Doublecortin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IRL3_LEIDO

TriTrypDb:

LdBPK_292700.1 , LdCL_290033100 , LDHU3_29.3980

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRL3

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0035556	intracellular signal transduction	3	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.662
CLV_C14_Caspase3-7	372	376	PF00656	0.591
CLV_C14_Caspase3-7	414	418	PF00656	0.592
CLV_C14_Caspase3-7	659	663	PF00656	0.409
CLV_MEL_PAP_1	68	74	PF00089	0.435
CLV_NRD_NRD_1	195	197	PF00675	0.616
CLV_NRD_NRD_1	263	265	PF00675	0.662
CLV_NRD_NRD_1	339	341	PF00675	0.629
CLV_NRD_NRD_1	411	413	PF00675	0.696
CLV_NRD_NRD_1	459	461	PF00675	0.506
CLV_NRD_NRD_1	567	569	PF00675	0.702
CLV_NRD_NRD_1	6	8	PF00675	0.470
CLV_PCSK_KEX2_1	195	197	PF00082	0.688
CLV_PCSK_KEX2_1	227	229	PF00082	0.720
CLV_PCSK_KEX2_1	339	341	PF00082	0.743
CLV_PCSK_KEX2_1	410	412	PF00082	0.707
CLV_PCSK_KEX2_1	584	586	PF00082	0.726
CLV_PCSK_KEX2_1	6	8	PF00082	0.470
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.720
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.678
CLV_PCSK_PC7_1	191	197	PF00082	0.615
CLV_PCSK_SKI1_1	107	111	PF00082	0.486
CLV_PCSK_SKI1_1	128	132	PF00082	0.347
CLV_PCSK_SKI1_1	161	165	PF00082	0.768
CLV_PCSK_SKI1_1	170	174	PF00082	0.556
CLV_PCSK_SKI1_1	473	477	PF00082	0.481
CLV_PCSK_SKI1_1	526	530	PF00082	0.565
CLV_PCSK_SKI1_1	613	617	PF00082	0.412
CLV_PCSK_SKI1_1	658	662	PF00082	0.458
CLV_Separin_Metazoa	281	285	PF03568	0.640
CLV_Separin_Metazoa	438	442	PF03568	0.500
DEG_ODPH_VHL_1	586	599	PF01847	0.535
DEG_SCF_FBW7_1	353	360	PF00400	0.774
DEG_SPOP_SBC_1	548	552	PF00917	0.693
DEG_SPOP_SBC_1	553	557	PF00917	0.578
DEG_SPOP_SBC_1	558	562	PF00917	0.550
DOC_CYCLIN_yCln2_LP_2	173	176	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.496
DOC_MAPK_gen_1	638	647	PF00069	0.497
DOC_MAPK_HePTP_8	635	647	PF00069	0.496
DOC_MAPK_MEF2A_6	115	122	PF00069	0.380
DOC_MAPK_MEF2A_6	288	295	PF00069	0.639
DOC_MAPK_MEF2A_6	638	647	PF00069	0.497
DOC_PP1_RVXF_1	126	132	PF00149	0.437
DOC_PP1_RVXF_1	420	426	PF00149	0.478
DOC_PP1_RVXF_1	458	465	PF00149	0.388
DOC_PP1_RVXF_1	631	638	PF00149	0.426
DOC_PP2B_LxvP_1	172	175	PF13499	0.619
DOC_PP2B_LxvP_1	190	193	PF13499	0.542
DOC_PP2B_LxvP_1	521	524	PF13499	0.565
DOC_PP4_FxxP_1	209	212	PF00568	0.612
DOC_PP4_FxxP_1	240	243	PF00568	0.691
DOC_PP4_FxxP_1	674	677	PF00568	0.404
DOC_SPAK_OSR1_1	673	677	PF12202	0.490
DOC_USP7_MATH_1	146	150	PF00917	0.692
DOC_USP7_MATH_1	234	238	PF00917	0.727
DOC_USP7_MATH_1	246	250	PF00917	0.721
DOC_USP7_MATH_1	344	348	PF00917	0.725
DOC_USP7_MATH_1	357	361	PF00917	0.574
DOC_USP7_MATH_1	373	377	PF00917	0.561
DOC_USP7_MATH_1	416	420	PF00917	0.556
DOC_USP7_MATH_1	517	521	PF00917	0.571
DOC_USP7_MATH_1	538	542	PF00917	0.651
DOC_USP7_MATH_1	548	552	PF00917	0.651
DOC_USP7_MATH_1	558	562	PF00917	0.546
DOC_USP7_MATH_1	564	568	PF00917	0.632
DOC_USP7_MATH_1	574	578	PF00917	0.679
DOC_USP7_MATH_1	580	584	PF00917	0.621
DOC_USP7_MATH_1	70	74	PF00917	0.434
DOC_USP7_UBL2_3	685	689	PF12436	0.422
DOC_WW_Pin1_4	174	179	PF00397	0.577
DOC_WW_Pin1_4	229	234	PF00397	0.676
DOC_WW_Pin1_4	287	292	PF00397	0.815
DOC_WW_Pin1_4	324	329	PF00397	0.594
DOC_WW_Pin1_4	353	358	PF00397	0.635
DOC_WW_Pin1_4	390	395	PF00397	0.703
DOC_WW_Pin1_4	527	532	PF00397	0.642
DOC_WW_Pin1_4	533	538	PF00397	0.582
DOC_WW_Pin1_4	559	564	PF00397	0.654
DOC_WW_Pin1_4	586	591	PF00397	0.774
LIG_14-3-3_CanoR_1	107	113	PF00244	0.502
LIG_14-3-3_CanoR_1	155	159	PF00244	0.677
LIG_14-3-3_CanoR_1	161	167	PF00244	0.615
LIG_14-3-3_CanoR_1	235	241	PF00244	0.676
LIG_14-3-3_CanoR_1	441	445	PF00244	0.539
LIG_14-3-3_CanoR_1	468	475	PF00244	0.462
LIG_14-3-3_CanoR_1	493	502	PF00244	0.410
LIG_14-3-3_CanoR_1	518	524	PF00244	0.522
LIG_14-3-3_CanoR_1	58	62	PF00244	0.486
LIG_14-3-3_CanoR_1	613	618	PF00244	0.417
LIG_14-3-3_CanoR_1	71	75	PF00244	0.347
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BIR_III_2	516	520	PF00653	0.480
LIG_BIR_III_4	648	652	PF00653	0.388
LIG_BRCT_BRCA1_1	236	240	PF00533	0.637
LIG_BRCT_BRCA1_1	643	647	PF00533	0.403
LIG_FHA_1	158	164	PF00498	0.689
LIG_FHA_1	266	272	PF00498	0.689
LIG_FHA_1	299	305	PF00498	0.634
LIG_FHA_1	457	463	PF00498	0.384
LIG_FHA_1	577	583	PF00498	0.632
LIG_FHA_1	612	618	PF00498	0.418
LIG_FHA_1	630	636	PF00498	0.466
LIG_FHA_2	215	221	PF00498	0.675
LIG_FHA_2	341	347	PF00498	0.768
LIG_FHA_2	370	376	PF00498	0.616
LIG_IRF3_LxIS_1	436	443	PF10401	0.471
LIG_LIR_Apic_2	237	243	PF02991	0.697
LIG_LIR_Apic_2	672	677	PF02991	0.417
LIG_LIR_Gen_1	449	458	PF02991	0.462
LIG_LIR_Gen_1	508	519	PF02991	0.499
LIG_LIR_Nem_3	449	455	PF02991	0.511
LIG_LIR_Nem_3	508	514	PF02991	0.480
LIG_LIR_Nem_3	609	615	PF02991	0.592
LIG_LIR_Nem_3	85	91	PF02991	0.385
LIG_MAD2	170	178	PF02301	0.530
LIG_MYND_1	309	313	PF01753	0.551
LIG_MYND_1	351	355	PF01753	0.681
LIG_NRBOX	656	662	PF00104	0.487
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.424
LIG_PTAP_UEV_1	196	201	PF05743	0.606
LIG_PTB_Apo_2	601	608	PF02174	0.391
LIG_PTB_Phospho_1	601	607	PF10480	0.382
LIG_Rb_pABgroove_1	641	649	PF01858	0.386
LIG_RPA_C_Fungi	217	229	PF08784	0.610
LIG_SH2_CRK	612	616	PF00017	0.498
LIG_SH2_GRB2like	602	605	PF00017	0.461
LIG_SH2_SRC	602	605	PF00017	0.461
LIG_SH2_STAP1	607	611	PF00017	0.527
LIG_SH2_STAT5	88	91	PF00017	0.575
LIG_SH2_STAT5	98	101	PF00017	0.366
LIG_SH3_1	280	286	PF00018	0.643
LIG_SH3_2	283	288	PF14604	0.652
LIG_SH3_2	563	568	PF14604	0.642
LIG_SH3_3	172	178	PF00018	0.578
LIG_SH3_3	194	200	PF00018	0.651
LIG_SH3_3	208	214	PF00018	0.550
LIG_SH3_3	240	246	PF00018	0.702
LIG_SH3_3	280	286	PF00018	0.679
LIG_SH3_3	560	566	PF00018	0.676
LIG_SUMO_SIM_par_1	653	659	PF11976	0.472
LIG_TRAF2_1	217	220	PF00917	0.640
LIG_ULM_U2AF65_1	460	465	PF00076	0.479
LIG_WRC_WIRS_1	109	114	PF05994	0.441
LIG_WW_3	281	285	PF00397	0.640
MOD_CDC14_SPxK_1	565	568	PF00782	0.618
MOD_CDK_SPxK_1	229	235	PF00069	0.631
MOD_CDK_SPxK_1	562	568	PF00069	0.619
MOD_CDK_SPxxK_3	527	534	PF00069	0.645
MOD_CDK_SPxxK_3	562	569	PF00069	0.656
MOD_CK1_1	138	144	PF00069	0.588
MOD_CK1_1	165	171	PF00069	0.677
MOD_CK1_1	2	8	PF00069	0.408
MOD_CK1_1	327	333	PF00069	0.626
MOD_CK1_1	418	424	PF00069	0.541
MOD_CK1_1	552	558	PF00069	0.755
MOD_CK1_1	559	565	PF00069	0.684
MOD_CK1_1	589	595	PF00069	0.690
MOD_CK2_1	2	8	PF00069	0.408
MOD_CK2_1	214	220	PF00069	0.731
MOD_CK2_1	36	42	PF00069	0.441
MOD_CK2_1	647	653	PF00069	0.386
MOD_Cter_Amidation	639	642	PF01082	0.458
MOD_GlcNHglycan	148	151	PF01048	0.669
MOD_GlcNHglycan	167	170	PF01048	0.470
MOD_GlcNHglycan	197	200	PF01048	0.669
MOD_GlcNHglycan	201	204	PF01048	0.752
MOD_GlcNHglycan	37	41	PF01048	0.491
MOD_GlcNHglycan	375	378	PF01048	0.644
MOD_GlcNHglycan	380	383	PF01048	0.583
MOD_GlcNHglycan	417	421	PF01048	0.553
MOD_GlcNHglycan	483	486	PF01048	0.544
MOD_GlcNHglycan	551	554	PF01048	0.695
MOD_GlcNHglycan	648	652	PF01048	0.464
MOD_GlcNHglycan	668	671	PF01048	0.246
MOD_GSK3_1	195	202	PF00069	0.637
MOD_GSK3_1	294	301	PF00069	0.686
MOD_GSK3_1	340	347	PF00069	0.730
MOD_GSK3_1	353	360	PF00069	0.721
MOD_GSK3_1	369	376	PF00069	0.522
MOD_GSK3_1	406	413	PF00069	0.600
MOD_GSK3_1	469	476	PF00069	0.575
MOD_GSK3_1	548	555	PF00069	0.728
MOD_GSK3_1	558	565	PF00069	0.620
MOD_GSK3_1	574	581	PF00069	0.561
MOD_GSK3_1	613	620	PF00069	0.455
MOD_N-GLC_1	434	439	PF02516	0.572
MOD_NEK2_1	333	338	PF00069	0.670
MOD_NEK2_1	440	445	PF00069	0.482
MOD_NEK2_1	469	474	PF00069	0.558
MOD_NEK2_1	494	499	PF00069	0.452
MOD_NEK2_1	647	652	PF00069	0.459
MOD_NEK2_2	70	75	PF00069	0.431
MOD_PIKK_1	135	141	PF00454	0.500
MOD_PIKK_1	246	252	PF00454	0.660
MOD_PKA_1	195	201	PF00069	0.681
MOD_PKA_1	265	271	PF00069	0.645
MOD_PKA_1	339	345	PF00069	0.743
MOD_PKA_1	410	416	PF00069	0.675
MOD_PKA_1	641	647	PF00069	0.421
MOD_PKA_2	154	160	PF00069	0.663
MOD_PKA_2	17	23	PF00069	0.475
MOD_PKA_2	195	201	PF00069	0.624
MOD_PKA_2	221	227	PF00069	0.683
MOD_PKA_2	234	240	PF00069	0.671
MOD_PKA_2	338	344	PF00069	0.744
MOD_PKA_2	410	416	PF00069	0.691
MOD_PKA_2	440	446	PF00069	0.554
MOD_PKA_2	467	473	PF00069	0.592
MOD_PKA_2	517	523	PF00069	0.542
MOD_PKA_2	57	63	PF00069	0.493
MOD_PKA_2	617	623	PF00069	0.464
MOD_PKA_2	70	76	PF00069	0.337
MOD_PKB_1	410	418	PF00069	0.534
MOD_Plk_1	403	409	PF00069	0.663
MOD_Plk_1	41	47	PF00069	0.506
MOD_Plk_1	64	70	PF00069	0.443
MOD_Plk_4	307	313	PF00069	0.645
MOD_Plk_4	447	453	PF00069	0.481
MOD_Plk_4	626	632	PF00069	0.473
MOD_Plk_4	641	647	PF00069	0.305
MOD_ProDKin_1	174	180	PF00069	0.581
MOD_ProDKin_1	229	235	PF00069	0.679
MOD_ProDKin_1	287	293	PF00069	0.817
MOD_ProDKin_1	324	330	PF00069	0.595
MOD_ProDKin_1	353	359	PF00069	0.635
MOD_ProDKin_1	390	396	PF00069	0.707
MOD_ProDKin_1	527	533	PF00069	0.644
MOD_ProDKin_1	559	565	PF00069	0.653
MOD_ProDKin_1	586	592	PF00069	0.771
MOD_SUMO_for_1	278	281	PF00179	0.665
MOD_SUMO_rev_2	477	485	PF00179	0.496
MOD_SUMO_rev_2	634	643	PF00179	0.489
TRG_DiLeu_BaEn_1	656	661	PF01217	0.423
TRG_ENDOCYTIC_2	612	615	PF00928	0.500
TRG_ENDOCYTIC_2	88	91	PF00928	0.380
TRG_ER_diArg_1	195	197	PF00400	0.688
TRG_ER_diArg_1	338	340	PF00400	0.619
TRG_ER_diArg_1	410	412	PF00400	0.661
TRG_NLS_MonoExtC_3	459	465	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.458
TRG_PTS2	1	14	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KBS3	Trypanosoma rangeli	33%	100%
A4HHQ7	Leishmania braziliensis	67%	100%
A4I4T5	Leishmania infantum	100%	100%
E9AEC1	Leishmania major	91%	100%
E9ALG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%