Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IRZ9_LEIDO

TriTrypDb:

LdBPK_301900.1 , LdCL_300024300 , LDHU3_30.2610

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.515
CLV_C14_Caspase3-7	402	406	PF00656	0.580
CLV_NRD_NRD_1	128	130	PF00675	0.705
CLV_NRD_NRD_1	143	145	PF00675	0.454
CLV_NRD_NRD_1	164	166	PF00675	0.530
CLV_NRD_NRD_1	181	183	PF00675	0.552
CLV_NRD_NRD_1	303	305	PF00675	0.603
CLV_NRD_NRD_1	408	410	PF00675	0.631
CLV_NRD_NRD_1	448	450	PF00675	0.586
CLV_PCSK_KEX2_1	127	129	PF00082	0.715
CLV_PCSK_KEX2_1	143	145	PF00082	0.446
CLV_PCSK_KEX2_1	164	166	PF00082	0.534
CLV_PCSK_KEX2_1	181	183	PF00082	0.552
CLV_PCSK_KEX2_1	230	232	PF00082	0.613
CLV_PCSK_KEX2_1	303	305	PF00082	0.603
CLV_PCSK_KEX2_1	33	35	PF00082	0.629
CLV_PCSK_KEX2_1	393	395	PF00082	0.658
CLV_PCSK_KEX2_1	408	410	PF00082	0.547
CLV_PCSK_KEX2_1	448	450	PF00082	0.587
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.585
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.629
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.651
CLV_PCSK_PC7_1	123	129	PF00082	0.715
CLV_PCSK_PC7_1	226	232	PF00082	0.608
CLV_PCSK_SKI1_1	165	169	PF00082	0.588
CLV_Separin_Metazoa	62	66	PF03568	0.566
DEG_APCC_DBOX_1	163	171	PF00400	0.551
DEG_APCC_DBOX_1	77	85	PF00400	0.639
DOC_ANK_TNKS_1	35	42	PF00023	0.612
DOC_CYCLIN_yClb3_PxF_3	245	253	PF00134	0.595
DOC_MAPK_gen_1	230	238	PF00069	0.621
DOC_MAPK_gen_1	448	456	PF00069	0.577
DOC_MAPK_gen_1	76	83	PF00069	0.637
DOC_MAPK_HePTP_8	359	371	PF00069	0.534
DOC_MAPK_MEF2A_6	230	238	PF00069	0.621
DOC_MAPK_MEF2A_6	362	371	PF00069	0.636
DOC_PP1_RVXF_1	417	424	PF00149	0.579
DOC_USP7_MATH_1	198	202	PF00917	0.665
DOC_USP7_MATH_1	21	25	PF00917	0.617
DOC_USP7_MATH_1	251	255	PF00917	0.647
DOC_USP7_MATH_1	48	52	PF00917	0.621
DOC_USP7_MATH_1	501	505	PF00917	0.664
DOC_USP7_MATH_1	515	519	PF00917	0.524
DOC_WW_Pin1_4	132	137	PF00397	0.664
DOC_WW_Pin1_4	171	176	PF00397	0.610
DOC_WW_Pin1_4	194	199	PF00397	0.662
DOC_WW_Pin1_4	510	515	PF00397	0.518
LIG_14-3-3_CanoR_1	127	132	PF00244	0.655
LIG_14-3-3_CanoR_1	164	173	PF00244	0.595
LIG_14-3-3_CanoR_1	194	198	PF00244	0.635
LIG_14-3-3_CanoR_1	25	31	PF00244	0.582
LIG_14-3-3_CanoR_1	408	416	PF00244	0.578
LIG_14-3-3_CanoR_1	516	522	PF00244	0.592
LIG_14-3-3_CanoR_1	71	79	PF00244	0.632
LIG_14-3-3_CanoR_1	80	84	PF00244	0.612
LIG_BIR_III_4	336	340	PF00653	0.660
LIG_BRCT_BRCA1_1	202	206	PF00533	0.671
LIG_FHA_1	3	9	PF00498	0.680
LIG_FHA_1	321	327	PF00498	0.552
LIG_FHA_1	445	451	PF00498	0.523
LIG_FHA_1	458	464	PF00498	0.558
LIG_FHA_1	475	481	PF00498	0.397
LIG_FHA_1	59	65	PF00498	0.600
LIG_FHA_1	591	597	PF00498	0.678
LIG_FHA_2	247	253	PF00498	0.600
LIG_FHA_2	276	282	PF00498	0.652
LIG_FHA_2	400	406	PF00498	0.628
LIG_FHA_2	432	438	PF00498	0.594
LIG_FHA_2	506	512	PF00498	0.626
LIG_FHA_2	96	102	PF00498	0.638
LIG_LIR_Apic_2	207	213	PF02991	0.663
LIG_LIR_Gen_1	312	320	PF02991	0.627
LIG_LIR_Gen_1	50	59	PF02991	0.646
LIG_LIR_LC3C_4	414	418	PF02991	0.565
LIG_LIR_Nem_3	312	318	PF02991	0.626
LIG_LIR_Nem_3	50	56	PF02991	0.645
LIG_NRBOX	234	240	PF00104	0.629
LIG_PCNA_yPIPBox_3	523	533	PF02747	0.552
LIG_PTAP_UEV_1	244	249	PF05743	0.646
LIG_PTB_Apo_2	449	456	PF02174	0.515
LIG_PTB_Phospho_1	449	455	PF10480	0.512
LIG_SH2_CRK	296	300	PF00017	0.656
LIG_SH2_CRK	469	473	PF00017	0.560
LIG_SH2_GRB2like	332	335	PF00017	0.624
LIG_SH2_PTP2	210	213	PF00017	0.612
LIG_SH2_SRC	315	318	PF00017	0.567
LIG_SH2_SRC	332	335	PF00017	0.493
LIG_SH2_STAT3	142	145	PF00017	0.580
LIG_SH2_STAT3	398	401	PF00017	0.664
LIG_SH2_STAT3	537	540	PF00017	0.628
LIG_SH2_STAT5	148	151	PF00017	0.564
LIG_SH2_STAT5	166	169	PF00017	0.487
LIG_SH2_STAT5	210	213	PF00017	0.618
LIG_SH2_STAT5	315	318	PF00017	0.567
LIG_SH2_STAT5	332	335	PF00017	0.512
LIG_SH2_STAT5	391	394	PF00017	0.561
LIG_SH2_STAT5	455	458	PF00017	0.627
LIG_SH2_STAT5	469	472	PF00017	0.427
LIG_SH3_3	170	176	PF00018	0.523
LIG_SH3_3	242	248	PF00018	0.632
LIG_SH3_3	276	282	PF00018	0.624
LIG_SH3_3	42	48	PF00018	0.573
LIG_SH3_3	477	483	PF00018	0.574
LIG_SH3_3	549	555	PF00018	0.579
LIG_SH3_3	597	603	PF00018	0.827
LIG_SH3_CIN85_PxpxPR_1	599	604	PF14604	0.712
LIG_TRAF2_1	113	116	PF00917	0.562
LIG_TRAF2_1	220	223	PF00917	0.631
LIG_TRAF2_1	98	101	PF00917	0.640
LIG_WW_3	599	603	PF00397	0.708
MOD_CDC14_SPxK_1	513	516	PF00782	0.492
MOD_CDK_SPxK_1	510	516	PF00069	0.493
MOD_CK1_1	130	136	PF00069	0.673
MOD_CK1_1	197	203	PF00069	0.664
MOD_CK1_1	214	220	PF00069	0.477
MOD_CK1_1	246	252	PF00069	0.631
MOD_CK1_1	407	413	PF00069	0.650
MOD_CK1_1	457	463	PF00069	0.619
MOD_CK1_1	542	548	PF00069	0.605
MOD_CK2_1	246	252	PF00069	0.596
MOD_CK2_1	379	385	PF00069	0.572
MOD_CK2_1	95	101	PF00069	0.666
MOD_CMANNOS	151	154	PF00535	0.582
MOD_Cter_Amidation	162	165	PF01082	0.531
MOD_Cter_Amidation	31	34	PF01082	0.636
MOD_GlcNHglycan	10	13	PF01048	0.635
MOD_GlcNHglycan	132	135	PF01048	0.622
MOD_GlcNHglycan	139	142	PF01048	0.549
MOD_GlcNHglycan	2	5	PF01048	0.651
MOD_GlcNHglycan	213	216	PF01048	0.600
MOD_GlcNHglycan	245	248	PF01048	0.685
MOD_GlcNHglycan	252	256	PF01048	0.641
MOD_GlcNHglycan	50	53	PF01048	0.593
MOD_GlcNHglycan	517	520	PF01048	0.634
MOD_GlcNHglycan	534	537	PF01048	0.529
MOD_GlcNHglycan	544	547	PF01048	0.582
MOD_GSK3_1	193	200	PF00069	0.655
MOD_GSK3_1	295	302	PF00069	0.651
MOD_GSK3_1	4	11	PF00069	0.643
MOD_GSK3_1	431	438	PF00069	0.601
MOD_GSK3_1	501	508	PF00069	0.656
MOD_GSK3_1	515	522	PF00069	0.555
MOD_N-GLC_1	321	326	PF02516	0.512
MOD_NEK2_1	274	279	PF00069	0.612
MOD_NEK2_1	327	332	PF00069	0.588
MOD_NEK2_1	439	444	PF00069	0.570
MOD_NEK2_1	474	479	PF00069	0.565
MOD_NEK2_1	524	529	PF00069	0.629
MOD_NEK2_1	590	595	PF00069	0.679
MOD_NEK2_1	8	13	PF00069	0.639
MOD_NEK2_1	95	100	PF00069	0.597
MOD_NEK2_2	4	9	PF00069	0.663
MOD_NEK2_2	505	510	PF00069	0.633
MOD_PIKK_1	297	303	PF00454	0.666
MOD_PIKK_1	309	315	PF00454	0.567
MOD_PIKK_1	407	413	PF00454	0.566
MOD_PK_1	496	502	PF00069	0.636
MOD_PKA_1	127	133	PF00069	0.696
MOD_PKA_1	303	309	PF00069	0.602
MOD_PKA_2	106	112	PF00069	0.709
MOD_PKA_2	127	133	PF00069	0.696
MOD_PKA_2	193	199	PF00069	0.630
MOD_PKA_2	303	309	PF00069	0.602
MOD_PKA_2	407	413	PF00069	0.650
MOD_PKA_2	515	521	PF00069	0.604
MOD_PKA_2	70	76	PF00069	0.636
MOD_PKA_2	79	85	PF00069	0.612
MOD_Plk_1	146	152	PF00069	0.519
MOD_Plk_1	345	351	PF00069	0.502
MOD_Plk_1	496	502	PF00069	0.625
MOD_Plk_1	90	96	PF00069	0.569
MOD_Plk_2-3	399	405	PF00069	0.629
MOD_Plk_4	146	152	PF00069	0.499
MOD_Plk_4	166	172	PF00069	0.547
MOD_Plk_4	26	32	PF00069	0.599
MOD_Plk_4	275	281	PF00069	0.651
MOD_Plk_4	327	333	PF00069	0.610
MOD_Plk_4	501	507	PF00069	0.618
MOD_Plk_4	79	85	PF00069	0.644
MOD_ProDKin_1	132	138	PF00069	0.658
MOD_ProDKin_1	171	177	PF00069	0.611
MOD_ProDKin_1	194	200	PF00069	0.662
MOD_ProDKin_1	510	516	PF00069	0.521
TRG_DiLeu_BaEn_1	40	45	PF01217	0.621
TRG_DiLeu_BaEn_4	223	229	PF01217	0.587
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.623
TRG_ENDOCYTIC_2	296	299	PF00928	0.657
TRG_ENDOCYTIC_2	315	318	PF00928	0.416
TRG_ENDOCYTIC_2	468	471	PF00928	0.547
TRG_ER_diArg_1	127	129	PF00400	0.711
TRG_ER_diArg_1	142	144	PF00400	0.451
TRG_ER_diArg_1	164	166	PF00400	0.541
TRG_ER_diArg_1	303	305	PF00400	0.603
TRG_ER_diArg_1	448	450	PF00400	0.547
TRG_ER_diArg_1	601	604	PF00400	0.720
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.497
TRG_PTS1	602	605	PF00515	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HIC5	Leishmania braziliensis	69%	100%
A4I5L7	Leishmania infantum	99%	100%
E9B0W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7A4	Leishmania major	93%	100%