Choline/ethanolamine_phosphotransferase_putative/ GeneDB:LmjF.36.5900

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRT0_LEIDO

TriTrypDb:

LdBPK_366160.1 , LdCL_360069000 , LDHU3_36.8130

Length:

417

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, choline/ethanolamine phosphotransferase (CEPT)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IRT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRT0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004307	ethanolaminephosphotransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	8
GO:0004142	diacylglycerol cholinephosphotransferase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.382
CLV_NRD_NRD_1	119	121	PF00675	0.182
CLV_NRD_NRD_1	2	4	PF00675	0.442
CLV_NRD_NRD_1	28	30	PF00675	0.240
CLV_PCSK_KEX2_1	119	121	PF00082	0.182
CLV_PCSK_SKI1_1	245	249	PF00082	0.280
CLV_PCSK_SKI1_1	43	47	PF00082	0.302
DEG_APCC_DBOX_1	157	165	PF00400	0.211
DEG_APCC_DBOX_1	244	252	PF00400	0.225
DEG_APCC_DBOX_1	325	333	PF00400	0.263
DEG_ODPH_VHL_1	284	297	PF01847	0.196
DOC_CKS1_1	138	143	PF01111	0.208
DOC_CKS1_1	152	157	PF01111	0.208
DOC_MAPK_MEF2A_6	245	252	PF00069	0.297
DOC_MAPK_MEF2A_6	277	284	PF00069	0.384
DOC_PP1_RVXF_1	243	250	PF00149	0.234
DOC_PP1_RVXF_1	336	343	PF00149	0.423
DOC_PP4_FxxP_1	138	141	PF00568	0.221
DOC_USP7_MATH_1	2	6	PF00917	0.585
DOC_USP7_MATH_1	352	356	PF00917	0.404
DOC_USP7_MATH_1	363	367	PF00917	0.290
DOC_USP7_MATH_1	413	417	PF00917	0.547
DOC_WW_Pin1_4	122	127	PF00397	0.420
DOC_WW_Pin1_4	137	142	PF00397	0.153
DOC_WW_Pin1_4	151	156	PF00397	0.208
LIG_14-3-3_CanoR_1	158	167	PF00244	0.196
LIG_14-3-3_CanoR_1	3	12	PF00244	0.554
LIG_14-3-3_CanoR_1	326	330	PF00244	0.405
LIG_14-3-3_CanoR_1	331	337	PF00244	0.426
LIG_Actin_WH2_2	254	272	PF00022	0.276
LIG_BRCT_BRCA1_1	228	232	PF00533	0.315
LIG_BRCT_BRCA1_1	245	249	PF00533	0.166
LIG_BRCT_BRCA1_1	254	258	PF00533	0.237
LIG_eIF4E_1	99	105	PF01652	0.208
LIG_FHA_1	138	144	PF00498	0.208
LIG_FHA_1	179	185	PF00498	0.422
LIG_FHA_1	212	218	PF00498	0.295
LIG_FHA_1	236	242	PF00498	0.301
LIG_FHA_1	257	263	PF00498	0.256
LIG_FHA_1	67	73	PF00498	0.236
LIG_FHA_1	76	82	PF00498	0.210
LIG_FHA_2	152	158	PF00498	0.225
LIG_IRF3_LxIS_1	400	407	PF10401	0.501
LIG_LIR_Apic_2	136	141	PF02991	0.391
LIG_LIR_Apic_2	151	155	PF02991	0.221
LIG_LIR_Apic_2	16	22	PF02991	0.544
LIG_LIR_Gen_1	140	150	PF02991	0.256
LIG_LIR_Gen_1	168	177	PF02991	0.286
LIG_LIR_Gen_1	246	257	PF02991	0.248
LIG_LIR_Gen_1	339	350	PF02991	0.423
LIG_LIR_Gen_1	395	404	PF02991	0.409
LIG_LIR_Nem_3	140	145	PF02991	0.307
LIG_LIR_Nem_3	168	173	PF02991	0.300
LIG_LIR_Nem_3	221	227	PF02991	0.333
LIG_LIR_Nem_3	246	252	PF02991	0.214
LIG_LIR_Nem_3	255	261	PF02991	0.221
LIG_LIR_Nem_3	313	319	PF02991	0.235
LIG_LIR_Nem_3	339	345	PF02991	0.423
LIG_LIR_Nem_3	395	400	PF02991	0.402
LIG_LIR_Nem_3	67	71	PF02991	0.354
LIG_LIR_Nem_3	94	98	PF02991	0.336
LIG_LYPXL_yS_3	224	227	PF13949	0.247
LIG_MLH1_MIPbox_1	228	232	PF16413	0.410
LIG_PCNA_PIPBox_1	153	162	PF02747	0.205
LIG_PCNA_yPIPBox_3	146	158	PF02747	0.240
LIG_Pex14_1	342	346	PF04695	0.160
LIG_Pex14_1	95	99	PF04695	0.208
LIG_Pex14_2	138	142	PF04695	0.326
LIG_Pex14_2	170	174	PF04695	0.221
LIG_Rb_pABgroove_1	125	133	PF01858	0.382
LIG_SH2_CRK	152	156	PF00017	0.204
LIG_SH2_CRK	316	320	PF00017	0.297
LIG_SH2_CRK	337	341	PF00017	0.512
LIG_SH2_GRB2like	186	189	PF00017	0.472
LIG_SH2_GRB2like	49	52	PF00017	0.430
LIG_SH2_NCK_1	220	224	PF00017	0.352
LIG_SH2_PTP2	19	22	PF00017	0.525
LIG_SH2_SRC	186	189	PF00017	0.472
LIG_SH2_SRC	19	22	PF00017	0.525
LIG_SH2_STAP1	220	224	PF00017	0.410
LIG_SH2_STAP1	99	103	PF00017	0.221
LIG_SH2_STAT3	44	47	PF00017	0.437
LIG_SH2_STAT5	186	189	PF00017	0.451
LIG_SH2_STAT5	19	22	PF00017	0.480
LIG_SH2_STAT5	24	27	PF00017	0.421
LIG_SH2_STAT5	403	406	PF00017	0.471
LIG_SH2_STAT5	44	47	PF00017	0.362
LIG_SH2_STAT5	85	88	PF00017	0.202
LIG_SH3_3	184	190	PF00018	0.542
LIG_SH3_3	219	225	PF00018	0.280
LIG_SH3_3	251	257	PF00018	0.313
LIG_SH3_3	265	271	PF00018	0.454
LIG_SH3_3	296	302	PF00018	0.268
LIG_SH3_3	303	309	PF00018	0.284
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.429
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.435
LIG_TYR_ITIM	222	227	PF00017	0.246
LIG_TYR_ITIM	314	319	PF00017	0.333
LIG_UBA3_1	408	415	PF00899	0.506
LIG_WW_1	21	24	PF00397	0.475
MOD_CDK_SPxxK_3	151	158	PF00069	0.189
MOD_CK1_1	148	154	PF00069	0.333
MOD_CK1_1	162	168	PF00069	0.193
MOD_CK1_1	178	184	PF00069	0.378
MOD_CK1_1	243	249	PF00069	0.221
MOD_CK1_1	39	45	PF00069	0.441
MOD_CK1_1	395	401	PF00069	0.412
MOD_CK1_1	407	413	PF00069	0.462
MOD_CK2_1	151	157	PF00069	0.225
MOD_GlcNHglycan	203	206	PF01048	0.350
MOD_GlcNHglycan	213	217	PF01048	0.520
MOD_GlcNHglycan	332	335	PF01048	0.319
MOD_GlcNHglycan	354	357	PF01048	0.314
MOD_GlcNHglycan	394	397	PF01048	0.380
MOD_GSK3_1	118	125	PF00069	0.420
MOD_GSK3_1	159	166	PF00069	0.285
MOD_GSK3_1	207	214	PF00069	0.221
MOD_GSK3_1	252	259	PF00069	0.279
MOD_GSK3_1	269	276	PF00069	0.533
MOD_GSK3_1	318	325	PF00069	0.208
MOD_GSK3_1	32	39	PF00069	0.467
MOD_N-GLC_1	145	150	PF02516	0.297
MOD_N-GLC_1	235	240	PF02516	0.435
MOD_N-GLC_1	302	307	PF02516	0.418
MOD_NEK2_1	145	150	PF00069	0.417
MOD_NEK2_1	159	164	PF00069	0.163
MOD_NEK2_1	201	206	PF00069	0.207
MOD_NEK2_1	252	257	PF00069	0.219
MOD_NEK2_1	312	317	PF00069	0.244
MOD_NEK2_1	318	323	PF00069	0.208
MOD_NEK2_1	369	374	PF00069	0.298
MOD_NEK2_1	392	397	PF00069	0.211
MOD_NEK2_1	404	409	PF00069	0.427
MOD_NEK2_1	75	80	PF00069	0.223
MOD_NEK2_2	235	240	PF00069	0.250
MOD_NEK2_2	302	307	PF00069	0.226
MOD_PIKK_1	395	401	PF00454	0.408
MOD_PK_1	402	408	PF00069	0.429
MOD_PK_1	8	14	PF00069	0.521
MOD_PKA_1	3	9	PF00069	0.566
MOD_PKA_2	118	124	PF00069	0.382
MOD_PKA_2	2	8	PF00069	0.584
MOD_PKA_2	269	275	PF00069	0.506
MOD_PKA_2	325	331	PF00069	0.231
MOD_Plk_1	145	151	PF00069	0.354
MOD_Plk_1	212	218	PF00069	0.287
MOD_Plk_1	302	308	PF00069	0.255
MOD_Plk_1	312	318	PF00069	0.189
MOD_Plk_1	36	42	PF00069	0.432
MOD_Plk_4	148	154	PF00069	0.313
MOD_Plk_4	165	171	PF00069	0.133
MOD_Plk_4	207	213	PF00069	0.238
MOD_Plk_4	36	42	PF00069	0.424
MOD_Plk_4	369	375	PF00069	0.270
MOD_ProDKin_1	122	128	PF00069	0.420
MOD_ProDKin_1	137	143	PF00069	0.153
MOD_ProDKin_1	151	157	PF00069	0.208
MOD_SUMO_rev_2	111	118	PF00179	0.382
TRG_ENDOCYTIC_2	107	110	PF00928	0.195
TRG_ENDOCYTIC_2	224	227	PF00928	0.293
TRG_ENDOCYTIC_2	316	319	PF00928	0.286
TRG_ENDOCYTIC_2	337	340	PF00928	0.429
TRG_ENDOCYTIC_2	389	392	PF00928	0.208
TRG_ENDOCYTIC_2	403	406	PF00928	0.421
TRG_ENDOCYTIC_2	49	52	PF00928	0.428
TRG_ENDOCYTIC_2	83	86	PF00928	0.226
TRG_ENDOCYTIC_2	99	102	PF00928	0.218
TRG_NLS_MonoExtN_4	26	33	PF00514	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I260	Leptomonas seymouri	64%	100%
A0A0S4JA45	Bodo saltans	38%	95%
A0A1X0NLI0	Trypanosomatidae	49%	92%
A0A3R7NAX1	Trypanosoma rangeli	48%	97%
A4HQA8	Leishmania braziliensis	80%	100%
A4IE03	Leishmania infantum	100%	100%
D0A400	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9AU25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O82567	Arabidopsis thaliana	31%	100%
O82568	Arabidopsis thaliana	32%	100%
P17898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q4Q0H0	Leishmania major	94%	100%
Q550W1	Dictyostelium discoideum	29%	100%
Q55AQ3	Dictyostelium discoideum	31%	100%
V5B3K4	Trypanosoma cruzi	49%	96%