Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IRH8_LEIDO

TriTrypDb:

LdBPK_292190.1 , LdCL_290027900 , LDHU3_29.3110

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.781
CLV_C14_Caspase3-7	405	409	PF00656	0.773
CLV_NRD_NRD_1	219	221	PF00675	0.826
CLV_NRD_NRD_1	233	235	PF00675	0.548
CLV_NRD_NRD_1	271	273	PF00675	0.675
CLV_NRD_NRD_1	284	286	PF00675	0.728
CLV_NRD_NRD_1	295	297	PF00675	0.765
CLV_NRD_NRD_1	30	32	PF00675	0.718
CLV_NRD_NRD_1	301	303	PF00675	0.680
CLV_NRD_NRD_1	307	309	PF00675	0.645
CLV_NRD_NRD_1	368	370	PF00675	0.683
CLV_NRD_NRD_1	379	381	PF00675	0.705
CLV_NRD_NRD_1	389	391	PF00675	0.605
CLV_NRD_NRD_1	393	395	PF00675	0.559
CLV_PCSK_FUR_1	217	221	PF00082	0.708
CLV_PCSK_FUR_1	269	273	PF00082	0.669
CLV_PCSK_KEX2_1	219	221	PF00082	0.826
CLV_PCSK_KEX2_1	233	235	PF00082	0.548
CLV_PCSK_KEX2_1	271	273	PF00082	0.666
CLV_PCSK_KEX2_1	283	285	PF00082	0.740
CLV_PCSK_KEX2_1	295	297	PF00082	0.804
CLV_PCSK_KEX2_1	300	302	PF00082	0.624
CLV_PCSK_KEX2_1	368	370	PF00082	0.639
CLV_PCSK_KEX2_1	389	391	PF00082	0.659
CLV_PCSK_KEX2_1	393	395	PF00082	0.632
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.670
CLV_PCSK_PC7_1	296	302	PF00082	0.696
CLV_PCSK_PC7_1	389	395	PF00082	0.629
CLV_PCSK_SKI1_1	248	252	PF00082	0.661
CLV_PCSK_SKI1_1	254	258	PF00082	0.677
CLV_PCSK_SKI1_1	31	35	PF00082	0.604
CLV_PCSK_SKI1_1	428	432	PF00082	0.698
CLV_PCSK_SKI1_1	92	96	PF00082	0.552
DEG_SPOP_SBC_1	57	61	PF00917	0.696
DOC_CYCLIN_RxL_1	88	98	PF00134	0.580
DOC_MAPK_DCC_7	37	46	PF00069	0.750
DOC_MAPK_gen_1	243	253	PF00069	0.591
DOC_MAPK_gen_1	269	276	PF00069	0.660
DOC_MAPK_gen_1	404	412	PF00069	0.628
DOC_MAPK_MEF2A_6	190	199	PF00069	0.721
DOC_MAPK_MEF2A_6	246	255	PF00069	0.620
DOC_MAPK_MEF2A_6	37	46	PF00069	0.750
DOC_MAPK_MEF2A_6	92	99	PF00069	0.558
DOC_MAPK_NFAT4_5	248	256	PF00069	0.583
DOC_PP1_RVXF_1	255	261	PF00149	0.506
DOC_PP4_FxxP_1	438	441	PF00568	0.688
DOC_USP7_MATH_1	25	29	PF00917	0.686
DOC_USP7_MATH_1	326	330	PF00917	0.796
DOC_USP7_MATH_1	345	349	PF00917	0.780
DOC_USP7_MATH_1	35	39	PF00917	0.646
DOC_USP7_MATH_1	375	379	PF00917	0.745
DOC_USP7_MATH_1	402	406	PF00917	0.745
DOC_USP7_MATH_1	76	80	PF00917	0.805
DOC_USP7_UBL2_3	282	286	PF12436	0.687
DOC_USP7_UBL2_3	381	385	PF12436	0.725
DOC_WW_Pin1_4	189	194	PF00397	0.762
DOC_WW_Pin1_4	209	214	PF00397	0.632
DOC_WW_Pin1_4	324	329	PF00397	0.807
DOC_WW_Pin1_4	355	360	PF00397	0.682
DOC_WW_Pin1_4	418	423	PF00397	0.692
LIG_14-3-3_CanoR_1	233	242	PF00244	0.693
LIG_14-3-3_CanoR_1	295	303	PF00244	0.721
LIG_14-3-3_CanoR_1	31	40	PF00244	0.677
LIG_14-3-3_CanoR_1	311	320	PF00244	0.721
LIG_14-3-3_CanoR_1	428	433	PF00244	0.697
LIG_14-3-3_CanoR_1	43	52	PF00244	0.681
LIG_14-3-3_CanoR_1	96	100	PF00244	0.669
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BIR_III_1	1	5	PF00653	0.544
LIG_BIR_III_3	1	5	PF00653	0.544
LIG_BIR_III_4	330	334	PF00653	0.711
LIG_eIF4E_1	236	242	PF01652	0.496
LIG_FAT_LD_1	128	136	PF03623	0.564
LIG_FHA_1	196	202	PF00498	0.699
LIG_FHA_1	312	318	PF00498	0.759
LIG_FHA_1	393	399	PF00498	0.747
LIG_FHA_1	405	411	PF00498	0.562
LIG_FHA_1	85	91	PF00498	0.571
LIG_FHA_2	112	118	PF00498	0.649
LIG_FHA_2	178	184	PF00498	0.741
LIG_FHA_2	200	206	PF00498	0.716
LIG_FHA_2	313	319	PF00498	0.748
LIG_IRF3_LxIS_1	197	204	PF10401	0.657
LIG_LIR_Apic_2	353	359	PF02991	0.695
LIG_LIR_Gen_1	344	354	PF02991	0.518
LIG_LIR_Nem_3	344	349	PF02991	0.512
LIG_MAD2	16	24	PF02301	0.707
LIG_MYND_2	4	8	PF01753	0.544
LIG_NRBOX	90	96	PF00104	0.663
LIG_Pex14_2	412	416	PF04695	0.571
LIG_SH2_STAP1	236	240	PF00017	0.639
LIG_SH3_3	194	200	PF00018	0.657
LIG_SH3_3	322	328	PF00018	0.766
LIG_SH3_3	408	414	PF00018	0.671
LIG_SH3_3	94	100	PF00018	0.790
LIG_SH3_4	381	388	PF00018	0.727
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.635
LIG_SUMO_SIM_par_1	192	198	PF11976	0.674
LIG_SUMO_SIM_par_1	199	205	PF11976	0.663
LIG_TRAF2_1	109	112	PF00917	0.766
LIG_TRAF2_1	180	183	PF00917	0.762
MOD_CK1_1	165	171	PF00069	0.734
MOD_CK1_1	221	227	PF00069	0.686
MOD_CK1_1	267	273	PF00069	0.728
MOD_CK1_1	347	353	PF00069	0.776
MOD_CK1_1	371	377	PF00069	0.765
MOD_CK1_1	392	398	PF00069	0.748
MOD_CK1_1	45	51	PF00069	0.744
MOD_CK2_1	111	117	PF00069	0.733
MOD_CK2_1	177	183	PF00069	0.730
MOD_CK2_1	304	310	PF00069	0.768
MOD_CK2_1	326	332	PF00069	0.805
MOD_GlcNHglycan	140	143	PF01048	0.558
MOD_GlcNHglycan	186	189	PF01048	0.760
MOD_GlcNHglycan	229	232	PF01048	0.710
MOD_GlcNHglycan	349	352	PF01048	0.709
MOD_GlcNHglycan	370	373	PF01048	0.816
MOD_GlcNHglycan	80	83	PF01048	0.749
MOD_GSK3_1	189	196	PF00069	0.787
MOD_GSK3_1	260	267	PF00069	0.618
MOD_GSK3_1	290	297	PF00069	0.637
MOD_GSK3_1	31	38	PF00069	0.669
MOD_GSK3_1	350	357	PF00069	0.655
MOD_GSK3_1	364	371	PF00069	0.672
MOD_GSK3_1	400	407	PF00069	0.714
MOD_GSK3_1	44	51	PF00069	0.658
MOD_GSK3_1	6	13	PF00069	0.795
MOD_GSK3_1	63	70	PF00069	0.508
MOD_GSK3_1	74	81	PF00069	0.728
MOD_N-GLC_1	224	229	PF02516	0.632
MOD_N-GLC_1	234	239	PF02516	0.507
MOD_NEK2_1	260	265	PF00069	0.790
MOD_NEK2_1	44	49	PF00069	0.692
MOD_NEK2_1	95	100	PF00069	0.683
MOD_PIKK_1	130	136	PF00454	0.611
MOD_PIKK_1	290	296	PF00454	0.653
MOD_PIKK_1	375	381	PF00454	0.843
MOD_PKA_1	31	37	PF00069	0.607
MOD_PKA_1	368	374	PF00069	0.640
MOD_PKA_1	389	395	PF00069	0.735
MOD_PKA_2	218	224	PF00069	0.810
MOD_PKA_2	287	293	PF00069	0.720
MOD_PKA_2	294	300	PF00069	0.772
MOD_PKA_2	310	316	PF00069	0.527
MOD_PKA_2	36	42	PF00069	0.723
MOD_PKA_2	368	374	PF00069	0.853
MOD_PKA_2	389	395	PF00069	0.765
MOD_PKA_2	95	101	PF00069	0.667
MOD_Plk_1	111	117	PF00069	0.741
MOD_Plk_1	165	171	PF00069	0.649
MOD_Plk_2-3	111	117	PF00069	0.777
MOD_Plk_4	36	42	PF00069	0.777
MOD_ProDKin_1	189	195	PF00069	0.760
MOD_ProDKin_1	209	215	PF00069	0.631
MOD_ProDKin_1	324	330	PF00069	0.762
MOD_ProDKin_1	355	361	PF00069	0.683
MOD_ProDKin_1	418	424	PF00069	0.693
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.749
TRG_ER_diArg_1	217	220	PF00400	0.744
TRG_ER_diArg_1	232	234	PF00400	0.527
TRG_ER_diArg_1	269	272	PF00400	0.669
TRG_ER_diArg_1	300	302	PF00400	0.721
TRG_ER_diArg_1	388	390	PF00400	0.731
TRG_NLS_Bipartite_1	271	287	PF00514	0.599
TRG_NLS_Bipartite_1	368	384	PF00514	0.633
TRG_NLS_MonoCore_2	281	286	PF00514	0.627
TRG_NLS_MonoCore_2	379	384	PF00514	0.725
TRG_NLS_MonoExtC_3	281	286	PF00514	0.725
TRG_NLS_MonoExtN_4	282	287	PF00514	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW7	Leptomonas seymouri	29%	100%
A4HHK6	Leishmania braziliensis	54%	95%
A4I4R7	Leishmania infantum	100%	100%
E9AE69	Leishmania major	84%	100%
E9ALL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%