PRKCSH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IRP6_LEIDO

TriTrypDb:

LdBPK_365690.1 , LdCL_360064300 , LDHU3_36.7560

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.667
CLV_NRD_NRD_1	139	141	PF00675	0.694
CLV_NRD_NRD_1	177	179	PF00675	0.588
CLV_PCSK_FUR_1	137	141	PF00082	0.630
CLV_PCSK_FUR_1	175	179	PF00082	0.510
CLV_PCSK_FUR_1	237	241	PF00082	0.494
CLV_PCSK_KEX2_1	139	141	PF00082	0.673
CLV_PCSK_KEX2_1	177	179	PF00082	0.588
CLV_PCSK_KEX2_1	239	241	PF00082	0.509
CLV_PCSK_KEX2_1	380	382	PF00082	0.658
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.509
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.658
CLV_PCSK_SKI1_1	213	217	PF00082	0.588
CLV_PCSK_SKI1_1	239	243	PF00082	0.614
CLV_PCSK_SKI1_1	341	345	PF00082	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.669
DOC_CYCLIN_RxL_1	235	246	PF00134	0.626
DOC_CYCLIN_yClb1_LxF_4	262	268	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.459
DOC_MAPK_MEF2A_6	13	20	PF00069	0.577
DOC_PP2B_LxvP_1	163	166	PF13499	0.497
DOC_PP2B_LxvP_1	79	82	PF13499	0.641
DOC_PP4_FxxP_1	367	370	PF00568	0.536
DOC_USP7_MATH_1	138	142	PF00917	0.714
DOC_USP7_MATH_1	185	189	PF00917	0.586
DOC_USP7_MATH_1	339	343	PF00917	0.733
DOC_USP7_MATH_1	6	10	PF00917	0.596
DOC_WW_Pin1_4	2	7	PF00397	0.718
DOC_WW_Pin1_4	243	248	PF00397	0.653
DOC_WW_Pin1_4	258	263	PF00397	0.676
LIG_14-3-3_CanoR_1	103	110	PF00244	0.681
LIG_14-3-3_CanoR_1	184	194	PF00244	0.524
LIG_14-3-3_CanoR_1	381	387	PF00244	0.543
LIG_BRCT_BRCA1_1	287	291	PF00533	0.512
LIG_deltaCOP1_diTrp_1	129	133	PF00928	0.581
LIG_deltaCOP1_diTrp_1	358	367	PF00928	0.438
LIG_FHA_1	111	117	PF00498	0.635
LIG_FHA_1	259	265	PF00498	0.667
LIG_FHA_1	37	43	PF00498	0.475
LIG_FHA_2	214	220	PF00498	0.570
LIG_FHA_2	254	260	PF00498	0.736
LIG_FHA_2	383	389	PF00498	0.494
LIG_LIR_Apic_2	54	60	PF02991	0.572
LIG_LIR_Gen_1	288	297	PF02991	0.450
LIG_LIR_Gen_1	325	334	PF02991	0.680
LIG_LIR_Gen_1	36	46	PF02991	0.525
LIG_LIR_Nem_3	219	224	PF02991	0.388
LIG_LIR_Nem_3	288	294	PF02991	0.471
LIG_LIR_Nem_3	325	330	PF02991	0.662
LIG_LIR_Nem_3	358	364	PF02991	0.427
LIG_LIR_Nem_3	36	41	PF02991	0.547
LIG_NRBOX	237	243	PF00104	0.558
LIG_Pex14_1	306	310	PF04695	0.543
LIG_Pex14_1	313	317	PF04695	0.188
LIG_PTB_Apo_2	281	288	PF02174	0.550
LIG_PTB_Apo_2	304	311	PF02174	0.459
LIG_PTB_Phospho_1	281	287	PF10480	0.548
LIG_PTB_Phospho_1	304	310	PF10480	0.456
LIG_RPA_C_Fungi	173	185	PF08784	0.577
LIG_SH2_CRK	287	291	PF00017	0.524
LIG_SH2_CRK	327	331	PF00017	0.706
LIG_SH2_CRK	38	42	PF00017	0.547
LIG_SH2_CRK	57	61	PF00017	0.574
LIG_SH2_NCK_1	57	61	PF00017	0.574
LIG_SH2_STAP1	38	42	PF00017	0.547
LIG_SH2_STAT3	231	234	PF00017	0.527
LIG_SH2_STAT5	179	182	PF00017	0.487
LIG_SH2_STAT5	310	313	PF00017	0.494
LIG_SH2_STAT5	327	330	PF00017	0.622
LIG_SH2_STAT5	38	41	PF00017	0.554
LIG_SH3_2	244	249	PF14604	0.615
LIG_SH3_3	113	119	PF00018	0.719
LIG_SH3_3	241	247	PF00018	0.556
LIG_SH3_3	90	96	PF00018	0.667
LIG_Sin3_3	15	22	PF02671	0.490
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.453
LIG_TRAF2_1	152	155	PF00917	0.641
LIG_TRFH_1	222	226	PF08558	0.439
LIG_WRC_WIRS_1	411	416	PF05994	0.559
MOD_CDC14_SPxK_1	246	249	PF00782	0.666
MOD_CDK_SPxK_1	243	249	PF00069	0.642
MOD_CK1_1	200	206	PF00069	0.547
MOD_CK1_1	274	280	PF00069	0.470
MOD_CK1_1	299	305	PF00069	0.592
MOD_CK1_1	382	388	PF00069	0.459
MOD_CK1_1	84	90	PF00069	0.777
MOD_CK2_1	213	219	PF00069	0.585
MOD_CK2_1	253	259	PF00069	0.694
MOD_CK2_1	382	388	PF00069	0.432
MOD_CMANNOS	130	133	PF00535	0.576
MOD_CMANNOS	313	316	PF00535	0.480
MOD_GlcNHglycan	126	129	PF01048	0.487
MOD_GlcNHglycan	187	190	PF01048	0.530
MOD_GlcNHglycan	287	290	PF01048	0.532
MOD_GlcNHglycan	318	321	PF01048	0.456
MOD_GlcNHglycan	32	35	PF01048	0.634
MOD_GlcNHglycan	69	72	PF01048	0.606
MOD_GlcNHglycan	8	11	PF01048	0.656
MOD_GlcNHglycan	83	86	PF01048	0.728
MOD_GSK3_1	197	204	PF00069	0.546
MOD_GSK3_1	2	9	PF00069	0.656
MOD_GSK3_1	248	255	PF00069	0.665
MOD_GSK3_1	267	274	PF00069	0.434
MOD_GSK3_1	312	319	PF00069	0.441
MOD_GSK3_1	375	382	PF00069	0.719
MOD_GSK3_1	63	70	PF00069	0.620
MOD_GSK3_1	80	87	PF00069	0.588
MOD_N-GLC_1	339	344	PF02516	0.657
MOD_N-GLC_1	375	380	PF02516	0.665
MOD_N-GLC_1	60	65	PF02516	0.601
MOD_NEK2_1	1	6	PF00069	0.703
MOD_NEK2_1	267	272	PF00069	0.538
MOD_NEK2_2	89	94	PF00069	0.745
MOD_PKA_2	102	108	PF00069	0.678
MOD_PKA_2	124	130	PF00069	0.465
MOD_PKA_2	138	144	PF00069	0.544
MOD_PKA_2	248	254	PF00069	0.739
MOD_PKA_2	285	291	PF00069	0.548
MOD_PKA_2	299	305	PF00069	0.427
MOD_PKA_2	89	95	PF00069	0.757
MOD_PKB_1	366	374	PF00069	0.595
MOD_Plk_1	339	345	PF00069	0.671
MOD_Plk_4	312	318	PF00069	0.450
MOD_Plk_4	325	331	PF00069	0.515
MOD_Plk_4	36	42	PF00069	0.566
MOD_Plk_4	360	366	PF00069	0.398
MOD_Plk_4	60	66	PF00069	0.606
MOD_Plk_4	89	95	PF00069	0.657
MOD_ProDKin_1	2	8	PF00069	0.709
MOD_ProDKin_1	243	249	PF00069	0.661
MOD_ProDKin_1	258	264	PF00069	0.655
TRG_DiLeu_BaEn_1	154	159	PF01217	0.604
TRG_DiLeu_BaEn_4	154	160	PF01217	0.595
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.494
TRG_ENDOCYTIC_2	221	224	PF00928	0.483
TRG_ENDOCYTIC_2	287	290	PF00928	0.529
TRG_ENDOCYTIC_2	327	330	PF00928	0.701
TRG_ENDOCYTIC_2	38	41	PF00928	0.544
TRG_ENDOCYTIC_2	72	75	PF00928	0.589
TRG_ER_diArg_1	122	125	PF00400	0.605
TRG_ER_diArg_1	137	140	PF00400	0.472
TRG_ER_diArg_1	174	177	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P921	Leptomonas seymouri	58%	100%
A0A1X0P090	Trypanosomatidae	29%	100%
A0A422NKF7	Trypanosoma rangeli	32%	100%
A4HQ60	Leishmania braziliensis	79%	100%
A4IDV9	Leishmania infantum	100%	100%
D0A457	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0L6	Leishmania major	92%	100%