Mitochondrial_carrier_protein_putative/Pfam:PF001 53

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IS12_LEIDO

TriTrypDb:

LdBPK_366920.1 , LdCL_360081700 , LDHU3_36.9230

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

A0A3Q8IS12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.352
CLV_C14_Caspase3-7	7	11	PF00656	0.750
CLV_NRD_NRD_1	366	368	PF00675	0.702
CLV_PCSK_KEX2_1	227	229	PF00082	0.516
CLV_PCSK_KEX2_1	296	298	PF00082	0.326
CLV_PCSK_KEX2_1	366	368	PF00082	0.702
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.516
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.326
CLV_PCSK_SKI1_1	18	22	PF00082	0.490
CLV_PCSK_SKI1_1	310	314	PF00082	0.219
DEG_APCC_DBOX_1	17	25	PF00400	0.580
DEG_APCC_DBOX_1	203	211	PF00400	0.317
DEG_APCC_DBOX_1	301	309	PF00400	0.566
DOC_CDC14_PxL_1	24	32	PF14671	0.689
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.454
DOC_MAPK_DCC_7	47	57	PF00069	0.601
DOC_MAPK_gen_1	296	303	PF00069	0.499
DOC_MAPK_MEF2A_6	204	212	PF00069	0.408
DOC_PP2B_LxvP_1	251	254	PF13499	0.311
DOC_PP2B_LxvP_1	34	37	PF13499	0.569
DOC_USP7_MATH_1	164	168	PF00917	0.495
DOC_USP7_MATH_1	173	177	PF00917	0.488
DOC_USP7_MATH_1	272	276	PF00917	0.312
DOC_USP7_MATH_1	40	44	PF00917	0.644
DOC_USP7_MATH_1	8	12	PF00917	0.741
DOC_WW_Pin1_4	13	18	PF00397	0.723
DOC_WW_Pin1_4	154	159	PF00397	0.473
LIG_14-3-3_CanoR_1	188	194	PF00244	0.482
LIG_14-3-3_CanoR_1	240	246	PF00244	0.438
LIG_14-3-3_CanoR_1	29	35	PF00244	0.687
LIG_14-3-3_CanoR_1	47	55	PF00244	0.512
LIG_14-3-3_CanoR_1	56	62	PF00244	0.460
LIG_14-3-3_CanoR_1	88	95	PF00244	0.518
LIG_14-3-3_CanoR_1	99	107	PF00244	0.515
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BRCT_BRCA1_1	100	104	PF00533	0.498
LIG_BRCT_BRCA1_1	199	203	PF00533	0.416
LIG_BRCT_BRCA1_1	337	341	PF00533	0.311
LIG_BRCT_BRCA1_1	66	70	PF00533	0.571
LIG_deltaCOP1_diTrp_1	140	146	PF00928	0.526
LIG_EH_1	160	164	PF12763	0.454
LIG_EH_1	282	286	PF12763	0.364
LIG_EVH1_1	36	40	PF00568	0.578
LIG_FHA_1	188	194	PF00498	0.462
LIG_FHA_1	207	213	PF00498	0.297
LIG_FHA_1	259	265	PF00498	0.359
LIG_FHA_1	31	37	PF00498	0.605
LIG_FHA_1	40	46	PF00498	0.559
LIG_FHA_1	58	64	PF00498	0.541
LIG_FHA_1	84	90	PF00498	0.442
LIG_HCF-1_HBM_1	180	183	PF13415	0.495
LIG_LIR_Gen_1	46	57	PF02991	0.521
LIG_LIR_Gen_1	65	76	PF02991	0.410
LIG_LIR_LC3C_4	209	212	PF02991	0.437
LIG_LIR_Nem_3	101	107	PF02991	0.513
LIG_LIR_Nem_3	122	128	PF02991	0.451
LIG_LIR_Nem_3	140	146	PF02991	0.451
LIG_LIR_Nem_3	157	163	PF02991	0.498
LIG_LIR_Nem_3	216	222	PF02991	0.263
LIG_LIR_Nem_3	224	229	PF02991	0.223
LIG_LIR_Nem_3	46	52	PF02991	0.527
LIG_LIR_Nem_3	65	71	PF02991	0.438
LIG_PCNA_yPIPBox_3	310	322	PF02747	0.412
LIG_Pex14_1	219	223	PF04695	0.272
LIG_Pex14_2	66	70	PF04695	0.497
LIG_PTB_Apo_2	280	287	PF02174	0.297
LIG_PTB_Phospho_1	280	286	PF10480	0.316
LIG_SH2_CRK	68	72	PF00017	0.495
LIG_SH2_STAT5	126	129	PF00017	0.430
LIG_SH2_STAT5	225	228	PF00017	0.218
LIG_SH2_STAT5	286	289	PF00017	0.456
LIG_SH3_3	156	162	PF00018	0.498
LIG_SH3_3	208	214	PF00018	0.332
LIG_SH3_3	298	304	PF00018	0.535
LIG_SH3_3	34	40	PF00018	0.665
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.495
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.408
LIG_TRAF2_1	137	140	PF00917	0.609
LIG_TYR_ITIM	123	128	PF00017	0.479
LIG_WRC_WIRS_1	58	63	PF05994	0.501
MOD_CDK_SPK_2	13	18	PF00069	0.590
MOD_CK1_1	175	181	PF00069	0.528
MOD_CK1_1	350	356	PF00069	0.371
MOD_CK1_1	43	49	PF00069	0.581
MOD_Cter_Amidation	294	297	PF01082	0.326
MOD_GlcNHglycan	10	13	PF01048	0.535
MOD_GlcNHglycan	115	118	PF01048	0.263
MOD_GlcNHglycan	184	187	PF01048	0.216
MOD_GlcNHglycan	241	244	PF01048	0.637
MOD_GlcNHglycan	258	261	PF01048	0.629
MOD_GlcNHglycan	42	45	PF01048	0.416
MOD_GlcNHglycan	89	92	PF01048	0.294
MOD_GSK3_1	172	179	PF00069	0.465
MOD_GSK3_1	182	189	PF00069	0.445
MOD_GSK3_1	335	342	PF00069	0.336
MOD_GSK3_1	39	46	PF00069	0.588
MOD_GSK3_1	57	64	PF00069	0.490
MOD_GSK3_1	83	90	PF00069	0.465
MOD_NEK2_1	203	208	PF00069	0.338
MOD_NEK2_1	22	27	PF00069	0.681
MOD_NEK2_1	57	62	PF00069	0.459
MOD_NEK2_1	66	71	PF00069	0.452
MOD_PIKK_1	164	170	PF00454	0.464
MOD_PIKK_1	350	356	PF00454	0.424
MOD_PKA_2	187	193	PF00069	0.471
MOD_PKA_2	203	209	PF00069	0.308
MOD_PKA_2	239	245	PF00069	0.458
MOD_PKA_2	87	93	PF00069	0.469
MOD_PKA_2	98	104	PF00069	0.497
MOD_Plk_1	22	28	PF00069	0.670
MOD_Plk_4	115	121	PF00069	0.453
MOD_Plk_4	189	195	PF00069	0.502
MOD_Plk_4	203	209	PF00069	0.297
MOD_Plk_4	272	278	PF00069	0.259
MOD_Plk_4	66	72	PF00069	0.473
MOD_ProDKin_1	13	19	PF00069	0.721
MOD_ProDKin_1	154	160	PF00069	0.473
MOD_SUMO_for_1	313	316	PF00179	0.526
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.416
TRG_ENDOCYTIC_2	125	128	PF00928	0.447
TRG_ENDOCYTIC_2	223	226	PF00928	0.254
TRG_ENDOCYTIC_2	68	71	PF00928	0.446
TRG_ER_diArg_1	288	291	PF00400	0.454
TRG_ER_diArg_1	366	368	PF00400	0.312
TRG_ER_FFAT_2	178	189	PF00635	0.528
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.216

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	80%	100%
A0A0N1IHK9	Leptomonas seymouri	30%	94%
A0A0S4J045	Bodo saltans	26%	100%
A0A0S4JF45	Bodo saltans	25%	90%
A0A0S4JH99	Bodo saltans	28%	72%
A0A1X0NN16	Trypanosomatidae	53%	100%
A0A1X0NQB5	Trypanosomatidae	29%	96%
A0A1X0NUM8	Trypanosomatidae	24%	100%
A0A1X0P6Z0	Trypanosomatidae	28%	92%
A0A3Q8IC78	Leishmania donovani	29%	100%
A0A3R7L1P3	Trypanosoma rangeli	58%	100%
A0A3S7WUZ5	Leishmania donovani	26%	83%
A0A422NGL1	Trypanosoma rangeli	29%	100%
A0A422P0Q3	Trypanosoma rangeli	29%	94%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A4H690	Leishmania braziliensis	28%	100%
A4H9K7	Leishmania braziliensis	24%	100%
A4HQI4	Leishmania braziliensis	92%	100%
A4HUL3	Leishmania infantum	29%	100%
A4HXX3	Leishmania infantum	26%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
D0A9Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AHZ3	Leishmania infantum	100%	100%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F4HT41	Arabidopsis thaliana	26%	100%
O43772	Homo sapiens	23%	100%
P16260	Homo sapiens	26%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P97521	Rattus norvegicus	24%	100%
Q4Q094	Leishmania major	97%	100%
Q4QDU2	Leishmania major	26%	100%
Q4QHB2	Leishmania major	30%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54VX4	Dictyostelium discoideum	25%	100%
Q7XA87	Arabidopsis thaliana	23%	100%
Q8C0K5	Mus musculus	26%	100%
Q8HXY2	Macaca fascicularis	24%	100%
Q9CA93	Arabidopsis thaliana	25%	100%
Q9Z2Z6	Mus musculus	24%	100%
V5BTA6	Trypanosoma cruzi	25%	100%
V5BTU3	Trypanosoma cruzi	30%	100%
V5DDT9	Trypanosoma cruzi	57%	96%
V5DN72	Trypanosoma cruzi	25%	94%