Ku70/Ku80 beta-barrel domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU80 protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRQ2_LEIDO

TriTrypDb:

LdBPK_300340.1 , LdCL_300008500 , LDHU3_30.0480

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0043564	Ku70:Ku80 complex	3	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRQ2

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006302	double-strand break repair	6	12
GO:0006303	double-strand break repair via nonhomologous end joining	7	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0032200	telomere organization	6	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051276	chromosome organization	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010165	response to X-ray	5	1
GO:0010212	response to ionizing radiation	4	1
GO:0010332	response to gamma radiation	5	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071480	cellular response to gamma radiation	6	1
GO:0071481	cellular response to X-ray	6	1
GO:0104004	cellular response to environmental stimulus	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042162	telomeric DNA binding	6	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043565	sequence-specific DNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.457
CLV_C14_Caspase3-7	452	456	PF00656	0.495
CLV_C14_Caspase3-7	549	553	PF00656	0.498
CLV_C14_Caspase3-7	687	691	PF00656	0.425
CLV_C14_Caspase3-7	743	747	PF00656	0.553
CLV_NRD_NRD_1	103	105	PF00675	0.171
CLV_NRD_NRD_1	201	203	PF00675	0.409
CLV_NRD_NRD_1	239	241	PF00675	0.391
CLV_NRD_NRD_1	275	277	PF00675	0.335
CLV_NRD_NRD_1	383	385	PF00675	0.226
CLV_NRD_NRD_1	693	695	PF00675	0.257
CLV_NRD_NRD_1	743	745	PF00675	0.257
CLV_PCSK_FUR_1	237	241	PF00082	0.386
CLV_PCSK_KEX2_1	103	105	PF00082	0.171
CLV_PCSK_KEX2_1	130	132	PF00082	0.223
CLV_PCSK_KEX2_1	239	241	PF00082	0.387
CLV_PCSK_KEX2_1	275	277	PF00082	0.262
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.219
CLV_PCSK_PC7_1	126	132	PF00082	0.245
CLV_PCSK_SKI1_1	248	252	PF00082	0.325
CLV_PCSK_SKI1_1	257	261	PF00082	0.235
CLV_PCSK_SKI1_1	358	362	PF00082	0.278
CLV_PCSK_SKI1_1	385	389	PF00082	0.291
CLV_PCSK_SKI1_1	535	539	PF00082	0.492
CLV_PCSK_SKI1_1	54	58	PF00082	0.257
CLV_PCSK_SKI1_1	770	774	PF00082	0.260
CLV_Separin_Metazoa	682	686	PF03568	0.569
DEG_APCC_DBOX_1	481	489	PF00400	0.376
DEG_ODPH_VHL_1	83	95	PF01847	0.426
DEG_SPOP_SBC_1	572	576	PF00917	0.438
DOC_CDC14_PxL_1	434	442	PF14671	0.426
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.400
DOC_MAPK_DCC_7	416	425	PF00069	0.457
DOC_MAPK_gen_1	130	138	PF00069	0.448
DOC_MAPK_gen_1	147	155	PF00069	0.616
DOC_MAPK_gen_1	202	210	PF00069	0.426
DOC_MAPK_gen_1	239	249	PF00069	0.472
DOC_MAPK_gen_1	332	342	PF00069	0.453
DOC_MAPK_gen_1	384	391	PF00069	0.517
DOC_MAPK_gen_1	482	490	PF00069	0.384
DOC_MAPK_gen_1	775	784	PF00069	0.476
DOC_MAPK_MEF2A_6	161	168	PF00069	0.349
DOC_MAPK_MEF2A_6	240	249	PF00069	0.369
DOC_MAPK_MEF2A_6	3	12	PF00069	0.365
DOC_MAPK_MEF2A_6	384	391	PF00069	0.518
DOC_MAPK_MEF2A_6	433	442	PF00069	0.441
DOC_MAPK_MEF2A_6	775	784	PF00069	0.520
DOC_PIKK_1	446	453	PF02985	0.588
DOC_PP1_RVXF_1	132	139	PF00149	0.410
DOC_PP1_RVXF_1	428	435	PF00149	0.508
DOC_PP2B_LxvP_1	176	179	PF13499	0.466
DOC_PP2B_LxvP_1	233	236	PF13499	0.472
DOC_PP4_FxxP_1	736	739	PF00568	0.457
DOC_USP7_MATH_1	179	183	PF00917	0.672
DOC_USP7_MATH_1	229	233	PF00917	0.402
DOC_USP7_MATH_1	379	383	PF00917	0.479
DOC_USP7_MATH_1	397	401	PF00917	0.395
DOC_USP7_MATH_1	409	413	PF00917	0.458
DOC_USP7_MATH_1	499	503	PF00917	0.475
DOC_USP7_MATH_1	522	526	PF00917	0.525
DOC_USP7_MATH_1	537	541	PF00917	0.341
DOC_USP7_MATH_1	573	577	PF00917	0.678
DOC_USP7_MATH_1	587	591	PF00917	0.571
DOC_USP7_MATH_1	645	649	PF00917	0.430
DOC_USP7_MATH_1	651	655	PF00917	0.437
DOC_USP7_UBL2_3	494	498	PF12436	0.712
DOC_WW_Pin1_4	216	221	PF00397	0.501
DOC_WW_Pin1_4	222	227	PF00397	0.469
DOC_WW_Pin1_4	582	587	PF00397	0.689
LIG_14-3-3_CanoR_1	126	132	PF00244	0.510
LIG_14-3-3_CanoR_1	257	265	PF00244	0.550
LIG_14-3-3_CanoR_1	275	284	PF00244	0.349
LIG_14-3-3_CanoR_1	390	399	PF00244	0.529
LIG_14-3-3_CanoR_1	433	440	PF00244	0.516
LIG_14-3-3_CanoR_1	482	490	PF00244	0.448
LIG_14-3-3_CanoR_1	514	521	PF00244	0.466
LIG_Actin_WH2_2	672	687	PF00022	0.427
LIG_BIR_II_1	1	5	PF00653	0.365
LIG_BIR_III_2	396	400	PF00653	0.462
LIG_BRCT_BRCA1_1	516	520	PF00533	0.434
LIG_Clathr_ClatBox_1	720	724	PF01394	0.426
LIG_deltaCOP1_diTrp_1	560	568	PF00928	0.435
LIG_DLG_GKlike_1	270	278	PF00625	0.426
LIG_eIF4E_1	715	721	PF01652	0.478
LIG_FHA_1	326	332	PF00498	0.441
LIG_FHA_1	355	361	PF00498	0.515
LIG_FHA_1	573	579	PF00498	0.643
LIG_FHA_1	78	84	PF00498	0.490
LIG_FHA_2	188	194	PF00498	0.406
LIG_FHA_2	264	270	PF00498	0.481
LIG_FHA_2	498	504	PF00498	0.620
LIG_FHA_2	514	520	PF00498	0.585
LIG_FHA_2	645	651	PF00498	0.469
LIG_FHA_2	752	758	PF00498	0.435
LIG_FHA_2	785	791	PF00498	0.515
LIG_LIR_Apic_2	733	739	PF02991	0.457
LIG_LIR_Gen_1	108	118	PF02991	0.483
LIG_LIR_Gen_1	172	179	PF02991	0.556
LIG_LIR_Gen_1	195	204	PF02991	0.498
LIG_LIR_Gen_1	287	296	PF02991	0.463
LIG_LIR_Gen_1	349	359	PF02991	0.527
LIG_LIR_Gen_1	525	536	PF02991	0.568
LIG_LIR_Gen_1	654	663	PF02991	0.478
LIG_LIR_Gen_1	678	688	PF02991	0.426
LIG_LIR_Nem_3	108	113	PF02991	0.483
LIG_LIR_Nem_3	172	176	PF02991	0.495
LIG_LIR_Nem_3	195	200	PF02991	0.486
LIG_LIR_Nem_3	287	293	PF02991	0.421
LIG_LIR_Nem_3	435	440	PF02991	0.462
LIG_LIR_Nem_3	468	473	PF02991	0.420
LIG_LIR_Nem_3	525	531	PF02991	0.553
LIG_LIR_Nem_3	654	658	PF02991	0.478
LIG_LIR_Nem_3	678	684	PF02991	0.420
LIG_LIR_Nem_3	734	740	PF02991	0.515
LIG_LYPXL_yS_3	437	440	PF13949	0.457
LIG_MYND_1	507	511	PF01753	0.473
LIG_NBox_RRM_1	112	122	PF00076	0.515
LIG_PCNA_yPIPBox_3	471	484	PF02747	0.406
LIG_SH2_CRK	478	482	PF00017	0.347
LIG_SH2_GRB2like	715	718	PF00017	0.436
LIG_SH2_NCK_1	528	532	PF00017	0.407
LIG_SH2_NCK_1	66	70	PF00017	0.410
LIG_SH2_PTP2	290	293	PF00017	0.457
LIG_SH2_SRC	37	40	PF00017	0.510
LIG_SH2_SRC	569	572	PF00017	0.456
LIG_SH2_STAP1	547	551	PF00017	0.569
LIG_SH2_STAT5	137	140	PF00017	0.425
LIG_SH2_STAT5	290	293	PF00017	0.479
LIG_SH2_STAT5	351	354	PF00017	0.419
LIG_SH2_STAT5	740	743	PF00017	0.457
LIG_SH3_3	328	334	PF00018	0.457
LIG_SH3_3	416	422	PF00018	0.515
LIG_SH3_3	460	466	PF00018	0.397
LIG_SH3_3	581	587	PF00018	0.703
LIG_SH3_3	656	662	PF00018	0.457
LIG_SH3_4	566	573	PF00018	0.472
LIG_Sin3_3	373	380	PF02671	0.457
LIG_SUMO_SIM_anti_2	150	157	PF11976	0.432
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.259
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.387
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.479
LIG_SUMO_SIM_par_1	6	11	PF11976	0.320
LIG_TRAF2_1	266	269	PF00917	0.435
LIG_TRAF2_1	277	280	PF00917	0.435
LIG_TRAF2_1	304	307	PF00917	0.457
LIG_TRAF2_1	444	447	PF00917	0.434
LIG_TRAF2_1	754	757	PF00917	0.540
LIG_TYR_ITIM	288	293	PF00017	0.502
LIG_WRC_WIRS_1	652	657	PF05994	0.435
MOD_CK1_1	219	225	PF00069	0.449
MOD_CK1_1	483	489	PF00069	0.407
MOD_CK1_1	585	591	PF00069	0.635
MOD_CK1_1	618	624	PF00069	0.667
MOD_CK1_1	629	635	PF00069	0.561
MOD_CK2_1	102	108	PF00069	0.426
MOD_CK2_1	187	193	PF00069	0.420
MOD_CK2_1	222	228	PF00069	0.434
MOD_CK2_1	263	269	PF00069	0.462
MOD_CK2_1	274	280	PF00069	0.437
MOD_CK2_1	317	323	PF00069	0.489
MOD_CK2_1	408	414	PF00069	0.402
MOD_CK2_1	440	446	PF00069	0.456
MOD_CK2_1	497	503	PF00069	0.621
MOD_CK2_1	751	757	PF00069	0.435
MOD_GlcNHglycan	193	197	PF01048	0.583
MOD_GlcNHglycan	411	414	PF01048	0.254
MOD_GlcNHglycan	442	445	PF01048	0.226
MOD_GlcNHglycan	485	488	PF01048	0.444
MOD_GlcNHglycan	490	493	PF01048	0.454
MOD_GlcNHglycan	523	527	PF01048	0.397
MOD_GlcNHglycan	531	534	PF01048	0.446
MOD_GlcNHglycan	54	57	PF01048	0.286
MOD_GlcNHglycan	587	590	PF01048	0.669
MOD_GlcNHglycan	592	595	PF01048	0.565
MOD_GlcNHglycan	615	620	PF01048	0.645
MOD_GlcNHglycan	638	641	PF01048	0.699
MOD_GlcNHglycan	746	749	PF01048	0.232
MOD_GlcNHglycan	759	762	PF01048	0.196
MOD_GSK3_1	212	219	PF00069	0.417
MOD_GSK3_1	257	264	PF00069	0.427
MOD_GSK3_1	270	277	PF00069	0.388
MOD_GSK3_1	405	412	PF00069	0.435
MOD_GSK3_1	455	462	PF00069	0.416
MOD_GSK3_1	509	516	PF00069	0.524
MOD_GSK3_1	618	625	PF00069	0.709
MOD_GSK3_1	636	643	PF00069	0.629
MOD_GSK3_1	98	105	PF00069	0.426
MOD_N-GLC_1	488	493	PF02516	0.594
MOD_N-GLC_2	133	135	PF02516	0.291
MOD_NEK2_1	10	15	PF00069	0.371
MOD_NEK2_1	274	279	PF00069	0.454
MOD_NEK2_1	354	359	PF00069	0.515
MOD_NEK2_1	380	385	PF00069	0.515
MOD_NEK2_1	405	410	PF00069	0.549
MOD_NEK2_1	440	445	PF00069	0.470
MOD_NEK2_1	513	518	PF00069	0.428
MOD_NEK2_1	644	649	PF00069	0.543
MOD_NEK2_1	683	688	PF00069	0.443
MOD_NEK2_2	477	482	PF00069	0.386
MOD_PIKK_1	125	131	PF00454	0.504
MOD_PIKK_1	179	185	PF00454	0.676
MOD_PIKK_1	257	263	PF00454	0.472
MOD_PIKK_1	275	281	PF00454	0.402
MOD_PIKK_1	587	593	PF00454	0.726
MOD_PKA_1	275	281	PF00069	0.478
MOD_PKA_1	744	750	PF00069	0.418
MOD_PKA_2	102	108	PF00069	0.426
MOD_PKA_2	125	131	PF00069	0.520
MOD_PKA_2	274	280	PF00069	0.456
MOD_PKA_2	317	323	PF00069	0.441
MOD_PKA_2	325	331	PF00069	0.515
MOD_PKA_2	432	438	PF00069	0.513
MOD_PKA_2	513	519	PF00069	0.491
MOD_PKA_2	684	690	PF00069	0.419
MOD_PKA_2	731	737	PF00069	0.371
MOD_Plk_1	10	16	PF00069	0.390
MOD_Plk_1	192	198	PF00069	0.511
MOD_Plk_1	459	465	PF00069	0.405
MOD_Plk_2-3	455	461	PF00069	0.433
MOD_Plk_2-3	785	791	PF00069	0.601
MOD_Plk_4	151	157	PF00069	0.329
MOD_Plk_4	219	225	PF00069	0.403
MOD_Plk_4	459	465	PF00069	0.434
MOD_Plk_4	574	580	PF00069	0.624
MOD_ProDKin_1	216	222	PF00069	0.502
MOD_ProDKin_1	582	588	PF00069	0.690
MOD_SUMO_for_1	304	307	PF00179	0.457
MOD_SUMO_for_1	721	724	PF00179	0.543
MOD_SUMO_rev_2	195	204	PF00179	0.433
TRG_DiLeu_BaEn_1	349	354	PF01217	0.515
TRG_DiLeu_BaEn_1	414	419	PF01217	0.387
TRG_DiLeu_BaEn_1	550	555	PF01217	0.528
TRG_DiLeu_BaEn_2	107	113	PF01217	0.457
TRG_DiLeu_BaEn_2	337	343	PF01217	0.515
TRG_ENDOCYTIC_2	110	113	PF00928	0.515
TRG_ENDOCYTIC_2	290	293	PF00928	0.462
TRG_ENDOCYTIC_2	351	354	PF00928	0.419
TRG_ENDOCYTIC_2	437	440	PF00928	0.463
TRG_ENDOCYTIC_2	478	481	PF00928	0.346
TRG_ENDOCYTIC_2	528	531	PF00928	0.476
TRG_ENDOCYTIC_2	569	572	PF00928	0.500
TRG_ENDOCYTIC_2	66	69	PF00928	0.455
TRG_ENDOCYTIC_2	716	719	PF00928	0.457
TRG_ER_diArg_1	102	104	PF00400	0.371
TRG_ER_diArg_1	236	239	PF00400	0.391
TRG_ER_diArg_1	274	276	PF00400	0.535
TRG_NES_CRM1_1	111	124	PF08389	0.515
TRG_NES_CRM1_1	447	461	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA9	Leptomonas seymouri	55%	100%
A0A0S4JHV4	Bodo saltans	27%	97%
A0A1X0P2Y5	Trypanosomatidae	31%	95%
A0A422NMK3	Trypanosoma rangeli	36%	100%
A4HHY1	Leishmania braziliensis	78%	100%
A4I561	Leishmania infantum	100%	100%
C9ZQI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B0F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7S5	Leishmania major	92%	100%
Q54LY5	Dictyostelium discoideum	21%	100%
V5BGZ6	Trypanosoma cruzi	34%	100%