Zinc-binding dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRG0_LEIDO

TriTrypDb:

LdBPK_364380.1 , LdCL_360050900 , LDHU3_36.5920

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IRG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0016491	oxidoreductase activity	2	9
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.543
CLV_C14_Caspase3-7	201	205	PF00656	0.571
CLV_C14_Caspase3-7	226	230	PF00656	0.493
CLV_C14_Caspase3-7	318	322	PF00656	0.497
CLV_PCSK_SKI1_1	185	189	PF00082	0.444
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.495
DOC_MAPK_gen_1	142	150	PF00069	0.524
DOC_MAPK_gen_1	8	15	PF00069	0.561
DOC_MAPK_MEF2A_6	120	128	PF00069	0.496
DOC_MAPK_MEF2A_6	300	308	PF00069	0.628
DOC_MAPK_MEF2A_6	89	97	PF00069	0.357
DOC_MIT_MIM_1	201	210	PF04212	0.517
DOC_PP2B_LxvP_1	106	109	PF13499	0.548
DOC_PP4_FxxP_1	257	260	PF00568	0.500
DOC_PP4_FxxP_1	279	282	PF00568	0.435
LIG_14-3-3_CanoR_1	20	26	PF00244	0.599
LIG_14-3-3_CanoR_1	40	44	PF00244	0.240
LIG_Actin_WH2_2	285	302	PF00022	0.552
LIG_APCC_ABBA_1	304	309	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	15	19	PF00533	0.546
LIG_FHA_1	130	136	PF00498	0.434
LIG_FHA_1	156	162	PF00498	0.490
LIG_FHA_1	198	204	PF00498	0.493
LIG_FHA_1	21	27	PF00498	0.582
LIG_FHA_1	264	270	PF00498	0.506
LIG_FHA_2	224	230	PF00498	0.500
LIG_HCF-1_HBM_1	324	327	PF13415	0.559
LIG_HP1_1	93	97	PF01393	0.454
LIG_LIR_Gen_1	122	131	PF02991	0.532
LIG_LIR_Gen_1	216	227	PF02991	0.469
LIG_LIR_Nem_3	122	126	PF02991	0.538
LIG_LIR_Nem_3	216	222	PF02991	0.469
LIG_LIR_Nem_3	310	316	PF02991	0.416
LIG_LIR_Nem_3	42	48	PF02991	0.542
LIG_LIR_Nem_3	5	10	PF02991	0.583
LIG_MYND_1	117	121	PF01753	0.589
LIG_PCNA_PIPBox_1	292	301	PF02747	0.548
LIG_Pex14_2	280	284	PF04695	0.469
LIG_Pex14_2	68	72	PF04695	0.517
LIG_PTB_Apo_2	54	61	PF02174	0.517
LIG_PTB_Phospho_1	54	60	PF10480	0.517
LIG_SH2_CRK	285	289	PF00017	0.357
LIG_SH2_CRK	45	49	PF00017	0.447
LIG_SH2_NCK_1	219	223	PF00017	0.435
LIG_SH2_NCK_1	285	289	PF00017	0.357
LIG_SH2_PTP2	123	126	PF00017	0.528
LIG_SH2_STAT5	123	126	PF00017	0.477
LIG_SH2_STAT5	298	301	PF00017	0.568
LIG_SH2_STAT5	60	63	PF00017	0.517
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.501
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.517
LIG_SUMO_SIM_par_1	11	16	PF11976	0.565
LIG_SUMO_SIM_par_1	239	245	PF11976	0.500
LIG_SUMO_SIM_par_1	266	271	PF11976	0.502
LIG_TRAF2_1	179	182	PF00917	0.571
LIG_TYR_ITIM	217	222	PF00017	0.469
LIG_TYR_ITIM	43	48	PF00017	0.517
LIG_UBA3_1	242	250	PF00899	0.566
LIG_UBA3_1	267	272	PF00899	0.503
LIG_UBA3_1	295	300	PF00899	0.551
MOD_CK1_1	129	135	PF00069	0.448
MOD_CK1_1	2	8	PF00069	0.611
MOD_CK1_1	202	208	PF00069	0.434
MOD_CK1_1	21	27	PF00069	0.597
MOD_CK1_1	245	251	PF00069	0.508
MOD_CK1_1	258	264	PF00069	0.394
MOD_CK1_1	328	334	PF00069	0.503
MOD_CK2_1	176	182	PF00069	0.517
MOD_CK2_1	21	27	PF00069	0.609
MOD_GlcNHglycan	128	131	PF01048	0.484
MOD_GlcNHglycan	250	253	PF01048	0.436
MOD_GlcNHglycan	260	263	PF01048	0.484
MOD_GlcNHglycan	272	275	PF01048	0.266
MOD_GlcNHglycan	327	330	PF01048	0.502
MOD_GSK3_1	170	177	PF00069	0.469
MOD_GSK3_1	244	251	PF00069	0.484
MOD_GSK3_1	268	275	PF00069	0.535
MOD_N-GLC_1	48	53	PF02516	0.435
MOD_N-GLC_1	56	61	PF02516	0.435
MOD_NEK2_1	186	191	PF00069	0.493
MOD_NEK2_1	19	24	PF00069	0.560
MOD_NEK2_1	268	273	PF00069	0.413
MOD_NEK2_1	53	58	PF00069	0.502
MOD_OFUCOSY	172	178	PF10250	0.435
MOD_PKA_2	19	25	PF00069	0.591
MOD_PKA_2	39	45	PF00069	0.240
MOD_Plk_4	170	176	PF00069	0.469
MOD_Plk_4	21	27	PF00069	0.660
MOD_Plk_4	263	269	PF00069	0.538
MOD_Plk_4	291	297	PF00069	0.529
MOD_Plk_4	56	62	PF00069	0.517
MOD_Plk_4	74	80	PF00069	0.517
MOD_SUMO_for_1	119	122	PF00179	0.577
MOD_SUMO_rev_2	179	184	PF00179	0.517
TRG_DiLeu_BaEn_3	181	187	PF01217	0.571
TRG_ENDOCYTIC_2	123	126	PF00928	0.524
TRG_ENDOCYTIC_2	219	222	PF00928	0.435
TRG_ENDOCYTIC_2	285	288	PF00928	0.357
TRG_ENDOCYTIC_2	45	48	PF00928	0.447
TRG_ENDOCYTIC_2	99	102	PF00928	0.481
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D2YG03	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	26%	95%
A0A0N0P3I0	Leptomonas seymouri	74%	100%
A0A0N0P5I8	Leptomonas seymouri	27%	92%
A0A0N0P6Q4	Leptomonas seymouri	30%	100%
A0A0N0P7C5	Leptomonas seymouri	43%	100%
A0A0N1I4X2	Leptomonas seymouri	26%	73%
A0A0N1I913	Leptomonas seymouri	45%	98%
A0A0N1I9E8	Leptomonas seymouri	26%	100%
A0A0S4ILA6	Bodo saltans	29%	100%
A0A0S4ILS9	Bodo saltans	26%	100%
A0A0S4IT20	Bodo saltans	27%	99%
A0A0S4IUY2	Bodo saltans	30%	100%
A0A0S4JMB1	Bodo saltans	47%	97%
A0A0S4KHW9	Bodo saltans	30%	100%
A0A1X0NZZ5	Trypanosomatidae	28%	100%
A0A1X0P0B2	Trypanosomatidae	43%	100%
A0A1X0P8R2	Trypanosomatidae	29%	100%
A0A3R7L374	Trypanosoma rangeli	30%	100%
A0A3S7WR58	Leishmania donovani	27%	71%
A0A3S7WSH2	Leishmania donovani	43%	99%
A0A422NF38	Trypanosoma rangeli	26%	100%
A0A422NKE0	Trypanosoma rangeli	42%	100%
A0A451EJQ8	Leishmania donovani	31%	100%
A4H3L9	Leishmania braziliensis	31%	100%
A4H649	Leishmania braziliensis	27%	71%
A4H761	Leishmania braziliensis	43%	100%
A4HPT6	Leishmania braziliensis	86%	100%
A4HUG9	Leishmania infantum	27%	71%
A4HVK0	Leishmania infantum	43%	100%
A4I8R5	Leishmania infantum	24%	100%
A4IE56	Leishmania infantum	100%	100%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	100%
A6QQF5	Bos taurus	32%	97%
A7RK30	Nematostella vectensis	30%	93%
B0BNC9	Rattus norvegicus	32%	97%
B8NTZ8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	27%	92%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACK2	Leishmania major	31%	100%
E9AG46	Leishmania infantum	31%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	71%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
K4BW79	Solanum lycopersicum	29%	88%
O07615	Bacillus subtilis (strain 168)	29%	100%
O23939	Fragaria vesca	29%	100%
O35017	Bacillus subtilis (strain 168)	31%	100%
O35045	Bacillus subtilis (strain 168)	29%	100%
O45903	Caenorhabditis elegans	28%	99%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O94038	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	98%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
P00331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	98%
P07246	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	91%
P0DN30	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	29%	100%
P19333	Tetronarce californica	25%	90%
P20369	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	97%
P28304	Escherichia coli (strain K12)	28%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	29%	100%
P42865	Leishmania amazonensis	93%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%
P49383	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	98%
P49384	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	91%
Q07288	Kluyveromyces marxianus	24%	98%
Q08257	Homo sapiens	24%	100%
Q24K16	Bos taurus	44%	90%
Q28452	Lama guanicoe	27%	100%
Q28GQ2	Xenopus tropicalis	28%	97%
Q2FJ31	Staphylococcus aureus (strain USA300)	25%	100%
Q2G0G1	Staphylococcus aureus (strain NCTC 8325 / PS 47)	25%	100%
Q2YSX0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	25%	100%
Q32L99	Bos taurus	26%	97%
Q3MIE4	Rattus norvegicus	31%	84%
Q3UNZ8	Mus musculus	31%	97%
Q4J781	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	99%
Q4Q0Z7	Leishmania major	94%	100%
Q4Q4F7	Leishmania major	24%	100%
Q4QG82	Leishmania major	44%	100%
Q4QHF8	Leishmania major	28%	71%
Q53FA7	Homo sapiens	25%	100%
Q54YT4	Dictyostelium discoideum	25%	97%
Q5BK81	Rattus norvegicus	27%	97%
Q5HI63	Staphylococcus aureus (strain COL)	25%	100%
Q5R806	Pongo abelii	24%	97%
Q62465	Mus musculus	30%	84%
Q6GBM4	Staphylococcus aureus (strain MSSA476)	25%	100%
Q6GJ63	Staphylococcus aureus (strain MRSA252)	25%	100%
Q6GQN8	Danio rerio	27%	90%
Q7A742	Staphylococcus aureus (strain N315)	25%	100%
Q7YS70	Bos taurus	27%	91%
Q80TB8	Mus musculus	24%	82%
Q84V25	Fragaria ananassa	29%	100%
Q8BGC4	Mus musculus	44%	90%
Q8H0M1	Spinacia oleracea	27%	100%
Q8JFV8	Danio rerio	28%	70%
Q8LCU7	Arabidopsis thaliana	26%	91%
Q8N4Q0	Homo sapiens	44%	90%
Q8N8N7	Homo sapiens	24%	97%
Q8NXU1	Staphylococcus aureus (strain MW2)	25%	100%
Q941I0	Fragaria ananassa	28%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	98%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q99536	Homo sapiens	31%	87%
Q99W07	Staphylococcus aureus (strain Mu50 / ATCC 700699)	25%	100%
Q9AYU1	Triphysaria versicolor	29%	100%
Q9BV79	Homo sapiens	26%	91%
Q9DCS3	Mus musculus	25%	91%
Q9EQZ5	Cavia porcellus	31%	100%
Q9HCJ6	Homo sapiens	25%	81%
Q9SV68	Arabidopsis thaliana	30%	100%
Q9Z311	Rattus norvegicus	26%	91%
Q9ZUC1	Arabidopsis thaliana	30%	88%
S0DRW9	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	22%	100%
V5B1P3	Trypanosoma cruzi	28%	100%