Dynamin-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynamin-1-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IRJ0_LEIDO

TriTrypDb:

LdBPK_292310.1 , LdCL_290029200 , LDHU3_29.3420

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	1
GO:0016020	membrane	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRJ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003924	GTPase activity	7	13
GO:0005488	binding	1	13
GO:0005525	GTP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.628
CLV_NRD_NRD_1	102	104	PF00675	0.502
CLV_NRD_NRD_1	242	244	PF00675	0.514
CLV_NRD_NRD_1	250	252	PF00675	0.533
CLV_NRD_NRD_1	541	543	PF00675	0.756
CLV_NRD_NRD_1	662	664	PF00675	0.428
CLV_PCSK_KEX2_1	102	104	PF00082	0.502
CLV_PCSK_KEX2_1	250	252	PF00082	0.470
CLV_PCSK_KEX2_1	295	297	PF00082	0.472
CLV_PCSK_KEX2_1	538	540	PF00082	0.854
CLV_PCSK_KEX2_1	546	548	PF00082	0.846
CLV_PCSK_KEX2_1	553	555	PF00082	0.829
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.472
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.732
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.754
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.673
CLV_PCSK_PC7_1	542	548	PF00082	0.670
CLV_PCSK_SKI1_1	152	156	PF00082	0.389
CLV_PCSK_SKI1_1	186	190	PF00082	0.428
CLV_PCSK_SKI1_1	350	354	PF00082	0.446
CLV_PCSK_SKI1_1	377	381	PF00082	0.446
CLV_PCSK_SKI1_1	422	426	PF00082	0.516
CLV_PCSK_SKI1_1	457	461	PF00082	0.396
CLV_PCSK_SKI1_1	49	53	PF00082	0.399
CLV_PCSK_SKI1_1	535	539	PF00082	0.851
CLV_PCSK_SKI1_1	582	586	PF00082	0.732
CLV_PCSK_SKI1_1	587	591	PF00082	0.716
CLV_PCSK_SKI1_1	621	625	PF00082	0.413
CLV_PCSK_SKI1_1	647	651	PF00082	0.484
CLV_PCSK_SKI1_1	664	668	PF00082	0.283
DEG_Nend_UBRbox_2	1	3	PF02207	0.564
DOC_ANK_TNKS_1	600	607	PF00023	0.399
DOC_CDC14_PxL_1	132	140	PF14671	0.413
DOC_CYCLIN_RxL_1	274	285	PF00134	0.470
DOC_CYCLIN_RxL_1	455	462	PF00134	0.458
DOC_CYCLIN_RxL_1	647	655	PF00134	0.516
DOC_MAPK_DCC_7	23	31	PF00069	0.487
DOC_MAPK_gen_1	277	284	PF00069	0.446
DOC_MAPK_gen_1	476	484	PF00069	0.432
DOC_MAPK_JIP1_4	116	122	PF00069	0.399
DOC_MAPK_MEF2A_6	165	172	PF00069	0.527
DOC_MAPK_MEF2A_6	19	26	PF00069	0.563
DOC_MAPK_MEF2A_6	61	68	PF00069	0.399
DOC_MAPK_NFAT4_5	165	173	PF00069	0.527
DOC_MAPK_NFAT4_5	19	27	PF00069	0.553
DOC_PP1_RVXF_1	275	282	PF00149	0.470
DOC_PP1_RVXF_1	420	427	PF00149	0.399
DOC_PP2B_LxvP_1	24	27	PF13499	0.504
DOC_PP2B_LxvP_1	83	86	PF13499	0.527
DOC_PP2B_PxIxI_1	26	32	PF00149	0.399
DOC_USP7_MATH_1	108	112	PF00917	0.389
DOC_USP7_MATH_1	249	253	PF00917	0.534
DOC_USP7_MATH_1	512	516	PF00917	0.839
DOC_USP7_MATH_1	518	522	PF00917	0.850
DOC_USP7_MATH_1	53	57	PF00917	0.422
DOC_USP7_MATH_1	530	534	PF00917	0.556
DOC_USP7_MATH_1	555	559	PF00917	0.759
DOC_USP7_MATH_1	679	683	PF00917	0.468
DOC_USP7_MATH_1	692	696	PF00917	0.753
DOC_USP7_UBL2_3	19	23	PF12436	0.592
DOC_USP7_UBL2_3	307	311	PF12436	0.438
DOC_USP7_UBL2_3	553	557	PF12436	0.732
DOC_WW_Pin1_4	160	165	PF00397	0.399
DOC_WW_Pin1_4	170	175	PF00397	0.400
DOC_WW_Pin1_4	257	262	PF00397	0.527
DOC_WW_Pin1_4	507	512	PF00397	0.819
DOC_WW_Pin1_4	566	571	PF00397	0.798
LIG_14-3-3_CanoR_1	243	247	PF00244	0.523
LIG_14-3-3_CanoR_1	250	257	PF00244	0.532
LIG_14-3-3_CanoR_1	464	474	PF00244	0.477
LIG_14-3-3_CanoR_1	513	518	PF00244	0.668
LIG_Actin_WH2_2	211	228	PF00022	0.428
LIG_APCC_ABBA_1	330	335	PF00400	0.445
LIG_CORNRBOX	283	291	PF00104	0.399
LIG_deltaCOP1_diTrp_1	76	82	PF00928	0.400
LIG_FHA_1	157	163	PF00498	0.399
LIG_FHA_1	165	171	PF00498	0.399
LIG_FHA_1	196	202	PF00498	0.397
LIG_FHA_1	270	276	PF00498	0.399
LIG_FHA_1	321	327	PF00498	0.553
LIG_FHA_1	347	353	PF00498	0.458
LIG_FHA_1	374	380	PF00498	0.470
LIG_FHA_1	430	436	PF00498	0.334
LIG_FHA_2	129	135	PF00498	0.399
LIG_FHA_2	201	207	PF00498	0.399
LIG_FHA_2	412	418	PF00498	0.454
LIG_FHA_2	502	508	PF00498	0.747
LIG_FHA_2	524	530	PF00498	0.847
LIG_FHA_2	588	594	PF00498	0.712
LIG_IRF3_LxIS_1	168	173	PF10401	0.413
LIG_LIR_Apic_2	159	164	PF02991	0.399
LIG_LIR_Apic_2	462	466	PF02991	0.399
LIG_LIR_Gen_1	212	223	PF02991	0.437
LIG_LIR_Gen_1	252	262	PF02991	0.525
LIG_LIR_Gen_1	380	391	PF02991	0.399
LIG_LIR_Gen_1	402	413	PF02991	0.399
LIG_LIR_Gen_1	425	435	PF02991	0.473
LIG_LIR_Gen_1	478	489	PF02991	0.399
LIG_LIR_Gen_1	605	616	PF02991	0.428
LIG_LIR_Gen_1	633	644	PF02991	0.413
LIG_LIR_Gen_1	81	90	PF02991	0.446
LIG_LIR_Gen_1	92	100	PF02991	0.350
LIG_LIR_Nem_3	13	18	PF02991	0.531
LIG_LIR_Nem_3	212	218	PF02991	0.437
LIG_LIR_Nem_3	252	257	PF02991	0.505
LIG_LIR_Nem_3	260	266	PF02991	0.432
LIG_LIR_Nem_3	364	369	PF02991	0.399
LIG_LIR_Nem_3	380	386	PF02991	0.399
LIG_LIR_Nem_3	402	408	PF02991	0.399
LIG_LIR_Nem_3	425	431	PF02991	0.463
LIG_LIR_Nem_3	443	448	PF02991	0.268
LIG_LIR_Nem_3	478	484	PF02991	0.399
LIG_LIR_Nem_3	605	611	PF02991	0.399
LIG_LIR_Nem_3	633	639	PF02991	0.399
LIG_LIR_Nem_3	76	82	PF02991	0.389
LIG_LIR_Nem_3	92	96	PF02991	0.382
LIG_LYPXL_yS_3	445	448	PF13949	0.494
LIG_NRBOX	278	284	PF00104	0.399
LIG_Pex14_2	362	366	PF04695	0.399
LIG_PTB_Apo_2	84	91	PF02174	0.522
LIG_SH2_CRK	263	267	PF00017	0.413
LIG_SH2_CRK	463	467	PF00017	0.428
LIG_SH2_CRK	636	640	PF00017	0.399
LIG_SH2_GRB2like	123	126	PF00017	0.412
LIG_SH2_GRB2like	595	598	PF00017	0.442
LIG_SH2_NCK_1	263	267	PF00017	0.399
LIG_SH2_PTP2	161	164	PF00017	0.399
LIG_SH2_PTP2	383	386	PF00017	0.399
LIG_SH2_STAP1	123	127	PF00017	0.468
LIG_SH2_STAP1	254	258	PF00017	0.461
LIG_SH2_STAP1	636	640	PF00017	0.413
LIG_SH2_STAT5	161	164	PF00017	0.396
LIG_SH2_STAT5	274	277	PF00017	0.427
LIG_SH2_STAT5	328	331	PF00017	0.470
LIG_SH2_STAT5	360	363	PF00017	0.399
LIG_SH2_STAT5	369	372	PF00017	0.399
LIG_SH2_STAT5	383	386	PF00017	0.399
LIG_SH2_STAT5	607	610	PF00017	0.416
LIG_SH3_3	130	136	PF00018	0.399
LIG_SH3_3	481	487	PF00018	0.399
LIG_SH3_3	564	570	PF00018	0.824
LIG_SH3_3	66	72	PF00018	0.410
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.483
LIG_SUMO_SIM_par_1	167	173	PF11976	0.399
LIG_SUMO_SIM_par_1	624	629	PF11976	0.402
LIG_TRAF2_1	74	77	PF00917	0.413
LIG_UBA3_1	283	288	PF00899	0.413
LIG_UBA3_1	326	331	PF00899	0.376
LIG_UBA3_1	452	458	PF00899	0.558
LIG_UBA3_1	669	675	PF00899	0.399
LIG_WW_3	510	514	PF00397	0.764
MOD_CDC14_SPxK_1	510	513	PF00782	0.763
MOD_CDK_SPK_2	160	165	PF00069	0.512
MOD_CDK_SPxK_1	507	513	PF00069	0.753
MOD_CDK_SPxxK_3	566	573	PF00069	0.817
MOD_CK1_1	111	117	PF00069	0.389
MOD_CK1_1	569	575	PF00069	0.697
MOD_CK1_1	645	651	PF00069	0.427
MOD_CK2_1	249	255	PF00069	0.470
MOD_CK2_1	38	44	PF00069	0.399
MOD_CK2_1	411	417	PF00069	0.417
MOD_CK2_1	587	593	PF00069	0.575
MOD_CK2_1	71	77	PF00069	0.429
MOD_GlcNHglycan	110	113	PF01048	0.389
MOD_GlcNHglycan	373	376	PF01048	0.446
MOD_GlcNHglycan	520	523	PF01048	0.835
MOD_GlcNHglycan	532	535	PF01048	0.843
MOD_GlcNHglycan	55	58	PF01048	0.519
MOD_GlcNHglycan	597	600	PF01048	0.525
MOD_GSK3_1	156	163	PF00069	0.399
MOD_GSK3_1	170	177	PF00069	0.400
MOD_GSK3_1	257	264	PF00069	0.497
MOD_GSK3_1	269	276	PF00069	0.416
MOD_GSK3_1	33	40	PF00069	0.399
MOD_GSK3_1	333	340	PF00069	0.420
MOD_GSK3_1	365	372	PF00069	0.500
MOD_GSK3_1	373	380	PF00069	0.485
MOD_GSK3_1	394	401	PF00069	0.428
MOD_GSK3_1	466	473	PF00069	0.516
MOD_GSK3_1	518	525	PF00069	0.819
MOD_GSK3_1	53	60	PF00069	0.218
MOD_GSK3_1	638	645	PF00069	0.513
MOD_GSK3_1	686	693	PF00069	0.711
MOD_N-GLC_1	128	133	PF02516	0.413
MOD_N-GLC_1	337	342	PF02516	0.424
MOD_N-GLC_1	513	518	PF02516	0.869
MOD_N-GLC_1	587	592	PF02516	0.635
MOD_NEK2_1	128	133	PF00069	0.390
MOD_NEK2_1	179	184	PF00069	0.399
MOD_NEK2_1	302	307	PF00069	0.416
MOD_NEK2_1	333	338	PF00069	0.441
MOD_NEK2_1	394	399	PF00069	0.428
MOD_NEK2_1	626	631	PF00069	0.402
MOD_NEK2_2	679	684	PF00069	0.446
MOD_PIKK_1	179	185	PF00454	0.494
MOD_PIKK_1	233	239	PF00454	0.395
MOD_PIKK_1	31	37	PF00454	0.399
MOD_PIKK_1	523	529	PF00454	0.903
MOD_PIKK_1	658	664	PF00454	0.434
MOD_PKA_2	101	107	PF00069	0.448
MOD_PKA_2	242	248	PF00069	0.523
MOD_PKA_2	249	255	PF00069	0.532
MOD_PKA_2	512	518	PF00069	0.764
MOD_PKA_2	53	59	PF00069	0.399
MOD_Plk_1	128	134	PF00069	0.413
MOD_Plk_1	337	343	PF00069	0.446
MOD_Plk_1	587	593	PF00069	0.594
MOD_Plk_2-3	242	248	PF00069	0.527
MOD_Plk_4	123	129	PF00069	0.412
MOD_Plk_4	164	170	PF00069	0.414
MOD_Plk_4	365	371	PF00069	0.428
MOD_Plk_4	38	44	PF00069	0.399
MOD_Plk_4	394	400	PF00069	0.428
MOD_Plk_4	422	428	PF00069	0.527
MOD_ProDKin_1	160	166	PF00069	0.399
MOD_ProDKin_1	170	176	PF00069	0.400
MOD_ProDKin_1	257	263	PF00069	0.527
MOD_ProDKin_1	507	513	PF00069	0.824
MOD_ProDKin_1	566	572	PF00069	0.795
MOD_SUMO_for_1	475	478	PF00179	0.432
MOD_SUMO_rev_2	236	246	PF00179	0.420
MOD_SUMO_rev_2	525	533	PF00179	0.723
MOD_SUMO_rev_2	545	555	PF00179	0.850
TRG_DiLeu_BaEn_3	429	435	PF01217	0.413
TRG_DiLeu_BaEn_3	77	83	PF01217	0.428
TRG_ENDOCYTIC_2	254	257	PF00928	0.449
TRG_ENDOCYTIC_2	263	266	PF00928	0.348
TRG_ENDOCYTIC_2	383	386	PF00928	0.399
TRG_ENDOCYTIC_2	428	431	PF00928	0.426
TRG_ENDOCYTIC_2	445	448	PF00928	0.355
TRG_ENDOCYTIC_2	607	610	PF00928	0.399
TRG_ENDOCYTIC_2	636	639	PF00928	0.399
TRG_NES_CRM1_1	450	462	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD95	Leptomonas seymouri	82%	100%
A0A0S4IST4	Bodo saltans	54%	84%
A0A1X0P9B2	Trypanosomatidae	71%	100%
A0A422NEK1	Trypanosoma rangeli	66%	100%
A1E2I5	Macaca mulatta	33%	98%
A4HHM0	Leishmania braziliensis	85%	100%
A4I4S9	Leishmania infantum	100%	100%
A6H7I5	Bos taurus	44%	81%
C9ZLH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
C9ZLI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AE82	Leishmania major	94%	100%
E9ALK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
O00429	Homo sapiens	37%	95%
O35303	Rattus norvegicus	36%	93%
P20592	Homo sapiens	33%	98%
P21575	Rattus norvegicus	44%	81%
P21576	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	99%
P27619	Drosophila melanogaster	44%	80%
P33238	Anas platyrhynchos	32%	97%
P39052	Rattus norvegicus	44%	80%
P39053	Mus musculus	44%	81%
P39054	Mus musculus	44%	80%
P39055	Caenorhabditis elegans	41%	84%
P50570	Homo sapiens	44%	80%
P54861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	92%
Q05193	Homo sapiens	44%	81%
Q08877	Rattus norvegicus	43%	81%
Q08DF4	Bos taurus	45%	82%
Q09748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	90%
Q2KIA5	Bos taurus	36%	93%
Q2KTC2	Dicentrarchus labrax	32%	100%
Q39828	Glycine max	37%	100%
Q5U752	Solea senegalensis	32%	100%
Q6DKF0	Danio rerio	31%	100%
Q7SXN5	Danio rerio	39%	100%
Q7T2P0	Ictalurus punctatus	34%	100%
Q84XF3	Arabidopsis thaliana	37%	100%
Q8BZ98	Mus musculus	43%	81%
Q8JH68	Danio rerio	34%	100%
Q8K1M6	Mus musculus	37%	94%
Q8LF21	Arabidopsis thaliana	37%	100%
Q8LFT2	Arabidopsis thaliana	36%	90%
Q8S3C9	Arabidopsis thaliana	36%	100%
Q8S944	Arabidopsis thaliana	35%	87%
Q94464	Dictyostelium discoideum	49%	82%
Q9FNX5	Arabidopsis thaliana	36%	100%
Q9LQ55	Arabidopsis thaliana	23%	76%
Q9SE83	Arabidopsis thaliana	24%	77%
Q9U1M9	Dictyostelium discoideum	40%	76%
Q9UQ16	Homo sapiens	43%	81%
Q9URZ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q9ZP55	Arabidopsis thaliana	27%	100%
V5DTS8	Trypanosoma cruzi	68%	100%