Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IRR2_LEIDO

TriTrypDb:

LdBPK_300520.1 , LdCL_300010300 , LDHU3_30.0700

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.750
CLV_NRD_NRD_1	12	14	PF00675	0.671
CLV_NRD_NRD_1	121	123	PF00675	0.684
CLV_NRD_NRD_1	267	269	PF00675	0.676
CLV_NRD_NRD_1	436	438	PF00675	0.622
CLV_NRD_NRD_1	74	76	PF00675	0.667
CLV_PCSK_KEX2_1	12	14	PF00082	0.673
CLV_PCSK_KEX2_1	436	438	PF00082	0.665
CLV_PCSK_KEX2_1	466	468	PF00082	0.612
CLV_PCSK_KEX2_1	74	76	PF00082	0.713
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.670
CLV_PCSK_SKI1_1	129	133	PF00082	0.788
CLV_PCSK_SKI1_1	137	141	PF00082	0.747
CLV_PCSK_SKI1_1	467	471	PF00082	0.566
DEG_APCC_DBOX_1	435	443	PF00400	0.627
DEG_APCC_DBOX_1	466	474	PF00400	0.643
DEG_SCF_FBW7_1	139	144	PF00400	0.753
DEG_SPOP_SBC_1	67	71	PF00917	0.705
DOC_CKS1_1	130	135	PF01111	0.808
DOC_CKS1_1	142	147	PF01111	0.726
DOC_CKS1_1	166	171	PF01111	0.704
DOC_CKS1_1	193	198	PF01111	0.688
DOC_MAPK_gen_1	107	115	PF00069	0.592
DOC_PP1_RVXF_1	267	274	PF00149	0.680
DOC_PP2B_LxvP_1	162	165	PF13499	0.777
DOC_PP2B_LxvP_1	189	192	PF13499	0.756
DOC_PP4_FxxP_1	221	224	PF00568	0.693
DOC_PP4_FxxP_1	273	276	PF00568	0.734
DOC_PP4_FxxP_1	3	6	PF00568	0.698
DOC_USP7_MATH_1	153	157	PF00917	0.786
DOC_USP7_MATH_1	173	177	PF00917	0.808
DOC_USP7_MATH_1	249	253	PF00917	0.793
DOC_USP7_MATH_1	267	271	PF00917	0.682
DOC_USP7_MATH_1	289	293	PF00917	0.651
DOC_USP7_MATH_1	323	327	PF00917	0.805
DOC_USP7_MATH_1	6	10	PF00917	0.693
DOC_WW_Pin1_4	123	128	PF00397	0.647
DOC_WW_Pin1_4	129	134	PF00397	0.686
DOC_WW_Pin1_4	137	142	PF00397	0.840
DOC_WW_Pin1_4	151	156	PF00397	0.676
DOC_WW_Pin1_4	165	170	PF00397	0.664
DOC_WW_Pin1_4	180	185	PF00397	0.740
DOC_WW_Pin1_4	192	197	PF00397	0.675
DOC_WW_Pin1_4	199	204	PF00397	0.670
DOC_WW_Pin1_4	210	215	PF00397	0.779
DOC_WW_Pin1_4	219	224	PF00397	0.665
DOC_WW_Pin1_4	245	250	PF00397	0.678
DOC_WW_Pin1_4	263	268	PF00397	0.690
DOC_WW_Pin1_4	272	277	PF00397	0.693
DOC_WW_Pin1_4	280	285	PF00397	0.731
DOC_WW_Pin1_4	328	333	PF00397	0.751
DOC_WW_Pin1_4	364	369	PF00397	0.807
DOC_WW_Pin1_4	373	378	PF00397	0.841
DOC_WW_Pin1_4	384	389	PF00397	0.504
DOC_WW_Pin1_4	392	397	PF00397	0.543
DOC_WW_Pin1_4	81	86	PF00397	0.667
LIG_14-3-3_CanoR_1	229	235	PF00244	0.636
LIG_14-3-3_CanoR_1	268	272	PF00244	0.646
LIG_14-3-3_CanoR_1	355	363	PF00244	0.722
LIG_14-3-3_CanoR_1	386	396	PF00244	0.762
LIG_14-3-3_CanoR_1	411	421	PF00244	0.713
LIG_14-3-3_CanoR_1	436	440	PF00244	0.632
LIG_14-3-3_CanoR_1	5	15	PF00244	0.709
LIG_14-3-3_CanoR_1	66	76	PF00244	0.725
LIG_ActinCP_TwfCPI_2	3	13	PF01115	0.708
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	269	273	PF00533	0.681
LIG_EVH1_1	186	190	PF00568	0.726
LIG_EVH1_2	223	227	PF00568	0.663
LIG_FHA_1	114	120	PF00498	0.623
LIG_FHA_1	165	171	PF00498	0.719
LIG_FHA_1	283	289	PF00498	0.715
LIG_FHA_1	29	35	PF00498	0.770
LIG_FHA_1	67	73	PF00498	0.725
LIG_FHA_2	302	308	PF00498	0.835
LIG_FHA_2	319	325	PF00498	0.522
LIG_GSK3_LRP6_1	192	197	PF00069	0.734
LIG_LIR_Apic_2	2	6	PF02991	0.694
LIG_LIR_Apic_2	270	276	PF02991	0.734
LIG_LIR_Gen_1	49	59	PF02991	0.733
LIG_LIR_Nem_3	225	230	PF02991	0.641
LIG_LIR_Nem_3	49	55	PF02991	0.734
LIG_MYND_1	184	188	PF01753	0.685
LIG_PCNA_TLS_4	444	451	PF02747	0.683
LIG_SH2_CRK	166	170	PF00017	0.722
LIG_SH2_NCK_1	52	56	PF00017	0.728
LIG_SH2_SRC	429	432	PF00017	0.553
LIG_SH2_STAT5	166	169	PF00017	0.721
LIG_SH2_STAT5	429	432	PF00017	0.587
LIG_SH2_STAT5	450	453	PF00017	0.692
LIG_SH3_1	166	172	PF00018	0.694
LIG_SH3_2	169	174	PF14604	0.724
LIG_SH3_3	130	136	PF00018	0.569
LIG_SH3_3	166	172	PF00018	0.752
LIG_SH3_3	181	187	PF00018	0.661
LIG_SH3_3	190	196	PF00018	0.616
LIG_SH3_3	197	203	PF00018	0.623
LIG_SH3_3	211	217	PF00018	0.774
LIG_SH3_3	248	254	PF00018	0.748
LIG_SH3_3	31	37	PF00018	0.814
LIG_SH3_3	334	340	PF00018	0.689
LIG_SH3_3	453	459	PF00018	0.712
LIG_SUMO_SIM_par_1	285	301	PF11976	0.743
LIG_TRAF2_1	118	121	PF00917	0.628
LIG_UBA3_1	469	478	PF00899	0.640
LIG_WW_2	187	190	PF00397	0.676
LIG_WW_3	134	138	PF00397	0.525
LIG_WW_3	171	175	PF00397	0.729
MOD_CDC14_SPxK_1	126	129	PF00782	0.677
MOD_CDC14_SPxK_1	266	269	PF00782	0.730
MOD_CDC14_SPxK_1	275	278	PF00782	0.725
MOD_CDK_SPK_2	263	268	PF00069	0.737
MOD_CDK_SPK_2	392	397	PF00069	0.739
MOD_CDK_SPxK_1	123	129	PF00069	0.654
MOD_CDK_SPxK_1	137	143	PF00069	0.771
MOD_CDK_SPxK_1	168	174	PF00069	0.626
MOD_CDK_SPxK_1	263	269	PF00069	0.689
MOD_CDK_SPxK_1	272	278	PF00069	0.690
MOD_CDK_SPxK_1	280	286	PF00069	0.734
MOD_CDK_SPxK_1	328	334	PF00069	0.750
MOD_CDK_SPxxK_3	81	88	PF00069	0.659
MOD_CK1_1	154	160	PF00069	0.745
MOD_CK1_1	177	183	PF00069	0.797
MOD_CK1_1	222	228	PF00069	0.665
MOD_CK1_1	356	362	PF00069	0.745
MOD_CK1_1	364	370	PF00069	0.645
MOD_CK1_1	371	377	PF00069	0.732
MOD_CK1_1	387	393	PF00069	0.562
MOD_CK1_1	400	406	PF00069	0.762
MOD_CK1_1	409	415	PF00069	0.708
MOD_CK1_1	440	446	PF00069	0.684
MOD_CK1_1	53	59	PF00069	0.740
MOD_CK1_1	70	76	PF00069	0.686
MOD_CK2_1	302	308	PF00069	0.751
MOD_CK2_1	318	324	PF00069	0.672
MOD_CK2_1	377	383	PF00069	0.838
MOD_CK2_1	83	89	PF00069	0.595
MOD_GlcNHglycan	237	240	PF01048	0.694
MOD_GlcNHglycan	28	31	PF01048	0.702
MOD_GlcNHglycan	324	328	PF01048	0.755
MOD_GlcNHglycan	349	352	PF01048	0.715
MOD_GlcNHglycan	355	358	PF01048	0.671
MOD_GlcNHglycan	371	374	PF01048	0.542
MOD_GlcNHglycan	399	402	PF01048	0.756
MOD_GlcNHglycan	408	411	PF01048	0.739
MOD_GSK3_1	137	144	PF00069	0.782
MOD_GSK3_1	151	158	PF00069	0.635
MOD_GSK3_1	164	171	PF00069	0.615
MOD_GSK3_1	173	180	PF00069	0.721
MOD_GSK3_1	199	206	PF00069	0.721
MOD_GSK3_1	245	252	PF00069	0.775
MOD_GSK3_1	263	270	PF00069	0.688
MOD_GSK3_1	278	285	PF00069	0.704
MOD_GSK3_1	318	325	PF00069	0.724
MOD_GSK3_1	343	350	PF00069	0.753
MOD_GSK3_1	351	358	PF00069	0.665
MOD_GSK3_1	364	371	PF00069	0.611
MOD_GSK3_1	373	380	PF00069	0.765
MOD_GSK3_1	382	389	PF00069	0.767
MOD_GSK3_1	400	407	PF00069	0.612
MOD_GSK3_1	409	416	PF00069	0.777
MOD_GSK3_1	431	438	PF00069	0.580
MOD_GSK3_1	46	53	PF00069	0.690
MOD_GSK3_1	54	61	PF00069	0.661
MOD_GSK3_1	62	69	PF00069	0.649
MOD_GSK3_1	79	86	PF00069	0.469
MOD_NEK2_1	113	118	PF00069	0.640
MOD_NEK2_1	179	184	PF00069	0.739
MOD_NEK2_1	230	235	PF00069	0.636
MOD_NEK2_2	267	272	PF00069	0.732
MOD_PIKK_1	121	127	PF00454	0.673
MOD_PIKK_1	203	209	PF00454	0.829
MOD_PK_1	174	180	PF00069	0.530
MOD_PK_1	93	99	PF00069	0.657
MOD_PKA_2	121	127	PF00069	0.644
MOD_PKA_2	173	179	PF00069	0.808
MOD_PKA_2	230	236	PF00069	0.588
MOD_PKA_2	267	273	PF00069	0.644
MOD_PKA_2	333	339	PF00069	0.690
MOD_PKA_2	4	10	PF00069	0.648
MOD_PKA_2	410	416	PF00069	0.736
MOD_PKA_2	435	441	PF00069	0.601
MOD_PKA_2	67	73	PF00069	0.719
MOD_PKB_1	353	361	PF00069	0.713
MOD_PKB_1	64	72	PF00069	0.797
MOD_Plk_1	50	56	PF00069	0.727
MOD_Plk_2-3	302	308	PF00069	0.805
MOD_Plk_4	174	180	PF00069	0.530
MOD_Plk_4	222	228	PF00069	0.624
MOD_Plk_4	333	339	PF00069	0.706
MOD_Plk_4	93	99	PF00069	0.611
MOD_ProDKin_1	123	129	PF00069	0.654
MOD_ProDKin_1	137	143	PF00069	0.842
MOD_ProDKin_1	151	157	PF00069	0.675
MOD_ProDKin_1	165	171	PF00069	0.664
MOD_ProDKin_1	180	186	PF00069	0.736
MOD_ProDKin_1	192	198	PF00069	0.678
MOD_ProDKin_1	199	205	PF00069	0.670
MOD_ProDKin_1	210	216	PF00069	0.780
MOD_ProDKin_1	219	225	PF00069	0.657
MOD_ProDKin_1	245	251	PF00069	0.677
MOD_ProDKin_1	263	269	PF00069	0.689
MOD_ProDKin_1	272	278	PF00069	0.690
MOD_ProDKin_1	280	286	PF00069	0.734
MOD_ProDKin_1	328	334	PF00069	0.750
MOD_ProDKin_1	364	370	PF00069	0.807
MOD_ProDKin_1	373	379	PF00069	0.842
MOD_ProDKin_1	384	390	PF00069	0.503
MOD_ProDKin_1	392	398	PF00069	0.545
MOD_ProDKin_1	81	87	PF00069	0.663
MOD_SUMO_for_1	477	480	PF00179	0.603
MOD_SUMO_rev_2	106	116	PF00179	0.683
MOD_SUMO_rev_2	120	124	PF00179	0.496
TRG_DiLeu_BaEn_4	310	316	PF01217	0.826
TRG_DiLeu_BaEn_4	453	459	PF01217	0.649
TRG_ENDOCYTIC_2	52	55	PF00928	0.729
TRG_ER_diArg_1	11	13	PF00400	0.670
TRG_ER_diArg_1	435	437	PF00400	0.625
TRG_ER_diArg_1	63	66	PF00400	0.718
TRG_ER_diArg_1	74	76	PF00400	0.670
TRG_NLS_MonoExtC_3	318	324	PF00514	0.759
TRG_NLS_MonoExtN_4	316	323	PF00514	0.750
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G4	Leptomonas seymouri	39%	92%
A0A3R7MDG8	Trypanosoma rangeli	27%	100%
A4HI01	Leishmania braziliensis	72%	99%
A4I578	Leishmania infantum	96%	100%
E9B0H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7Q6	Leishmania major	94%	100%