GPI mannosyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mannosyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IS10_LEIDO

TriTrypDb:

LdBPK_302030.1 , LdCL_300025600 , LDHU3_30.2750

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0031501	mannosyltransferase complex	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:1990529	glycosylphosphatidylinositol-mannosyltransferase I complex	3	1

Expansion

Sequence features

A0A3Q8IS10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IS10

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0051751	alpha-1,4-mannosyltransferase activity	6	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.471
CLV_NRD_NRD_1	295	297	PF00675	0.260
CLV_PCSK_KEX2_1	265	267	PF00082	0.471
CLV_PCSK_KEX2_1	340	342	PF00082	0.227
CLV_PCSK_KEX2_1	430	432	PF00082	0.480
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.227
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.480
CLV_PCSK_PC7_1	426	432	PF00082	0.497
CLV_PCSK_SKI1_1	115	119	PF00082	0.266
CLV_PCSK_SKI1_1	13	17	PF00082	0.251
CLV_PCSK_SKI1_1	159	163	PF00082	0.446
CLV_PCSK_SKI1_1	23	27	PF00082	0.281
CLV_PCSK_SKI1_1	426	430	PF00082	0.433
CLV_PCSK_SKI1_1	54	58	PF00082	0.579
CLV_PCSK_SKI1_1	90	94	PF00082	0.299
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.333
DOC_MAPK_gen_1	115	125	PF00069	0.461
DOC_MAPK_gen_1	265	272	PF00069	0.333
DOC_MAPK_gen_1	415	422	PF00069	0.649
DOC_MAPK_HePTP_8	134	146	PF00069	0.416
DOC_MAPK_MEF2A_6	115	124	PF00069	0.490
DOC_MAPK_MEF2A_6	137	146	PF00069	0.416
DOC_MAPK_MEF2A_6	265	272	PF00069	0.333
DOC_MAPK_MEF2A_6	415	422	PF00069	0.644
DOC_MAPK_MEF2A_6	69	78	PF00069	0.292
DOC_PP1_RVXF_1	377	383	PF00149	0.199
DOC_PP1_RVXF_1	88	94	PF00149	0.315
DOC_PP2B_LxvP_1	368	371	PF13499	0.419
DOC_PP2B_LxvP_1	77	80	PF13499	0.238
DOC_PP4_FxxP_1	219	222	PF00568	0.299
DOC_PP4_FxxP_1	333	336	PF00568	0.299
DOC_WW_Pin1_4	250	255	PF00397	0.240
DOC_WW_Pin1_4	58	63	PF00397	0.292
DOC_WW_Pin1_4	68	73	PF00397	0.265
LIG_14-3-3_CanoR_1	110	119	PF00244	0.554
LIG_14-3-3_CanoR_1	137	146	PF00244	0.444
LIG_14-3-3_CanoR_1	159	167	PF00244	0.446
LIG_14-3-3_CanoR_1	200	206	PF00244	0.505
LIG_14-3-3_CanoR_1	38	48	PF00244	0.281
LIG_14-3-3_CanoR_1	65	69	PF00244	0.287
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	394	398	PF00533	0.293
LIG_eIF4E_1	103	109	PF01652	0.425
LIG_eIF4E_1	68	74	PF01652	0.349
LIG_FHA_1	12	18	PF00498	0.521
LIG_FHA_1	202	208	PF00498	0.527
LIG_FHA_1	367	373	PF00498	0.281
LIG_FHA_1	400	406	PF00498	0.366
LIG_FHA_1	417	423	PF00498	0.667
LIG_FHA_1	69	75	PF00498	0.263
LIG_FHA_2	40	46	PF00498	0.275
LIG_FHA_2	59	65	PF00498	0.333
LIG_FHA_2	92	98	PF00498	0.361
LIG_GBD_Chelix_1	360	368	PF00786	0.368
LIG_LIR_Apic_2	216	222	PF02991	0.390
LIG_LIR_Apic_2	330	336	PF02991	0.172
LIG_LIR_Gen_1	116	127	PF02991	0.494
LIG_LIR_Gen_1	145	153	PF02991	0.270
LIG_LIR_Gen_1	253	263	PF02991	0.247
LIG_LIR_Gen_1	307	316	PF02991	0.299
LIG_LIR_Gen_1	43	53	PF02991	0.258
LIG_LIR_Nem_3	116	122	PF02991	0.508
LIG_LIR_Nem_3	195	201	PF02991	0.505
LIG_LIR_Nem_3	223	227	PF02991	0.384
LIG_LIR_Nem_3	253	258	PF02991	0.258
LIG_LIR_Nem_3	307	313	PF02991	0.299
LIG_LIR_Nem_3	34	39	PF02991	0.308
LIG_LIR_Nem_3	43	49	PF02991	0.252
LIG_LIR_Nem_3	67	73	PF02991	0.272
LIG_LYPXL_S_1	175	179	PF13949	0.299
LIG_LYPXL_yS_3	176	179	PF13949	0.299
LIG_Pex14_1	256	260	PF04695	0.247
LIG_Pex14_1	324	328	PF04695	0.288
LIG_Pex14_2	169	173	PF04695	0.311
LIG_Pex14_2	215	219	PF04695	0.419
LIG_Pex14_2	252	256	PF04695	0.266
LIG_Pex14_2	281	285	PF04695	0.385
LIG_REV1ctd_RIR_1	195	204	PF16727	0.533
LIG_SH2_CRK	18	22	PF00017	0.417
LIG_SH2_CRK	180	184	PF00017	0.315
LIG_SH2_CRK	46	50	PF00017	0.254
LIG_SH2_CRK	70	74	PF00017	0.274
LIG_SH2_GRB2like	260	263	PF00017	0.247
LIG_SH2_NCK_1	41	45	PF00017	0.266
LIG_SH2_STAT3	230	233	PF00017	0.307
LIG_SH2_STAT5	103	106	PF00017	0.302
LIG_SH2_STAT5	160	163	PF00017	0.353
LIG_SH2_STAT5	224	227	PF00017	0.363
LIG_SH2_STAT5	234	237	PF00017	0.191
LIG_SH2_STAT5	260	263	PF00017	0.247
LIG_SH2_STAT5	321	324	PF00017	0.299
LIG_SH2_STAT5	36	39	PF00017	0.331
LIG_SH2_STAT5	399	402	PF00017	0.396
LIG_SH2_STAT5	41	44	PF00017	0.262
LIG_SH2_STAT5	70	73	PF00017	0.265
LIG_SH3_2	336	341	PF14604	0.427
LIG_SH3_3	333	339	PF00018	0.407
LIG_SH3_3	81	87	PF00018	0.232
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.363
LIG_SUMO_SIM_par_1	418	424	PF11976	0.606
LIG_SUMO_SIM_par_1	45	51	PF11976	0.274
LIG_TRAF2_1	192	195	PF00917	0.468
LIG_TYR_ITIM	16	21	PF00017	0.417
LIG_TYR_ITIM	39	44	PF00017	0.354
LIG_WRC_WIRS_1	143	148	PF05994	0.284
LIG_WRC_WIRS_1	328	333	PF05994	0.172
MOD_CDK_SPxxK_3	58	65	PF00069	0.364
MOD_CK1_1	11	17	PF00069	0.311
MOD_CK1_1	145	151	PF00069	0.359
MOD_CK1_1	355	361	PF00069	0.410
MOD_CK1_1	416	422	PF00069	0.586
MOD_CK2_1	346	352	PF00069	0.404
MOD_Cter_Amidation	263	266	PF01082	0.419
MOD_GlcNHglycan	114	118	PF01048	0.346
MOD_GlcNHglycan	273	277	PF01048	0.400
MOD_GlcNHglycan	357	360	PF01048	0.368
MOD_GSK3_1	109	116	PF00069	0.518
MOD_GSK3_1	133	140	PF00069	0.296
MOD_GSK3_1	348	355	PF00069	0.399
MOD_GSK3_1	64	71	PF00069	0.342
MOD_N-GLC_1	132	137	PF02516	0.356
MOD_N-GLC_1	250	255	PF02516	0.299
MOD_N-GLC_1	346	351	PF02516	0.232
MOD_NEK2_1	132	137	PF00069	0.334
MOD_NEK2_1	142	147	PF00069	0.316
MOD_NEK2_1	201	206	PF00069	0.446
MOD_NEK2_1	213	218	PF00069	0.165
MOD_NEK2_1	343	348	PF00069	0.414
MOD_NEK2_1	364	369	PF00069	0.363
MOD_NEK2_1	63	68	PF00069	0.414
MOD_PKA_2	109	115	PF00069	0.524
MOD_PKA_2	352	358	PF00069	0.399
MOD_PKA_2	416	422	PF00069	0.559
MOD_PKA_2	64	70	PF00069	0.356
MOD_PKA_2	8	14	PF00069	0.473
MOD_Plk_1	63	69	PF00069	0.412
MOD_Plk_4	220	226	PF00069	0.315
MOD_Plk_4	304	310	PF00069	0.299
MOD_Plk_4	327	333	PF00069	0.172
MOD_Plk_4	352	358	PF00069	0.354
MOD_ProDKin_1	250	256	PF00069	0.289
MOD_ProDKin_1	58	64	PF00069	0.365
MOD_ProDKin_1	68	74	PF00069	0.322
MOD_SUMO_for_1	192	195	PF00179	0.329
TRG_DiLeu_BaEn_2	305	311	PF01217	0.419
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.340
TRG_ENDOCYTIC_2	102	105	PF00928	0.310
TRG_ENDOCYTIC_2	176	179	PF00928	0.299
TRG_ENDOCYTIC_2	18	21	PF00928	0.357
TRG_ENDOCYTIC_2	255	258	PF00928	0.315
TRG_ENDOCYTIC_2	260	263	PF00928	0.315
TRG_ENDOCYTIC_2	29	32	PF00928	0.237
TRG_ENDOCYTIC_2	36	39	PF00928	0.259
TRG_ENDOCYTIC_2	388	391	PF00928	0.360
TRG_ENDOCYTIC_2	41	44	PF00928	0.294
TRG_ENDOCYTIC_2	46	49	PF00928	0.243
TRG_ENDOCYTIC_2	70	73	PF00928	0.324
TRG_ER_diArg_1	414	417	PF00400	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I387	Leptomonas seymouri	79%	100%
A0A0S4JVL8	Bodo saltans	54%	98%
A0A1X0P1P7	Trypanosomatidae	60%	95%
A0A422P3K4	Trypanosoma rangeli	59%	100%
A4HID4	Leishmania braziliensis	88%	100%
A4I5N0	Leishmania infantum	100%	100%
C9ZR01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B0X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P47088	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q2TXB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	32%	100%
Q4I073	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	33%	100%
Q4Q791	Leishmania major	94%	100%
Q4R4E1	Macaca fascicularis	34%	100%
Q4WAH2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	100%
Q500W7	Arabidopsis thaliana	31%	96%
Q54IA4	Dictyostelium discoideum	32%	98%
Q5AMR5	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	100%
Q5B7W0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	98%
Q5EA10	Bos taurus	35%	100%
Q5F380	Gallus gallus	33%	100%
Q5RAH7	Pongo abelii	34%	100%
Q66IJ4	Xenopus tropicalis	35%	100%
Q6BHI9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6CRE7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
Q6FXQ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q75C82	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%
Q7S4Z3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	89%
Q7T310	Danio rerio	35%	100%
Q8C2R7	Mus musculus	35%	100%
Q9BPQ5	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	63%	100%
Q9EQY6	Rattus norvegicus	33%	100%
Q9H3S5	Homo sapiens	34%	100%
Q9P6R5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BU12	Trypanosoma cruzi	60%	100%