LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IRU8_LEIDO
TriTrypDb:
LdBPK_301020.1 * , LdCL_300015400 , LDHU3_30.1340
Length:
587

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRU8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.565
CLV_NRD_NRD_1 116 118 PF00675 0.569
CLV_NRD_NRD_1 130 132 PF00675 0.549
CLV_NRD_NRD_1 201 203 PF00675 0.622
CLV_NRD_NRD_1 24 26 PF00675 0.553
CLV_NRD_NRD_1 27 29 PF00675 0.538
CLV_NRD_NRD_1 3 5 PF00675 0.549
CLV_NRD_NRD_1 333 335 PF00675 0.628
CLV_NRD_NRD_1 60 62 PF00675 0.580
CLV_NRD_NRD_1 90 92 PF00675 0.573
CLV_PCSK_FUR_1 25 29 PF00082 0.577
CLV_PCSK_KEX2_1 10 12 PF00082 0.565
CLV_PCSK_KEX2_1 116 118 PF00082 0.569
CLV_PCSK_KEX2_1 129 131 PF00082 0.552
CLV_PCSK_KEX2_1 179 181 PF00082 0.729
CLV_PCSK_KEX2_1 26 28 PF00082 0.540
CLV_PCSK_KEX2_1 3 5 PF00082 0.549
CLV_PCSK_KEX2_1 333 335 PF00082 0.615
CLV_PCSK_KEX2_1 90 92 PF00082 0.573
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.729
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.575
CLV_PCSK_PC7_1 112 118 PF00082 0.564
CLV_PCSK_PC7_1 22 28 PF00082 0.581
CLV_PCSK_SKI1_1 203 207 PF00082 0.567
CLV_PCSK_SKI1_1 4 8 PF00082 0.545
CLV_PCSK_SKI1_1 532 536 PF00082 0.578
CLV_PCSK_SKI1_1 582 586 PF00082 0.596
DEG_SPOP_SBC_1 39 43 PF00917 0.546
DOC_CDC14_PxL_1 402 410 PF14671 0.649
DOC_CKS1_1 211 216 PF01111 0.684
DOC_CYCLIN_yClb1_LxF_4 535 541 PF00134 0.582
DOC_CYCLIN_yCln2_LP_2 285 291 PF00134 0.623
DOC_CYCLIN_yCln2_LP_2 485 491 PF00134 0.622
DOC_PP2B_LxvP_1 215 218 PF13499 0.624
DOC_PP2B_LxvP_1 251 254 PF13499 0.584
DOC_PP2B_LxvP_1 285 288 PF13499 0.639
DOC_PP4_FxxP_1 540 543 PF00568 0.574
DOC_PP4_FxxP_1 546 549 PF00568 0.524
DOC_USP7_MATH_1 175 179 PF00917 0.613
DOC_USP7_MATH_1 230 234 PF00917 0.628
DOC_USP7_MATH_1 241 245 PF00917 0.539
DOC_USP7_MATH_1 305 309 PF00917 0.587
DOC_USP7_MATH_1 39 43 PF00917 0.558
DOC_USP7_MATH_1 442 446 PF00917 0.638
DOC_WW_Pin1_4 140 145 PF00397 0.656
DOC_WW_Pin1_4 185 190 PF00397 0.665
DOC_WW_Pin1_4 210 215 PF00397 0.673
DOC_WW_Pin1_4 226 231 PF00397 0.576
DOC_WW_Pin1_4 237 242 PF00397 0.575
DOC_WW_Pin1_4 287 292 PF00397 0.629
DOC_WW_Pin1_4 34 39 PF00397 0.551
DOC_WW_Pin1_4 375 380 PF00397 0.660
DOC_WW_Pin1_4 409 414 PF00397 0.682
DOC_WW_Pin1_4 462 467 PF00397 0.695
DOC_WW_Pin1_4 495 500 PF00397 0.640
DOC_WW_Pin1_4 511 516 PF00397 0.459
DOC_WW_Pin1_4 54 59 PF00397 0.528
LIG_14-3-3_CanoR_1 116 123 PF00244 0.561
LIG_14-3-3_CanoR_1 209 214 PF00244 0.575
LIG_14-3-3_CanoR_1 295 302 PF00244 0.686
LIG_14-3-3_CanoR_1 320 327 PF00244 0.624
LIG_14-3-3_CanoR_1 333 337 PF00244 0.634
LIG_14-3-3_CanoR_1 435 440 PF00244 0.637
LIG_14-3-3_CanoR_1 497 503 PF00244 0.618
LIG_14-3-3_CanoR_1 69 79 PF00244 0.575
LIG_Clathr_ClatBox_1 538 542 PF01394 0.576
LIG_CtBP_PxDLS_1 182 186 PF00389 0.675
LIG_CtBP_PxDLS_1 515 519 PF00389 0.494
LIG_FHA_1 147 153 PF00498 0.614
LIG_FHA_1 210 216 PF00498 0.558
LIG_FHA_1 313 319 PF00498 0.643
LIG_FHA_1 35 41 PF00498 0.552
LIG_FHA_1 426 432 PF00498 0.608
LIG_FHA_1 446 452 PF00498 0.555
LIG_FHA_1 533 539 PF00498 0.641
LIG_FHA_2 196 202 PF00498 0.583
LIG_FHA_2 238 244 PF00498 0.657
LIG_FHA_2 395 401 PF00498 0.629
LIG_FHA_2 560 566 PF00498 0.569
LIG_HCF-1_HBM_1 556 559 PF13415 0.574
LIG_LIR_Apic_2 208 214 PF02991 0.662
LIG_LIR_Gen_1 391 401 PF02991 0.740
LIG_LIR_Nem_3 391 396 PF02991 0.755
LIG_LIR_Nem_3 397 402 PF02991 0.631
LIG_PDZ_Class_1 582 587 PF00595 0.603
LIG_Pex14_2 530 534 PF04695 0.574
LIG_Rb_LxCxE_1 308 330 PF01857 0.579
LIG_SH2_CRK 211 215 PF00017 0.613
LIG_SH2_SRC 45 48 PF00017 0.560
LIG_SH2_STAT5 211 214 PF00017 0.554
LIG_SH2_STAT5 45 48 PF00017 0.560
LIG_SH3_1 410 416 PF00018 0.741
LIG_SH3_3 141 147 PF00018 0.660
LIG_SH3_3 163 169 PF00018 0.655
LIG_SH3_3 285 291 PF00018 0.623
LIG_SH3_3 376 382 PF00018 0.643
LIG_SH3_3 401 407 PF00018 0.720
LIG_SH3_3 410 416 PF00018 0.698
LIG_SH3_3 485 491 PF00018 0.665
LIG_SH3_3 52 58 PF00018 0.635
LIG_SH3_3 538 544 PF00018 0.567
LIG_SUMO_SIM_anti_2 267 273 PF11976 0.574
LIG_SUMO_SIM_par_1 548 553 PF11976 0.709
LIG_TRAF2_1 143 146 PF00917 0.553
LIG_TRAF2_1 277 280 PF00917 0.604
LIG_TRAF2_1 571 574 PF00917 0.596
LIG_WW_3 192 196 PF00397 0.674
MOD_CDK_SPK_2 409 414 PF00069 0.682
MOD_CDK_SPxK_1 210 216 PF00069 0.678
MOD_CDK_SPxxK_3 54 61 PF00069 0.572
MOD_CK1_1 119 125 PF00069 0.568
MOD_CK1_1 188 194 PF00069 0.614
MOD_CK1_1 34 40 PF00069 0.553
MOD_CK1_1 348 354 PF00069 0.592
MOD_CK1_1 388 394 PF00069 0.644
MOD_CK1_1 41 47 PF00069 0.546
MOD_CK1_1 417 423 PF00069 0.670
MOD_CK1_1 425 431 PF00069 0.608
MOD_CK1_1 433 439 PF00069 0.528
MOD_CK1_1 445 451 PF00069 0.525
MOD_CK1_1 453 459 PF00069 0.586
MOD_CK1_1 465 471 PF00069 0.571
MOD_CK1_1 48 54 PF00069 0.534
MOD_CK1_1 493 499 PF00069 0.618
MOD_CK1_1 526 532 PF00069 0.532
MOD_CK1_1 57 63 PF00069 0.533
MOD_CK1_1 68 74 PF00069 0.535
MOD_CK2_1 140 146 PF00069 0.548
MOD_CK2_1 195 201 PF00069 0.592
MOD_CK2_1 274 280 PF00069 0.620
MOD_CK2_1 287 293 PF00069 0.533
MOD_CK2_1 320 326 PF00069 0.654
MOD_CK2_1 41 47 PF00069 0.562
MOD_CK2_1 453 459 PF00069 0.681
MOD_CK2_1 568 574 PF00069 0.599
MOD_Cter_Amidation 23 26 PF01082 0.583
MOD_DYRK1A_RPxSP_1 54 58 PF00069 0.569
MOD_GlcNHglycan 154 157 PF01048 0.687
MOD_GlcNHglycan 166 169 PF01048 0.597
MOD_GlcNHglycan 259 262 PF01048 0.569
MOD_GlcNHglycan 296 299 PF01048 0.690
MOD_GlcNHglycan 347 350 PF01048 0.687
MOD_GlcNHglycan 523 528 PF01048 0.542
MOD_GlcNHglycan 73 76 PF01048 0.647
MOD_GSK3_1 205 212 PF00069 0.558
MOD_GSK3_1 226 233 PF00069 0.681
MOD_GSK3_1 237 244 PF00069 0.607
MOD_GSK3_1 266 273 PF00069 0.661
MOD_GSK3_1 332 339 PF00069 0.732
MOD_GSK3_1 34 41 PF00069 0.552
MOD_GSK3_1 344 351 PF00069 0.587
MOD_GSK3_1 369 376 PF00069 0.660
MOD_GSK3_1 385 392 PF00069 0.657
MOD_GSK3_1 430 437 PF00069 0.639
MOD_GSK3_1 461 468 PF00069 0.651
MOD_GSK3_1 489 496 PF00069 0.614
MOD_GSK3_1 497 504 PF00069 0.565
MOD_GSK3_1 63 70 PF00069 0.577
MOD_LATS_1 114 120 PF00433 0.561
MOD_LATS_1 67 73 PF00433 0.594
MOD_N-GLC_1 241 246 PF02516 0.654
MOD_N-GLC_1 445 450 PF02516 0.607
MOD_NEK2_1 152 157 PF00069 0.696
MOD_NEK2_1 164 169 PF00069 0.615
MOD_NEK2_1 205 210 PF00069 0.589
MOD_NEK2_1 234 239 PF00069 0.683
MOD_NEK2_1 40 45 PF00069 0.567
MOD_NEK2_1 408 413 PF00069 0.738
MOD_NEK2_1 461 466 PF00069 0.710
MOD_PIKK_1 188 194 PF00454 0.669
MOD_PIKK_1 338 344 PF00454 0.673
MOD_PIKK_1 417 423 PF00454 0.643
MOD_PIKK_1 48 54 PF00454 0.565
MOD_PK_1 435 441 PF00069 0.574
MOD_PKA_1 116 122 PF00069 0.562
MOD_PKA_2 102 108 PF00069 0.543
MOD_PKA_2 116 122 PF00069 0.554
MOD_PKA_2 18 24 PF00069 0.577
MOD_PKA_2 294 300 PF00069 0.687
MOD_PKA_2 332 338 PF00069 0.742
MOD_PKA_2 434 440 PF00069 0.627
MOD_PKA_2 68 74 PF00069 0.579
MOD_PKB_1 207 215 PF00069 0.544
MOD_Plk_1 119 125 PF00069 0.559
MOD_Plk_1 241 247 PF00069 0.656
MOD_Plk_1 385 391 PF00069 0.658
MOD_Plk_2-3 568 574 PF00069 0.599
MOD_Plk_4 154 160 PF00069 0.606
MOD_Plk_4 266 272 PF00069 0.605
MOD_Plk_4 41 47 PF00069 0.562
MOD_Plk_4 414 420 PF00069 0.691
MOD_Plk_4 559 565 PF00069 0.625
MOD_ProDKin_1 140 146 PF00069 0.657
MOD_ProDKin_1 185 191 PF00069 0.665
MOD_ProDKin_1 210 216 PF00069 0.678
MOD_ProDKin_1 226 232 PF00069 0.576
MOD_ProDKin_1 237 243 PF00069 0.574
MOD_ProDKin_1 287 293 PF00069 0.632
MOD_ProDKin_1 34 40 PF00069 0.552
MOD_ProDKin_1 375 381 PF00069 0.657
MOD_ProDKin_1 409 415 PF00069 0.685
MOD_ProDKin_1 462 468 PF00069 0.696
MOD_ProDKin_1 495 501 PF00069 0.640
MOD_ProDKin_1 511 517 PF00069 0.459
MOD_ProDKin_1 54 60 PF00069 0.527
MOD_SUMO_for_1 327 330 PF00179 0.592
MOD_SUMO_rev_2 197 205 PF00179 0.636
MOD_SUMO_rev_2 573 581 PF00179 0.581
MOD_SUMO_rev_2 95 101 PF00179 0.552
TRG_DiLeu_BaLyEn_6 246 251 PF01217 0.636
TRG_DiLeu_BaLyEn_6 404 409 PF01217 0.656
TRG_ER_diArg_1 129 131 PF00400 0.574
TRG_ER_diArg_1 2 4 PF00400 0.568
TRG_ER_diArg_1 206 209 PF00400 0.609
TRG_ER_diArg_1 25 28 PF00400 0.576
TRG_ER_diArg_1 82 85 PF00400 0.691
TRG_NLS_Bipartite_1 10 30 PF00514 0.577
TRG_NLS_MonoCore_2 24 29 PF00514 0.580
TRG_NLS_MonoExtC_3 25 31 PF00514 0.580
TRG_NLS_MonoExtN_4 22 29 PF00514 0.581
TRG_Pf-PMV_PEXEL_1 179 183 PF00026 0.679

Homologs

Protein Taxonomy Sequence identity Coverage
A4HI51 Leishmania braziliensis 64% 100%
A4I5C7 Leishmania infantum 99% 100%
E9B0M5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q7K7 Leishmania major 84% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS