DnaJ_domain_containing_protein_putative/Pfam:PF00 226

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRL6_LEIDO

TriTrypDb:

LdBPK_365200.1 , LdCL_360059200 , LDHU3_36.6970

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.621
CLV_NRD_NRD_1	118	120	PF00675	0.547
CLV_NRD_NRD_1	203	205	PF00675	0.408
CLV_NRD_NRD_1	222	224	PF00675	0.518
CLV_NRD_NRD_1	247	249	PF00675	0.712
CLV_NRD_NRD_1	251	253	PF00675	0.714
CLV_NRD_NRD_1	271	273	PF00675	0.570
CLV_NRD_NRD_1	43	45	PF00675	0.565
CLV_PCSK_FUR_1	116	120	PF00082	0.559
CLV_PCSK_KEX2_1	116	118	PF00082	0.584
CLV_PCSK_KEX2_1	203	205	PF00082	0.408
CLV_PCSK_KEX2_1	222	224	PF00082	0.470
CLV_PCSK_KEX2_1	247	249	PF00082	0.671
CLV_PCSK_KEX2_1	251	253	PF00082	0.674
CLV_PCSK_KEX2_1	273	275	PF00082	0.603
CLV_PCSK_KEX2_1	340	342	PF00082	0.644
CLV_PCSK_KEX2_1	43	45	PF00082	0.565
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.490
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.674
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.644
CLV_PCSK_PC7_1	247	253	PF00082	0.696
CLV_PCSK_SKI1_1	104	108	PF00082	0.652
CLV_PCSK_SKI1_1	167	171	PF00082	0.521
CLV_PCSK_SKI1_1	196	200	PF00082	0.516
CLV_PCSK_SKI1_1	247	251	PF00082	0.711
CLV_PCSK_SKI1_1	4	8	PF00082	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DOC_CYCLIN_RxL_1	18	26	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.505
DOC_MAPK_gen_1	284	294	PF00069	0.630
DOC_PP4_FxxP_1	267	270	PF00568	0.737
DOC_USP7_MATH_1	226	230	PF00917	0.673
DOC_USP7_MATH_1	314	318	PF00917	0.754
DOC_USP7_MATH_1	32	36	PF00917	0.626
DOC_WW_Pin1_4	236	241	PF00397	0.700
DOC_WW_Pin1_4	250	255	PF00397	0.719
DOC_WW_Pin1_4	266	271	PF00397	0.713
DOC_WW_Pin1_4	304	309	PF00397	0.687
DOC_WW_Pin1_4	317	322	PF00397	0.711
LIG_14-3-3_CanoR_1	182	188	PF00244	0.477
LIG_14-3-3_CanoR_1	234	240	PF00244	0.608
LIG_14-3-3_CanoR_1	30	39	PF00244	0.580
LIG_BRCT_BRCA1_1	165	169	PF00533	0.484
LIG_deltaCOP1_diTrp_1	275	283	PF00928	0.621
LIG_FHA_1	145	151	PF00498	0.582
LIG_FHA_2	134	140	PF00498	0.600
LIG_FHA_2	147	153	PF00498	0.647
LIG_FHA_2	168	174	PF00498	0.461
LIG_FHA_2	197	203	PF00498	0.425
LIG_FHA_2	291	297	PF00498	0.529
LIG_FHA_2	68	74	PF00498	0.392
LIG_LIR_Apic_2	282	286	PF02991	0.671
LIG_LIR_Apic_2	83	88	PF02991	0.555
LIG_LIR_Gen_1	137	144	PF02991	0.509
LIG_LIR_Gen_1	70	80	PF02991	0.420
LIG_LIR_Nem_3	137	143	PF02991	0.522
LIG_LIR_Nem_3	166	171	PF02991	0.464
LIG_LIR_Nem_3	176	181	PF02991	0.403
LIG_LIR_Nem_3	335	339	PF02991	0.514
LIG_LIR_Nem_3	70	75	PF02991	0.387
LIG_MAD2	21	29	PF02301	0.536
LIG_MLH1_MIPbox_1	165	169	PF16413	0.484
LIG_NRBOX	299	305	PF00104	0.635
LIG_PCNA_yPIPBox_3	297	309	PF02747	0.644
LIG_Pex14_1	276	280	PF04695	0.671
LIG_PTB_Apo_2	204	211	PF02174	0.411
LIG_PTB_Apo_2	66	73	PF02174	0.404
LIG_PTB_Phospho_1	66	72	PF10480	0.402
LIG_SH2_CRK	178	182	PF00017	0.406
LIG_SH2_CRK	339	343	PF00017	0.644
LIG_SH2_CRK	85	89	PF00017	0.652
LIG_SH2_GRB2like	336	339	PF00017	0.519
LIG_SH2_NCK_1	72	76	PF00017	0.511
LIG_SH2_NCK_1	85	89	PF00017	0.692
LIG_SH2_SRC	255	258	PF00017	0.629
LIG_SH2_STAT3	288	291	PF00017	0.629
LIG_SH2_STAT5	216	219	PF00017	0.432
LIG_SH2_STAT5	46	49	PF00017	0.415
LIG_SH3_3	26	32	PF00018	0.595
LIG_SH3_3	275	281	PF00018	0.597
LIG_TRAF2_1	151	154	PF00917	0.547
LIG_TRAF2_1	293	296	PF00917	0.476
LIG_TYR_ITSM	174	181	PF00017	0.457
LIG_TYR_ITSM	68	75	PF00017	0.513
LIG_WRC_WIRS_1	168	173	PF05994	0.416
MOD_CDC14_SPxK_1	269	272	PF00782	0.619
MOD_CDK_SPK_2	304	309	PF00069	0.687
MOD_CDK_SPxK_1	266	272	PF00069	0.645
MOD_CDK_SPxxK_3	266	273	PF00069	0.672
MOD_CK1_1	130	136	PF00069	0.523
MOD_CK1_1	146	152	PF00069	0.586
MOD_CK1_1	229	235	PF00069	0.768
MOD_CK1_1	317	323	PF00069	0.728
MOD_CK2_1	146	152	PF00069	0.590
MOD_CK2_1	196	202	PF00069	0.419
MOD_CK2_1	250	256	PF00069	0.686
MOD_CK2_1	276	282	PF00069	0.620
MOD_CK2_1	290	296	PF00069	0.346
MOD_CK2_1	67	73	PF00069	0.403
MOD_GlcNHglycan	125	128	PF01048	0.703
MOD_GlcNHglycan	224	227	PF01048	0.546
MOD_GlcNHglycan	229	232	PF01048	0.639
MOD_GlcNHglycan	316	319	PF01048	0.749
MOD_GlcNHglycan	58	61	PF01048	0.500
MOD_GlcNHglycan	77	80	PF01048	0.456
MOD_GlcNHglycan	82	85	PF01048	0.560
MOD_GSK3_1	123	130	PF00069	0.623
MOD_GSK3_1	144	151	PF00069	0.602
MOD_GSK3_1	163	170	PF00069	0.492
MOD_GSK3_1	222	229	PF00069	0.596
MOD_GSK3_1	235	242	PF00069	0.691
MOD_LATS_1	165	171	PF00433	0.463
MOD_N-GLC_1	144	149	PF02516	0.577
MOD_NEK2_1	163	168	PF00069	0.531
MOD_NEK2_1	2	7	PF00069	0.555
MOD_NEK2_1	23	28	PF00069	0.456
MOD_NEK2_1	233	238	PF00069	0.722
MOD_NEK2_1	74	79	PF00069	0.431
MOD_NEK2_2	183	188	PF00069	0.445
MOD_PKA_1	222	228	PF00069	0.681
MOD_PKA_2	222	228	PF00069	0.620
MOD_PKA_2	233	239	PF00069	0.643
MOD_Plk_1	127	133	PF00069	0.657
MOD_Plk_1	173	179	PF00069	0.377
MOD_Plk_2-3	148	154	PF00069	0.644
MOD_Plk_2-3	290	296	PF00069	0.631
MOD_Plk_4	173	179	PF00069	0.404
MOD_Plk_4	196	202	PF00069	0.419
MOD_ProDKin_1	236	242	PF00069	0.701
MOD_ProDKin_1	250	256	PF00069	0.719
MOD_ProDKin_1	266	272	PF00069	0.711
MOD_ProDKin_1	304	310	PF00069	0.692
MOD_ProDKin_1	317	323	PF00069	0.713
MOD_SUMO_rev_2	148	158	PF00179	0.605
TRG_DiLeu_BaEn_4	295	301	PF01217	0.593
TRG_ENDOCYTIC_2	178	181	PF00928	0.398
TRG_ENDOCYTIC_2	339	342	PF00928	0.529
TRG_ENDOCYTIC_2	46	49	PF00928	0.419
TRG_ENDOCYTIC_2	72	75	PF00928	0.381
TRG_ER_diArg_1	116	119	PF00400	0.567
TRG_ER_diArg_1	203	205	PF00400	0.408
TRG_ER_diArg_1	250	252	PF00400	0.706
TRG_ER_diArg_1	271	274	PF00400	0.671
TRG_ER_diArg_1	341	344	PF00400	0.622
TRG_ER_diArg_1	42	44	PF00400	0.553
TRG_NLS_MonoExtC_3	339	344	PF00514	0.549
TRG_PTS1	343	346	PF00515	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P554	Leptomonas seymouri	66%	92%
A0A1X0P394	Trypanosomatidae	39%	87%
A0A3R7NA51	Trypanosoma rangeli	49%	97%
A4HQ14	Leishmania braziliensis	81%	100%
A4ICE4	Leishmania infantum	100%	100%
D0A8V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q0R5	Leishmania major	90%	98%
V5BDN3	Trypanosoma cruzi	48%	100%