2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diphthamide synthesis protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRF6_LEIDO

TriTrypDb:

LdBPK_291900.1 , LdCL_290024700 , LDHU3_29.2720

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IRF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRF6

Function

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Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	11
GO:0006448	regulation of translational elongation	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010608	post-transcriptional regulation of gene expression	6	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	249	251	PF00675	0.266
CLV_NRD_NRD_1	44	46	PF00675	0.472
CLV_PCSK_KEX2_1	249	251	PF00082	0.314
CLV_PCSK_KEX2_1	290	292	PF00082	0.347
CLV_PCSK_KEX2_1	36	38	PF00082	0.366
CLV_PCSK_KEX2_1	44	46	PF00082	0.344
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.347
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.383
CLV_PCSK_SKI1_1	290	294	PF00082	0.302
CLV_PCSK_SKI1_1	33	37	PF00082	0.381

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHA4	Leptomonas seymouri	90%	100%
A0A0S4JS33	Bodo saltans	70%	94%
A0A1D8PL26	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	71%
A0A1X0P135	Trypanosomatidae	78%	100%
A0A3R7MRI9	Trypanosoma rangeli	75%	100%
A0A8C2MDK8	Cricetulus griseus	50%	85%
A4HIY1	Leishmania braziliensis	95%	100%
A4I4N6	Leishmania infantum	100%	100%
A4QN59	Danio rerio	27%	75%
A7SKJ3	Nematostella vectensis	25%	70%

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