Choline/Carnitine o-acyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carnitine/choline acetyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IRB8_LEIDO

TriTrypDb:

LdBPK_291400.1 , LdCL_290019100 , LDHU3_29.1900

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IRB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IRB8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0004095	carnitine O-palmitoyltransferase activity	7	3
GO:0008374	O-acyltransferase activity	5	3
GO:0016406	carnitine O-acyltransferase activity	6	3
GO:0016409	palmitoyltransferase activity	5	3
GO:0016416	O-palmitoyltransferase activity	6	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.552
CLV_NRD_NRD_1	209	211	PF00675	0.489
CLV_PCSK_KEX2_1	2	4	PF00082	0.465
CLV_PCSK_KEX2_1	209	211	PF00082	0.471
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.484
CLV_PCSK_PC7_1	205	211	PF00082	0.365
CLV_PCSK_SKI1_1	482	486	PF00082	0.383
CLV_PCSK_SKI1_1	526	530	PF00082	0.428
CLV_PCSK_SKI1_1	542	546	PF00082	0.291
CLV_PCSK_SKI1_1	598	602	PF00082	0.472
CLV_Separin_Metazoa	258	262	PF03568	0.424
DEG_APCC_DBOX_1	31	39	PF00400	0.409
DEG_APCC_DBOX_1	400	408	PF00400	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_SPOP_SBC_1	450	454	PF00917	0.518
DEG_SPOP_SBC_1	544	548	PF00917	0.490
DOC_CKS1_1	251	256	PF01111	0.378
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.365
DOC_MAPK_gen_1	377	386	PF00069	0.378
DOC_MAPK_MEF2A_6	214	222	PF00069	0.409
DOC_PP1_RVXF_1	323	329	PF00149	0.466
DOC_PP2B_LxvP_1	14	17	PF13499	0.446
DOC_PP2B_LxvP_1	143	146	PF13499	0.471
DOC_PP2B_LxvP_1	19	22	PF13499	0.340
DOC_PP4_FxxP_1	550	553	PF00568	0.354
DOC_USP7_MATH_1	20	24	PF00917	0.399
DOC_USP7_MATH_1	284	288	PF00917	0.490
DOC_USP7_MATH_1	501	505	PF00917	0.409
DOC_USP7_MATH_1	562	566	PF00917	0.409
DOC_USP7_MATH_1	73	77	PF00917	0.486
DOC_USP7_MATH_1	92	96	PF00917	0.269
DOC_USP7_MATH_2	179	185	PF00917	0.365
DOC_USP7_UBL2_3	425	429	PF12436	0.378
DOC_WW_Pin1_4	153	158	PF00397	0.359
DOC_WW_Pin1_4	175	180	PF00397	0.359
DOC_WW_Pin1_4	220	225	PF00397	0.359
DOC_WW_Pin1_4	227	232	PF00397	0.359
DOC_WW_Pin1_4	250	255	PF00397	0.378
DOC_WW_Pin1_4	37	42	PF00397	0.409
DOC_WW_Pin1_4	586	591	PF00397	0.344
DOC_WW_Pin1_4	94	99	PF00397	0.479
LIG_14-3-3_CanoR_1	3	13	PF00244	0.593
LIG_14-3-3_CanoR_1	32	36	PF00244	0.496
LIG_14-3-3_CanoR_1	362	367	PF00244	0.389
LIG_14-3-3_CanoR_1	401	411	PF00244	0.471
LIG_14-3-3_CanoR_1	490	499	PF00244	0.396
LIG_14-3-3_CanoR_1	542	550	PF00244	0.415
LIG_14-3-3_CanoR_1	556	561	PF00244	0.386
LIG_14-3-3_CanoR_1	580	590	PF00244	0.344
LIG_APCC_ABBA_1	197	202	PF00400	0.359
LIG_APCC_ABBA_1	260	265	PF00400	0.490
LIG_APCC_Cbox_2	494	500	PF00515	0.409
LIG_CSL_BTD_1	38	41	PF09270	0.409
LIG_eIF4E_1	153	159	PF01652	0.365
LIG_FHA_1	126	132	PF00498	0.464
LIG_FHA_1	138	144	PF00498	0.361
LIG_FHA_1	170	176	PF00498	0.444
LIG_FHA_1	227	233	PF00498	0.407
LIG_FHA_1	347	353	PF00498	0.413
LIG_FHA_1	431	437	PF00498	0.477
LIG_FHA_1	444	450	PF00498	0.302
LIG_FHA_1	484	490	PF00498	0.513
LIG_FHA_1	589	595	PF00498	0.409
LIG_FHA_2	176	182	PF00498	0.399
LIG_FHA_2	319	325	PF00498	0.490
LIG_FHA_2	386	392	PF00498	0.386
LIG_FHA_2	450	456	PF00498	0.499
LIG_FHA_2	605	611	PF00498	0.568
LIG_FHA_2	70	76	PF00498	0.507
LIG_FHA_2	80	86	PF00498	0.477
LIG_LIR_Apic_2	547	553	PF02991	0.354
LIG_LIR_Gen_1	412	422	PF02991	0.344
LIG_LIR_LC3C_4	265	270	PF02991	0.490
LIG_LIR_Nem_3	551	557	PF02991	0.403
LIG_PCNA_yPIPBox_3	252	263	PF02747	0.490
LIG_Pex14_1	243	247	PF04695	0.359
LIG_Pex14_1	554	558	PF04695	0.378
LIG_Pex14_2	550	554	PF04695	0.503
LIG_PTB_Apo_2	295	302	PF02174	0.438
LIG_PTB_Apo_2	425	432	PF02174	0.365
LIG_PTB_Phospho_1	295	301	PF10480	0.490
LIG_PTB_Phospho_1	425	431	PF10480	0.365
LIG_RPA_C_Fungi	375	387	PF08784	0.359
LIG_SH2_SRC	83	86	PF00017	0.378
LIG_SH2_STAP1	509	513	PF00017	0.409
LIG_SH2_STAT5	558	561	PF00017	0.419
LIG_SH2_STAT5	572	575	PF00017	0.276
LIG_SH2_STAT5	83	86	PF00017	0.344
LIG_SH3_3	14	20	PF00018	0.434
LIG_SH3_3	143	149	PF00018	0.471
LIG_SH3_3	40	46	PF00018	0.400
LIG_SUMO_SIM_anti_2	184	191	PF11976	0.417
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.415
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.403
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.407
LIG_SUMO_SIM_anti_2	382	391	PF11976	0.440
LIG_SUMO_SIM_par_1	184	191	PF11976	0.362
LIG_SUMO_SIM_par_1	217	223	PF11976	0.373
LIG_SUMO_SIM_par_1	229	236	PF11976	0.393
LIG_TRAF2_1	246	249	PF00917	0.490
LIG_TRAF2_1	292	295	PF00917	0.418
LIG_TRAF2_1	379	382	PF00917	0.490
LIG_TRAF2_1	453	456	PF00917	0.403
LIG_TRAF2_1	97	100	PF00917	0.365
LIG_UBA3_1	457	462	PF00899	0.490
LIG_WRC_WIRS_1	557	562	PF05994	0.490
MOD_CDK_SPxxK_3	175	182	PF00069	0.378
MOD_CK1_1	125	131	PF00069	0.490
MOD_CK1_1	169	175	PF00069	0.409
MOD_CK1_1	230	236	PF00069	0.378
MOD_CK1_1	320	326	PF00069	0.464
MOD_CK1_1	345	351	PF00069	0.350
MOD_CK1_1	371	377	PF00069	0.395
MOD_CK1_1	543	549	PF00069	0.365
MOD_CK1_1	584	590	PF00069	0.359
MOD_CK1_1	604	610	PF00069	0.264
MOD_CK2_1	175	181	PF00069	0.406
MOD_CK2_1	2	8	PF00069	0.516
MOD_CK2_1	279	285	PF00069	0.461
MOD_CK2_1	289	295	PF00069	0.408
MOD_CK2_1	385	391	PF00069	0.386
MOD_CK2_1	429	435	PF00069	0.471
MOD_CK2_1	449	455	PF00069	0.410
MOD_CK2_1	501	507	PF00069	0.428
MOD_CK2_1	543	549	PF00069	0.387
MOD_CK2_1	604	610	PF00069	0.588
MOD_CK2_1	69	75	PF00069	0.375
MOD_CK2_1	79	85	PF00069	0.330
MOD_CK2_1	94	100	PF00069	0.344
MOD_CMANNOS	328	331	PF00535	0.344
MOD_GlcNHglycan	124	127	PF01048	0.490
MOD_GlcNHglycan	285	289	PF01048	0.409
MOD_GlcNHglycan	344	347	PF01048	0.406
MOD_GlcNHglycan	4	7	PF01048	0.597
MOD_GlcNHglycan	404	407	PF01048	0.464
MOD_GlcNHglycan	57	60	PF01048	0.376
MOD_GlcNHglycan	583	586	PF01048	0.336
MOD_GlcNHglycan	75	78	PF01048	0.359
MOD_GlcNHglycan	90	93	PF01048	0.423
MOD_GSK3_1	137	144	PF00069	0.493
MOD_GSK3_1	153	160	PF00069	0.320
MOD_GSK3_1	162	169	PF00069	0.431
MOD_GSK3_1	20	27	PF00069	0.374
MOD_GSK3_1	226	233	PF00069	0.406
MOD_GSK3_1	342	349	PF00069	0.393
MOD_GSK3_1	364	371	PF00069	0.378
MOD_GSK3_1	37	44	PF00069	0.359
MOD_GSK3_1	387	394	PF00069	0.449
MOD_GSK3_1	431	438	PF00069	0.490
MOD_GSK3_1	497	504	PF00069	0.514
MOD_GSK3_1	540	547	PF00069	0.359
MOD_GSK3_1	584	591	PF00069	0.365
MOD_GSK3_1	69	76	PF00069	0.370
MOD_GSK3_1	88	95	PF00069	0.486
MOD_N-GLC_1	103	108	PF02516	0.420
MOD_N-GLC_1	227	232	PF02516	0.390
MOD_N-GLC_1	55	60	PF02516	0.409
MOD_NEK2_1	103	108	PF00069	0.316
MOD_NEK2_1	162	167	PF00069	0.392
MOD_NEK2_1	174	179	PF00069	0.392
MOD_NEK2_1	218	223	PF00069	0.436
MOD_NEK2_1	263	268	PF00069	0.490
MOD_NEK2_1	318	323	PF00069	0.440
MOD_NEK2_1	364	369	PF00069	0.344
MOD_NEK2_1	449	454	PF00069	0.490
MOD_NEK2_1	537	542	PF00069	0.368
MOD_NEK2_1	54	59	PF00069	0.346
MOD_NEK2_1	601	606	PF00069	0.480
MOD_NEK2_1	88	93	PF00069	0.409
MOD_NEK2_2	271	276	PF00069	0.365
MOD_NEK2_2	31	36	PF00069	0.434
MOD_PIKK_1	116	122	PF00454	0.346
MOD_PIKK_1	548	554	PF00454	0.406
MOD_PK_1	362	368	PF00069	0.490
MOD_PKA_1	2	8	PF00069	0.516
MOD_PKA_2	2	8	PF00069	0.625
MOD_PKA_2	31	37	PF00069	0.359
MOD_PKA_2	489	495	PF00069	0.401
MOD_PKA_2	579	585	PF00069	0.438
MOD_Plk_1	103	109	PF00069	0.455
MOD_Plk_1	279	285	PF00069	0.511
MOD_Plk_4	103	109	PF00069	0.405
MOD_Plk_4	230	236	PF00069	0.359
MOD_Plk_4	263	269	PF00069	0.518
MOD_Plk_4	334	340	PF00069	0.518
MOD_Plk_4	368	374	PF00069	0.419
MOD_ProDKin_1	153	159	PF00069	0.359
MOD_ProDKin_1	175	181	PF00069	0.359
MOD_ProDKin_1	220	226	PF00069	0.359
MOD_ProDKin_1	227	233	PF00069	0.359
MOD_ProDKin_1	250	256	PF00069	0.378
MOD_ProDKin_1	37	43	PF00069	0.409
MOD_ProDKin_1	586	592	PF00069	0.344
MOD_ProDKin_1	94	100	PF00069	0.479
MOD_SUMO_for_1	407	410	PF00179	0.465
TRG_DiLeu_BaEn_2	409	415	PF01217	0.465
TRG_DiLeu_BaEn_2	532	538	PF01217	0.409
TRG_DiLeu_BaEn_4	455	461	PF01217	0.409
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.403
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.471
TRG_ENDOCYTIC_2	247	250	PF00928	0.368
TRG_ENDOCYTIC_2	557	560	PF00928	0.419
TRG_ER_diArg_1	209	211	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E3	Leptomonas seymouri	75%	100%
A0A0N1I7U1	Leptomonas seymouri	23%	72%
A0A0S4JAG1	Bodo saltans	27%	86%
A0A0S4JRH6	Bodo saltans	27%	92%
A0A0S4JRL8	Bodo saltans	24%	78%
A0A0S4JY55	Bodo saltans	36%	100%
A0A0S4KE24	Bodo saltans	24%	76%
A0A1X0NT49	Trypanosomatidae	25%	85%
A0A1X0NT60	Trypanosomatidae	25%	92%
A0A1X0NZS6	Trypanosomatidae	51%	100%
A0A1X0P523	Trypanosomatidae	24%	83%
A0A1X0P5Y2	Trypanosomatidae	24%	79%
A0A3R7L2D0	Trypanosoma rangeli	49%	100%
A0A3S5IQT1	Trypanosoma rangeli	25%	84%
A0A422NAV0	Trypanosoma rangeli	23%	85%
A0A422NSK2	Trypanosoma rangeli	24%	93%
A4HC81	Leishmania braziliensis	22%	100%
A4HHE2	Leishmania braziliensis	91%	100%
A4I4I8	Leishmania infantum	100%	100%
B2ZGJ1	Danio rerio	24%	98%
C9ZL75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZRI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	94%
D0A627	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
E9ADY9	Leishmania major	98%	100%
E9ALU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
F1LN46	Rattus norvegicus	24%	78%
O19094	Bos taurus	26%	100%
P07668	Drosophila melanogaster	23%	87%
P11466	Rattus norvegicus	24%	100%
P13222	Sus scrofa	23%	98%
P18886	Rattus norvegicus	25%	95%
P23786	Homo sapiens	25%	95%
P28329	Homo sapiens	25%	84%
P32198	Rattus norvegicus	26%	81%
P32738	Rattus norvegicus	24%	98%
P32756	Caenorhabditis elegans	22%	100%
P32796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	94%
P43155	Homo sapiens	26%	100%
P47934	Mus musculus	25%	100%
P50416	Homo sapiens	26%	81%
P52825	Mus musculus	25%	95%
P52826	Columba livia	25%	100%
P75448	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	22%	100%
P80235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	91%
P97742	Mus musculus	25%	81%
Q00614	Candida tropicalis	23%	100%
Q03059	Mus musculus	24%	98%
Q2KJB7	Bos taurus	26%	95%
Q58DK1	Bos taurus	28%	81%
Q5U3U3	Danio rerio	26%	94%
Q60HG9	Macaca fascicularis	25%	95%
Q63704	Rattus norvegicus	28%	81%
Q68Y62	Equus caballus	26%	81%
Q6P4X5	Xenopus tropicalis	26%	95%
Q704S8	Rattus norvegicus	25%	100%
Q7ZXE1	Xenopus laevis	26%	95%
Q8BGD5	Mus musculus	25%	79%
Q8HY46	Sus scrofa	26%	81%
Q8TCG5	Homo sapiens	25%	78%
Q90YJ9	Gallus gallus	23%	98%
Q924X2	Mus musculus	28%	81%
Q92523	Homo sapiens	27%	81%
Q9DC50	Mus musculus	23%	100%
Q9UKG9	Homo sapiens	25%	100%
V5BH74	Trypanosoma cruzi	49%	100%
V5BP17	Trypanosoma cruzi	22%	92%
V5BQH8	Trypanosoma cruzi	27%	79%
V5D4R1	Trypanosoma cruzi	25%	79%
V5DBT5	Trypanosoma cruzi	24%	92%