LeishMANIAdb
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Rac_serine-threonine_kinase_putative/GeneDB:LmjF. 30.0800

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Rac_serine-threonine_kinase_putative/GeneDB:LmjF. 30.0800
Gene product:
rac serine-threonine kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IRT6_LEIDO
TriTrypDb:
LdBPK_300850.1 , LdCL_300013600 , LDHU3_30.1060
Length:
510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRT6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0004672 protein kinase activity 3 9
GO:0004674 protein serine/threonine kinase activity 4 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 345 347 PF00675 0.467
CLV_NRD_NRD_1 369 371 PF00675 0.522
CLV_NRD_NRD_1 437 439 PF00675 0.798
CLV_NRD_NRD_1 495 497 PF00675 0.827
CLV_NRD_NRD_1 79 81 PF00675 0.554
CLV_PCSK_FUR_1 435 439 PF00082 0.804
CLV_PCSK_KEX2_1 345 347 PF00082 0.467
CLV_PCSK_KEX2_1 437 439 PF00082 0.798
CLV_PCSK_SKI1_1 109 113 PF00082 0.583
CLV_PCSK_SKI1_1 154 158 PF00082 0.433
CLV_PCSK_SKI1_1 227 231 PF00082 0.433
CLV_PCSK_SKI1_1 313 317 PF00082 0.514
CLV_PCSK_SKI1_1 336 340 PF00082 0.438
CLV_PCSK_SKI1_1 370 374 PF00082 0.610
CLV_PCSK_SKI1_1 388 392 PF00082 0.503
CLV_PCSK_SKI1_1 48 52 PF00082 0.568
CLV_PCSK_SKI1_1 497 501 PF00082 0.860
DEG_APCC_DBOX_1 153 161 PF00400 0.466
DOC_CKS1_1 375 380 PF01111 0.657
DOC_CYCLIN_RxL_1 40 51 PF00134 0.514
DOC_CYCLIN_yClb1_LxF_4 297 303 PF00134 0.514
DOC_CYCLIN_yCln2_LP_2 372 378 PF00134 0.686
DOC_MAPK_gen_1 227 236 PF00069 0.514
DOC_MAPK_gen_1 354 364 PF00069 0.643
DOC_PP1_RVXF_1 279 286 PF00149 0.433
DOC_PP2B_LxvP_1 372 375 PF13499 0.683
DOC_PP2B_PxIxI_1 322 328 PF00149 0.490
DOC_PP4_FxxP_1 505 508 PF00568 0.817
DOC_USP7_UBL2_3 126 130 PF12436 0.447
DOC_USP7_UBL2_3 503 507 PF12436 0.813
DOC_WW_Pin1_4 374 379 PF00397 0.635
DOC_WW_Pin1_4 397 402 PF00397 0.755
DOC_WW_Pin1_4 420 425 PF00397 0.885
DOC_WW_Pin1_4 449 454 PF00397 0.892
DOC_WW_Pin1_4 462 467 PF00397 0.690
DOC_WW_Pin1_4 6 11 PF00397 0.490
LIG_14-3-3_CanoR_1 345 351 PF00244 0.514
LIG_14-3-3_CanoR_1 437 442 PF00244 0.604
LIG_14-3-3_CanoR_1 460 466 PF00244 0.824
LIG_14-3-3_CanoR_1 80 88 PF00244 0.543
LIG_Actin_WH2_2 38 55 PF00022 0.514
LIG_APCC_ABBAyCdc20_2 222 228 PF00400 0.514
LIG_BIR_II_1 1 5 PF00653 0.475
LIG_DLG_GKlike_1 437 445 PF00625 0.620
LIG_EH1_1 178 186 PF00400 0.514
LIG_eIF4E_1 179 185 PF01652 0.514
LIG_eIF4E_1 268 274 PF01652 0.514
LIG_FHA_1 14 20 PF00498 0.526
LIG_FHA_1 314 320 PF00498 0.488
LIG_FHA_1 329 335 PF00498 0.503
LIG_FHA_1 389 395 PF00498 0.720
LIG_FHA_1 58 64 PF00498 0.506
LIG_FHA_2 100 106 PF00498 0.608
LIG_FHA_2 190 196 PF00498 0.514
LIG_FHA_2 29 35 PF00498 0.568
LIG_FHA_2 427 433 PF00498 0.799
LIG_FHA_2 49 55 PF00498 0.470
LIG_LIR_Apic_2 265 271 PF02991 0.433
LIG_LIR_Apic_2 504 508 PF02991 0.814
LIG_LIR_Gen_1 15 26 PF02991 0.514
LIG_LIR_Gen_1 189 199 PF02991 0.514
LIG_LIR_Gen_1 2 10 PF02991 0.514
LIG_LIR_Gen_1 294 303 PF02991 0.486
LIG_LIR_Nem_3 116 120 PF02991 0.493
LIG_LIR_Nem_3 15 21 PF02991 0.443
LIG_LIR_Nem_3 189 194 PF02991 0.442
LIG_LIR_Nem_3 2 7 PF02991 0.437
LIG_LIR_Nem_3 284 288 PF02991 0.433
LIG_LIR_Nem_3 294 300 PF02991 0.433
LIG_LIR_Nem_3 363 367 PF02991 0.503
LIG_Pex14_1 14 18 PF04695 0.514
LIG_Pex14_2 106 110 PF04695 0.514
LIG_Pex14_2 386 390 PF04695 0.589
LIG_PTB_Apo_2 358 365 PF02174 0.638
LIG_SH2_CRK 117 121 PF00017 0.514
LIG_SH2_PTP2 18 21 PF00017 0.568
LIG_SH2_SRC 18 21 PF00017 0.568
LIG_SH2_SRC 218 221 PF00017 0.466
LIG_SH2_STAP1 208 212 PF00017 0.466
LIG_SH2_STAP1 413 417 PF00017 0.692
LIG_SH2_STAT3 170 173 PF00017 0.433
LIG_SH2_STAT3 193 196 PF00017 0.568
LIG_SH2_STAT5 18 21 PF00017 0.294
LIG_SH2_STAT5 193 196 PF00017 0.495
LIG_SH2_STAT5 218 221 PF00017 0.466
LIG_SH2_STAT5 262 265 PF00017 0.447
LIG_SH2_STAT5 268 271 PF00017 0.406
LIG_SH2_STAT5 4 7 PF00017 0.450
LIG_SH2_STAT5 411 414 PF00017 0.683
LIG_SH2_STAT5 72 75 PF00017 0.468
LIG_SH3_3 251 257 PF00018 0.536
LIG_SH3_3 316 322 PF00018 0.514
LIG_SH3_3 372 378 PF00018 0.554
LIG_SH3_3 4 10 PF00018 0.490
LIG_SH3_3 52 58 PF00018 0.523
LIG_TRAF2_1 171 174 PF00917 0.514
LIG_TRAF2_1 418 421 PF00917 0.867
LIG_TYR_ITIM 224 229 PF00017 0.433
LIG_TYR_ITSM 14 21 PF00017 0.514
LIG_UBA3_1 334 341 PF00899 0.514
MOD_CDK_SPxxK_3 6 13 PF00069 0.490
MOD_CK1_1 462 468 PF00069 0.919
MOD_CK1_1 93 99 PF00069 0.733
MOD_CK2_1 168 174 PF00069 0.488
MOD_CK2_1 189 195 PF00069 0.451
MOD_CK2_1 415 421 PF00069 0.792
MOD_CK2_1 426 432 PF00069 0.802
MOD_CK2_1 48 54 PF00069 0.470
MOD_CK2_1 93 99 PF00069 0.801
MOD_GlcNHglycan 1 4 PF01048 0.442
MOD_GlcNHglycan 136 140 PF01048 0.453
MOD_GlcNHglycan 36 40 PF01048 0.568
MOD_GlcNHglycan 95 98 PF01048 0.723
MOD_GSK3_1 258 265 PF00069 0.426
MOD_GSK3_1 420 427 PF00069 0.883
MOD_GSK3_1 437 444 PF00069 0.651
MOD_GSK3_1 445 452 PF00069 0.837
MOD_GSK3_1 458 465 PF00069 0.906
MOD_GSK3_1 497 504 PF00069 0.879
MOD_GSK3_1 53 60 PF00069 0.543
MOD_GSK3_1 91 98 PF00069 0.721
MOD_N-GLC_1 397 402 PF02516 0.823
MOD_N-GLC_1 445 450 PF02516 0.865
MOD_N-GLC_1 458 463 PF02516 0.900
MOD_N-GLC_1 501 506 PF02516 0.883
MOD_N-GLC_1 91 96 PF02516 0.692
MOD_NEK2_1 168 173 PF00069 0.445
MOD_NEK2_1 441 446 PF00069 0.821
MOD_NEK2_2 84 89 PF00069 0.568
MOD_PIKK_1 399 405 PF00454 0.764
MOD_PKA_1 125 131 PF00069 0.466
MOD_PKA_1 437 443 PF00069 0.783
MOD_PKA_1 497 503 PF00069 0.867
MOD_PKA_2 437 443 PF00069 0.824
MOD_PKA_2 459 465 PF00069 0.846
MOD_PKA_2 79 85 PF00069 0.568
MOD_PKB_1 435 443 PF00069 0.821
MOD_Plk_1 501 507 PF00069 0.885
MOD_Plk_1 68 74 PF00069 0.568
MOD_Plk_2-3 189 195 PF00069 0.479
MOD_Plk_2-3 99 105 PF00069 0.696
MOD_Plk_4 68 74 PF00069 0.490
MOD_ProDKin_1 374 380 PF00069 0.647
MOD_ProDKin_1 397 403 PF00069 0.760
MOD_ProDKin_1 420 426 PF00069 0.885
MOD_ProDKin_1 449 455 PF00069 0.893
MOD_ProDKin_1 462 468 PF00069 0.691
MOD_ProDKin_1 6 12 PF00069 0.490
MOD_SUMO_for_1 229 232 PF00179 0.433
MOD_SUMO_rev_2 105 111 PF00179 0.564
MOD_SUMO_rev_2 140 150 PF00179 0.514
MOD_SUMO_rev_2 20 26 PF00179 0.504
MOD_SUMO_rev_2 329 334 PF00179 0.568
MOD_SUMO_rev_2 44 50 PF00179 0.570
MOD_SUMO_rev_2 76 82 PF00179 0.501
TRG_DiLeu_BaEn_1 330 335 PF01217 0.514
TRG_ENDOCYTIC_2 117 120 PF00928 0.514
TRG_ENDOCYTIC_2 179 182 PF00928 0.415
TRG_ENDOCYTIC_2 18 21 PF00928 0.287
TRG_ENDOCYTIC_2 226 229 PF00928 0.433
TRG_ENDOCYTIC_2 4 7 PF00928 0.437
TRG_ER_diArg_1 345 347 PF00400 0.473
TRG_ER_diArg_1 434 437 PF00400 0.800
TRG_NLS_Bipartite_1 480 500 PF00514 0.872
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 227 232 PF00026 0.433
TRG_Pf-PMV_PEXEL_1 313 317 PF00026 0.514
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.736

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J7 Leptomonas seymouri 29% 100%
A0A0S4IWM4 Bodo saltans 25% 69%
A0A0S4J842 Bodo saltans 26% 95%
A0A0S4JER5 Bodo saltans 44% 100%
A0A0S4JI67 Bodo saltans 30% 100%
A0A0S4JM47 Bodo saltans 24% 94%
A0A1X0P3J5 Trypanosomatidae 40% 100%
A0A3Q8IC87 Leishmania donovani 28% 98%
A0A3Q8IIG1 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 33% 100%
A0A3S5H5U5 Leishmania donovani 28% 100%
A0A3S7WTN9 Leishmania donovani 31% 100%
A0A3S7WWE7 Leishmania donovani 25% 100%
A0A3S7X7Y2 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 41% 100%
A0A3S7X9S2 Leishmania donovani 39% 100%
A0A422NZ62 Trypanosoma rangeli 35% 74%
A0A422P4V9 Trypanosoma rangeli 41% 100%
A4H4S9 Leishmania braziliensis 28% 100%
A4H8C4 Leishmania braziliensis 30% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HBL4 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 30% 100%
A4HCE6 Leishmania braziliensis 28% 100%
A4HED7 Leishmania braziliensis 34% 100%
A4HFF3 Leishmania braziliensis 26% 100%
A4HI35 Leishmania braziliensis 93% 100%
A4HLR0 Leishmania braziliensis 28% 100%
A4HN71 Leishmania braziliensis 41% 100%
A4HNT2 Leishmania braziliensis 22% 100%
A4HWP5 Leishmania infantum 31% 100%
A4HZA2 Leishmania infantum 25% 100%
A4HZV1 Leishmania infantum 28% 98%
A4I1T4 Leishmania infantum 33% 100%
A4I435 Leishmania infantum 27% 100%
A4I5B1 Leishmania infantum 100% 100%
A4I9Y5 Leishmania infantum 25% 100%
A4IBT4 Leishmania infantum 41% 100%
A4IBT9 Leishmania infantum 41% 100%
C6K3W8 Leptomonas seymouri 73% 97%
C9ZQP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZTP2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E8NHS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AFM1 Leishmania major 39% 100%
E9AG71 Leishmania infantum 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 98%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B0K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
O13310 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P05126 Bos taurus 33% 76%
P05771 Homo sapiens 33% 76%
P05772 Oryctolagus cuniculus 33% 76%
P18961 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 75%
P23443 Homo sapiens 42% 97%
P28867 Mus musculus 33% 76%
P31748 AKT8 murine leukemia virus 36% 100%
P31749 Homo sapiens 35% 100%
P31750 Mus musculus 36% 100%
P38070 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 97%
P47196 Rattus norvegicus 36% 100%
P53894 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 67%
P54644 Dictyostelium discoideum 37% 100%
P67998 Oryctolagus cuniculus 42% 97%
P67999 Rattus norvegicus 42% 97%
P68403 Rattus norvegicus 33% 76%
P68404 Mus musculus 33% 76%
Q09831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 90%
Q09898 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 84%
Q4Q204 Leishmania major 24% 100%
Q4Q2Z2 Leishmania major 24% 100%
Q4Q7M5 Leishmania major 98% 100%
Q4Q7W2 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 35% 100%
Q4QBQ2 Leishmania major 28% 100%
Q4QBR6 Leishmania major 29% 99%
Q4QCK0 Leishmania major 25% 100%
Q4QF23 Leishmania major 33% 100%
Q4QFK4 Leishmania major 25% 100%
Q4QIV8 Leishmania major 28% 100%
Q54IH8 Dictyostelium discoideum 28% 94%
Q5AP53 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 70%
Q5R7A7 Pongo abelii 37% 100%
Q63531 Rattus norvegicus 40% 69%
Q6BLJ9 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 71%
Q6CFS5 Yarrowia lipolytica (strain CLIB 122 / E 150) 30% 87%
Q6TGC6 Pneumocystis carinii 31% 100%
Q6TJY3 Bos taurus 42% 97%
Q7LZQ8 Xenopus laevis 33% 76%
Q8BSK8 Mus musculus 42% 97%
Q8R4V0 Rattus norvegicus 37% 100%
Q96BR1 Homo sapiens 37% 100%
Q98TY9 Xenopus laevis 34% 100%
Q9ERE3 Mus musculus 37% 100%
Q9GNR4 Leishmania major 41% 100%
Q9UBS0 Homo sapiens 40% 100%
Q9UK32 Homo sapiens 24% 68%
Q9Z1M4 Mus musculus 40% 100%
V5BCH2 Trypanosoma cruzi 34% 100%
V5DQT5 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS