_CanoR_1	415	421	PF00244	0.562
LIG_14-3-3_CanoR_1	483	487	PF00244	0.522
LIG_14-3-3_CanoR_1	90	99	PF00244	0.770
LIG_BRCT_BRCA1_1	28	32	PF00533	0.690
LIG_BRCT_BRCA1_1	512	516	PF00533	0.335
LIG_Clathr_ClatBox_1	520	524	PF01394	0.413
LIG_deltaCOP1_diTrp_1	459	466	PF00928	0.486
LIG_EH1_1	515	523	PF00400	0.327
LIG_FHA_1	113	119	PF00498	0.657
LIG_FHA_1	124	130	PF00498	0.595
LIG_FHA_1	179	185	PF00498	0.737
LIG_FHA_1	423	429	PF00498	0.555
LIG_FHA_1	527	533	PF00498	0.493
LIG_FHA_1	7	13	PF00498	0.736
LIG_FHA_1	93	99	PF00498	0.724
LIG_FHA_2	128	134	PF00498	0.622
LIG_FHA_2	206	212	PF00498	0.762
LIG_FHA_2	418	424	PF00498	0.591
LIG_FHA_2	491	497	PF00498	0.603
LIG_LIR_Apic_2	375	380	PF02991	0.475
LIG_LIR_Apic_2	459	465	PF02991	0.479
LIG_LIR_Gen_1	157	166	PF02991	0.622
LIG_LIR_Gen_1	241	251	PF02991	0.512
LIG_LIR_Gen_1	279	287	PF02991	0.548
LIG_LIR_Gen_1	513	523	PF02991	0.343
LIG_LIR_Nem_3	147	151	PF02991	0.606
LIG_LIR_Nem_3	157	161	PF02991	0.615
LIG_LIR_Nem_3	241	247	PF02991	0.505
LIG_LIR_Nem_3	279	285	PF02991	0.557
LIG_LIR_Nem_3	353	359	PF02991	0.588
LIG_LIR_Nem_3	404	409	PF02991	0.536
LIG_LIR_Nem_3	423	427	PF02991	0.409
LIG_LIR_Nem_3	513	519	PF02991	0.343
LIG_MYND_1	85	89	PF01753	0.787
LIG_NRBOX	516	522	PF00104	0.362
LIG_PCNA_PIPBox_1	326	335	PF02747	0.475
LIG_PCNA_yPIPBox_3	314	323	PF02747	0.576
LIG_Pex14_1	140	144	PF04695	0.561
LIG_Pex14_1	466	470	PF04695	0.477
LIG_SH2_CRK	148	152	PF00017	0.568
LIG_SH2_CRK	158	162	PF00017	0.541
LIG_SH2_CRK	244	248	PF00017	0.512
LIG_SH2_NCK_1	244	248	PF00017	0.575
LIG_SH2_NCK_1	471	475	PF00017	0.562
LIG_SH2_STAP1	144	148	PF00017	0.649
LIG_SH2_STAP1	244	248	PF00017	0.526
LIG_SH2_STAT5	154	157	PF00017	0.540
LIG_SH2_STAT5	377	380	PF00017	0.465
LIG_SH2_STAT5	405	408	PF00017	0.536
LIG_SH3_3	107	113	PF00018	0.649
LIG_SH3_3	160	166	PF00018	0.626
LIG_SH3_3	224	230	PF00018	0.741
LIG_SH3_3	345	351	PF00018	0.575
LIG_SH3_3	83	89	PF00018	0.783
LIG_SH3_CIN85_PxpxPR_1	72	77	PF14604	0.703
LIG_SUMO_SIM_par_1	357	362	PF11976	0.578
LIG_SUMO_SIM_par_1	387	392	PF11976	0.491
LIG_SUMO_SIM_par_1	518	524	PF11976	0.343
LIG_TYR_ITIM	242	247	PF00017	0.504
LIG_UBA3_1	494	502	PF00899	0.550
LIG_WRC_WIRS_1	390	395	PF05994	0.562
MOD_CDK_SPxxK_3	70	77	PF00069	0.703
MOD_CK1_1	157	163	PF00069	0.654
MOD_CK1_1	178	184	PF00069	0.690
MOD_CK1_1	196	202	PF00069	0.727
MOD_CK1_1	228	234	PF00069	0.713
MOD_CK1_1	482	488	PF00069	0.557
MOD_CK1_1	70	76	PF00069	0.728
MOD_CK2_1	127	133	PF00069	0.601
MOD_CK2_1	417	423	PF00069	0.591
MOD_CK2_1	490	496	PF00069	0.601
MOD_Cter_Amidation	204	207	PF01082	0.492
MOD_Cter_Amidation	502	505	PF01082	0.421
MOD_GlcNHglycan	217	220	PF01048	0.550
MOD_GlcNHglycan	230	233	PF01048	0.469
MOD_GlcNHglycan	310	313	PF01048	0.301
MOD_GlcNHglycan	399	402	PF01048	0.362
MOD_GlcNHglycan	4	7	PF01048	0.604
MOD_GlcNHglycan	452	455	PF01048	0.327
MOD_GlcNHglycan	49	52	PF01048	0.594
MOD_GlcNHglycan	69	72	PF01048	0.546
MOD_GlcNHglycan	77	80	PF01048	0.561
MOD_GSK3_1	123	130	PF00069	0.600
MOD_GSK3_1	188	195	PF00069	0.711
MOD_GSK3_1	2	9	PF00069	0.692
MOD_GSK3_1	22	29	PF00069	0.720
MOD_GSK3_1	221	228	PF00069	0.739
MOD_GSK3_1	238	245	PF00069	0.423
MOD_GSK3_1	389	396	PF00069	0.490
MOD_GSK3_1	482	489	PF00069	0.558
MOD_GSK3_1	59	66	PF00069	0.780
MOD_GSK3_1	75	82	PF00069	0.735
MOD_N-GLC_1	123	128	PF02516	0.475
MOD_N-GLC_1	477	482	PF02516	0.316
MOD_NEK2_1	120	125	PF00069	0.670
MOD_NEK2_1	21	26	PF00069	0.712
MOD_NEK2_1	285	290	PF00069	0.510
MOD_NEK2_1	310	315	PF00069	0.476
MOD_NEK2_1	32	37	PF00069	0.716
MOD_NEK2_1	391	396	PF00069	0.475
MOD_NEK2_1	397	402	PF00069	0.475
MOD_NEK2_1	527	532	PF00069	0.468
MOD_NEK2_1	92	97	PF00069	0.722
MOD_NEK2_2	255	260	PF00069	0.588
MOD_PIKK_1	213	219	PF00454	0.796
MOD_PIKK_1	52	58	PF00454	0.795
MOD_PK_1	175	181	PF00069	0.697
MOD_PKA_2	188	194	PF00069	0.730
MOD_PKA_2	205	211	PF00069	0.693
MOD_PKA_2	221	227	PF00069	0.779
MOD_PKA_2	482	488	PF00069	0.557
MOD_Plk_1	59	65	PF00069	0.799
MOD_Plk_4	157	163	PF00069	0.611
MOD_Plk_4	255	261	PF00069	0.580
MOD_Plk_4	482	488	PF00069	0.533
MOD_Plk_4	490	496	PF00069	0.590
MOD_ProDKin_1	162	168	PF00069	0.566
MOD_ProDKin_1	189	195	PF00069	0.677
MOD_ProDKin_1	347	353	PF00069	0.518
MOD_ProDKin_1	417	423	PF00069	0.578
MOD_ProDKin_1	63	69	PF00069	0.757
MOD_ProDKin_1	70	76	PF00069	0.683
MOD_ProDKin_1	93	99	PF00069	0.771
TRG_DiLeu_BaEn_1	423	428	PF01217	0.559
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.660
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.792
TRG_ENDOCYTIC_2	148	151	PF00928	0.570
TRG_ENDOCYTIC_2	158	161	PF00928	0.555
TRG_ENDOCYTIC_2	244	247	PF00928	0.507
TRG_ENDOCYTIC_2	470	473	PF00928	0.458
TRG_ENDOCYTIC_2	506	509	PF00928	0.562
TRG_ER_diArg_1	100	103	PF00400	0.816
TRG_ER_diArg_1	113	116	PF00400	0.641
TRG_ER_diArg_1	170	173	PF00400	0.582
TRG_ER_diArg_1	174	176	PF00400	0.627
TRG_ER_diArg_1	188	190	PF00400	0.763
TRG_ER_diArg_1	30	32	PF00400	0.739
TRG_ER_diArg_1	435	437	PF00400	0.559
TRG_ER_diArg_1	504	506	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P4	Leptomonas seymouri	65%	79%
A0A0S4IQM3	Bodo saltans	42%	100%
A0A1X0P1X6	Trypanosomatidae	47%	82%
A0A422NW98	Trypanosoma rangeli	43%	87%
A4HIF4	Leishmania braziliensis	81%	100%
A4I5Q0	Leishmania infantum	100%	100%
C9ZR20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	83%
E9B0Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q771	Leishmania major	94%	100%
V5BGV1	Trypanosoma cruzi	42%	86%