Rac_serine-threonine_kinase_putative/GeneDB:LmjF. 30.0800

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rac serine-threonine kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRT6_LEIDO

TriTrypDb:

LdBPK_300850.1 , LdCL_300013600 , LDHU3_30.1060

Length:

510

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRT6

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0004674	protein serine/threonine kinase activity	4	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	345	347	PF00675	0.467
CLV_NRD_NRD_1	369	371	PF00675	0.522
CLV_NRD_NRD_1	437	439	PF00675	0.798
CLV_NRD_NRD_1	495	497	PF00675	0.827
CLV_NRD_NRD_1	79	81	PF00675	0.554
CLV_PCSK_FUR_1	435	439	PF00082	0.804
CLV_PCSK_KEX2_1	345	347	PF00082	0.467
CLV_PCSK_KEX2_1	437	439	PF00082	0.798
CLV_PCSK_SKI1_1	109	113	PF00082	0.583
CLV_PCSK_SKI1_1	154	158	PF00082	0.433

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J7	Leptomonas seymouri	29%	100%
A0A0S4IWM4	Bodo saltans	25%	69%
A0A0S4J842	Bodo saltans	26%	95%
A0A0S4JER5	Bodo saltans	44%	100%
A0A0S4JI67	Bodo saltans	30%	100%
A0A0S4JM47	Bodo saltans	24%	94%
A0A1X0P3J5	Trypanosomatidae	40%	100%
A0A3Q8IC87	Leishmania donovani	28%	98%
A0A3Q8IIG1	Leishmania donovani	27%	100%
A0A3Q8INQ4	Leishmania donovani	33%	100%

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