Trypanothione synthetase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IRG9_LEIDO

TriTrypDb:

LdBPK_364510.1 , LdCL_360052300 , LDHU3_36.6130

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRG9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016874	ligase activity	2	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5
GO:0016880	acid-ammonia (or amide) ligase activity	4	5
GO:0047479	trypanothione synthase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.493
CLV_C14_Caspase3-7	197	201	PF00656	0.528
CLV_C14_Caspase3-7	680	684	PF00656	0.417
CLV_NRD_NRD_1	283	285	PF00675	0.381
CLV_NRD_NRD_1	392	394	PF00675	0.594
CLV_NRD_NRD_1	59	61	PF00675	0.495
CLV_NRD_NRD_1	659	661	PF00675	0.436
CLV_NRD_NRD_1	686	688	PF00675	0.445
CLV_PCSK_KEX2_1	283	285	PF00082	0.381
CLV_PCSK_KEX2_1	394	396	PF00082	0.595
CLV_PCSK_KEX2_1	59	61	PF00082	0.495
CLV_PCSK_KEX2_1	659	661	PF00082	0.436
CLV_PCSK_KEX2_1	686	688	PF00082	0.445
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.595
CLV_PCSK_PC7_1	390	396	PF00082	0.565
CLV_PCSK_SKI1_1	455	459	PF00082	0.507
CLV_PCSK_SKI1_1	548	552	PF00082	0.552
CLV_PCSK_SKI1_1	59	63	PF00082	0.495
CLV_PCSK_SKI1_1	599	603	PF00082	0.597
DEG_APCC_DBOX_1	274	282	PF00400	0.417
DEG_SPOP_SBC_1	647	651	PF00917	0.483
DOC_CKS1_1	210	215	PF01111	0.599
DOC_CKS1_1	476	481	PF01111	0.582
DOC_CYCLIN_RxL_1	269	277	PF00134	0.473
DOC_CYCLIN_RxL_1	57	66	PF00134	0.295
DOC_CYCLIN_RxL_1	653	666	PF00134	0.486
DOC_MAPK_FxFP_2	744	747	PF00069	0.614
DOC_MAPK_gen_1	272	282	PF00069	0.383
DOC_MAPK_MEF2A_6	275	282	PF00069	0.429
DOC_MAPK_NFAT4_5	275	283	PF00069	0.519
DOC_PP1_RVXF_1	270	277	PF00149	0.472
DOC_PP1_RVXF_1	446	452	PF00149	0.492
DOC_PP1_RVXF_1	523	530	PF00149	0.389
DOC_PP1_RVXF_1	546	553	PF00149	0.535
DOC_PP4_FxxP_1	152	155	PF00568	0.428
DOC_PP4_FxxP_1	242	245	PF00568	0.557
DOC_PP4_FxxP_1	348	351	PF00568	0.449
DOC_PP4_FxxP_1	619	622	PF00568	0.382
DOC_PP4_FxxP_1	744	747	PF00568	0.614
DOC_USP7_MATH_1	155	159	PF00917	0.541
DOC_USP7_MATH_1	307	311	PF00917	0.697
DOC_USP7_MATH_1	371	375	PF00917	0.538
DOC_USP7_MATH_1	412	416	PF00917	0.706
DOC_USP7_MATH_1	506	510	PF00917	0.536
DOC_USP7_MATH_1	559	563	PF00917	0.633
DOC_USP7_MATH_1	641	645	PF00917	0.580
DOC_USP7_UBL2_3	668	672	PF12436	0.501
DOC_WW_Pin1_4	121	126	PF00397	0.342
DOC_WW_Pin1_4	151	156	PF00397	0.437
DOC_WW_Pin1_4	209	214	PF00397	0.546
DOC_WW_Pin1_4	220	225	PF00397	0.455
DOC_WW_Pin1_4	333	338	PF00397	0.576
DOC_WW_Pin1_4	413	418	PF00397	0.780
DOC_WW_Pin1_4	475	480	PF00397	0.531
DOC_WW_Pin1_4	557	562	PF00397	0.547
DOC_WW_Pin1_4	643	648	PF00397	0.715
DOC_WW_Pin1_4	663	668	PF00397	0.500
DOC_WW_Pin1_4	696	701	PF00397	0.711
DOC_WW_Pin1_4	7	12	PF00397	0.610
LIG_14-3-3_CanoR_1	275	279	PF00244	0.386
LIG_14-3-3_CanoR_1	409	417	PF00244	0.605
LIG_14-3-3_CanoR_1	455	463	PF00244	0.553
LIG_14-3-3_CanoR_1	482	491	PF00244	0.626
LIG_14-3-3_CanoR_1	507	511	PF00244	0.367
LIG_14-3-3_CanoR_1	648	653	PF00244	0.508
LIG_14-3-3_CanoR_1	75	82	PF00244	0.319
LIG_BRCT_BRCA1_1	221	225	PF00533	0.565
LIG_BRCT_BRCA1_1	650	654	PF00533	0.408
LIG_BRCT_BRCA1_1	740	744	PF00533	0.589
LIG_deltaCOP1_diTrp_1	441	451	PF00928	0.459
LIG_eIF4E_1	57	63	PF01652	0.319
LIG_FHA_1	178	184	PF00498	0.527
LIG_FHA_1	275	281	PF00498	0.530
LIG_FHA_1	294	300	PF00498	0.345
LIG_FHA_1	469	475	PF00498	0.620
LIG_FHA_1	570	576	PF00498	0.677
LIG_FHA_1	64	70	PF00498	0.295
LIG_FHA_1	671	677	PF00498	0.638
LIG_FHA_1	722	728	PF00498	0.757
LIG_FHA_2	171	177	PF00498	0.572
LIG_FHA_2	221	227	PF00498	0.469
LIG_FHA_2	300	306	PF00498	0.607
LIG_FHA_2	333	339	PF00498	0.607
LIG_FHA_2	344	350	PF00498	0.437
LIG_FHA_2	428	434	PF00498	0.635
LIG_FHA_2	84	90	PF00498	0.319
LIG_LIR_Apic_2	346	351	PF02991	0.500
LIG_LIR_Apic_2	396	402	PF02991	0.638
LIG_LIR_Apic_2	616	622	PF02991	0.391
LIG_LIR_Apic_2	741	747	PF02991	0.591
LIG_LIR_Gen_1	167	177	PF02991	0.311
LIG_LIR_Gen_1	508	514	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.353
LIG_LIR_Nem_3	167	172	PF02991	0.291
LIG_LIR_Nem_3	20	24	PF02991	0.423
LIG_LIR_Nem_3	290	294	PF02991	0.325
LIG_LIR_Nem_3	318	324	PF02991	0.498
LIG_LIR_Nem_3	346	350	PF02991	0.501
LIG_LIR_Nem_3	374	379	PF02991	0.528
LIG_LIR_Nem_3	44	50	PF02991	0.397
LIG_LIR_Nem_3	492	496	PF02991	0.452
LIG_LIR_Nem_3	508	513	PF02991	0.412
LIG_LIR_Nem_3	591	595	PF02991	0.401
LIG_LIR_Nem_3	651	657	PF02991	0.394
LIG_LYPXL_S_1	375	379	PF13949	0.528
LIG_LYPXL_yS_3	376	379	PF13949	0.532
LIG_MAD2	498	506	PF02301	0.524
LIG_MYND_1	121	125	PF01753	0.353
LIG_PCNA_PIPBox_1	369	378	PF02747	0.574
LIG_SH2_CRK	169	173	PF00017	0.494
LIG_SH2_SRC	159	162	PF00017	0.486
LIG_SH2_STAP1	57	61	PF00017	0.319
LIG_SH2_STAP1	581	585	PF00017	0.470
LIG_SH2_STAT5	148	151	PF00017	0.540
LIG_SH2_STAT5	159	162	PF00017	0.416
LIG_SH2_STAT5	34	37	PF00017	0.470
LIG_SH2_STAT5	347	350	PF00017	0.491
LIG_SH2_STAT5	41	44	PF00017	0.417
LIG_SH2_STAT5	47	50	PF00017	0.263
LIG_SH2_STAT5	496	499	PF00017	0.454
LIG_SH2_STAT5	607	610	PF00017	0.550
LIG_SH2_STAT5	662	665	PF00017	0.504
LIG_SH2_STAT5	94	97	PF00017	0.350
LIG_SH3_1	292	298	PF00018	0.564
LIG_SH3_2	199	204	PF14604	0.457
LIG_SH3_3	115	121	PF00018	0.330
LIG_SH3_3	196	202	PF00018	0.441
LIG_SH3_3	207	213	PF00018	0.464
LIG_SH3_3	292	298	PF00018	0.516
LIG_SH3_3	422	428	PF00018	0.692
LIG_SH3_3	433	439	PF00018	0.558
LIG_SH3_3	500	506	PF00018	0.467
LIG_SH3_3	535	541	PF00018	0.575
LIG_SUMO_SIM_anti_2	473	478	PF11976	0.587
LIG_SUMO_SIM_par_1	420	426	PF11976	0.765
LIG_SUMO_SIM_par_1	471	478	PF11976	0.559
LIG_SUMO_SIM_par_1	723	730	PF11976	0.781
LIG_TRAF2_1	430	433	PF00917	0.578
LIG_UBA3_1	320	327	PF00899	0.387
LIG_WRC_WIRS_1	131	136	PF05994	0.389
LIG_WRC_WIRS_1	171	176	PF05994	0.390
LIG_WRC_WIRS_1	372	377	PF05994	0.577
MOD_CDK_SPK_2	643	648	PF00069	0.715
MOD_CDK_SPK_2	663	668	PF00069	0.459
MOD_CDK_SPxK_1	333	339	PF00069	0.570
MOD_CDK_SPxxK_3	475	482	PF00069	0.583
MOD_CK1_1	188	194	PF00069	0.450
MOD_CK1_1	45	51	PF00069	0.461
MOD_CK1_1	562	568	PF00069	0.603
MOD_CK1_1	570	576	PF00069	0.594
MOD_CK1_1	646	652	PF00069	0.564
MOD_CK1_1	7	13	PF00069	0.673
MOD_CK1_1	726	732	PF00069	0.694
MOD_CK2_1	151	157	PF00069	0.528
MOD_CK2_1	170	176	PF00069	0.509
MOD_CK2_1	299	305	PF00069	0.678
MOD_CK2_1	427	433	PF00069	0.656
MOD_CK2_1	83	89	PF00069	0.319
MOD_GlcNHglycan	190	193	PF01048	0.512
MOD_GlcNHglycan	245	248	PF01048	0.592
MOD_GlcNHglycan	267	270	PF01048	0.492
MOD_GlcNHglycan	309	312	PF01048	0.565
MOD_GlcNHglycan	35	38	PF01048	0.432
MOD_GlcNHglycan	382	385	PF01048	0.554
MOD_GlcNHglycan	395	398	PF01048	0.472
MOD_GlcNHglycan	561	564	PF01048	0.667
MOD_GlcNHglycan	577	580	PF01048	0.519
MOD_GlcNHglycan	628	631	PF01048	0.418
MOD_GSK3_1	151	158	PF00069	0.494
MOD_GSK3_1	403	410	PF00069	0.729
MOD_GSK3_1	41	48	PF00069	0.507
MOD_GSK3_1	423	430	PF00069	0.395
MOD_GSK3_1	508	515	PF00069	0.449
MOD_GSK3_1	622	629	PF00069	0.382
MOD_GSK3_1	643	650	PF00069	0.637
MOD_GSK3_1	83	90	PF00069	0.319
MOD_N-GLC_1	155	160	PF02516	0.488
MOD_N-GLC_1	256	261	PF02516	0.542
MOD_N-GLC_1	299	304	PF02516	0.674
MOD_N-GLC_1	330	335	PF02516	0.627
MOD_N-GLC_1	412	417	PF02516	0.652
MOD_N-GLC_1	632	637	PF02516	0.647
MOD_N-GLC_2	533	535	PF02516	0.550
MOD_NEK2_1	274	279	PF00069	0.456
MOD_NEK2_1	299	304	PF00069	0.600
MOD_NEK2_1	423	428	PF00069	0.744
MOD_NEK2_1	470	475	PF00069	0.539
MOD_NEK2_1	484	489	PF00069	0.604
MOD_NEK2_1	527	532	PF00069	0.549
MOD_NEK2_1	62	67	PF00069	0.295
MOD_NEK2_1	712	717	PF00069	0.505
MOD_NEK2_2	371	376	PF00069	0.525
MOD_NEK2_2	681	686	PF00069	0.506
MOD_NEK2_2	92	97	PF00069	0.389
MOD_PIKK_1	103	109	PF00454	0.377
MOD_PIKK_1	458	464	PF00454	0.607
MOD_PIKK_1	484	490	PF00454	0.597
MOD_PK_1	648	654	PF00069	0.512
MOD_PKA_1	393	399	PF00069	0.594
MOD_PKA_2	274	280	PF00069	0.384
MOD_PKA_2	408	414	PF00069	0.610
MOD_PKA_2	506	512	PF00069	0.415
MOD_PKA_2	570	576	PF00069	0.705
MOD_PKA_2	647	653	PF00069	0.591
MOD_PKA_2	74	80	PF00069	0.319
MOD_PKB_1	393	401	PF00069	0.611
MOD_Plk_1	155	161	PF00069	0.494
MOD_Plk_1	299	305	PF00069	0.662
MOD_Plk_1	42	48	PF00069	0.506
MOD_Plk_1	458	464	PF00069	0.536
MOD_Plk_1	548	554	PF00069	0.456
MOD_Plk_4	155	161	PF00069	0.528
MOD_Plk_4	259	265	PF00069	0.533
MOD_Plk_4	343	349	PF00069	0.494
MOD_Plk_4	371	377	PF00069	0.484
MOD_Plk_4	42	48	PF00069	0.510
MOD_Plk_4	548	554	PF00069	0.523
MOD_Plk_4	704	710	PF00069	0.457
MOD_Plk_4	738	744	PF00069	0.604
MOD_ProDKin_1	121	127	PF00069	0.342
MOD_ProDKin_1	151	157	PF00069	0.446
MOD_ProDKin_1	209	215	PF00069	0.552
MOD_ProDKin_1	220	226	PF00069	0.453
MOD_ProDKin_1	333	339	PF00069	0.570
MOD_ProDKin_1	413	419	PF00069	0.779
MOD_ProDKin_1	475	481	PF00069	0.528
MOD_ProDKin_1	557	563	PF00069	0.566
MOD_ProDKin_1	643	649	PF00069	0.699
MOD_ProDKin_1	663	669	PF00069	0.510
MOD_ProDKin_1	696	702	PF00069	0.706
MOD_ProDKin_1	7	13	PF00069	0.602
MOD_SUMO_for_1	363	366	PF00179	0.605
MOD_SUMO_rev_2	675	684	PF00179	0.474
TRG_ENDOCYTIC_2	169	172	PF00928	0.409
TRG_ENDOCYTIC_2	347	350	PF00928	0.491
TRG_ENDOCYTIC_2	376	379	PF00928	0.532
TRG_ENDOCYTIC_2	47	50	PF00928	0.305
TRG_ENDOCYTIC_2	496	499	PF00928	0.521
TRG_ENDOCYTIC_2	52	55	PF00928	0.293
TRG_ER_diArg_1	282	284	PF00400	0.438
TRG_ER_diArg_1	59	61	PF00400	0.295
TRG_ER_diArg_1	659	661	PF00400	0.462
TRG_ER_diArg_1	686	688	PF00400	0.527
TRG_NES_CRM1_1	338	353	PF08389	0.557
TRG_NLS_MonoExtN_4	390	397	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF5	Leptomonas seymouri	64%	99%
A0A1X0P094	Trypanosomatidae	41%	100%
A4IE44	Leishmania infantum	99%	100%
E9ATL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0Y4	Leishmania major	93%	100%
V5BQ93	Trypanosoma cruzi	39%	100%