Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IRK3_LEIDO

TriTrypDb:

LdBPK_292530.1 , LdCL_290031400 , LDHU3_29.3770

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.564
CLV_C14_Caspase3-7	389	393	PF00656	0.634
CLV_C14_Caspase3-7	9	13	PF00656	0.782
CLV_NRD_NRD_1	108	110	PF00675	0.616
CLV_NRD_NRD_1	181	183	PF00675	0.504
CLV_NRD_NRD_1	217	219	PF00675	0.444
CLV_NRD_NRD_1	240	242	PF00675	0.486
CLV_NRD_NRD_1	270	272	PF00675	0.608
CLV_NRD_NRD_1	289	291	PF00675	0.275
CLV_NRD_NRD_1	450	452	PF00675	0.485
CLV_NRD_NRD_1	453	455	PF00675	0.497
CLV_NRD_NRD_1	458	460	PF00675	0.506
CLV_NRD_NRD_1	501	503	PF00675	0.550
CLV_NRD_NRD_1	624	626	PF00675	0.643
CLV_NRD_NRD_1	80	82	PF00675	0.418
CLV_PCSK_FUR_1	179	183	PF00082	0.599
CLV_PCSK_FUR_1	268	272	PF00082	0.522
CLV_PCSK_FUR_1	451	455	PF00082	0.499
CLV_PCSK_KEX2_1	108	110	PF00082	0.660
CLV_PCSK_KEX2_1	181	183	PF00082	0.469
CLV_PCSK_KEX2_1	239	241	PF00082	0.460
CLV_PCSK_KEX2_1	270	272	PF00082	0.559
CLV_PCSK_KEX2_1	289	291	PF00082	0.278
CLV_PCSK_KEX2_1	449	451	PF00082	0.482
CLV_PCSK_KEX2_1	453	455	PF00082	0.482
CLV_PCSK_KEX2_1	501	503	PF00082	0.582
CLV_PCSK_KEX2_1	624	626	PF00082	0.714
CLV_PCSK_PC7_1	449	455	PF00082	0.498
CLV_PCSK_SKI1_1	210	214	PF00082	0.570
DEG_APCC_DBOX_1	220	228	PF00400	0.523
DEG_COP1_1	199	207	PF00400	0.630
DEG_COP1_1	222	232	PF00400	0.541
DEG_COP1_1	253	262	PF00400	0.444
DEG_SCF_FBW7_1	425	432	PF00400	0.771
DEG_SPOP_SBC_1	478	482	PF00917	0.624
DEG_SPOP_SBC_1	543	547	PF00917	0.690
DEG_SPOP_SBC_1	597	601	PF00917	0.700
DEG_SPOP_SBC_1	616	620	PF00917	0.734
DOC_CKS1_1	307	312	PF01111	0.616
DOC_CKS1_1	413	418	PF01111	0.681
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.615
DOC_MAPK_DCC_7	91	101	PF00069	0.585
DOC_MAPK_gen_1	139	149	PF00069	0.556
DOC_MAPK_gen_1	84	94	PF00069	0.698
DOC_MAPK_MEF2A_6	87	94	PF00069	0.682
DOC_PP1_RVXF_1	291	298	PF00149	0.559
DOC_USP7_MATH_1	163	167	PF00917	0.566
DOC_USP7_MATH_1	258	262	PF00917	0.655
DOC_USP7_MATH_1	345	349	PF00917	0.707
DOC_USP7_MATH_1	377	381	PF00917	0.670
DOC_USP7_MATH_1	398	402	PF00917	0.715
DOC_USP7_MATH_1	403	407	PF00917	0.725
DOC_USP7_MATH_1	435	439	PF00917	0.596
DOC_USP7_MATH_1	46	50	PF00917	0.659
DOC_USP7_MATH_1	478	482	PF00917	0.690
DOC_USP7_MATH_1	486	490	PF00917	0.751
DOC_USP7_MATH_1	500	504	PF00917	0.667
DOC_USP7_MATH_1	542	546	PF00917	0.642
DOC_USP7_MATH_1	597	601	PF00917	0.606
DOC_USP7_MATH_1	628	632	PF00917	0.615
DOC_USP7_MATH_1	675	679	PF00917	0.690
DOC_USP7_UBL2_3	165	169	PF12436	0.632
DOC_WW_Pin1_4	299	304	PF00397	0.572
DOC_WW_Pin1_4	306	311	PF00397	0.563
DOC_WW_Pin1_4	38	43	PF00397	0.721
DOC_WW_Pin1_4	394	399	PF00397	0.710
DOC_WW_Pin1_4	412	417	PF00397	0.734
DOC_WW_Pin1_4	425	430	PF00397	0.648
DOC_WW_Pin1_4	544	549	PF00397	0.655
DOC_WW_Pin1_4	556	561	PF00397	0.525
DOC_WW_Pin1_4	624	629	PF00397	0.657
DOC_WW_Pin1_4	92	97	PF00397	0.642
LIG_14-3-3_CanoR_1	34	42	PF00244	0.619
LIG_14-3-3_CanoR_1	586	592	PF00244	0.618
LIG_14-3-3_CanoR_1	596	606	PF00244	0.686
LIG_14-3-3_CanoR_1	615	622	PF00244	0.723
LIG_14-3-3_CterR_2	681	685	PF00244	0.552
LIG_BIR_III_4	392	396	PF00653	0.669
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.590
LIG_deltaCOP1_diTrp_1	657	663	PF00928	0.530
LIG_FHA_1	327	333	PF00498	0.725
LIG_FHA_1	51	57	PF00498	0.615
LIG_FHA_2	365	371	PF00498	0.601
LIG_IRF3_LxIS_1	229	236	PF10401	0.366
LIG_LIR_Apic_2	166	171	PF02991	0.716
LIG_LIR_Apic_2	382	387	PF02991	0.637
LIG_LIR_Nem_3	302	307	PF02991	0.533
LIG_LIR_Nem_3	550	554	PF02991	0.694
LIG_Pex14_2	15	19	PF04695	0.584
LIG_RPA_C_Fungi	176	188	PF08784	0.390
LIG_SH2_PTP2	384	387	PF00017	0.680
LIG_SH2_SRC	384	387	PF00017	0.693
LIG_SH2_STAP1	284	288	PF00017	0.516
LIG_SH2_STAP1	57	61	PF00017	0.531
LIG_SH2_STAT5	384	387	PF00017	0.693
LIG_SH2_STAT5	566	569	PF00017	0.524
LIG_SH3_3	146	152	PF00018	0.533
LIG_SH3_3	224	230	PF00018	0.483
LIG_SH3_3	300	306	PF00018	0.577
LIG_SH3_3	311	317	PF00018	0.647
LIG_SH3_3	631	637	PF00018	0.701
LIG_SH3_3	669	675	PF00018	0.527
LIG_SH3_3	98	104	PF00018	0.670
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.592
LIG_TRAF2_1	638	641	PF00917	0.751
LIG_TRAF2_1	650	653	PF00917	0.605
MOD_CDC14_SPxK_1	41	44	PF00782	0.669
MOD_CDC14_SPxK_1	627	630	PF00782	0.647
MOD_CDK_SPxK_1	38	44	PF00069	0.774
MOD_CDK_SPxK_1	624	630	PF00069	0.644
MOD_CK1_1	35	41	PF00069	0.692
MOD_CK1_1	380	386	PF00069	0.652
MOD_CK1_1	394	400	PF00069	0.729
MOD_CK1_1	481	487	PF00069	0.733
MOD_CK1_1	547	553	PF00069	0.702
MOD_CK1_1	598	604	PF00069	0.670
MOD_CK1_1	620	626	PF00069	0.624
MOD_CK1_1	677	683	PF00069	0.754
MOD_CK2_1	18	24	PF00069	0.721
MOD_CK2_1	190	196	PF00069	0.581
MOD_CK2_1	364	370	PF00069	0.520
MOD_CK2_1	647	653	PF00069	0.695
MOD_CMANNOS	660	663	PF00535	0.532
MOD_GlcNHglycan	105	108	PF01048	0.702
MOD_GlcNHglycan	157	160	PF01048	0.544
MOD_GlcNHglycan	192	195	PF01048	0.587
MOD_GlcNHglycan	20	23	PF01048	0.752
MOD_GlcNHglycan	210	213	PF01048	0.595
MOD_GlcNHglycan	27	30	PF01048	0.749
MOD_GlcNHglycan	356	359	PF01048	0.594
MOD_GlcNHglycan	375	378	PF01048	0.687
MOD_GlcNHglycan	392	396	PF01048	0.515
MOD_GlcNHglycan	416	419	PF01048	0.685
MOD_GlcNHglycan	488	491	PF01048	0.723
MOD_GlcNHglycan	496	499	PF01048	0.640
MOD_GlcNHglycan	502	505	PF01048	0.612
MOD_GlcNHglycan	536	539	PF01048	0.705
MOD_GlcNHglycan	600	603	PF01048	0.684
MOD_GlcNHglycan	649	652	PF01048	0.683
MOD_GSK3_1	25	32	PF00069	0.648
MOD_GSK3_1	322	329	PF00069	0.728
MOD_GSK3_1	332	339	PF00069	0.717
MOD_GSK3_1	345	352	PF00069	0.604
MOD_GSK3_1	373	380	PF00069	0.630
MOD_GSK3_1	394	401	PF00069	0.625
MOD_GSK3_1	403	410	PF00069	0.602
MOD_GSK3_1	423	430	PF00069	0.652
MOD_GSK3_1	436	443	PF00069	0.459
MOD_GSK3_1	46	53	PF00069	0.662
MOD_GSK3_1	477	484	PF00069	0.645
MOD_GSK3_1	530	537	PF00069	0.585
MOD_GSK3_1	538	545	PF00069	0.604
MOD_GSK3_1	616	623	PF00069	0.678
MOD_GSK3_1	624	631	PF00069	0.695
MOD_GSK3_1	675	682	PF00069	0.552
MOD_NEK2_1	189	194	PF00069	0.502
MOD_NEK2_1	332	337	PF00069	0.738
MOD_NEK2_1	36	41	PF00069	0.789
MOD_NEK2_1	549	554	PF00069	0.724
MOD_NEK2_1	679	684	PF00069	0.546
MOD_NEK2_2	628	633	PF00069	0.609
MOD_PIKK_1	403	409	PF00454	0.705
MOD_PIKK_1	6	12	PF00454	0.714
MOD_PIKK_1	636	642	PF00454	0.663
MOD_PK_1	271	277	PF00069	0.536
MOD_PKA_2	345	351	PF00069	0.683
MOD_PKA_2	373	379	PF00069	0.610
MOD_PKA_2	500	506	PF00069	0.511
MOD_PKA_2	585	591	PF00069	0.584
MOD_PKA_2	595	601	PF00069	0.641
MOD_PKA_2	616	622	PF00069	0.698
MOD_PKB_1	23	31	PF00069	0.635
MOD_PKB_1	594	602	PF00069	0.557
MOD_PKB_1	615	623	PF00069	0.542
MOD_Plk_1	32	38	PF00069	0.739
MOD_Plk_1	468	474	PF00069	0.560
MOD_Plk_1	527	533	PF00069	0.522
MOD_Plk_2-3	386	392	PF00069	0.675
MOD_Plk_4	380	386	PF00069	0.697
MOD_Plk_4	436	442	PF00069	0.638
MOD_Plk_4	549	555	PF00069	0.587
MOD_Plk_4	617	623	PF00069	0.755
MOD_ProDKin_1	299	305	PF00069	0.575
MOD_ProDKin_1	306	312	PF00069	0.559
MOD_ProDKin_1	38	44	PF00069	0.723
MOD_ProDKin_1	394	400	PF00069	0.684
MOD_ProDKin_1	412	418	PF00069	0.732
MOD_ProDKin_1	425	431	PF00069	0.645
MOD_ProDKin_1	544	550	PF00069	0.656
MOD_ProDKin_1	556	562	PF00069	0.522
MOD_ProDKin_1	624	630	PF00069	0.658
MOD_ProDKin_1	92	98	PF00069	0.637
MOD_SUMO_rev_2	127	135	PF00179	0.607
MOD_SUMO_rev_2	77	83	PF00179	0.416
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.509
TRG_ENDOCYTIC_2	57	60	PF00928	0.544
TRG_ER_diArg_1	108	110	PF00400	0.664
TRG_ER_diArg_1	178	181	PF00400	0.531
TRG_ER_diArg_1	239	241	PF00400	0.497
TRG_ER_diArg_1	268	271	PF00400	0.580
TRG_ER_diArg_1	288	290	PF00400	0.259
TRG_ER_diArg_1	449	451	PF00400	0.560
TRG_ER_diArg_1	453	455	PF00400	0.570
TRG_ER_diArg_1	576	579	PF00400	0.524
TRG_ER_diArg_1	624	626	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y8	Leptomonas seymouri	61%	100%
A0A0S4IQ31	Bodo saltans	30%	100%
A0A0S4JIT3	Bodo saltans	27%	100%
A0A0S4JTQ5	Bodo saltans	24%	90%
A0A1X0P950	Trypanosomatidae	33%	100%
A0A3R7MS13	Trypanosoma rangeli	32%	100%
A4HHP1	Leishmania braziliensis	76%	100%
A4I4V6	Leishmania infantum	99%	100%
E9AEA4	Leishmania major	86%	97%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC37	Trypanosoma cruzi	34%	100%