V-type proton ATPase subunit a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRH9_LEIDO

TriTrypDb:

LdBPK_364720.1 , LdCL_360054300 , LDHU3_36.6350

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRH9

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	13
GO:0032886	regulation of microtubule-based process	4	13
GO:0050789	regulation of biological process	2	13
GO:0050794	regulation of cellular process	3	13
GO:0060632	regulation of microtubule-based movement	5	13
GO:0065007	biological regulation	1	13

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.432
CLV_C14_Caspase3-7	33	37	PF00656	0.476
CLV_C14_Caspase3-7	97	101	PF00656	0.430
CLV_NRD_NRD_1	223	225	PF00675	0.268
CLV_NRD_NRD_1	90	92	PF00675	0.518
CLV_PCSK_KEX2_1	7	9	PF00082	0.382
CLV_PCSK_KEX2_1	90	92	PF00082	0.492
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.382
DEG_APCC_DBOX_1	44	52	PF00400	0.452
DEG_SPOP_SBC_1	25	29	PF00917	0.325
DOC_CYCLIN_RxL_1	78	89	PF00134	0.490
DOC_MAPK_gen_1	186	196	PF00069	0.446
DOC_MAPK_gen_1	87	95	PF00069	0.551
DOC_MAPK_MEF2A_6	107	114	PF00069	0.451
DOC_MAPK_MEF2A_6	189	196	PF00069	0.446
DOC_PP1_RVXF_1	162	169	PF00149	0.525
DOC_PP1_RVXF_1	45	51	PF00149	0.371
DOC_USP7_MATH_1	116	120	PF00917	0.438
DOC_USP7_MATH_1	175	179	PF00917	0.497
DOC_USP7_MATH_1	198	202	PF00917	0.531
DOC_USP7_MATH_2	10	16	PF00917	0.548
DOC_USP7_UBL2_3	182	186	PF12436	0.452
DOC_USP7_UBL2_3	191	195	PF12436	0.442
DOC_USP7_UBL2_3	56	60	PF12436	0.409
DOC_USP7_UBL2_3	7	11	PF12436	0.419
LIG_14-3-3_CanoR_1	146	151	PF00244	0.530
LIG_14-3-3_CanoR_1	45	51	PF00244	0.485
LIG_14-3-3_CanoR_1	81	86	PF00244	0.461
LIG_CaM_IQ_9	216	232	PF13499	0.537
LIG_EH1_1	144	152	PF00400	0.485
LIG_FHA_1	191	197	PF00498	0.482
LIG_FHA_1	26	32	PF00498	0.423
LIG_FHA_1	33	39	PF00498	0.377
LIG_FHA_1	71	77	PF00498	0.528
LIG_FHA_2	133	139	PF00498	0.513
LIG_LIR_Apic_2	243	248	PF02991	0.467
LIG_LIR_Gen_1	15	26	PF02991	0.401
LIG_LIR_Gen_1	79	89	PF02991	0.447
LIG_LIR_Nem_3	15	21	PF02991	0.413
LIG_LIR_Nem_3	177	183	PF02991	0.484
LIG_LIR_Nem_3	79	85	PF02991	0.426
LIG_PCNA_PIPBox_1	215	224	PF02747	0.456
LIG_PCNA_yPIPBox_3	224	233	PF02747	0.499
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.451
LIG_SH2_STAP1	14	18	PF00017	0.459
LIG_SH2_STAT3	223	226	PF00017	0.505
LIG_SH2_STAT5	183	186	PF00017	0.456
LIG_SH2_STAT5	71	74	PF00017	0.512
LIG_SH2_STAT5	82	85	PF00017	0.301
LIG_SH3_3	202	208	PF00018	0.450
LIG_TRAF2_1	10	13	PF00917	0.539
LIG_WW_3	203	207	PF00397	0.456
MOD_CK1_1	24	30	PF00069	0.324
MOD_CK2_1	134	140	PF00069	0.478
MOD_GlcNHglycan	117	121	PF01048	0.423
MOD_GlcNHglycan	161	164	PF01048	0.488
MOD_GlcNHglycan	169	172	PF01048	0.247
MOD_GlcNHglycan	199	203	PF01048	0.324
MOD_GlcNHglycan	242	245	PF01048	0.260
MOD_GSK3_1	153	160	PF00069	0.558
MOD_GSK3_1	21	28	PF00069	0.422
MOD_GSK3_1	236	243	PF00069	0.443
MOD_GSK3_1	81	88	PF00069	0.526
MOD_N-GLC_1	132	137	PF02516	0.464
MOD_NEK2_1	167	172	PF00069	0.453
MOD_NEK2_1	21	26	PF00069	0.363
MOD_NEK2_1	240	245	PF00069	0.519
MOD_NEK2_1	41	46	PF00069	0.385
MOD_NEK2_2	257	262	PF00069	0.495
MOD_PKA_2	175	181	PF00069	0.536
MOD_PKA_2	46	52	PF00069	0.418
MOD_Plk_1	132	138	PF00069	0.511
MOD_Plk_1	157	163	PF00069	0.456
MOD_Plk_1	236	242	PF00069	0.456
MOD_Plk_2-3	132	138	PF00069	0.476
MOD_Plk_4	146	152	PF00069	0.401
MOD_Plk_4	46	52	PF00069	0.486
MOD_SUMO_for_1	10	13	PF00179	0.473
MOD_SUMO_rev_2	207	214	PF00179	0.456
MOD_SUMO_rev_2	227	232	PF00179	0.317
TRG_DiLeu_BaEn_1	228	233	PF01217	0.509
TRG_DiLeu_BaEn_1	98	103	PF01217	0.426
TRG_ENDOCYTIC_2	18	21	PF00928	0.381
TRG_ENDOCYTIC_2	82	85	PF00928	0.394
TRG_ER_diArg_1	45	48	PF00400	0.362
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY2	Leptomonas seymouri	83%	100%
A0A0S4JE13	Bodo saltans	23%	92%
A0A0S4JHQ4	Bodo saltans	23%	92%
A0A0S4JRV9	Bodo saltans	57%	100%
A0A1X0P0N8	Trypanosomatidae	65%	100%
A0A3R7NWF2	Trypanosoma rangeli	66%	100%
A4HPL6	Leishmania braziliensis	24%	100%
A4HPW7	Leishmania braziliensis	93%	100%
A4IDM9	Leishmania infantum	100%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ATC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9ATN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0W4	Leishmania major	97%	100%
Q9VZH1	Drosophila melanogaster	24%	92%
V5B520	Trypanosoma cruzi	67%	100%
V5B6Z0	Trypanosoma cruzi	25%	94%