Adenylyl_cyclase-associated_protein_putative/Gene DB:LmjF.36.5590

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylyl cyclase-associated protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRQ9_LEIDO

TriTrypDb:

LdBPK_365830.1 , LdCL_360065700 , LDHU3_36.7730

Length:

271

Annotations

Annotations by Jardim et al.

Structural Proteins, Adenylyl cyclase-associated

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0007010	cytoskeleton organization	5	7
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0007015	actin filament organization	5	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008092	cytoskeletal protein binding	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	86	88	PF00675	0.566
CLV_PCSK_KEX2_1	112	114	PF00082	0.274
CLV_PCSK_KEX2_1	85	87	PF00082	0.545
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.274
CLV_PCSK_SKI1_1	52	56	PF00082	0.505
DEG_SPOP_SBC_1	223	227	PF00917	0.391
DOC_ANK_TNKS_1	251	258	PF00023	0.366
DOC_MAPK_MEF2A_6	166	175	PF00069	0.292
DOC_MAPK_MEF2A_6	201	209	PF00069	0.274
DOC_PP2B_PxIxI_1	194	200	PF00149	0.344
DOC_USP7_MATH_1	223	227	PF00917	0.306
DOC_USP7_MATH_1	25	29	PF00917	0.574
DOC_USP7_MATH_1	267	271	PF00917	0.391
DOC_USP7_UBL2_3	258	262	PF12436	0.338
DOC_WW_Pin1_4	119	124	PF00397	0.308
LIG_14-3-3_CanoR_1	201	206	PF00244	0.395
LIG_14-3-3_CanoR_1	52	61	PF00244	0.509
LIG_BRCT_BRCA1_1	267	271	PF00533	0.366
LIG_FHA_1	151	157	PF00498	0.345
LIG_FHA_1	194	200	PF00498	0.277
LIG_FHA_1	216	222	PF00498	0.324
LIG_FHA_1	225	231	PF00498	0.306
LIG_FHA_1	249	255	PF00498	0.446
LIG_FHA_1	46	52	PF00498	0.556
LIG_FHA_2	93	99	PF00498	0.692
LIG_PDZ_Class_3	266	271	PF00595	0.298
LIG_Pex14_1	114	118	PF04695	0.298
LIG_PROFILIN_1	11	17	PF00235	0.537
LIG_PROFILIN_1	4	10	PF00235	0.545
LIG_SH2_PTP2	149	152	PF00017	0.338
LIG_SH2_STAT5	149	152	PF00017	0.304
LIG_SH2_STAT5	208	211	PF00017	0.377
LIG_SH3_3	1	7	PF00018	0.564
LIG_SH3_3	227	233	PF00018	0.298
LIG_SH3_3	8	14	PF00018	0.550
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.274
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.276
LIG_SUMO_SIM_par_1	104	109	PF11976	0.341
LIG_SUMO_SIM_par_1	195	200	PF11976	0.391
LIG_TRAF2_1	81	84	PF00917	0.542
LIG_TRAF2_1	96	99	PF00917	0.596
MOD_CK2_1	119	125	PF00069	0.290
MOD_CK2_1	173	179	PF00069	0.341
MOD_CK2_1	70	76	PF00069	0.557
MOD_CK2_1	92	98	PF00069	0.690
MOD_GlcNHglycan	25	28	PF01048	0.671
MOD_GSK3_1	215	222	PF00069	0.360
MOD_GSK3_1	89	96	PF00069	0.572
MOD_N-GLC_1	162	167	PF02516	0.366
MOD_N-GLC_1	45	50	PF02516	0.500
MOD_PK_1	155	161	PF00069	0.298
MOD_PK_1	201	207	PF00069	0.274
MOD_PKA_2	200	206	PF00069	0.396
MOD_PKA_2	215	221	PF00069	0.391
MOD_PKA_2	93	99	PF00069	0.648
MOD_PKB_1	50	58	PF00069	0.512
MOD_Plk_4	157	163	PF00069	0.290
MOD_ProDKin_1	119	125	PF00069	0.308
MOD_SUMO_rev_2	56	60	PF00179	0.500
MOD_SUMO_rev_2	71	80	PF00179	0.448
TRG_ENDOCYTIC_2	149	152	PF00928	0.327
TRG_ER_diArg_1	85	87	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P914	Leptomonas seymouri	73%	99%
A0A1X0P0T3	Trypanosomatidae	57%	94%
A0A3R7NFV7	Trypanosoma rangeli	61%	98%
A4HQ75	Leishmania braziliensis	86%	100%
A4IDX3	Leishmania infantum	100%	100%
D0A444	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4Q0K2	Leishmania major	96%	100%